81 results about "Saccharolipid" patented technology

The invention discloses a method for preparing acid sophorolipid, and belongs to the technical field of biological fermentation. According to the method, candida is used as a fermentation strain, a composite carbon source culture medium containing a water-soluble carbon source and an oil-soluble carbon source is adopted, and the content of residual oil is monitored in real time in the fermentation process; when the residual oil content exceeds a threshold value of 5g / L, the emulsifying agent of 0.1 g / L-0. 5g / L is supplemented, and the stirring rotating speed is increased by 20-50rpm, so that the emulsification of an oil phase and the utilization of the thalli on the oil-soluble carbon source are promoted. By accurately controlling the residual oil content in the fermentation process, the proportion of the acidic sophorolipid and the carbon source conversion rate are remarkably increased, the proportion of the acidic sophorolipid is increased to 60% from 30% of a traditional process, the carbon source conversion rate is increased to 65% from 40%, the problems that the increasing means of the proportion of the acidic sophorolipid is single, and the carbon source is wasted are effectively solved, and the method is suitable for industrial production. The method has the advantages of simple process, low cost, environmental protection and the like.

The invention discloses a full bio-based PHA (polyhydroxyalkanoate) liquid bioplastic emulsion and a preparation method thereof. The emulsion takes polyhydroxyalkanoate (PHA) as a matrix, alkyl polyglycoside, fermented glycolipid and a bio-based nonionic surfactant are compounded with pullulan, alginate or micro-nano cellulose to serve as a stable system, and plasticizers such as acetyl tributyl citrate and citric acid, phytic acid or tannic acid are added to serve as compacting agents. The solid content of the emulsion is 35-58%, the volume average particle size D50 is 0.12-0.90 [mu] m, the absolute value of Zeta potential is not less than 30 mV, and the content of volatile organic compounds (VOC) is not higher than 50 g / L; fluorine-containing organic matters are not artificially added, and the total organic fluorine is less than or equal to 100ppm. The overall bio-based carbon content of all organic components in the formula is not lower than 95% according to mass weighting calculation. The invention also provides application of the emulsion in the fields of paper barrier coatings, heat-sealing adhesives and non-woven fabric finishing.

The invention discloses a composite combined preparation for synergistically treating and conditioning diabetes, relates to the technical field of foods, health foods or dietary supplements for adjuvant therapy and health care of diabetes, and in particular relates to a composite combined preparation for synergistically treating and conditioning diabetes. The preparation comprises albumin peptide, saussurea involucrata culture, vitamin B1, vitamin B2, wheat oligopeptide, corn oligopeptide, collagen peptide, mulberry leaf extract, rhizoma polygonati extract, sea-buckthorn extract, isomaltitol, maltodextrin, ginseng extract and bitter gourd extract. Through the synergistic effect of all the components, comprehensive auxiliary conditioning on diabetes is realized from multiple targets of maintaining colloid osmotic pressure and nutrition, regulating glycolipid metabolism in multiple ways, protecting pancreatic beta cell functions, enhancing insulin sensitivity, preventing nerve and blood vessel complications, meeting special diet requirements and the like. The composition can be prepared into food, health-care food or dietary supplement and other dosage forms.

The invention discloses bifidobacterium adolescentis for relieving estrogen-related metabolic disorder and obesity and application thereof, and belongs to the technical field of microorganisms. The bifidobacterium adolescentis CCFM1506 screened by the invention can effectively improve ovariectomized individual estrogen disorder symptoms, obviously slow down the weight increase speed and weight increment of estrogen disorder individuals, increase the expression quantity of serum estradiol, CYP11A1 and ERalpha in adrenal gland and the high-density lipoprotein content in serum, reduce the total cholesterol and glucose level and improve the ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized abnormal glucose and lipid metabolism is adjusted; the invention has the advantages of simple preparation method and wide application prospect, can be used for preparing medicines for relieving or treating estrogen-related metabolic disorders and obesity, and can be used for preparing health-care products beneficial to controlling in-vivo fat and maintaining the health level of blood fat, and has obvious physiological effects and wide application prospects, and can be used for preparing the medicines for relieving or treating the estrogen-related metabolic disorders and obesity and preparing health-care products beneficial to controlling in-vivo fat and maintaining the health level of blood fat. A new thought and a new basis are provided for developing functional foods or medicines based on the probiotics.

