61 results about "Chlorpromazine" patented technology

The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient chlorpromazine or a chlorpromazine analog and an antiproliferative agent simultaneously or within 14 days of each other in amounts sufficient to treat the patient.

The invention provides a kit for detecting anti-psychosis drugs in a serum and plasma by a liquid chromatography tandem mass spectrometry method. The kit comprises drug standards: amsulpiride, aripiprazole, dehydroaripiprazole, chlorpromazine, clozapine, n-desmethylclozapine, risperidone, 9-hydroxyrisperidone, quetiapine, olanzapine, ziprasidone; drug internal standard compounds: amplepiride-d5, aripiprazole-d8, chlorpromazine-d3, clozapine-d8, risperidone-d4, 9-hydroxyrisperidone-d4, quetiapine-d8, olanzapine-d8, ziprasidone-d8; drug extraction compounds: methanol solution 60% (volume ratio),acetonitrile solution 20%, isopropanol solution 10%, purified water 10%; negative plasma; and a diluent: 50% aqueous methanol solution. The kit can be used to simultaneously detect anti-psychosis drugs and active metabolites thereof, the detection time is short and the flux is large.

The present invention discloses a method of detecting chlorpromazine, and a special enzyme linked immunosorbent kit thereof. The enzyme linked immunosorbent kit comprises haptens and specific antibodies of the chlorpromazine; and the specific antibodies are polyclonal antibodies or monoclonal antibodies of the chlorpromazine. The kit adopts the high specificity monoclonal antibodies of the chlorpromazine, which guarantees the reliability of detection results, and the experimental results show that the kit has the characteristics of high specificity, high sensitivity, high precision, high accuracy and the like; and the main reagents of the kit all adopt the form of working liquid, the operation is convenient, and the cost is low. The operation of the method which adopts the kit to detect the chlorpromazine is simple, the operation has low requirements for the pretreatment of the sample, and the method can be used for simultaneously and rapidly detecting samples in bulk. Therefore, the method which adopts the enzyme linked immunosorbent kit for detection can perform on-site monitoring and is suitable for qualitative and quantitative screening of the samples in bulk.

The invention discloses an immune colloidal gold detect card of chlorpromazine, and a preparation method thereof, and belongs to the technical field of animal-derived food veterinary drug residue detection. A test strip of an outer housing of the immune colloidal gold detect card is composed of a PVC slab, a sample pad, a colloidal gold conjugate pad, a coating membrane, and an absorbent pad; a colloidal gold membrane is a glass cellulose membrane containing chlorpromazine monoclonal antibodies; the coating membrane is a nitrocellulose memebrane, and is provided with a T line and a C line; the T line contains chlorpromazine protein conjugates via coating; and the C line contains goat anti-mouse IgG antibodies via coating. The immune colloidal gold detect card is used for rapid detection of chlorpromazine effectively, and is convenient and rapid for using; and detection results are accurate.

The invention relates to a device for detecting chlorpromazine and diazepam class medicines, in particular to a chlorpromazine-diazepam bigeminy test card. The chlorpromazine-diazepam bigeminy test card comprises a casing and a test paper strip. The test paper strip comprises a base plate, and a sample absorption cushion, a colloidal gold label cushion, a detection reaction area and an absorption cushion which are adhered in order on the base plate, wherein the colloidal gold label cushion contains a colloidal gold label of a chlorpromazine antibody and a diazepam antibody, the detection reaction area at least comprises a quality control line and two detection lines, and the two detection lines are respectively coated with coupling compound formed by the chlorpromazine diazepam coupled with carrier protein. The chlorpromazine-diazepam bigeminy test card has the advantages of capability of simultaneously detecting the chlorpromazine and diazepam in urine or fodder, animal tissues, meat and liver, easy preparation, detection cost saved, convenient use, quick detection, high sensitivity and correct results.

