141 results about "Saccharolipid" patented technology

The invention discloses a kitchen waste oil-based sophorolipid high-yield candida utilis strain and an application thereof. Belongs to the technical field of directional domestication breeding. According to the method, wild candida bombicola is used as an original strain, and is sequentially domesticated in a culture medium containing kitchen waste oil with the concentration gradient of 2%, 4%, 6%, 8% and 10% to obtain the S.bombicola x10. The invention further discloses an application of the domesticated strain in fermentation production of sophorolipid, after the strain is subjected to shake flask fermentation, the sophorolipid yield reaches 60.19 g / L and is improved by 16.22% compared with that of a wild strain, and the acid type sophorolipid yield is improved by 32.11%. When the concentration of the lactone sophorolipid generated by fermentation is 1.25 mg / mL, the growth of the bacillus subtilis is completely inhibited. The invention provides an excellent production strain for industrial production of sophorolipid, and has good theoretical research significance and practical application value.

The invention belongs to the technical field of preparation of postbiotics, and discloses a preparation method and application of lactic acid bacteria fermented Chinese chestnut protein postbiotics for improving systemic chronic inflammations, Chinese chestnuts are subjected to shelling, grinding and degreasing treatment, and degreased Chinese chestnut powder is obtained; resuspending the degreased Chinese chestnut powder in distilled water, adjusting the pH value, and stirring; performing solid-liquid separation and magnetic stirring; carrying out solid-liquid separation, resuspending and adjusting the pH value; dialyzing to obtain Chinese chestnut protein powder; mixing with glucose powder, and redissolving in distilled water; and mixing with lactic acid bacteria and carrying out aerobic fermentation to obtain the Chinese chestnut protein metaplasm product. The bioactive peptides contained in the Chinese chestnut protein metaplasm prepared by the method have potential anti-inflammatory activity, can effectively inhibit proinflammatory medium secretion of macrophages and intestinal epithelial cells, and improve glucose and lipid metabolism disorder and intestinal barrier function damage related to chronic inflammation of a body. The bioactive peptide contained in the postbiotic product disclosed by the invention has an anti-inflammatory effect.

The invention provides an efficient fermentation production method and application of acid type sophorolipid, and the production method comprises the following steps: (1) in a growth stage, adding a composite nitrogen source and growth factors into a basic culture medium to promote the growth of zymophyte and realize high-density fermentation, the zymophyte being candida utilis subjected to genetic engineering modification; (2) in the product synthesis stage, mixed syrup and vegetable oil are used as carbon sources, and the concentration of glucose in a fermentation tank is maintained at 1-5g / L and the concentration of residual oil is maintained at 1-5g / L by regulating and controlling the material supplementing rate. The fermentation production method provided by the invention solves the problems of slow thallus growth, long fermentation period, low production intensity, uncontrollable product composition, more byproducts, peculiar smell of fermentation tail gas and the like in the existing sophorolipid production process, and has industrial application value.

The invention relates to an oligomeric bio-based surfactant and a preparation method and application thereof, the oligomeric bio-based surfactant has a structure as shown in the following formula 1 or formula 2: # imgabs0 # imgabs1 # X1-X2 are selected from-(CH2) n-or substituted or unsubstituted thienyl with the carbon atom number of 4-10, n represents the number of CH2, and n is any integer selected from 0-12; z1-Z5 are respectively and independently selected from a disaccharide group, R1-R5 are respectively and independently selected from-CH (CH3)-Y-COOH, and Y is selected from a saturated or unsaturated linear alkyl group with the carbon atom number of 9-19. Compared with unmodified sophorolipid, the sophorolipid is modified. The oligomeric bio-based surfactant disclosed by the invention has a lower contact angle and higher wettability; meanwhile, molecules have a branched space structure and intramolecular sugar ring steric hindrance, fusion of foams can be promoted, the low-foam characteristic is shown, and the low-foam bio-based cleaning agent has a good industrial application prospect as a green and efficient low-foam bio-based cleaning agent.

