Loxoprofen sodium tablet and preparation process thereof
A technology for loxoprofen sodium and its preparation process, which is applied in the field of loxoprofen sodium tablets and its preparation, can solve problems affecting the properties of the main drug, and achieve the effects of good consistency, stable dissolution rate, and simple operation
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Embodiment 1-7
[0037] The formula of embodiment 1-7 is as shown in table 1.
[0038] Table 1.
[0039] number of copies Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 loxoprofen sodium 100 120 105 115 110 110 110 microcrystalline cellulose 250 200 230 220 225 225 225 Sophorolipids 10 20 15 10 12 12 12 Konjac Glucomannan 20 10 18 12 16 14 15 Crospovidone 20 15 16 18 17 17 17 Magnesium stearate 1 3 2 4 3 3 3
Embodiment 1-7 and comparative example 1-2
[0046] Embodiment 1-7 and comparative example 1-2 are all prepared according to the following preparation method:
[0047] (1) Get 102g loxoprofen sodium and microcrystalline cellulose, sophorolipids, konjac glucomannan, and crospovidone converted according to the ratio of parts in Table 1, and mix uniformly to obtain a mixture according to the principle of equal increase 1. Add mixture 1 to the feed hopper of the hot-melt extruder, the screw speed of the feed is 45rpm, and simultaneously add 95% ethanol (consumption 70g / 1000 pieces) with a peristaltic pump at the liquid inlet, and the peristaltic pump The rotating speed is 15rpm, and the prepared wet granules are connected at the discharge port.
[0048] (2) After the wet granules prepared in the step (1) are dried in a boiling dryer, magnesium stearate in the prescribed amount is added to obtain the mixture 2.
[0049] (3) Compress the mixture 2 obtained in step (2) with a 9mm dimple, and control the hardness of the plain t...
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