3results about How to "Dissolution stability" patented technology

This invention belongs to the field of pharmaceutical formulations, specifically relating to a levocarnitine oral gel and its preparation method. This invention discloses a stable levocarnitine oral gel composition comprising levocarnitine, a gel matrix, an alkali metal salt, and sodium polyacrylate. The stable levocarnitine oral gel disclosed in this invention is easy to swallow, has good medication adherence, does not undergo dehydration and shrinkage during the observation period, has stable product quality, good safety, and is convenient to carry and use; the process is simpler, with high production efficiency and lower risk, making it suitable for large-scale industrial production.

The application provides a brexpiprazole oral film, a preparation method and application thereof. The brexpiprazole oral film comprises the following components: an active drug and a film-forming material, wherein the active drug is 7-[4-(4-benzo[B]thiophene-4-yl-1-piperazine) butoxy]-2(1H)-quinolinone as shown in formula I and / or a pharmaceutically acceptable salt thereof, the particle size D 90 ≤70 μm of the active drug; the film-forming material is one or more of hydroxypropyl methyl cellulose, polyvinyl alcohol and hydroxypropyl cellulose; and the brexpiprazole oral film does not contain dimethyl silicone oil. The brexpiprazole oral film of the application has a good dissolution rate, does not have a sand feeling after being dissolved in the oral cavity, has a uniform appearance, good flexibility, does not settle during the preparation of the film liquid, and has a uniform content.

The present application relates to the technical field of laser spectrum gas detection, and particularly discloses a TDLAS double-gas concentration synchronous calibration and decoupling method in the presence of spectral aliasing interference, which comprises the following steps: acquiring a multi-frequency band harmonic signal optimized adaptively while collecting environmental parameters, and determining an optimal frequency band signal based on a signal quality index; calculating a spectral aliasing coefficient according to the characteristics of the optimal frequency band signal, dynamically adjusting the operation parameters of a search algorithm based on the numerical interval of the spectral aliasing coefficient, and determining an initial range of double-gas concentration in a search space. The present application combines an improved genetic algorithm based on the dynamic adjustment of the search strategy of the spectral aliasing coefficient with an incremental support vector regression model, realizes the hierarchical processing from coarse calibration to fine decoupling, can automatically balance the calculation efficiency and search accuracy when the degree of spectral aliasing changes, and can online correct the model in combination with the aging characteristics.