This present disclosure provides various diamine centered PEG-saccharide-lipid conjugates. In various embodiments, the conjugates can safely be used as water solubility or bioavailability enhancers.. In one aspect, the present disclosure provides a PEG-saccharide- lipid conjugate having the structural formula (I) wherein m has a number-average value in the range of 2-10; S is a mono-, di- or trisaccharide group, in which each saccharide unit is a sugar, a sugar alcohol, an amino sugar or a sugar acid; L is -C(O)-R1 in which R1 is an alkanyl or alkenyl group having a number-average number of carbons in the range of 6-22, and / or is a steroid acyl group; P is -(CH2-CH2-O)nR2 in which "n" has a number-average value in the range of 5-50 (e.g., 8-45) and R2 is hydrogen and / or alkanyl and has a number average number of carbons in the range 0-4.

The invention discloses a method for producing feed by using corn sugar residues, and belongs to the technical field of fermentation. The method comprises the following steps: pretreating, proportioning, adding an antibacterial agent, fermenting, drying and crushing, coating, cooling and the like, mixing corn sugar residues, corn germ meal and threonine mother liquor according to a specific ratio, adding zinc oxide and a chitosan antibacterial agent, and inoculating Saccharomyces cerevisiae ATCC 9763 for fermenting. And performing multi-stage drying and crushing on the fermentation product, spraying a coating emulsion prepared from a defatted soybean meal extract, curcumin, vitamin E, lecithin and sophorolipid, and performing air cooling to prepare the feed. According to the method, by-products are fully utilized, the crude protein content of the feed is 32-34.5%, the diameter of an inhibition zone is 18.1-20.2 mm, the moisture absorption rate is 2.7-3.4%, the palatability score is 8.0-8.6, and the fermentation yield is 92-94%. The innovation point lies in specific strain fermentation and functional coating, and is suitable for industrial production.

The invention discloses a method for preparing acid sophorolipid, and belongs to the technical field of biological fermentation. According to the method, candida is used as a fermentation strain, a composite carbon source culture medium containing a water-soluble carbon source and an oil-soluble carbon source is adopted, and the content of residual oil is monitored in real time in the fermentation process; when the residual oil content exceeds a threshold value of 5g / L, the emulsifying agent of 0.1 g / L-0. 5g / L is supplemented, and the stirring rotating speed is increased by 20-50rpm, so that the emulsification of an oil phase and the utilization of the thalli on the oil-soluble carbon source are promoted. By accurately controlling the residual oil content in the fermentation process, the proportion of the acidic sophorolipid and the carbon source conversion rate are remarkably increased, the proportion of the acidic sophorolipid is increased to 60% from 30% of a traditional process, the carbon source conversion rate is increased to 65% from 40%, the problems that the increasing means of the proportion of the acidic sophorolipid is single, and the carbon source is wasted are effectively solved, and the method is suitable for industrial production. The method has the advantages of simple process, low cost, environmental protection and the like.

The invention discloses a three-sludge treatment agent and a preparation method thereof, and belongs to the technical field of oily sludge treatment, the three-sludge treatment agent comprises a treatment agent A and a treatment agent B. The treatment agent B comprises the following raw materials by mass: 30-40 parts of polyacrylamide, 8-10 parts of modified attapulgite clay, 5-6 parts of a compound, and 40-55 parts of deionized water. The modified attapulgite clay is strongly combined with protective films at oil-water and oil-sludge interfaces in the oil sludge through electrostatic force, hydrogen bonds and hydrophobic interaction, the protective films at the oil-water and oil-sludge interfaces are destroyed, oil drops are released and coalesced to form an oil phase, and separation of oil, water and sludge is achieved; positive charges carried in the modified attapulgite clay can be adsorbed to the surfaces of sludge particles with negative charges to be settled and separated out; carboxyl groups contained in the modified hemicellulose can be combined with hydrophilic groups of sophorolipid to form stable mixed micelles, so that the situation that the sophorolipid is easily influenced by the environment to lose efficacy, and oil drops are regathered and precipitated is avoided.

