10 results about "Chlorpromazine" patented technology

The invention discloses a chlorpromazine-d6 compound as well as hydrochloride, a preparation method and application thereof, and belongs to the technical field of organic synthesis and analysis detection, the chlorpromazine-d6 compound is 3-(2-chloro-10-phenothiazinyl)-N, N-bis (methyl-d3)-1-propylamine, and the preparation method comprises the following steps: taking 2-chlorophenothiazine as a raw material, adding a catalyst, and reacting at the temperature of 60-80 DEG C for 1-2 hours to obtain the chlorpromazine-d6 compound. Carrying out aza-Michael addition and reductive amination reaction to finally obtain chlorpromazine-d6; the obtained chlorpromazine-d6 is subjected to hydrochloric acid acidification, such that chlorpromazine-d6 hydrochloride is obtained; the invention provides a novel deuterated internal standard substance for analysis and detection. In addition, the invention provides a new process for preparing chlorpromazine-d6 and hydrochloride thereof with proprietary intellectual property rights, the preparation method is novel, and has the advantages of simple operation, mild reaction conditions, short process route, high efficiency, low cost, environmental protection and the like; the obtained chlorpromazine-d6 and the hydrochloride thereof have the advantages of high chemical purity, high deuteration rate, high deuterium atom stability and the like.

The application provides an anti-chlorpromazine monoclonal antibody and application and product thereof, and relates to the technical field of biology.The anti-chlorpromazine monoclonal antibody provided by the application has a variable region, which comprises a complementarity determining region CDR1-VH with an amino acid sequence as shown in SEQ ID NO.1, a complementarity determining region CDR2-VH with an amino acid sequence as shown in SEQ ID NO.2, a complementarity determining region CDR3-VH with an amino acid sequence as shown in SEQ ID NO.3, a complementarity determining region CDR1-VL with an amino acid sequence as shown in SEQ ID NO.4, a complementarity determining region CDR2-VL with an amino acid sequence as shown in SEQ ID NO.5 and a complementarity determining region CDR3-VL with an amino acid sequence as shown in SEQ ID NO.6.The antibody has good specific binding capacity for chlorpromazine.

The application relates to a synthesis method of a phenothiazine derivative, and belongs to the technical field of synthesis in organic chemistry. A diaryl iodonium salt and N-(2-mercapto phenyl)-4-methyl benzene sulfonamide are used as starting materials, and chlorpromazine and perphenazine are obtained through a plurality of steps of substitution reaction, reduction reaction, addition reaction and deprotection reaction. In the application, the reaction raw materials are easy to obtain, the yield is high, and chlorpromazine and perphenazine can be successfully obtained.

The invention discloses a magnetic reduced graphene oxide / hydrophobized gold nanoparticle composite material as well as a preparation method and application thereof in chlorpromazine analysis, and belongs to the technical field of detection and analysis. The magnetic reduced graphene oxide / hydrophobized gold nanoparticle composite material comprises reduced graphene oxide, Fe3O4 particles are loaded on nanosheets of the reduced graphene oxide to form magnetic reduced graphene oxide, gold nanoparticles are modified on the nanosheets of the magnetic reduced graphene oxide, and the Fe3O4 particles are loaded on the nanosheets of the magnetic reduced graphene oxide to form the magnetic reduced graphene oxide / hydrophobized gold nanoparticle composite material. The gold nanoparticles are grafted with n-octadecanethiol through gold-sulfur bonds. The composite material disclosed by the invention has excellent magnetism, selective adsorption performance on chlorpromazine, conductivity and catalytic activity, and when the composite material is used as an adsorbent for detecting chlorpromazine in animal-derived food by a magnetic solid-phase extraction-electrochemical detection combined technology, the composite material has good anti-interference performance, accuracy and stability.

The invention relates to the field of food safety detection, in particular to a preparation method of a carbon cloth electrode for detecting chlorpromazine. Comprising the following steps: performing surface cleaning and drying on carbon cloth to obtain pretreated carbon cloth; the pretreated carbon cloth is put into a plasma cleaning machine for activating treatment, and activated carbon cloth is obtained; cutting the activated carbon cloth, and packaging the cut carbon cloth to obtain the carbon cloth electrode for detecting chlorpromazine. According to the preparation method, the raw material cost is low, only oxygen is needed as the raw material in the plasma reaction process, other reactants do not need to be added, activation of the carbon cloth can be achieved, the electrochemical detection performance of the carbon cloth is improved, the technology is simple, the requirement for equipment is not high, the preparation cost can be effectively reduced, the production efficiency is improved, and batch manufacturing is facilitated.

