Blonanserin-containing medicinal composition and preparation method thereof

Abstract

The invention discloses a blonanserin-containing medicinal composition, which consists of the following components in percentage by weight: 3.3 to 20 percent of blonanserin, 60 to 85 percent of filler, 5 to 25 percent of disintegrating agent, 2 to 6 percent of adhesive, 0.25 to 5 percent of lubricant and 0.5 to 2 percent of fluidizer. The medicinal composition has the dissolution rate of over 75 percent in a dissolution medium with the pH of 4.0 to 6.0 so as to effectively solve the problem of dissolution rate of blonanserin medicaments.

Description

technical field

[0001] The invention relates to an antipsychotic medicine and a preparation method thereof, in particular to a medicine composition containing blonanserin and a preparation method thereof. Background technique

[0002] Schizophrenia (schizophrenia) is a common psychiatric disease, characterized by changes in basic personality, split thinking, emotion, and behavior, and incoordination between mental activities and the environment. 1.0% of the burden, the number of patients in my country has exceeded 8 million, and it is increasing year by year, which has caused a series of social problems such as suicide.

[0003] Since the discovery of the antipsychotic effects of chlorpromazine in the early 1950s, schizophrenia has been dominated by drug treatment. Currently commonly used antipsychotic drugs are divided into two categories: typical and atypical according to their different receptor blocking effects: the former representative drugs are chlorpromazine and halo...

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