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Desloratadine syrup and preparation method thereof

A technology for desloratadine and syrup, which is applied in the field of drug syrup and its preparation, and can solve problems such as complex process, difficult production, and inconvenient use

Inactive Publication Date: 2009-03-25
AVENTIS PHARMA HAINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of dry suspension has a complicated process and is difficult to produce; and the dry suspension needs to be washed with water, which is inconvenient to use, especially for children with poor applicability

Method used

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  • Desloratadine syrup and preparation method thereof
  • Desloratadine syrup and preparation method thereof
  • Desloratadine syrup and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] prescription composition

[0021]

[0022] Preparation:

[0023] (1) Add sucrose to purified water, heat to 80°C-100°C, keep warm for 0.5h, and cool to 65°C-85°C;

[0024] (2) Add EDTA-2Na, anhydrous citric acid, disodium hydrogen phosphate, sodium benzoate, sorbitol, menthol, carmine to the above solution, stir to dissolve, cool to room temperature for later use;

[0025] (3) Add the main ingredient and arginine to glycerin, stir evenly, add the solution to the syrup, stir evenly, filter and add water to the full amount. Packed into 1000 bottles.

Embodiment 2

[0027] prescription composition

[0028]

[0029] Preparation:

[0030] (1) Add sucrose to purified water, heat to 80°C-100°C, keep warm for 0.5h, and cool to 65°C-85°C;

[0031] (2) Add EDTA-2Na, anhydrous citric acid, sodium citrate, ethylparaben, sorbitol, strawberry saccharin, lemon yellow, carmine to the above solution, stir to dissolve, cool to room temperature for later use ;

[0032] (3) Add the main ingredient and arginine to glycerin, stir evenly, add the solution to the syrup, stir evenly, filter and add water to the full amount. Packed into 1000 bottles.

Embodiment 3

[0034] prescription composition

[0035]

[0036] Preparation:

[0037] (1) Add sucrose to purified water, heat to 80°C-100°C, keep warm for 0.5h, and cool to 65°C-85°C;

[0038] (2) Add α-tocopherol, phosphoric acid, disodium hydrogen phosphate, sodium benzoate, sorbitol, menthol, sunset yellow, carmine to the above solution, stir to dissolve, cool to room temperature for subsequent use;

[0039] (3) Add the main ingredient and PVP K30 to propylene glycol, stir evenly, add the solution to the syrup, stir evenly, filter and add water to the full amount. Packed into 1000 bottles.

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Abstract

The invention discloses a syrup of and the preparation method thereof. The insolubleness and instability problems of desloratadine are successfully solved through addition of cosolvent and stabilizer, and the control of pH value. The syrup of antihistamines desloratadine can facilitate the oral-taking of patients with weak swallowing capability, has good taste and good stability.

Description

technical field [0001] The invention relates to a medicine syrup and a preparation method thereof, in particular to a syrup containing desloratadine and a preparation method thereof. Background technique [0002] Desloratadine is a non-sedating long-acting tricyclic antihistamine, which is the active metabolite of loratadine. Clinically, it is mainly used for the treatment of (seasonal and non-seasonal) allergic rhinitis, chronic idiopathic urticaria, and atopic dermatitis and other diseases. It has the advantages of anti-allergic, anti-histamine, and anti-inflammatory three-in-one, and has the advantages of quick onset, strong potency, no cardiotoxicity, less drug interactions, and no food contraindications. [0003] Desloratadine is currently available in clinical dosage forms including ordinary tablets, dispersible tablets, capsules, and dry suspensions. Ordinary tablets and capsules should be swallowed with water. Because these dosage forms are relatively large, they a...

Claims

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Application Information

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IPC IPC(8): A61K31/4545A61K9/00A61P37/08A61P11/02A61P17/00
Inventor 宋扬
Owner AVENTIS PHARMA HAINAN
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