Pimavanserin tablet and preparation method thereof
A technology of pimavanserin and tablets, which is applied in the field of pharmaceutical preparations and can solve the problems of poor stability of common preparations
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Embodiment 1
[0018] Prescription composition:
[0019]
[0020] Preparation Process:
[0021] Pass pimavanserin and all auxiliary materials through 80-mesh sieve respectively for later use; weigh the colloidal silicon dioxide, polyethylene glycol and the main drug in the prescribed amount and add them to the granulation pot, and stir at a stirring speed of 500r / min, Dry mix for 5 minutes at a shear speed of 1000r / min; then add pregelatinized starch, microcrystalline cellulose and sodium starch glycolate and mix well; slowly add 15% hydroxypropyl cellulose aqueous solution to make a soft material; granulate with a 24-mesh sieve , dried at 55°C for 1 hour, sieved with a 24-mesh sieve, weighed and mixed with the prescribed amount of magnesium stearate, and pressed into tablets.
Embodiment 2
[0023] Prescription composition:
[0024]
[0025] Preparation Process:
[0026] Pass pimavanserin and all auxiliary materials through 80-mesh sieve respectively for later use; weigh the colloidal silicon dioxide, polyethylene glycol and the main drug in the prescribed amount and add them to the granulation pot, and stir at a stirring speed of 500r / min, Dry mix for 5 minutes at a shear speed of 1000r / min; then add pregelatinized starch, microcrystalline cellulose and sodium starch glycolate and mix well; slowly add 10% hydroxypropyl cellulose aqueous solution to make a soft material; granulate with a 24-mesh sieve , dried at 55°C for 1 hour, sieved with a 24-mesh sieve, weighed and mixed with the prescribed amount of magnesium stearate, and pressed into tablets.
Embodiment 3
[0028] Prescription composition:
[0029]
[0030] Preparation Process:
[0031] Pass pimavanserin and all auxiliary materials through 80-mesh sieve respectively for later use; weigh the colloidal silicon dioxide, polyethylene glycol and the main drug in the prescribed amount and add them to the granulation pot, and stir at a stirring speed of 500r / min, Dry mix for 5 minutes at a shear speed of 1000r / min; then add pregelatinized starch, microcrystalline cellulose and sodium starch glycolate and mix well; slowly add 5% hydroxypropyl cellulose aqueous solution to make a soft material; granulate with a 24-mesh sieve , dried at 55°C for 1 hour, sieved with a 24-mesh sieve, weighed and mixed with the prescribed amount of magnesium stearate, and pressed into tablets.
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