The invention belongs to the field of microbial fermentation and the technical field of daily chemicals, and particularly relates to deacetylated sophorolipid as well as a preparation method and application thereof. By using cheap culture medium components and screening out saccharomycetes with high yield of lactone type sophorolipid, the problem that the production cost of the sophorolipid is too high is effectively solved, and the application of the sophorolipid in various fields is promoted; through the step of carrying out enzymolysis on a fermentation substrate in advance, the problems of long single fermentation period, low thallus utilization rate, high energy consumption and high cost of traditional saccharomycetes are solved. A multi-round fermentation circulation system is designed, and bacteria liquid is settled and recycled and then inoculated and fermented, so that thalli are efficiently and repeatedly utilized, the unit yield is increased, the fermentation period is shortened, and the production cost is effectively controlled. The structure is adjusted through a resin modification technology, a final product mainly comprises acetylated sophorolipid, and compared with acetylated sophorolipid and deacetylated sophorolipid, the sophorolipid has better foam stability and sensitive skin repairing effect and is suitable for the application fields of cosmetics, washing care and the like.

The invention belongs to the technical field of biological medicine, and particularly relates to wheat bran araboxylan and application thereof. The invention provides wheat bran AX with specific molecular weight and monosaccharide composition. The wheat bran AX comprises the following monosaccharides: 0.20%-0.22% of glucuronic acid, 0.58%-0.62% of galacturonic acid, 0.21%-0.23% of rhamnose, 0.6%-0.7% of glucose, 1.4%-1.5% of galactose, 18%-19.2% of xylose and 21%-23% of arabinose. Compared with commercially available wheat bran AX, inulin, fructo-oligosaccharide and other common dietary fibers, the self-made wheat bran AX has higher diversity of microbial communities in the fermentation process, has a better intestinal flora regulating effect, further has a good relieving effect on the abnormal glucose and lipid metabolism of the body, and can be used for preventing and treating the abnormal glucose and lipid metabolism of the body. Therefore, the traditional Chinese medicine composition has a good regulation effect on various diseases such as non-alcoholic fatty liver and the like caused by abnormal glucose and lipid metabolism of the organism.

The application provides a nanoemulsion and a preparation method and application thereof. The total amount of raw materials for preparing the nanoemulsion is 100%, and the raw materials include the following components: 1-40% of a composite surfactant, 1-25% of an oil phase, 1-30% of a co-surfactant, and the balance of a water phase; wherein the mass of the composite surfactant is 100%, and the composite surfactant includes the following components: 5-25% of a biological surfactant, 35-65% of a fatty alcohol polyoxyethylene ether surfactant, 1-20% of dodecyl benzene sulfonic acid and / or sodium salt thereof, 1-20% of oleic acid, and 1-5% of citric acid; the biological surfactant includes one or more than two combinations of sophorolipid, rhamnolipid, trehalose lipid, surfactin, alkyl polyglycoside, phosphatidylcholine, amino acid lipid, saponin, phospholipid, or derivatives thereof; and the average particle size of the emulsion droplets in the nanoemulsion is 1.5-5 nm. The nanoemulsion has excellent recovery performance.

The invention discloses a biocontrol bacterium agent and a preparation method and application thereof.The biocontrol bacterium agent comprises a nano carrier and biocontrol bacteria, the carrier is halloysite nanotubes modified by coating the surfaces of the halloysite nanotubes with lecithin, sucrose ester or sophorolipid, and the biocontrol bacteria are bacillus subtilis; the preparation method comprises the following steps: (1) soaking halloysite nanotubes in a hydrochloric acid solution for pretreatment; (2) adding halloysite, lecithin, sucrose ester or sophorolipid into a solvent, uniformly mixing, reacting, and after the reaction is completed, washing and drying to obtain a modified halloysite nanotube; and (3) mixing a bacillus subtilis liquid with the modified halloysite nanotube, incubating, and drying to obtain the halloysite nanotube. According to the invention, lecithin, sucrose ester or sophorolipid is adopted to modify the halloysite nanotube and then is used as a carrier, so that the loading effect on bacillus subtilis is improved, and the fungicide has excellent prevention and treatment effects on tobacco brown spot, black shank, anthracnose and sweet leaf fungus damping-off.

