53 results about "Amino sugar" patented technology

The invention discloses a fluorescent probe for identifying D-galactosamine as well as a preparation method and an identification method thereof, and belongs to the technical field of chemical analysis and detection. The fluorescent probe takes BINOL as a skeleton, and the preparation method of the fluorescent probe comprises the following steps: sequentially synthesizing intermediates (R)-2, (R)-3 and (R)-4, dissolving (R)-4 in a mixed solution of absolute ethyl alcohol and dichloromethane, adding hydrochloric acid, reacting overnight, quenching, separating a water phase and an organic phase, removing a solvent under reduced pressure, and purifying by a silica gel column to obtain a yellow solid product (R)-5, namely the fluorescent probe. The fluorescent probe disclosed by the invention is simple to prepare and low in cost, the D-galactosamine (D-GalN) can be identified from various amino sugars and amino acids in acetonitrile, and the detection method is simple to operate, high in sensitivity and convenient in post-treatment.

The invention relates to a process for producing an alcohol-free disinfectant comprising at least one polyaminosaccharide and at least one carboxylic acid, comprising the steps of: - mixing the polyaminosaccharide with the carboxylic acid to obtain a mixture of the polysaccharide and the carboxylic acid; - treating the mixture in a shear film mixer to obtain a homogeneous disinfectant.

The utility model discloses filling equipment for preparing nicotinamide glucosamine oral liquid, which comprises a driving unit which comprises an electric conveying belt and a support plate fixedly connected to one side of the electric conveying belt, a filling unit which comprises a rectangular frame fixedly connected to the output end of the cross slide rail, and a driving unit which comprises a driving unit and a filling unit, the inner wall of the rectangular frame is rotationally connected with a threaded rod and a limiting rod, one side of the rectangular frame is rotationally connected with a rotating rod, the rotating rod penetrates through the rectangular frame and is fixedly connected with the threaded rod, and the outer wall of the limiting rod is slidably sleeved with a plurality of evenly-distributed movable plates. By rotating the threaded rod, the multiple movable plates can drive the multiple injection pipes to be away from or close to each other at equal intervals, so that the intervals among the multiple injection pipes can be adjusted according to the diameters of oral liquid bottles, and bottles with different diameters can be filled conveniently.

The invention provides a glucosamine and chondroitin sulfate pharmaceutical composition as well as a preparation method and application thereof, and belongs to the technical field of biological pharmaceutical preparations, the composition comprises sodium chondroitin sulfate, glucosamine sulfate, dimethyl sulfone, non-denatured type II collagen, frankincense extract and auxiliary materials in specific parts by mass, compared with the prior art, the composition provided by the invention has the advantages that by selecting the components, adding the composite synergist optionally and optimizing the ratio and synergistic effect of the components, the effects of the composition in promoting cartilage regeneration and inhibiting joint inflammation are remarkably improved, the anti-inflammatory and anti-oxidation effects are enhanced, and the bioavailability is also improved, so that a breakthrough progress is realized in the field of joint health.

The invention provides dandelion amino sugar as well as an extraction method and application thereof, and the extraction method comprises the following steps: putting dandelion leaves into an extraction kettle, conveying hot water into the extraction kettle, and pressurizing for subcritical extraction. According to the method, subcritical water is adopted to extract amino sugar in dandelion, the subcritical water not only has relatively strong dissolving capacity for polysaccharide, but also can promote full extraction of amino sugar, and water is adopted as an extraction solvent, so that environmental pollution is avoided. Meanwhile, the method has the advantages of high extraction yield, high efficiency and the like, and is expected to be applied to industrial extraction of taraxacum mongolicum amino sugar. In addition, the amino sugar obtained by the invention has a relatively strong ovarian improving function, specifically, the ovarian microenvironment can be improved, and the cyst nourishing rate can be increased.

The invention discloses C2-quaternary carbon amino sugar as well as a preparation method and application thereof. According to the preparation method, C2-position functionalized glyene is taken as a raw material, di-tert-butyldiaziridone is taken as a nitrogen source, and a double amination reaction of unsaturated bonds of sugar rings is realized by utilizing a copper-catalyzed nitrogen-nitrogen bond activation strategy, so that the C2-quaternary carbon amino sugar compound is constructed. In-vitro antifungal activity research results show that the C2-quaternary carbon amino sugar has certain inhibitory activity on tested fungi, and the compounds I-2 and I-3 show good broad-spectrum antibacterial biological activity and can be used as an agricultural bactericide. The C2-quaternary carbon amino sugar developed by the invention has the remarkable characteristics of simple and efficient synthesis method, cheap and easily available raw materials, mild reaction conditions and the like, and has a good application prospect.