The invention discloses a full bio-based PHA (polyhydroxyalkanoate) liquid bioplastic emulsion and a preparation method thereof. The emulsion takes polyhydroxyalkanoate (PHA) as a matrix, alkyl polyglycoside, fermented glycolipid and a bio-based nonionic surfactant are compounded with pullulan, alginate or micro-nano cellulose to serve as a stable system, and plasticizers such as acetyl tributyl citrate and citric acid, phytic acid or tannic acid are added to serve as compacting agents. The solid content of the emulsion is 35-58%, the volume average particle size D50 is 0.12-0.90 [mu] m, the absolute value of Zeta potential is not less than 30 mV, and the content of volatile organic compounds (VOC) is not higher than 50 g / L; fluorine-containing organic matters are not artificially added, and the total organic fluorine is less than or equal to 100ppm. The overall bio-based carbon content of all organic components in the formula is not lower than 95% according to mass weighting calculation. The invention also provides application of the emulsion in the fields of paper barrier coatings, heat-sealing adhesives and non-woven fabric finishing.

The invention discloses a remediation agent for high-concentration hexavalent chromium polluted soil and a preparation method and a remediation method thereof, and belongs to the technical field of soil pollution remediation. The remediation agent for the high-concentration hexavalent chromium contaminated soil comprises an acidic precursor, an iron-sulfur reducing agent and a synergist, the acidic precursor comprises organic acid and propylene glycol alginate; the iron-sulfur reducing agent comprises an iron-based reducing agent and a sulfur-based reducing agent; the synergist is prepared from sophorolipid and alkyl glucoside. The remediation agent can be used for high-concentration hexavalent chromium contaminated soil, hexavalent chromium in the soil is exposed in a Cr < 6 + > ion form as much as possible by replacing the hexavalent chromium in the soil, then the hexavalent chromium is converted into trivalent chromium by using a reducing agent, and the removal efficiency of the hexavalent chromium reaches up to 99.6%. In addition, the soil remediation agent is simple in use mode, rapid and thorough in reaction and lasting in effect.

The invention discloses a bumblebee candida for efficiently producing sophorolipid as well as a construction method and application of the bumblebee candida. According to the invention, metabolic transformation is carried out on a wild type strain of candida bumblebee, a peroxisome membrane transporter gene PXA1 is knocked out, so that a beta-oxidation pathway of fatty acid competing with a sophorolipid synthesis pathway is moderately inhibited, and on the basis, an endogenous potent promoter pENO is utilized to enhance expression of CYP52M1; therefore, the bumblebee candida engineering bacteria for efficiently producing sophorolipid are constructed. Compared with an original strain, the recombinant candida bumblebee has the advantages that efficient conversion of a fermentation substrate and high yield of sophorolipid can be realized, and the sophorolipid yield of shake flask fermentation reaches 88.50 g / L. The strain is fermented in a 5L fermentation tank and fermented for 7 days after rapeseed oil is added, 232.27 g / L of crude sophorolipid is produced, and high productivity is kept.

The invention discloses application of 2-hydroxybutyric acid and derivatives thereof in preparation of drugs for preventing and / or treating metabolic diseases, and belongs to the technical field of biological medicines. Experiments prove that the 2-hydroxybutyric acid and the derivatives thereof can effectively inhibit obesity induced by high fat diet and reduce body fat, and have good improvement effects on related glucose and lipid metabolism disorders, including reduction of fasting blood-glucose, improvement of glucose tolerance, reduction of liver lipid deposition and improvement of liver functions. More importantly, the 2-hydroxybutyric acid does not affect ingestion, the metabolism improvement effect of the 2-hydroxybutyric acid depends on activation of fat heat production, and energy consumption can be directly promoted, so that obvious gastrointestinal tract adverse reactions cannot be generated, and potential mental side effects of existing appetite inhibiting drugs do not exist.

The invention relates to the technical field of cleaning agents, and particularly discloses a composite cleaning agent as well as a preparation method and application thereof. The composite cleaning agent comprises the following raw material components in percentage by mass: 5%-10% of inorganic particles, 5%-15% of a surfactant, 15%-30% of a cleaning aid and the balance of water, wherein the surface active agent is prepared from rhamnolipid, fatty acid methyl ester ethoxylate, cocamidopropyl betaine and sophorolipid; the inorganic particles comprise soluble sodium salt and nano silicon dioxide; the cleaning auxiliary agent comprises a geranium extracting solution, a herba portulacae extracting solution, lauric acid and glycerol. The composite cleaning agent is simple in raw material components, simple and convenient in preparation method, low in cost and free of secondary pollution to the environment. The composite cleaning agent effectively solves the problems that an existing train cleaning agent is poor in cleaning effect, complex in manufacturing process and unfriendly to the environment.