The invention relates to an ELISA Kit and a detection method for detecting chlorpromazine in the veterinary medicine residual detection analysis technical field. The chlorpromazine ELISA Kit comprises a chlorpromazine standard solution, a developer, a concentrated cleaning solution, a termination solution and a sample diluent. In addition, the chlorpromazine ELISA Kit also comprises a chlorpromazine specificity antibody, an enzyme label plate and an enzyme label, wherein the enzyme label is an enzyme labeling chlorpromazine antigen. The ELISA Kit for detecting chlorpromazine provided by the invention has low requirements on the preliminary treatment of a sample, a simple sample preliminary treatment process and a capability of detecting a large number of samples quickly. The ELISA Kit for detecting chlorpromazine which is characterized in high specificity, high sensitivity, high precision, high accuracy, etc. will contribute much to the detection of chlorpromazine residual.

The invention discloses a protein chip for detecting multiple veterinary drug residues and a kit thereof. The protein chip comprises a substrate and dot coatings of veterinary drug antibody, wherein the dot coatings are distributed in an array type, the substrate is a glass substrate or a membrane substrate; and the dot coatings of the veterinary drug antibody refer to eight types of veterinary drug antibodies, i.e. an anti-chloramphenicol antibody, an anti-chlorpromazine antibody, an anti-colchicin antibody, an anti-dapsone antibody, an anti-stilboestrol antibody, an anti-dimetridazole antibody, an anti-furazolidone antibody and an anti-metronidazole antibody which are uniformly distributed and in dot lattice on the substrate. The protein chip can obtain the reaction results with multiple indexes by only one-step reaction and can be suitable for simultaneously detecting eight veterinary drugs, i.e. chloramphenicol, chlorpromazine, colchicin, dapsone, stilboestrol, dimetridazole, furazolidone and metronidazole which are contained in a sample, thereby ensuring the safety and the sanitation of a large quantity of meat products.

The invention provides a kit for detecting chlorpromazine (CPZ) and a detecting method thereof, belonging to the technical field of time resolved fluoroimmunoassay (TRFIA) and used for detecting the content of CPZ in meat, fish and other animal derived foods. The kit prepared by the method is used for detecting CPZ by using TRFIA, and the detection is based on a labeled immunoreaction. A microporous plate is coated with CPZ-OVA (ovalbumin), a CPZ standard or sample is added, and a CPZ antibody is added; free CPZ competes for the CPZ antibody with the CPZ-OVA on the microporous plate, the CPZ antibody which is not connected is washed off and removed, Eu3+- antiMIgG is added, and the Eu3+- antiMIgG which is not connected is washed off and removed after the labeled immunoreaction; after an enhancing solution is added, the fluorescence intensity cps of the enhancing solution is detected by using a time-resolved fluorescence spectrofluorometer, the fluorescence intensity is in inverse proportion to the concentration of CPZ in the sample; and the content of CPZ in the detected sample can be determined in comparison with a standard curve. The kit for detecting CPZ provided by the invention has the advantages of simple structure, convenience in use, low cost and high sensitivity.

The invention relates to a method using a colloidal gold immuno chromatographic assay to test chlorpromazine in the technical field of biological engineering. CPZ hapten is connected with aminobenzoic acid through diazo reaction, and the CPZ hapten and KLH and BSA amidogens form peptide linkages by carboxyl on benzene rings so as to form the CPZ conjugates of CPZ-KLH and CPZ-BSA. The antigen CPZ-KLH is used for preparing polyclonal antibodies, the antigen CPZ-BSA is used for an indirect Elisa adsorption assay for testing polyclonal antibody titers, the polyclonal antibodies are labeled by the colloidal gold used as a tracer label, the CPZ-BSA antigen is immobilized on a test line on a membrane, and anti-rabbit polyclonal antibodies are immobilized on a control line; and the gold-labeled antibody, the corresponding antigens and the antibodies are specifically bound to perform the operation of colour development through isolation, and negative and positive results are displayed by the colour development of the test and the control lines.The invention can directly test chlorpromazine micromolecules in samples and has the advantages of fast test speed and short required time.