The application discloses a non-natural sugar and a synthesis method and application thereof. At room temperature, hydroxyl groups of an amino sugar are fully trimethylsilyl-protected, amino groups on the sugar are selectively exposed, and after coupling and conversion of the amino groups at room temperature, a non-natural sugar with orthogonal groups and full trimethylsilyl protection is obtained. The non-natural sugar with orthogonal groups and full trimethylsilyl protection is removed from trimethylsilyl protection groups, and a non-natural sugar without protection groups is obtained. The application takes into account the advantages of existing non-natural sugars, ensures that the non-natural sugars can be efficiently utilized by cells, effectively avoids S side reactions with cysteine in proteins in the metabolic process of the non-natural sugars, and simultaneously realizes efficient metabolic labeling. In a cell test, the use concentration of 1,6-bisacylated non-natural sugar is one order of magnitude lower than that of non-natural sugar without protection groups.

The invention discloses a total synthesis method and application of furanose ring pyrrole spiroketal alkaloid, and belongs to the technical field of chemical synthesis and biological medicine. According to the method, D-glucose is used as a raw material and reacts with dibenzylamine, 1-dibenzylamino-1-deoxy-D fructose is prepared through an Amadori rearrangement reaction, 1-amino-1-deoxy-D fructose is prepared through direct hydrogenation debenzylation, or 2-hydroxyl of 1-dibenzylamino-1-deoxy-D fructose is protected by adding methyl and then debenzylation protection is carried out, and 1-amino-1-deoxy-D fructose is obtained. The preparation method comprises the following steps: preparing 1-amino-1-deoxy-2-methoxyl-D-fructose; and respectively carrying out Maillard condensation reaction on the two obtained amino sugars and dihydropyrone, and then completing spiro reaction under an acidic condition to obtain acorine B and pinosine C. The acorine B and pinosine C synthesized by the invention can obviously reduce the weight of an aged mouse, reduce the fat index, reduce lipid droplets in the liver and fat in thymus, reduce the number of aged cells and improve the proportion of T cells in immune cells, and have the potentials of reducing fat and resisting immune aging.

The invention belongs to the technical field of bioengineering, and provides an engineering bacterium for producing an amino sugar intermediate as well as a construction method and application thereof, the engineering bacterium for producing the amino sugar intermediate inhibits synthesis of validamycin by knocking out genes on the basis of streptomyces hygroscopicus, and valilone synthetase is over-expressed. The engineering bacterium disclosed by the invention realizes high-yield effective alcohol amine through multiple modifications, and the yield reaches 513.8 mg / L.

1.The name of the design product: packaging bag (amino sugar glycosaminoglycan paste-new). 2.The use of the design product: for product packaging. 3.The design points of the design product: the combination of shape, pattern and color. 4.The picture or photo that best indicates the design points: front view. 5.The design for which protection is sought contains color. 6.The design product is a planar product, and the left view, right view, top view and bottom view are omitted.

The invention relates to an S-4FB glucosamine modified carboxyl microsphere for latex immunoturbidimetry, a synthesis method and application. On the basis of carboxyl polystyrene microspheres, the S-4FB-glucosamine modified microspheres for latex immunoturbidimetric determination are obtained through glucosamine modification and S-4FB modification, the prepared S-4FB-glucosamine modified carboxyl microspheres have active groups and can be directly coupled with biomolecules with amino groups, operation is easy, convenient and efficient, coupling efficiency is high, and the S-4FB-glucosamine modified carboxyl microspheres have good application prospects. The anti-interference capability is strong, and the stability is good. When the S-4FB-glucosamine modified carboxyl microspheres are used as indicating microspheres for preparing a detection reagent, the repeatability, linearity, acceleration stability and kit correlation of the reagent are superior to those of unmodified carboxyl polystyrene microspheres. Therefore, the S-4FB-glucosamine modified carboxyl microspheres disclosed by the invention have a wide application prospect in the aspect of in-vitro detection.