The invention discloses an intestinal insulinotropic analogue and application thereof, the intestinal insulinotropic analogue can simultaneously act on a GLP-1 receptor, a glagon receptor and a GIP receptor, and can simultaneously play the activities of the GLP-1, the glagon and the GIP; according to the present invention, the GLP-1 has the diabetes treatment effect, the glucagon has the beneficial effects of weight, energy metabolism and lipid metabolism, and the GIP has the beneficial effects of sugar, lipid metabolism and appetite inhibition so as to produce the synergistic effect on sugar, lipid and energy metabolism; the application of the polypeptide to preparation of drugs for treating metabolic syndromes, such as diabetes, dyslipidemia, fatty liver diseases, obesity and the like, has greater potential.

The present invention belongs to the technical field of daily cosmetics, and specifically relates to a makeup remover cream composition and a preparation method thereof, wherein the makeup remover cream composition comprises 60-80 parts of component A, 10-25 parts of component B, and 0.2-1 parts of component C by mass, wherein the component A comprises vegetable oil, grease, and synthetic wax; the component B comprises trehalose lipid, yucca saponin extract, and nonionic surfactant, polyol, and water. The nonionic surfactant is PEG-7 glyceryl cocoate: PEG-20 glyceryl triisostearate: PEG-3 glyceryl isostearate in a mass ratio of 2.5-5 parts: 2.5-5 parts: 0.5-1 parts. The makeup remover cream prepared by the present invention by compounding a plurality of formula ingredients with biosurfactants, yucca extracts, and nonionic surfactants can efficiently remove water-based and oily makeup while being gentle and non-irritating.

The invention discloses a composite combined preparation for synergistically treating and conditioning diabetes, relates to the technical field of foods, health foods or dietary supplements for adjuvant therapy and health care of diabetes, and in particular relates to a composite combined preparation for synergistically treating and conditioning diabetes. The preparation comprises albumin peptide, saussurea involucrata culture, vitamin B1, vitamin B2, wheat oligopeptide, corn oligopeptide, collagen peptide, mulberry leaf extract, rhizoma polygonati extract, sea-buckthorn extract, isomaltitol, maltodextrin, ginseng extract and bitter gourd extract. Through the synergistic effect of all the components, comprehensive auxiliary conditioning on diabetes is realized from multiple targets of maintaining colloid osmotic pressure and nutrition, regulating glycolipid metabolism in multiple ways, protecting pancreatic beta cell functions, enhancing insulin sensitivity, preventing nerve and blood vessel complications, meeting special diet requirements and the like. The composition can be prepared into food, health-care food or dietary supplement and other dosage forms.

The invention discloses bifidobacterium adolescentis for relieving estrogen-related metabolic disorder and obesity and application thereof, and belongs to the technical field of microorganisms. The bifidobacterium adolescentis CCFM1506 screened by the invention can effectively improve ovariectomized individual estrogen disorder symptoms, obviously slow down the weight increase speed and weight increment of estrogen disorder individuals, increase the expression quantity of serum estradiol, CYP11A1 and ERalpha in adrenal gland and the high-density lipoprotein content in serum, reduce the total cholesterol and glucose level and improve the ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized abnormal glucose and lipid metabolism is adjusted; the invention has the advantages of simple preparation method and wide application prospect, can be used for preparing medicines for relieving or treating estrogen-related metabolic disorders and obesity, and can be used for preparing health-care products beneficial to controlling in-vivo fat and maintaining the health level of blood fat, and has obvious physiological effects and wide application prospects, and can be used for preparing the medicines for relieving or treating the estrogen-related metabolic disorders and obesity and preparing health-care products beneficial to controlling in-vivo fat and maintaining the health level of blood fat. A new thought and a new basis are provided for developing functional foods or medicines based on the probiotics.