The invention discloses a chlorpromazine derivative for detecting the content of chlorpromazine in a human body biological sample and a preparation method of the chlorpromazine derivative. A series ofanti-chlorpromazine specific antibodies developed by utilizing the novel chlorpromazine derivative disclosed by the invention can be used for preparing various chlorpromazine immunological detectionreagents with high sensitivity, strong specificity and good detection effect. The invention also provides preparation methods and corresponding using methods of three chlorpromazine immunoassay reagents. The three chlorpromazine immunoassay methods provided by the invention are convenient to operate, rapid in detection, accurate in result, high in sensitivity and strong in specificity, and can beused for quantitatively detecting of the content of chlorpromazine in human blood samples. The defects of complex operation, low automation degree and the like of a chlorpromazine detection method inthe prior art are avoided, and clinical individualized reasonable medication can be effectively guided.

The invention belongs to the technical field of organic synthesis and provides a polymerization inhibitor for acrylic acid monomer refining. The polymerization inhibitor comprises, by mass, 94-95% of hydroquinone, 4.0-5.0% of chlorpromazine and 1.0-2.0% of promethazine. Through use of two common chemical products in the original polymerization inhibitor, the modified polymerization inhibitor does not need change of original reaction conditions of the production device. The novel polymerization inhibitor can be prepared through simple and easy processes. The modified polymerization inhibitor can substantially prolong a rectifying tower continuous production period to 200 days in acrylic acid monomer production.

The invention relates to application of chloroquine and chlorpromazine to preparation of drugs for treating and preventing lung infection and injuries, in particular to application of the chloroquine, the chlorpromazine, derivatives of the chloroquine and the chlorpromazine, mixture of the chloroquine and the chlorpromazine, and drug compositions containing the chloroquine or the chlorpromazine to the preparation of drugs for treating and / preventing lung infection and injuries caused by influenza viruses to mammals including human.

The invention discloses a method for preparing high morphine hydrochloride I. The method comprises the following steps of: taking ethanol amine as a starting material and generating N-benzyl ethanol amine III through a condensation reaction with phenyl aldehyde; reacting the obtained compound III with chlorpromazine chloride or bromidepropionyl bromide to generate homologous N-halogenated propionyl group-N-benzyl ethanol amine IV; generating a seven-membered ring intermediate body V through performing a ring closing reaction on the obtained compound IV; converting the obtained compound V under a reducing condition to a compound VI; and generating a target compound I from the obtained compound VI under a oxidation-reduction condition. The method provided by the invention has the advantagesof high overall yield, convenience for purifying the intermediate body, high purity of the target product and suitability for industrialized production and the like.

The invention relates to an application of 15 active pharmaceutical ingredients in coronavirus resistance. Specifically, the invention relates to bosutinib, hydroxypiperazine chlorpromazine, iodoamine hydrochloride, flupentixol hydrochloride, nortiline hydrochloride, isobutrazine tartrate, dapoxetine, chlorprothiene hydrochloride, protiline hydrochloride, promethazine hydrochloride, gefitinib, solifenacin succinate and azelastine hydrochloride. The clomastine fumarate and the toremifene or the composition of the clomastine fumarate and the toremifene is used as an inhibitor for inhibiting the activity of coronavirus spike protein; and / or (b) the invention relates to an application of a medicine for treating and / or preventing and relieving related diseases caused by coronavirus infection.

The invention relates to a new synthesis method of 5- hydroxide radical-1-indenone, which mainly solves the technical problems that reaction conditions are demanding, post-processing is difficult and raw materials are not available of the existing synthesis method. The invention utilizes phenol to be reacted with 3-chlorpromazine chloride to obtain corresponding 3- chloride acid ester of phenol, closing ring to obtain the 5- hydroxide radical-1-indenone under the action of trifluoroacetic acid. The reaction formula is shown as follow. The obtained 5- hydroxide radical-1-indenone is used for medicinal chemistry and organic synthesis.

The invention provides a time-resolved immunoassay kit for detecting chlorpromazine residues and a detection method thereof. The kit of the invention comprises an ELISA (enzyme-linked immunosorbent assay) coated with chlorpromazine antigen, lanthanide element-labeled goat anti-rabbit or goat anti-mouse antibodies, anti-chlorpromazine antibodies, and the like. The invention also discloses a method for detecting chlorpromazine residues using the above kit. The kit for detecting chlorpromazine residues provided by the invention adopts indirect competitive time-resolved immunoassay technology, has high sensitivity and good stability, greatly simplifies operation procedures and reaction time, reduces errors due to complex operation, reduces cost, is suitable for screening of a large number of samples, and has very important operation significance.

