Blonanserin-containing medicinal composition and preparation method thereof

A technology of blonanserin and its composition, which is applied in the field of antipsychotic drugs and its preparation, can solve problems such as the dissolution rate of blonanserin, and achieve the effect of solving drug solubility

Inactive Publication Date: 2011-06-01
泰州万全医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to provide a pharmaceutical composition containing blonanserin and a preparation method in order to solve the problem of the dissolution rate of blonanserin

Method used

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  • Blonanserin-containing medicinal composition and preparation method thereof
  • Blonanserin-containing medicinal composition and preparation method thereof
  • Blonanserin-containing medicinal composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 2 mg blonanserin tablets

[0033]

[0034] Control the particle size of blonanserin at 3-5 μm through an air-jet mill, mix with lactose, 3 g of low-substituted hydroxypropyl cellulose, and microcrystalline cellulose PH101, then add 25 g of hydroxypropyl cellulose Solution (2%) as binder, wet granulation, and then dry the granules in a constant temperature drying oven at 50°C until the moisture is less than 5%, add 6g of low-substituted hydroxypropyl cellulose, add magnesium stearate, micro-powder silica gel , mix well, and compress into tablets.

Embodiment 2

[0036] 4mg Blonanserin Tablets

[0037]

[0038] Micronize the raw materials to 5-20 μm, mix with lactose, 7g low-substituted hydroxypropyl cellulose, and microcrystalline cellulose PH101, add 6g hydroxypropyl cellulose solution (2%) as a binder, and wet process Then dry the granules in a constant temperature drying oven at 50°C until the water content is less than 5%, add 12g of low-substituted hydroxypropyl cellulose, magnesium stearate and micro-powder silica gel, mix well, and press into tablets.

Embodiment 3

[0040] 8 mg blonanserin tablets

[0041]

[0042] Micronize the raw material to 20-40 μm, mix with lactose, 12g low-substituted hydroxypropyl cellulose, and microcrystalline cellulose PH101, add 108g hydroxypropyl cellulose solution (2%) as a binder, and wet process Then dry the granules in a constant temperature drying oven at 50°C until the water content is less than 5%, add 24g of low-substituted hydroxypropyl cellulose, magnesium stearate and micro-powder silica gel, mix well, and press into tablets.

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Abstract

The invention discloses a blonanserin-containing medicinal composition, which consists of the following components in percentage by weight: 3.3 to 20 percent of blonanserin, 60 to 85 percent of filler, 5 to 25 percent of disintegrating agent, 2 to 6 percent of adhesive, 0.25 to 5 percent of lubricant and 0.5 to 2 percent of fluidizer. The medicinal composition has the dissolution rate of over 75 percent in a dissolution medium with the pH of 4.0 to 6.0 so as to effectively solve the problem of dissolution rate of blonanserin medicaments.

Description

technical field [0001] The invention relates to an antipsychotic medicine and a preparation method thereof, in particular to a medicine composition containing blonanserin and a preparation method thereof. Background technique [0002] Schizophrenia (schizophrenia) is a common psychiatric disease, characterized by changes in basic personality, split thinking, emotion, and behavior, and incoordination between mental activities and the environment. 1.0% of the burden, the number of patients in my country has exceeded 8 million, and it is increasing year by year, which has caused a series of social problems such as suicide. [0003] Since the discovery of the antipsychotic effects of chlorpromazine in the early 1950s, schizophrenia has been dominated by drug treatment. Currently commonly used antipsychotic drugs are divided into two categories: typical and atypical according to their different receptor blocking effects: the former representative drugs are chlorpromazine and halo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61K9/20A61P25/18
Inventor 杨帆丁翔陈拥军
Owner 泰州万全医药科技有限公司
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