The invention belongs to the field of microbial fermentation and the technical field of daily chemicals, and particularly relates to deacetylated sophorolipid as well as a preparation method and application thereof. By using cheap culture medium components and screening out saccharomycetes with high yield of lactone type sophorolipid, the problem that the production cost of the sophorolipid is too high is effectively solved, and the application of the sophorolipid in various fields is promoted; through the step of carrying out enzymolysis on a fermentation substrate in advance, the problems of long single fermentation period, low thallus utilization rate, high energy consumption and high cost of traditional saccharomycetes are solved. A multi-round fermentation circulation system is designed, and bacteria liquid is settled and recycled and then inoculated and fermented, so that thalli are efficiently and repeatedly utilized, the unit yield is increased, the fermentation period is shortened, and the production cost is effectively controlled. The structure is adjusted through a resin modification technology, a final product mainly comprises acetylated sophorolipid, and compared with acetylated sophorolipid and deacetylated sophorolipid, the sophorolipid has better foam stability and sensitive skin repairing effect and is suitable for the application fields of cosmetics, washing care and the like.

The invention belongs to the technical field of biological medicine, and particularly relates to wheat bran araboxylan and application thereof. The invention provides wheat bran AX with specific molecular weight and monosaccharide composition. The wheat bran AX comprises the following monosaccharides: 0.20%-0.22% of glucuronic acid, 0.58%-0.62% of galacturonic acid, 0.21%-0.23% of rhamnose, 0.6%-0.7% of glucose, 1.4%-1.5% of galactose, 18%-19.2% of xylose and 21%-23% of arabinose. Compared with commercially available wheat bran AX, inulin, fructo-oligosaccharide and other common dietary fibers, the self-made wheat bran AX has higher diversity of microbial communities in the fermentation process, has a better intestinal flora regulating effect, further has a good relieving effect on the abnormal glucose and lipid metabolism of the body, and can be used for preventing and treating the abnormal glucose and lipid metabolism of the body. Therefore, the traditional Chinese medicine composition has a good regulation effect on various diseases such as non-alcoholic fatty liver and the like caused by abnormal glucose and lipid metabolism of the organism.

The application provides a nanoemulsion and a preparation method and application thereof. The total amount of raw materials for preparing the nanoemulsion is 100%, and the raw materials include the following components: 1-40% of a composite surfactant, 1-25% of an oil phase, 1-30% of a co-surfactant, and the balance of a water phase; wherein the mass of the composite surfactant is 100%, and the composite surfactant includes the following components: 5-25% of a biological surfactant, 35-65% of a fatty alcohol polyoxyethylene ether surfactant, 1-20% of dodecyl benzene sulfonic acid and / or sodium salt thereof, 1-20% of oleic acid, and 1-5% of citric acid; the biological surfactant includes one or more than two combinations of sophorolipid, rhamnolipid, trehalose lipid, surfactin, alkyl polyglycoside, phosphatidylcholine, amino acid lipid, saponin, phospholipid, or derivatives thereof; and the average particle size of the emulsion droplets in the nanoemulsion is 1.5-5 nm. The nanoemulsion has excellent recovery performance.

This invention provides a cleaning agent composition in which thermal deterioration is suppressed. The cleaning agent composition is a liquid cleaning agent composition comprising (a) fatty acid salts and (b) a sophorose lipid, wherein the fatty acid salts (a) comprise (a-1) at least one member selected from the group consisting of salts of C14-C22 saturated fatty acids and (a-2) at least one member selected from the group consisting of salts of C14-C22 unsaturated fatty acids, whereinA) the total amount of the component (a) is 2-35 mass % based on the cleaning agent composition taken as 100 mass %;B) the proportion of the component (a-2) is 20 parts by mass or more based on 100 parts by mass of the total amount of the component (a); andC) the proportion of the component (b) is 3 parts by mass or more per 100 parts by mass of the component (a-2).