The invention mainly relates to the technical field of innovative drug research and development, and discloses a drug spray for treating beriberi, wherein the drug spray is prepared from the following raw materials: cynodon dactylon (l.) pers, dichondra repens forst, abrus cantoniensis, hypericum japonicum thunb, artemisia capillaries, agropyron cristatum, chenopodium acuminatum, rheum franzenbachii munt, ephedra sinica stapf, fruits of elm, acer ginnala maxim, vermiculite, sepiolite, lidocaine and chlorpromazine. According to the present invention, the drug spray has the following advantages that the raw materials are rich, the generation of the drug resistance can be avoided, pathogenic bacteria can be rapidly killed, the recurrence can be avoided after the long term medication, the pain on patients can be reduced, and the drug spray does not contain alcohol so as not to harm to the skin; with a variety of the plant traditional Chinese medicine components, the antibacterial effect and the bacterial inhibition effect can be achieved, the pathogenic bacteria at the affected area can be rapidly killed, the significant itching stopping effect can be achieved 4-5 min after the spraying of the drug spray, and the generation of the drug resistance of pathogenic bacteria can be avoided; the vermiculite and the sepiolite can adsorb the color of the plant traditional Chinese medicines after the multiple boiling, such that the stain on the shoes and the socks can be avoided, and the mineral elements in the spray can be enriched so as to promote the wound healing, accelerate the ecdysis, and make the skin smooth and delicate; and lidocaine and chlorpromazine can reduce the foot sweat secretion, can reduce the growth of pathogenic bacteria, and can relieve the pain and the etching caused by ulceration.

The invention relates to a method for detecting urine metabolites in the technical field of bioengineering, in particular to a method for detecting trimethyl tin chloride and chlorpromazine in the human urine, characterized in that the method comprises the following steps: firstly, centrifuging and storing the collected urine; secondly, taking the urine from the step 1, adding sodium hydroxide, sodium chloride, and ethyl acetate for spiral, centrifugation and extraction; thirdly, aspirating the organic phase, adding anhydrous sodium sulphate for water removal, and concentrating the organic phase by nitrogen at the normal temperature and pressure; and step 4, taking the concentrated liquid from the step 3 for the combined detection of gas chromatography and mass spectrum. The invention is a simple, fast, result-reliable, high-automation, easy-for-industrial application method for detecting trimethyl tin chloride and chlorpromazine in the human urine.

The invention belongs to the technical field of food safety, and particularly relates to a pretreatment method for chlorpromazine detection in an animal product. The pretreatment method disclosed by the invention comprises the following operations: weighing of a to-be-detected sample, extraction, cyclotron oscillation, centrifugation, solid-phase extraction and the like, wherein the used apparatus comprises a centrifugal machine, rotary evaporation and solid-phase extraction devices and the like. A sample solution prepared by using the pretreatment method can be directly detected by virtue of a gas chromatography-mass spectrometry method. Compared with an existing method, the pretreatment method has the advantages of being high in operation accuracy, high in repeatability, high in sensitivity and the like, has strong operability, is expected to be popularized and applied on a large scale in the industries such as agriculture, quality inspection departments, and entry and exit inspection and quarantine, and has significant economic benefits. According to the pretreatment method, whether chlorpromazine is contained in the animal product can be accurately detected; and the detected animal product is safe to eat and accords with the requirements of the national standard in China.

The present invention relates to a magnetic particle chemiluminescence kit for detecting chlorpromazine. The kit comprises a luminous marker, a fluorescein marker, a standard substance, a quality control substance and a separation reagent, wherein the luminous marker is isoluminol luminous marker labeled chlorpromazine hapten, the fluorescein marker is fluorescein labeled chlorpromazine monoclonal antibody or fluorescein derivative labeled chlorpromazine monoclonal antibody, and the separation reagent is sheep anti-FITC monoclonal antibody coated paramagnetic nanometer microbeads. The present invention further relates to a method for detecting chlorpromazine in foods of animal origin by using the kit, wherein the method provides characteristics of high sensitivity, high specificity and rapid detection for chlorpromazine detection.

