The invention mainly relates to the technical field of innovative drug research and development, and discloses a drug spray for treating beriberi, wherein the drug spray is prepared from the following raw materials: cynodon dactylon (l.) pers, dichondra repens forst, abrus cantoniensis, hypericum japonicum thunb, artemisia capillaries, agropyron cristatum, chenopodium acuminatum, rheum franzenbachii munt, ephedra sinica stapf, fruits of elm, acer ginnala maxim, vermiculite, sepiolite, lidocaine and chlorpromazine. According to the present invention, the drug spray has the following advantages that the raw materials are rich, the generation of the drug resistance can be avoided, pathogenic bacteria can be rapidly killed, the recurrence can be avoided after the long term medication, the pain on patients can be reduced, and the drug spray does not contain alcohol so as not to harm to the skin; with a variety of the plant traditional Chinese medicine components, the antibacterial effect and the bacterial inhibition effect can be achieved, the pathogenic bacteria at the affected area can be rapidly killed, the significant itching stopping effect can be achieved 4-5 min after the spraying of the drug spray, and the generation of the drug resistance of pathogenic bacteria can be avoided; the vermiculite and the sepiolite can adsorb the color of the plant traditional Chinese medicines after the multiple boiling, such that the stain on the shoes and the socks can be avoided, and the mineral elements in the spray can be enriched so as to promote the wound healing, accelerate the ecdysis, and make the skin smooth and delicate; and lidocaine and chlorpromazine can reduce the foot sweat secretion, can reduce the growth of pathogenic bacteria, and can relieve the pain and the etching caused by ulceration.