The invention discloses a biocontrol bacterium agent and a preparation method and application thereof.The biocontrol bacterium agent comprises a nano carrier and biocontrol bacteria, the carrier is halloysite nanotubes modified by coating the surfaces of the halloysite nanotubes with lecithin, sucrose ester or sophorolipid, and the biocontrol bacteria are bacillus subtilis; the preparation method comprises the following steps: (1) soaking halloysite nanotubes in a hydrochloric acid solution for pretreatment; (2) adding halloysite, lecithin, sucrose ester or sophorolipid into a solvent, uniformly mixing, reacting, and after the reaction is completed, washing and drying to obtain a modified halloysite nanotube; and (3) mixing a bacillus subtilis liquid with the modified halloysite nanotube, incubating, and drying to obtain the halloysite nanotube. According to the invention, lecithin, sucrose ester or sophorolipid is adopted to modify the halloysite nanotube and then is used as a carrier, so that the loading effect on bacillus subtilis is improved, and the fungicide has excellent prevention and treatment effects on tobacco brown spot, black shank, anthracnose and sweet leaf fungus damping-off.

The invention discloses a method for establishing a cross-generation genetic model of rats attacking nutritional imbalance twice, and relates to the technical field of animal model establishment, and the key points of the technical scheme are as follows: starting from the angle of paternal line, selecting SD male rats of 3 weeks old, adaptively feeding for 1 week, then starving and feeding for 4 weeks, and finally feeding for 17 weeks with high fat, evaluating the phenotype of fatty liver, and establishing the cross-generation genetic model of rats attacking nutritional imbalance twice. And establishing a parent (F0) which attacks the nutritional imbalance twice. After the parent generation (F0) and the normal exposed parent generation (F0) are mated, the male offspring (F1) is given with common diet and high-fat diet respectively, then after the parent generation (F0) and the normal exposed female generation (F0) are mated, the male offspring (F2) is given with common diet and high-fat diet respectively. According to the method, the fatty liver phenotype of the male rat of the F0-F2 model can be determined, and the glucolipid metabolism pathway and function change of the parental generation and the offspring generation can be known through an isotopic tracing technology, metabonomics and transcriptomics.

The invention discloses a medical sterilizing, antagonistic-free and fat-retaining disinfectant hand sanitizer and a preparation method thereof, and relates to the technical field of hand sanitizers. CHG is used as a main bactericide, sophorolipid, CAB and alpha-glucan oligosaccharide are used as a composite surfactant, and the antagonistic effect of sterilization effect reduction caused by CHG wrapping after a conventional surfactant forms micelles is eliminated; meanwhile, phytosterol ester, glycosylglycerol and madecassoside are introduced as skin fat-retaining components, so that the sebum retention rate is greater than or equal to 95%, meanwhile, the antibacterial rate on staphylococcus aureus is still kept 100%, and the hand washing liquid is suitable for high-frequency hand washing of medical staff.

The purpose of the present invention is to identify a novel substance / factor relating to the anti-inflammatory activity of sugar beet, and to provide the substance / factor. This will make it possible to develop health products such as pharmaceuticals, foods and cosmetics for inhibiting chronic inflammation. Provided is a lipopolysaccharide characterized by being obtained from a bacterium that has been preserved at a preservation number of NITE BP-03839, NITE BP-03840, NITE BP-03841, NITE BP-03842, or NITE BP-03843, and a method for producing the same. The invention also provides a medicine, a medicine for animals, a quasi-medicine, a cosmetic, a food, a functional food, a feed, a fertilizer or a bath lotion additive in which the lipopolysaccharide is mixed.

The invention relates to the technical field of oilfield chemistry, in particular to an environment-friendly biological blocking remover for oil extraction and a processing technology of the environment-friendly biological blocking remover. The environment-friendly biological blocking remover is prepared from the following components in percentage by weight: 4 to 6 percent of alkyl glycoside, 4 to 6 percent of sophorolipid, 3 to 5 percent of methylglycine diacetic acid, 5 to 8 percent of rhamnolipid, 6 to 8 percent of compound microorganism fermentation liquor, 5 to 8 percent of lipase, 5 to 8 percent of protease, 6 to 8 percent of polymer degrading enzyme, 2 to 4 percent of citric acid, 2 to 4 percent of mandelic acid, 1 to 2 percent of glycerol, 1 to 2 percent of trehalose and 31 to 57 percent of deionized water. The biological enzyme, the biological surfactant, the organic acid and the chelating agent cooperate to fundamentally disintegrate blockages, meanwhile, the microcapsule technology and the nano-bubble technology are used, the action period is greatly prolonged, blockages of deeper parts can be treated, and the treatment effect is good. And corrosion and damage of strong acid and strong alkali to underground pipe columns, tools and stratum rocks are avoided, and secondary damage caused by plug removal operation is prevented.