The invention relates to the technical field of biomedical treatment and provides a method for detecting the chlorpromazine content of blood through high performance liquid chromatography. The method comprises the steps of preparing 1mug / ml of a chlorpromazine standard solution, 1mug / ml of a diazepam internal standard solution, a blank sample, a normal human blood sample and a patient blood sample; putting into a chromatographic instrument to draw chromatograms, and judging whether the blood of a patient contains chlorpromazine according to the chromatograms; then drawing a chlorpromazine standard curve according to the chromatograms, comparing a chlorpromazine peak value in the chromatogram of the patient blood sample, a peak value of the diazepam internal standard solution and the chlorpromazine standard curve, and calculating the sodium valproate content of the blood of the patient. According to the method, the problems that the chromatograms contain multiple stray peaks, the sensitivity is low, the precision is low, the cost is high, the linear range of the drawn chlorpromazine standard curve is small, and peroxide often affects the stable extraction of the chlorpromazine are effectively solved.

The invention mainly relates to the field of planting and discloses a cotton seed seed-dressing agent. The cotton seed seed-dressing agent is prepared from the following raw materials: evolvulus alsinoides, deinanthe caerulca, meconopsis, delphinium, phlomis umbrosa, lomatogonium carinthiacum, swertia pseudochinensis, elephantopus scaber, hawkweed, lobelia sessilifolia, lactobacillus plantarum, corn extracts, curcuma aromatica extracts and chlorpromazine; the fragrance is strong, the antibacterial rate reaches 78 percent, the price is low and the economic income is increased by 7.9 percent; the cotton seed seed-dressing agent contains nutrition and also contains antibacterial components, so the stress resistance of cotton is enhanced, the germination rate of cotton seeds is increased by 89 percent and the survival rate reaches 92 percent; the cotton seed seed-dressing agent are prepared by extracting various plants, is safe and non-toxic, is harmless to human bodies and livestock during seed dressing, protects the environment and prevents diseases and pests from generating medicine resistance; the traditional Chinese medicines are fermented for two times and then are extracted for two times, so the extraction rate of the effective components is increased and is up to 53.7 percent, the utilization rate of the traditional Chinese medicines is increased, antibacterial substances are increased and the antibacterial effect is enhanced; and the chlorpromazine is added into the seed-dressing agent, so the antibacterial effect is remarkably enhanced and the application approaches of the chlorpromazine are increased.

Disclosed is an oral antidiarrheal powder for treating diarrhea occurring on infants, which is composed by the method that 2.5 portions to 3.12 portions of indomethacin, 1 portion to 1.25 portions of anisodamine, 2.5 portions to 3.12 portions of chlorpromazine and 992.51 portions to 994 portions of glucose powder are well mixed to reach enough amount together with the glucose powder with the equivalently increasing method, and are split charged in each packet for 1000 mg. Based on the modern medical theories, the invention is a compound oral administration preparation, which has the advantages of scientific and reasonable composing prescriptions,stable formulation,convenient using in clinic, definite pharmacological effects, fast symptom controlling, short course of treatment, little side-effect, sweet taste, small taken dosage, convenience and safety, and thus the invention is a safe and effective auxiliary therapy reagent for treating various diarrheas occurring on infants, particularly the diarrheas in spring and autumn. With low price, fast effect, short treatment cycle and good therapeutic effect whether for the infectious diarrhea or the non-infectious diarrhea, the invention is an effective preparation for treating diarrhea in clinic.

The invention discloses a specific monoclonal antibody for detecting various promethazine drugs such as anti-chlorpromazine, anti-promazine, anti-perphenazine drugs and an enzyme linked immunosorbent assay and kit for detecting the promethazine drugs. The monoclonal antibody disclosed by the invention is secreted from a hybridoma 3A5 with the preservation number of CCTCC NO: 201354. Compared with the prior art, the monoclonal antibody disclosed by the invention can be used for identifying various promethazine drugs simultaneously. The enzyme linked immunosorbent assay and kit disclosed by the invention have the advantages of being high in detection efficiency and sensitivity, good in precision and accuracy and the like.