The invention discloses a method for establishing a cross-generation genetic model of rats attacking nutritional imbalance twice, and relates to the technical field of animal model establishment, and the key points of the technical scheme are as follows: starting from the angle of paternal line, selecting SD male rats of 3 weeks old, adaptively feeding for 1 week, then starving and feeding for 4 weeks, and finally feeding for 17 weeks with high fat, evaluating the phenotype of fatty liver, and establishing the cross-generation genetic model of rats attacking nutritional imbalance twice. And establishing a parent (F0) which attacks the nutritional imbalance twice. After the parent generation (F0) and the normal exposed parent generation (F0) are mated, the male offspring (F1) is given with common diet and high-fat diet respectively, then after the parent generation (F0) and the normal exposed female generation (F0) are mated, the male offspring (F2) is given with common diet and high-fat diet respectively. According to the method, the fatty liver phenotype of the male rat of the F0-F2 model can be determined, and the glucolipid metabolism pathway and function change of the parental generation and the offspring generation can be known through an isotopic tracing technology, metabonomics and transcriptomics.

The invention discloses a medical sterilizing, antagonistic-free and fat-retaining disinfectant hand sanitizer and a preparation method thereof, and relates to the technical field of hand sanitizers. CHG is used as a main bactericide, sophorolipid, CAB and alpha-glucan oligosaccharide are used as a composite surfactant, and the antagonistic effect of sterilization effect reduction caused by CHG wrapping after a conventional surfactant forms micelles is eliminated; meanwhile, phytosterol ester, glycosylglycerol and madecassoside are introduced as skin fat-retaining components, so that the sebum retention rate is greater than or equal to 95%, meanwhile, the antibacterial rate on staphylococcus aureus is still kept 100%, and the hand washing liquid is suitable for high-frequency hand washing of medical staff.

The purpose of the present invention is to identify a novel substance / factor relating to the anti-inflammatory activity of sugar beet, and to provide the substance / factor. This will make it possible to develop health products such as pharmaceuticals, foods and cosmetics for inhibiting chronic inflammation. Provided is a lipopolysaccharide characterized by being obtained from a bacterium that has been preserved at a preservation number of NITE BP-03839, NITE BP-03840, NITE BP-03841, NITE BP-03842, or NITE BP-03843, and a method for producing the same. The invention also provides a medicine, a medicine for animals, a quasi-medicine, a cosmetic, a food, a functional food, a feed, a fertilizer or a bath lotion additive in which the lipopolysaccharide is mixed.

The invention relates to the technical field of oilfield chemistry, in particular to an environment-friendly biological blocking remover for oil extraction and a processing technology of the environment-friendly biological blocking remover. The environment-friendly biological blocking remover is prepared from the following components in percentage by weight: 4 to 6 percent of alkyl glycoside, 4 to 6 percent of sophorolipid, 3 to 5 percent of methylglycine diacetic acid, 5 to 8 percent of rhamnolipid, 6 to 8 percent of compound microorganism fermentation liquor, 5 to 8 percent of lipase, 5 to 8 percent of protease, 6 to 8 percent of polymer degrading enzyme, 2 to 4 percent of citric acid, 2 to 4 percent of mandelic acid, 1 to 2 percent of glycerol, 1 to 2 percent of trehalose and 31 to 57 percent of deionized water. The biological enzyme, the biological surfactant, the organic acid and the chelating agent cooperate to fundamentally disintegrate blockages, meanwhile, the microcapsule technology and the nano-bubble technology are used, the action period is greatly prolonged, blockages of deeper parts can be treated, and the treatment effect is good. And corrosion and damage of strong acid and strong alkali to underground pipe columns, tools and stratum rocks are avoided, and secondary damage caused by plug removal operation is prevented.

The present invention addresses the problem of producing a high-purity low-molecular-weight lipopolysaccharide at low cost from a preserved bacterium that produces a high-purity low-molecular-weight lipopolysaccharide. The present invention relates to: a lipopolysaccharide obtained from a preserved bacterium obtained by causing a change in genetic information of conventional Pantoea agglomerans; a method for producing a lipopolysaccharide by which a lipopolysaccharide is obtained from the preserved bacterium; and a method for producing a lipopolysaccharide. Also disclosed is a lipopolysaccharide complex for a pharmaceutical product, an animal drug, a quasi-drug, a cosmetic, a food, a functional food, a feed, a fertilizer, a bath agent or the like in which the lipopolysaccharide is blended.

