The invention discloses a process for synthesizing a
glimepiride raw material medicine. A
compound A, namely 3-ethyl-4-methyl-3-
pyrroline-2-
ketone and a compound B, namely 2-phenethyl
isocyanate are taken as start raw materials. The process is characterized in that when an intermediate 1 is synthesized, filtrate is applied mechanically, so that the loss of the intermediate 1 can be reduced, the yield can be increased, and the production efficiency can be improved; when an intermediate 2 is synthesized, hydrochloric
ether is adopted as a
solvent, so that isomer impurities can be greatly reduced, the content of the isomer impurities can be reduced to 0.5% or less from 8%, and later purification procedures can be simple to operate; when a
glimepiride metallic salt is synthesized, acetonitrileis adopted as a
solvent, sufficient reactions can be achieved, the reaction time can be greatly shortened, the residue of an intermediate 3 is reduced to 0.2% or less from 5-10%, in addition, a highsolvent recycling rate can be achieved. The process disclosed by the invention is simple and safe, low in production cost, high in yield, stable in intermediate and finished product quality and applicable to industrial large-scale production and hypoglycemic
drug, namely
glimepiride, synthesis processes with relatively great social, economic and environmental-friendly benefits.