The invention discloses a preparation method of a compound semen ziziphi spinosae nerve-soothing drink, relates to the technical field of preparation of compound semen ziziphi spinosae nerve-soothing drinks, and particularly relates to the preparation method of the compound semen ziziphi spinosae nerve-soothing drink. The compound semen ziziphi spinosae nerve-soothing drink is prepared from the following traditional Chinese medicine raw materials in parts by weight: 25 to 35 parts of semen ziziphi spinosae, 8 to 14 parts of lily bulbs, 6 to 12 parts of longan aril, 3 to 9 parts of Chinese yams, 3 to 9 parts of poria, 1 to 5 parts of lotus plumule, 200 to 300 parts of drinking water and 6 to 12 parts of sodium benzoate. In the preparation method of the compound semen ziziphi spinosae nerve-soothing drink, the semen ziziphi spinosae is sour in taste, rich in vitamin C and capable of astringing, so that the compound semen ziziphi spinosae nerve-soothing drink has a very good effect on people who often sweat or have parched mouths and scorched tongues and often take the drink; the semen ziziphi spinosae has the effects of tonifying liver and kidney and tranquilizing mind by nourishing heart; the semen ziziphi spinosae also has the effects of improving myocardial ischemia, and the semen ziziphi spinosae total saponins have the effects of protecting myocardial injury caused by oxygen deficit, sugar deficit and chlorpromazine.

The invention mainly relates to the field of planting, and discloses a seed dressing agent for corn seeds. The seed dressing agent is prepared from the following raw materials: sticktight, lindera communis, entire meconopsis, delphinium grandiflorum, potentilla discolor, lomatogonium carinthiacum, paris rhizome, common sage herb, hawkweed, milfoil, bacillus subtilis, a corn extract, a spiderflower extract and chlorpromazine. The seed dressing agent is rich in fragrance, the antibacterial rate reaches 79%, the price is low, and the economic income is increased by 8.7%; the seed dressing agent not only contains nutrients, but also contains antibacterial components to enhance cotton stress resistance, and enables the germination rate of the corn seeds to be improved by 100% and the survival rate to reach 97%; by virtue of extraction with various plants, the seed dressing agent is safe and nontoxic, is harmless to a human body, livestock and poultry, is environmentally friendly, and cannot enable insects to generate drug resistance; traditional Chinese medicines are fermented twice and then extracted twice to improve the extraction rate (reaching 53.3%) of active ingredients, so that the utilization ratio of the traditional Chinese medicines is increased, and the antibacterial effect is enhanced; and chlorpromazine is added into the seed dressing agent, the antibacterial effect after seed dressing of the corn seeds is obviously enhanced, and an application way of the chlorpromazine is increased.

The invention discloses a Chinese medicinal composition for antagonizing side effects caused by a chlorpromazine and a preparation method thereof. Bulk pharmaceuticals of the Chinese medicinal composition comprise gypsum, wine-treated rhubarb, unprocessed rehmannia root, figwort root, dwarf lilyturf root, suberect spatholobus stem and the like. The preparation method comprises the following stepsof: extracting gypsum with water and adding other bulk pharmaceuticals for performing water extraction; and purifying the extract with ethanol at a certain concentration, and the like. A composition preparation (gypsum-rhubarb hear clearing oral liquid) disclosed by the invention has a definite curative effect on the aspect of antagonizing side effects caused by the chlorpromazine.

The invention belongs to the technical field of medicine detection, and particularly discloses a biological analysis method for clinically researching the concentration of chlorpromazine and metabolite in a plasma sample, and the concentration of chlorpromazine and metabolite 7-hydroxy chlorpromazine in human plasma is measured by adopting an LC-MS / MS method. Methanol protein precipitation is adopted to confirm that isotope chlorpromazine-d6 / 7-hydroxy chlorpromazine-d6 is the first choice as an internal standard, a problem of many plasma matrix interference is solved, the sensitivity is high, the result is accurate and reliable, the matrix effect, the hyperlipidemia matrix effect and the hemolysis matrix effect are not interfered, the accuracy and precision are high, the dosage is small, and the method can be used for clinical large-batch sample analysis.