The invention discloses a salt-reducing freshness-enhancing high-temperature-resistant functional seasoning composition beneficial to maintaining intestinal microecological balance, and a preparation method and application thereof, and belongs to the technical field of food seasoning. The core of the composition is a synergistic dietary fiber combination composed of yeast beta-glucan, yeast mannan oligosaccharide and resistant dextrin according to the weight ratio of (3-5): (4-6): (2-4), edible salt and yeast extract are matched, the sodium content of the product is smaller than or equal to 14000mg / 100g, when clear soup is prepared according to the addition amount of 0.5% (w / v), the delicate flavor strength equivalent to that of traditional chicken essence can be kept, and the delicate flavor attenuation rate is smaller than or equal to 6.7% after heating is conducted for 60 min at the temperature of 100 DEG C. The product simultaneously realizes 0 sugar, 0 fat, low purine and sodium-potassium ratio balance, can synergistically promote proliferation of beneficial bacteria in intestinal tracts, solves the problem that salt reduction, fresh keeping, high temperature resistance and flavor stability of the existing seasoning are difficult to consider at the same time, and is suitable for industrial production.

The invention belongs to the technical field of skin care products, and relates to an L-carnosine-sophorolipid micelle and a preparation method and application thereof.The method comprises the steps that sophorolipid is dissolved in methyl alcohol or ethyl alcohol or acetone, L-carnosine is dissolved in an aqueous solution with the pH ranging from 2 to 7, after mixing and stirring are conducted according to the mass ratio of 3: 1-8: 1, vacuum rotary evaporation is conducted under the pressure ranging from-0.06 MPa to-0.08 MPa at the temperature ranging from 30 DEG C to 70 DEG C, an organic solvent is removed, a thin film is formed, and the L-carnosine-sophorolipid micelle is obtained. And hydrating with normal saline, purifying with a 1000Da ultrafiltration membrane, and freeze-drying to obtain the product. The obtained micelles are uniform in particle size, the encapsulation efficiency is up to 99.34%, the carnosinase resistance and the transdermal absorption efficiency of the L-carnosine can be improved, and meanwhile, the effects of scavenging free radicals, resisting inflammation, inhibiting bacteria and preserving moisture for a long time are synergistically reserved. The process is simple, convenient and controllable, the problems that the L-carnosine is poor in stability and low in bioavailability are solved, and the preparation method is suitable for smearing type skin care products and has important application value.

The application discloses a mild multi-effect scrub containing biosugar lipids and amino acid surfactants and a preparation method thereof. Sodium cocoyl glycinate, biosugar lipids, nicotinamide and hydrolyzed yeast extract are used as core components, physical scrub particles are matched, and cosmetic acceptable carriers such as polyols and thickening agents are compounded, and the mild multi-effect scrub is prepared through processes such as phase solubility, homogenization, temperature reduction and dispersion. The application reduces the irritation of the product from the two dimensions of chemical cleaning and physical friction, realizes the cleaning and exfoliation, simultaneously achieves the multiple effects of skin color lightening, bacteriostasis and acne removal, the core components have synergistic effects, the problems of strong irritation, single function and large environmental burden of traditional scrubs are solved, the product is suitable for sensitive skin, has environmental friendliness and verifiable efficacy, and has a wide application prospect.

The application discloses a full-bio-based PHA liquid bio-plastic emulsion and a preparation method thereof. The emulsion takes polyhydroxyalkanoate (PHA) as a matrix, adopts alkyl polysaccharide, a fermentation sugar lipid and a bio-based non-ionic surfactant to compound pullulan, alginate or micro-nano cellulose as a stabilizing system, and adds acetyl tri-butyl citrate and the like plasticizers and citric acid, phytic acid or tannic acid as compacting agents. The emulsion has a solid content of 35-58%, a volume average particle size D 50 of 0.12-0.90 μm, a Zeta potential absolute value of not less than 30 mV, a volatile organic compound (VOC) content of not higher than 50 g / L, no artificial addition of fluorine-containing organic matters, and total organic fluorine of ≤100 ppm. The overall bio-based carbon content of all organic components in the formula is not less than 95% according to mass weighting calculation. The application further provides applications of the emulsion in paper barrier coating, heat-sealing glue and non-woven fabric finishing fields.