The present invention addresses the problem of producing a high-purity low-molecular-weight lipopolysaccharide at low cost from a preserved bacterium that produces a high-purity low-molecular-weight lipopolysaccharide. The present invention relates to: a lipopolysaccharide obtained from a preserved bacterium obtained by causing a change in genetic information of conventional Pantoea agglomerans; a method for producing a lipopolysaccharide by which a lipopolysaccharide is obtained from the preserved bacterium; and a method for producing a lipopolysaccharide. Also disclosed is a lipopolysaccharide complex for a pharmaceutical product, an animal drug, a quasi-drug, a cosmetic, a food, a functional food, a feed, a fertilizer, a bath agent or the like in which the lipopolysaccharide is blended.

The invention discloses a pyrrole biphenyl derivative compound as well as a preparation method and application thereof in pharmacy, and belongs to the technical field of chemical medicine raw material medicine and preparation manufacturing. The compound has a structure as shown in # imgabs0 #. The compound is specifically combined with SGLT-2 protein through a pyrrole-benzene conjugated system, the glucose transport function of the SGLT-2 protein is inhibited, and the IC50 value of the SGLT-2 protein reaches 15-105 nM. The traditional Chinese medicine composition is suitable for preparing medicines for treating non-alcoholic liver diseases, solid tumors, hematological malignant tumors and autoimmune diseases, and especially has a remarkable effect on abnormal glycolipid metabolism of liver cells and energy deprivation of tumor cells. The compound has deuterated group enhanced metabolic stability, and can be prepared into dosage forms such as tablets, capsules, injection and the like.

The invention discloses a salt-reducing freshness-enhancing high-temperature-resistant functional seasoning composition beneficial to maintaining intestinal microecological balance, and a preparation method and application thereof, and belongs to the technical field of food seasoning. The core of the composition is a synergistic dietary fiber combination composed of yeast beta-glucan, yeast mannan oligosaccharide and resistant dextrin according to the weight ratio of (3-5): (4-6): (2-4), edible salt and yeast extract are matched, the sodium content of the product is smaller than or equal to 14000mg / 100g, when clear soup is prepared according to the addition amount of 0.5% (w / v), the delicate flavor strength equivalent to that of traditional chicken essence can be kept, and the delicate flavor attenuation rate is smaller than or equal to 6.7% after heating is conducted for 60 min at the temperature of 100 DEG C. The product simultaneously realizes 0 sugar, 0 fat, low purine and sodium-potassium ratio balance, can synergistically promote proliferation of beneficial bacteria in intestinal tracts, solves the problem that salt reduction, fresh keeping, high temperature resistance and flavor stability of the existing seasoning are difficult to consider at the same time, and is suitable for industrial production.

The invention belongs to the technical field of skin care products, and relates to an L-carnosine-sophorolipid micelle and a preparation method and application thereof.The method comprises the steps that sophorolipid is dissolved in methyl alcohol or ethyl alcohol or acetone, L-carnosine is dissolved in an aqueous solution with the pH ranging from 2 to 7, after mixing and stirring are conducted according to the mass ratio of 3: 1-8: 1, vacuum rotary evaporation is conducted under the pressure ranging from-0.06 MPa to-0.08 MPa at the temperature ranging from 30 DEG C to 70 DEG C, an organic solvent is removed, a thin film is formed, and the L-carnosine-sophorolipid micelle is obtained. And hydrating with normal saline, purifying with a 1000Da ultrafiltration membrane, and freeze-drying to obtain the product. The obtained micelles are uniform in particle size, the encapsulation efficiency is up to 99.34%, the carnosinase resistance and the transdermal absorption efficiency of the L-carnosine can be improved, and meanwhile, the effects of scavenging free radicals, resisting inflammation, inhibiting bacteria and preserving moisture for a long time are synergistically reserved. The process is simple, convenient and controllable, the problems that the L-carnosine is poor in stability and low in bioavailability are solved, and the preparation method is suitable for smearing type skin care products and has important application value.