4 results about "Crospovidones" patented technology

This invention relates to the field of food biotechnology, and more particularly to a selenium-enriched asparagus tea lozenge, its preparation method, and its application. Specifically, it comprises the following components in parts by weight: 60-90 parts selenium-enriched asparagus tea fermentation powder, 10-30 parts mannitol, 0.5-3 parts citric acid, 0.3-2 parts sodium carboxymethyl starch, 1-4 parts crospovidone, 0.05-0.5 parts menthol, and 0.1-1.5 parts magnesium stearate. The selenium-enriched asparagus tea lozenge prepared by this invention has a significant effect on improving sleep. In a zebrafish insomnia model, this lozenge effectively alleviated the hyperactivity induced by insomnia-inducing agents, significantly reduced the movement distance of the model animals, and showed a significant and stable sleep improvement effect, indicating that this lozenge has good application prospects in improving sleep.

The invention relates to the technical field of pharmaceutical preparations, in particular to a methylprednisolone pulse micro-tablet and a preparation method thereof. The methylprednisolone pulse microtablet comprises a quick release tablet core and a coating layer, the quick-release tablet core comprises methylprednisolone, a filler, an antistatic agent A, an antistatic agent B, an adhesive and a lubricant; the coating layer comprises a coating material and a plasticizer; wherein the antistatic agent A is selected from at least one of a combination of organic acid and bicarbonate or ammonium carbonate; the antistatic agent B is selected from at least one of polyoxyethylene, carbomer, high-expansion type pregelatinized starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, croscarmellose sodium and crospovidone. The antistatic agent A and the antistatic agent B have a synergistic effect, so that the electrostatic phenomenon can be effectively reduced, and particle adhesion and microchip agglomeration are avoided.

This invention belongs to the field of pharmaceutical formulation technology, specifically relating to a lozenge for refreshing the mind and freshening the breath, and its preparation method. The lozenge comprises a plain tablet and a shell. The plain tablet includes inner phase particles, an inner phase particle coating layer, and excipients: the inner phase particles use sodium carboxymethyl cellulose and crospovidone to construct an immediate-release framework, with immediate-release and sustained-release caffeine and theanine as stimulating ingredients, supplemented by poloxamer to enhance penetration, achieving rapid absorption and sustained release of caffeine, and the theanine alleviates the nerve stimulation caused by caffeine; the inner phase particle coating layer uses hydroxypropyl methylcellulose and hydroxypropyl cellulose to construct a sustained-release framework, with polyethylene glycol forming microporous channels to promote the sustained release of fermented ginsenosides, enhancing anti-fatigue ability to prolong the stimulating effect, and releasing eucalyptol and limonene to produce a cooling sensation and mask odor, supplemented by Lactobacillus rhamnosus to inhibit the growth of harmful bacteria in the mouth to reduce odor, thereby achieving the effects of rapid stimulating, long-lasting mental alertness, and fresh breath.

This invention discloses a dual-enzyme anhydrous compounded acid-base rapid-disintegration porous toothpaste, belonging to the field of oral care product technology. The toothpaste is composed of the following raw materials: 9.0 parts sodium bicarbonate, 4.5 parts anhydrous citric acid, 6.0 parts crospovidone, 27.5 parts microcrystalline cellulose, 1.5 parts embedded complex biological enzyme, 3.5 parts powdered sodium lauroyl sarcosinate, 1.5 parts powdered sodium cocoyl glutamate, 22.0 parts spherical micro-powdered hydrated silica, 0.75 parts sodium monofluorophosphate, 1.5 parts anhydrous sodium pyrophosphate, 7.0 parts low-hygroscopic sorbitol, 0.2 parts sucralose, 0.8 parts pre-adsorbed peppermint flavor, 0.75 parts magnesium stearate, and 0.5 parts powder-embedded phenoxyethanol. This invention utilizes an anhydrous powder formulation design, taking advantage of the synergistic disintegration effect of an acid-base effervescent system and cross-linked polyvinylpyrrolidone, combined with the chemical decomposition of plaque biofilm by microencapsulated dual enzymes, to achieve rapid disintegration of the lozenge in the mouth and release of micro-nano bubbles. It can complete oral cleaning without the need for toothbrush friction, and is characterized by being gentle, portable, rapid disintegration and leaving no residue.