A persistent encapsulation structure capable of preventing the degradation of bioactive substances, which encapsulation structure comprises a variety of encapsulation structure bodies (10), characterized by that the respective encapsulation structure body (10) has a polysaccharide structure (11) by which a plurality of bioactive substances (12) are encapsulated, wherein the bioactive substance (12) is selected from a group consisting of a bioactive fatty substance (121) and a bioactive non-fatty substance (122); that the polysaccharide structure (11) comprises at least one polysaccharide, wherein the at least one polysaccharide is first thoroughly mixed, then sheared at high pressure or homogenized at high speed and finally atomized dried, such that the polysaccharide structure (11) forms branched polysaccharides and linear polysaccharides which form a multitude of network structures; that the bioactive fatty substance (121) is selected from a group consisting of glycerophospholipids, sphingophospholipids, gangliosides, L-α- / glycerylphosphorylcholines, phosphatidylcholines, phosphatidylethanolamines, phosphatidylinositol, phosphatidylserines, phosphatidic acids, phosphatidylglycerol, ceramides, glucocerebrosides, glycolipids, cholesterols and fatty acid substances; and that the bioactive nonfatty substance (122) is selected from a group of coenzymes, vitamins, carotenes, carotenoids, curcuminoids, curcumin, curcumin extract, polyphenols, saponins, glycosides, terpenoids, ergothioneine, minerals, acid substances, functional polysaccharides, carbohydrates, functional proteins, peptides, amino acids and their derivatives.

This invention relates to a method for preparing lotus leaf-derived nanovesicles, comprising: (1) dissolving phospholipids and cholesterol in anhydrous ethanol to form a lipid solution; (2) dissolving lotus leaf-derived active ingredient extracts in dimethyl sulfoxide to form an active ingredient solution; (3) mixing the lipid solution and the active ingredient solution, removing the solvent by rotary evaporation to form a thin film; (4) adding phosphate buffer for hydration, and ultrasonically treating to obtain a suspension; (5) high-pressure homogenization to obtain lotus leaf-derived nanovesicles; (6) dialysis purification, and freeze-drying to obtain lotus leaf-derived nanovesicle lyophilized powder. This invention verifies, through the extraction process of lotus leaf-derived active ingredients, the preparation process of lotus leaf-derived nanovesicles, in vivo animal experimental design, and in vitro cell experimental design, that these nanovesicles possess functions such as fat reduction, improvement of glucose and lipid metabolism, and liver protection, and can be used to prepare fat-reducing drugs, drugs for improving glucose and lipid metabolism, or drugs for protecting organ function.

The invention discloses a method for preparing a granular biogas residue soil conditioner for both a feeding machine and a machine, which comprises 90-100 parts of biogas residue with the water content of 3-5% after dry-wet separation, 5-10 parts of an acid regulating agent, 3-5 parts of a binder, 20-30 parts of turf, 15-25 parts of perlite, 5-8 parts of mineral fertilizer, 2-4 parts of trace elements and 1-2 parts of sophorolipid with the concentration of 3% and used as a wetting agent. An acid regulating agent, a binding agent, trace elements and the like are scientifically proportioned, the acid regulating agent is formed by mixing vinegar residues and furfural residues according to a specific proportion according to different soil types and can be flexibly adjusted according to the soil acidity and alkalinity difference, and the binding agent is formed by mixing konjac polysaccharide and modified chitosan according to a certain proportion and is stable in binding performance in a humid environment; the forming effect of the modifier particles is remarkably improved, the modifier particles are not prone to being damped and broken in the storage process, the modifier particles can be evenly scattered in the field application process, it is guaranteed that the modifier makes full contact with soil, and therefore the soil improvement effect is effectively improved.

The invention belongs to the field of enzymes, and particularly relates to a CYP52M1 enzyme mutant and application of the CYP52M1 enzyme mutant in sophorolipid production. The CYP52M1 enzyme mutant is a CYP52M1 enzyme mutant which is obtained by mutating at least one site of amino acids at the 141 site, the 148 site and the 476 site of an amino acid sequence as shown in SEQ ID NO.1, and the CYP52M1 enzyme mutant is a CYP52M1 enzyme mutant, according to the mutation, phenylalanine at the 141 site of the amino acid sequence shown in SEQ ID NO.1 is mutated into alanine, tryptophan at the 148 site is mutated into alanine, or proline at the 476 site is mutated into alanine. The mutant enhances the substrate binding orientation and omega-hydroxylation ability, improves the fatty acid conversion efficiency, reduces the cost, and promotes the efficient synthesis of sophorolipid. The invention provides a new technical approach for improving the yield of the biosurfactant through an enzyme engineering means.