The invention discloses an euglena gracilis mutant strain with high protein yield and application thereof. According to the invention, an ARTP mutation breeding technology is combined with a chemical stress agent to mutate and screen euglena gracilis, and results show that under the condition that pyruvic acid is respectively combined with chlorpromazine hydrochloride, the fatality rate is stabilized at 93-94%, forward mutant strains with remarkable high-protein characters and stable physiological status can be more efficiently enriched, and the yield of the euglena gracilis is increased. The euglena gracilis mutant strain E3 has the advantages that the euglena gracilis mutant strain E3 can be directionally bred under the conditions, the protein content of the euglena gracilis mutant strain E3 is as high as 70% and is 43% higher than that of an original strain, the character of the euglena gracilis mutant strain E3 is stable in subculture, and the microbial preservation number of the euglena gracilis mutant strain E3 is CGMCC No.46624. The euglena gracilis mutant strain with high protein yield has application prospects in the aspects of preparing high-protein feed as a feed additive, preparing high-protein functional health food or high-protein cosmetics and the like.

The utility model relates to the technical field of sulfachlorpyridazine sodium production devices, and provides an intelligent centrifugal machine for sulfachlorpyridazine sodium production, which comprises a base, and a support square rod is fixedly mounted in the middle of the top end of the base; firstly, a worker can place a test tube containing medicine in a placement box, then the test tube is clamped and fixed through a clamping plate, then a second motor can be started while a first motor arranged through a control panel is started to rotate at a low speed, and a linkage plate moves to a designated position while a supporting plate is driven to rotate; and along with rotation of a supporting plate, a rotationally-installed containing box makes intermittent contact with a rubber roller, so that the effect of promoting mixing of the medicine can be achieved, when centrifugal machining needs to be conducted, a second motor can be started to rotate reversely, a linkage plate descends, then a first motor is started to rotate at a high speed, and then centrifugal machining is conducted on the medicine. And the production efficiency of the sulfachlorpyridazine sodium is improved to a certain extent.

1. Name of the product in this design: Packaging Kit (Chlorpromazine and Stomach Capsules). 2. Purpose of this design: For the outer packaging of the product. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the key design points: Design 1 3D view. 5. Other situations requiring explanation: Other explanation: Kit 1 is named as a packaging box, and Kit 2 is named as a packaging bottle.

The application provides a high-sensitivity detection method for multi-residues of veterinary drugs in pig urine, and belongs to the technical field of detection of veterinary drug residues. The application first performs enzymatic treatment on the sample to be detected, thereby improving the detection sensitivity of salbutamol and ractopamine; then performs acid hydrolysis and derivatization treatment on the sample to be detected, thereby improving the reversed-phase chromatographic retention performance and mass spectrometry ionization efficiency of nitrofurans in the compound to be detected, improving the sensitivity, improving the polarity of the compound to be detected, thereby improving the chromatographic separation effect, effectively separating the interfering substances in the matrix, improving the anti-interference ability of the detected substance, and indirectly improving the detection sensitivity; clenbuterol, metronidazole, dimetridazole, olaquindox, chlorpromazine and chloramphenicol are mainly in free state, and are not affected by enzymatic and acid hydrolysis and derivatization during detection, can be detected together with the above-mentioned compounds to be detected, and the mass spectrometry derivatization and sensitivity detection of multi-residues of cross-class veterinary drugs are realized.

The invention provides a method for improving vibrio splendidus infection resistance of stichopus japonicus, which is a method for preventing and treating stichopus japonicus diseases caused by vibrio splendidus by inhibiting pathogenesis related to vibrio splendidus outer membrane vesicles. The composition capable of improving the vibrio splendidus infection resistance of the stichopus japonicus comprises chlorpromazine and nystatin. The composition provided by the invention has no obvious toxicity to coelomic cells of the stichopus japonicus, and can inhibit endocytosis of OMVs to the maximum extent, so that the optimal prevention and control effect is realized. After the OMVs are treated by chlorpromazine and nystatin, the endocytosis efficiency of the OMVs is reduced by more than 50%.