The invention discloses a preparation method for celecoxib isomer, which includes the steps: firstly, preparing a crude product of 4, 4, 4-trifluoro-3-methoxyimino-1-(4-cresyl)-1-butanone from 4, 4, 4-trifluoro-1-(4-cresyl)-1, 3-butanedione with methoxylamine hydrochloride serving as ammoniation protective reagent; and secondly, adding p-amino sulfonyl phenylhydrazine hydrochloride into the prepared crude product, dissolving with ethyl acetate and acetic acid, obtaining a crude product after heating and backflow, and recrystallizing to obtain a pure product of 4-[3-(4-methylphenyl)-5-(trifluoromethyl)-1H-pyrazolyl] benzene sulfonamide, namely, the celecoxib isomer, which is white or almost white crystalline powder in appearance. The preparation method has the advantages of low cost, simplicity in post-processing, high yield and high selectivity.