This invention discloses the application of catalpol in the preparation of drugs for the prevention and treatment of schizophrenia and the alleviation of the glucose and lipid metabolism side effects of olanzapine. Using a schizophrenia model mouse model induced by the commonly used MK801, the therapeutic effect of catalpol on schizophrenia was investigated, and the therapeutic effect of catalpol on the glucose and lipid metabolism side effects of the commonly used drug olanzapine was investigated through long-term gavage administration. A systematic study of catalpol was conducted from pharmacodynamic, behavioral, and morphological perspectives. The results showed that catalpol effectively improved the behavioral characteristics of the schizophrenia model mice, alleviated negative symptoms and cognitive impairment; catalpol effectively improved olanzapine-induced obesity and lipid metabolism disorders. This provides a theoretical research basis for the development of catalpol into a drug for the treatment of schizophrenia.

The invention discloses onium salt derivatives containing tetrahydropyran side chains as well as a preparation method and application of the onium salt derivatives. The structure of the compound also comprises isomers, solvates and pharmaceutically acceptable salts thereof, and the compound has good inhibitory activity on alpha-glucosidase, and can improve glycolipid metabolism disorder of diabetic nephropathy model mice and protect renal functions. The compound enriches the structure type of the existing alpha-glucosidase inhibitor, and has the potential of preventing or treating hyperglycemia, diabetic complications, obesity, abnormal lipid metabolism or hypertension.

The invention relates to the field of bacterial membrane protein structures. More specifically, the invention relates to lipid nanodiscs compartmentalized by SlyB protein oligomers isolated from the outer membrane of Gram-negative bacteria. More specifically, the invention provides for a SlyB nanodisc structure wherein the SlyB-oligomer forms the membrane scaffold protein belt, which is surrounded by outer saccharolipid moieties anchored to the SlyB proteins, and which encloses a lipid bilayer nanodomain containing one or more phospholipid layers, wherein macromolecules such as (outer) membrane protein molecules may be captured and stabilized. More specifically, methods to produce and isolate chemically defined stable SlyB nanodisc particles are disclosed herein. Finally, the invention relates to the use of said SlyB nanodiscs as a self-adjuvanting vehicle, as part of an immunogenic composition, and provides for novel means for use in eliciting an immune response against macromolecules enclosed in said SlyB nanodiscs, or for use in a vaccine composition.

The invention relates to the field of gold nano antibacterial materials, and mainly relates to a gold nano composite antibacterial material based on hyaluronic acid modification and a preparation method and application thereof. A preparation method of a gold nano composite antibacterial material based on hyaluronic acid modification comprises the following steps: adding acetic acid and sophorolipid into a hyaluronic acid solution to obtain a mixed solution; adding a chloroauric acid solution into the mixed solution, and stirring to obtain a room-temperature solution; adding a sodium cyanoborohydride solution into the room-temperature solution under a violent stirring condition; after the sodium cyanoborohydride solution is added, reducing the stirring speed and stirring to obtain a reaction solution; and carrying out high-speed centrifugation, resuspension, filtration and sterilization on the reaction liquid to obtain the hyaluronic acid modification-based gold nano composite antibacterial material. The material not only has excellent broad-spectrum antibacterial performance and is especially effective to drug-resistant bacteria, but also has significantly improved biocompatibility, and is expected to reduce adverse effects on wound healing. Meanwhile, the method disclosed by the invention is relatively simple and controllable in process and suitable for large-scale preparation.

