Mangiferin salt and method of preparing the same and use thereof

A technology of mangiferin and glycoside salts, which is applied in the preparation of sugar derivatives, chemical instruments and methods, and pharmaceutical formulations, etc., can solve the problems of low bioavailability, no drugs on the market, and no organic or inorganic salts of mangiferin.

Active Publication Date: 2008-01-23
CHANGZHOU DEZE MEDICAL SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although mangiferin has a wide range of pharmacological effects, because mangiferin is almost insoluble in water, its bioavailability is low, and the route of drug administration is greatly r

Method used

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  • Mangiferin salt and method of preparing the same and use thereof
  • Mangiferin salt and method of preparing the same and use thereof
  • Mangiferin salt and method of preparing the same and use thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0029] Preparation Example 1: Preparation of Mangiferin

[0030] Take 100 kg of Anemarrhena decoction pieces and put them in a multi-functional extraction tank, add 800 liters of 80% ethanol, reflux extraction for 1.5 hours, filter out the medicinal liquid, then add 600 liters of 80% ethanol, reflux extraction for 1.5 hours, filter out the medicinal liquid, and combine the medicinal liquids , decompression will collect ethanol until there is no alcohol smell. Take an appropriate amount of medicinal solution, add pretreated D101 macroporous resin for adsorption, wash with deionized water until clear; then elute with 30% ethanol, collect the eluent, concentrate the eluent, and dry under reduced pressure to obtain the product. As detected by phase chromatography, the purity of mangiferin was 95.4%.

Embodiment 1

[0031] Embodiment 1: the preparation of mangiferin arginine salt

[0032]Weigh 42.2g (0.1mol) of mangiferin and add it to 80g dimethyl sulfoxide to dissolve it, weigh 17.4g (0.1mol) of L-arginine and add it to 20g absolute ethanol to dissolve it, and stir the arginine solution slowly Add it to the mangiferin solution, stir until the reaction is complete, add an appropriate amount of absolute ethanol to the reaction solution to produce a large amount of light yellow precipitate, filter, and dry the precipitate under reduced pressure to obtain 56.2 g of a yellow-green or yellow solid, with a yield of 94.3%.

[0033] Compound Identification:

[0034] MSm / z: 595[M-H] + , 421[MG-H] + , 387, 369, 351, 173 [Arg-H] + .

[0035] 13 CNMR (DMSO-d 6 )(δppm): 162.3(C-1), 107.8(C-2), 168.3(C-3), 93.8(C-4), 156.0(C-4a), 150.9(C-4b), 102.8(C -5), 154.2(C-6), 143.8(C-7), 108.2(C-8), 111.8(C-8a), 101.5(C-8b).179.2(C=O), 81.6(C- 1'), 73.0(C-2'), 70.8(C-3'), 70.5(C-4'), 78.1(C-5'), 61.6(C...

Embodiment 2

[0037] Embodiment 2: the preparation of mangiferin arginine salt

[0038] Weigh 42.2g (0.1mol) of mangiferin and add an appropriate amount of 60% ethanol to dissolve it, weigh 52.2g (0.3mol) of L-arginine and add it to an appropriate amount of 80% ethanol to dissolve, slowly add mangiferin to the arginine solution while stirring solution, stirred until the reaction was complete, and an appropriate amount of acetone was added to the reaction solution to produce a large amount of light yellow precipitate, filtered, and the precipitate was dried under reduced pressure to obtain 75.8 g of a yellow-green or yellow solid, with a yield of 80.3%.

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Abstract

The invention provides a mangiferin salt, in particular to a salt formed in the basic amino acid, organic amine and inorganic alkaline matter capable of being accepted by the mangiferin and medicine. The salt can solve the dissolubility, improve the pharmacological activity and be used for curing or curing auxiliary the diseases related closely to the oxidative damage. The general formula of the structure refers to the drawing, wherein, R is the basic amino acid, organic amine or inorganic alkaline metallic ion.

Description

Technical field: [0001] The invention relates to a mangiferin salt and its preparation method and application. Background technique: [0002] Mangiferin is a natural polyphenolic compound extracted from plants such as Liliaceae Anemarrhena, molecular formula: C 19 h 18 o 11 , molecular weight: 422. Its chemical structure is as follows: [0003] [0004] This ingredient can also be extracted from the leaves, fruits, and bark of mango trees and almond trees in the Anacardiaceae family, or from the Northeast Gentiana and Western Sichuan Swertia plants in the Gentianaceae family, or Guangshiwei, a plant in the Water Keelaceae family. [0005] Pharmacological studies of mangiferin have shown that it has a variety of biological activities, such as anti-oxidation, anti-tumor, antibacterial, anti-virus, hypoglycemic, anti-inflammatory, choleretic, immune regulation, etc. Among them, the antioxidant effect is considered to be the core of mangiferin. Activity, its in vitro and...

Claims

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Application Information

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IPC IPC(8): C07H17/04C07H1/08A61K31/7048A61K9/00A61P39/06
Inventor 徐广爱
Owner CHANGZHOU DEZE MEDICAL SCI CO LTD
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