7 results about "Chlorpromazine" patented technology

The application provides an anti-chlorpromazine monoclonal antibody and application and product thereof, and relates to the technical field of biology.The anti-chlorpromazine monoclonal antibody provided by the application has a variable region, which comprises a complementarity determining region CDR1-VH with an amino acid sequence as shown in SEQ ID NO.1, a complementarity determining region CDR2-VH with an amino acid sequence as shown in SEQ ID NO.2, a complementarity determining region CDR3-VH with an amino acid sequence as shown in SEQ ID NO.3, a complementarity determining region CDR1-VL with an amino acid sequence as shown in SEQ ID NO.4, a complementarity determining region CDR2-VL with an amino acid sequence as shown in SEQ ID NO.5 and a complementarity determining region CDR3-VL with an amino acid sequence as shown in SEQ ID NO.6.The antibody has good specific binding capacity for chlorpromazine.

The application relates to a synthesis method of a phenothiazine derivative, and belongs to the technical field of synthesis in organic chemistry. A diaryl iodonium salt and N-(2-mercapto phenyl)-4-methyl benzene sulfonamide are used as starting materials, and chlorpromazine and perphenazine are obtained through a plurality of steps of substitution reaction, reduction reaction, addition reaction and deprotection reaction. In the application, the reaction raw materials are easy to obtain, the yield is high, and chlorpromazine and perphenazine can be successfully obtained.

The invention discloses a magnetic reduced graphene oxide / hydrophobized gold nanoparticle composite material as well as a preparation method and application thereof in chlorpromazine analysis, and belongs to the technical field of detection and analysis. The magnetic reduced graphene oxide / hydrophobized gold nanoparticle composite material comprises reduced graphene oxide, Fe3O4 particles are loaded on nanosheets of the reduced graphene oxide to form magnetic reduced graphene oxide, gold nanoparticles are modified on the nanosheets of the magnetic reduced graphene oxide, and the Fe3O4 particles are loaded on the nanosheets of the magnetic reduced graphene oxide to form the magnetic reduced graphene oxide / hydrophobized gold nanoparticle composite material. The gold nanoparticles are grafted with n-octadecanethiol through gold-sulfur bonds. The composite material disclosed by the invention has excellent magnetism, selective adsorption performance on chlorpromazine, conductivity and catalytic activity, and when the composite material is used as an adsorbent for detecting chlorpromazine in animal-derived food by a magnetic solid-phase extraction-electrochemical detection combined technology, the composite material has good anti-interference performance, accuracy and stability.

The invention discloses an euglena gracilis mutant strain with high protein yield and application thereof. According to the invention, an ARTP mutation breeding technology is combined with a chemical stress agent to mutate and screen euglena gracilis, and results show that under the condition that pyruvic acid is respectively combined with chlorpromazine hydrochloride, the fatality rate is stabilized at 93-94%, forward mutant strains with remarkable high-protein characters and stable physiological status can be more efficiently enriched, and the yield of the euglena gracilis is increased. The euglena gracilis mutant strain E3 has the advantages that the euglena gracilis mutant strain E3 can be directionally bred under the conditions, the protein content of the euglena gracilis mutant strain E3 is as high as 70% and is 43% higher than that of an original strain, the character of the euglena gracilis mutant strain E3 is stable in subculture, and the microbial preservation number of the euglena gracilis mutant strain E3 is CGMCC No.46624. The euglena gracilis mutant strain with high protein yield has application prospects in the aspects of preparing high-protein feed as a feed additive, preparing high-protein functional health food or high-protein cosmetics and the like.

The utility model relates to the technical field of sulfachlorpyridazine sodium production devices, and provides an intelligent centrifugal machine for sulfachlorpyridazine sodium production, which comprises a base, and a support square rod is fixedly mounted in the middle of the top end of the base; firstly, a worker can place a test tube containing medicine in a placement box, then the test tube is clamped and fixed through a clamping plate, then a second motor can be started while a first motor arranged through a control panel is started to rotate at a low speed, and a linkage plate moves to a designated position while a supporting plate is driven to rotate; and along with rotation of a supporting plate, a rotationally-installed containing box makes intermittent contact with a rubber roller, so that the effect of promoting mixing of the medicine can be achieved, when centrifugal machining needs to be conducted, a second motor can be started to rotate reversely, a linkage plate descends, then a first motor is started to rotate at a high speed, and then centrifugal machining is conducted on the medicine. And the production efficiency of the sulfachlorpyridazine sodium is improved to a certain extent.

1. Name of the product in this design: Packaging Kit (Chlorpromazine and Stomach Capsules). 2. Purpose of this design: For the outer packaging of the product. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the key design points: Design 1 3D view. 5. Other situations requiring explanation: Other explanation: Kit 1 is named as a packaging box, and Kit 2 is named as a packaging bottle.

The invention provides a method for improving vibrio splendidus infection resistance of stichopus japonicus, which is a method for preventing and treating stichopus japonicus diseases caused by vibrio splendidus by inhibiting pathogenesis related to vibrio splendidus outer membrane vesicles. The composition capable of improving the vibrio splendidus infection resistance of the stichopus japonicus comprises chlorpromazine and nystatin. The composition provided by the invention has no obvious toxicity to coelomic cells of the stichopus japonicus, and can inhibit endocytosis of OMVs to the maximum extent, so that the optimal prevention and control effect is realized. After the OMVs are treated by chlorpromazine and nystatin, the endocytosis efficiency of the OMVs is reduced by more than 50%.