The invention relates to the technical field of microbial fermentation engineering, and relates to a sophorolipid fermentation method which comprises the following steps: inoculating a seed solution of a strain into a fermentation culture medium for fermentation to produce sophorolipid, in the fermentation process, fermentation is conducted for 24-36 h, the respiratory entropy RQ is detected, and according to the RQ value, the sugar and oil adding mass ratio is dynamically regulated and controlled in a staged mode; when the RQ value is 0.8 lt; when RQ is less than or equal to 1, controlling the mass ratio of the fed-batch sugar oil to be (1.8-2.2): 1; when the RQ value is 0.6 lt; when RQ is less than or equal to 0.8, controlling the mass ratio of the fed-batch sugar oil to be (0.8-1.2): 1; when the RQ value is larger than or equal to 0.4 and smaller than or equal to 0.6, the mass ratio of fed-batch sugar to oil is controlled to be (1.1-1.4): 1; according to the method, the carbon source conversion rate of sophorolipid fermentation can be increased at the same time, the sophorolipid yield is increased, the residual oil content is reduced, and the problem of poor washing performance is solved.

The invention discloses long-acting care low-foam antibacterial baby shower gel based on sophorolipid, and belongs to the technical field of baby wash supplies. The shower gel is prepared from the following components in percentage by mass: 10 to 20 percent of sophorolipid, 3 to 8 percent of amino acid surfactant, 8 to 10 percent of glycerol, 1 to 5 percent of beta-glucan, 0.5 to 1 percent of panthenol, 0.1 to 0.5 percent of rosemary essential oil microcapsules, 1 to 3 percent of camphor tree leaf extract microcapsules and the balance of water. The shower gel prepared by the invention is excellent in cleaning performance, can effectively remove dirt and redundant grease on the skin surfaces of infants and children, takes sophorolipid as a main surfactant, gives full play to the characteristics of natural bacteriostasis, low-foam mildness and skin friendliness of the sophorolipid, and cooperates with rosemary essential oil microcapsules and camphor tree leaf extract microcapsules to realize synergistic bacteriostasis, so that the shower gel has a good cleaning effect on the skin surfaces of the infants and children. The antibacterial effect and the antibacterial aging are improved, and the problems of short antibacterial effect and strong irritation of the existing baby shower gel are solved.

This invention relates to a cleaning composition R, preferably liquid, with a low reaction point, i.e., improved cold stability. The cleaning composition R is particularly suitable for rinsing hard surfaces such as dishes, especially as a hand dishwashing detergent. The invention therefore also relates to methods for treating a substrate S or a textile, wherein the preferably liquid cleaning composition R is used in these methods. Finally, the invention relates to the use of a combination of at least one glucolipid G and certain amphoteric surfactants TAmph to improve the cold storage stability of formulations containing primary alkyl sulfate surfactants TAs.

The application discloses a strain of Bifidobacterium adolescentis for relieving estrogen-related metabolic disorders and obesity and an application thereof, and belongs to the technical field of microorganisms. The Bifidobacterium adolescentis CCFM1506 screened by the application can effectively improve the symptoms of estrogen disorders of ovariectomized individuals, significantly slow down the weight growth rate and weight increment of individuals with estrogen disorders, increase the expression amounts of serum estradiol, CYP11A1 and ERa in adrenal glands and the high-density lipoprotein content in serum, reduce the total cholesterol and glucose levels, adjust abnormal glucose and lipid metabolism, increase SCFA in colon contents, relieve menopausal syndrome caused by the decrease of estrogen, and can be used for preparing medicines for relieving or treating estrogen-related metabolic disorders and obesity, or health care products for helping to control fat in the body and maintain the healthy level of blood lipids. The significant physiological effect and wide application prospect provide a new thought and new basis for developing functional foods or medicines based on probiotics.

This present disclosure provides various diamine centered poly(amino acid)-saccharide-lipid conjugates. In various embodiments, the conjugates can safely be used as water solubility or bioavailability enhancers. In one aspect, the present disclosure provides a conjugate having the structural formula wherein B is a residue of a compound having three or four available binding positions, e.g., an alkylene diamine; S is a saccharide, for example, a residue of a mono-, di- or trisaccharide group, in which each saccharide unit is a sugar, a sugar alcohol, an amino sugar or a sugar acid; L is a lipophilic carrier residue selected from fatty acid residues (for example, residues of lauric acid, myristic acid, linoleic acid, palmitic acid, oleic acid and elaidic acid), steroid acid and sterol residues, and residues of retinoids carotenoids, tocopherols, and tocotrienols; Q is a residue of ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol or hexaethylene glycol; P is a residue of a polyaminoacid homopolymer; R2 is a terminal group selected from H, methyl, ethyl and maleimide; D is a secondary group that is as defined above for L or is a methyl-capped poly(ethylene glycol) residue; and d is 0, or d is 1.