# imgabs0 # The invention relates to a novel silicon-based fluoride acceptor group (SiFA group) of formula (Ia, Ib, Ic) wherein R1 and R2 are each a linear or branched C3 to C10 alkyl group, and R3 is selected from (i)-OH or-O-, (ii) a sugar or amino sugar moiety, (iii) an amino acid or oligopeptide moiety, (iv) a PEG moiety, as well as compounds suitable for use in radiopharmaceuticals comprising such groups; and a combination of two or more selected from (ii), (iii) and (iv).

A process for converting amino sugar to fructose and ammonia using one enzyme. Also provided are compositions and enzymes for converting amino sugar to fructose and ammonia.

The invention discloses a method for detecting a soil microbial marker-amino sugar by direct ion chromatography, and relates to the technical field of biomarker analysis, and the method comprises the following steps: adding a soil sample into a 6mol / L hydrochloric acid solution, and hydrolyzing at 105 DEG C for 8 hours; drying the hydrolysate with nitrogen, redissolving with ultrapure water, centrifuging, taking supernate, and filtering with a 0.22 mu m filter membrane to obtain a to-be-detected solution; the method comprises the following steps: injecting a to-be-detected solution into an ion chromatography system provided with an electrochemical detector, and carrying out gradient elution by adopting an anion exchange chromatographic column and taking a mixed solution of sodium hydroxide and sodium acetate as a mobile phase to realize separation and quantitative detection of glucosamine (GlcN), galactosamine (GalN), aminomannose (ManN) and muramic acid (Mur). A highly toxic derivatization step necessary for a traditional method is omitted, a sample can be directly injected through three-step purification after acid hydrolysis, and efficient separation of four amino sugars is realized by matching with a special ion chromatography system.

This present disclosure provides various diamine centered poly(amino acid)-saccharide-lipid conjugates. In various embodiments, the conjugates can safely be used as water solubility or bioavailability enhancers. In one aspect, the present disclosure provides a conjugate having the structural formula wherein B is a residue of a compound having three or four available binding positions, e.g., an alkylene diamine; S is a saccharide, for example, a residue of a mono-, di- or trisaccharide group, in which each saccharide unit is a sugar, a sugar alcohol, an amino sugar or a sugar acid; L is a lipophilic carrier residue selected from fatty acid residues (for example, residues of lauric acid, myristic acid, linoleic acid, palmitic acid, oleic acid and elaidic acid), steroid acid and sterol residues, and residues of retinoids carotenoids, tocopherols, and tocotrienols; Q is a residue of ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol or hexaethylene glycol; P is a residue of a polyaminoacid homopolymer; R2 is a terminal group selected from H, methyl, ethyl and maleimide; D is a secondary group that is as defined above for L or is a methyl-capped poly(ethylene glycol) residue; and d is 0, or d is 1.

The invention relates to novel silicon-based fluoride acceptor groups (SiFA groups) of the following formulae, as well as to compounds suitable for use in radiopharmacy comprising such groupswherein R1 and R2 are each a linear or branched C3 to C10 alkyl group and R3 is selected from (i) —OH or —O−, (ii) a sugar moiety or an amino sugar moiety, (iii) an amino acid moiety or an oligopeptide moiety, (iv) a PEG moiety; and from combinations of two or more of (ii), (iii) and (iv).

The present invention relates to a polysaccharide comprising pendant amides, methods of making thereof, and copolymers, nanoparticles, compositions, thermoplastics, and membranes comprising the polysaccharide.

The invention belongs to the technical field of polysaccharide vaccine vector synthesis, and relates to a pentasaccharide repeating unit and decasaccharide repeating unit compound of zwitterionic polysaccharide PS A2 and a synthesis method thereof. The PS A2 pentasaccharide repeating unit is successfully synthesized through a [2 + 2 + 1] strategy, and the technical problems of construction of a mannoheptaose C6-position ether bond, determination of a side chain methyl configuration, efficient construction of a 1, 2-cis-glucosidic bond, synthesis of multiple amino sugars and the like in the synthesis process are solved. The pentasaccharide repeating unit is coupled with other compounds and can be used for researching the potential anticancer effect of the PS A2. The pentasaccharide repeating units with different chiral methyl groups on the side chains provided by the invention can be used for subsequently performing activity screening on the two pentasaccharide repeating units to compare the influence of different methyl chirality on antigenicity, so that a foundation is laid for bacteroides fragilis sugar vaccines; the decasaccharide repeating unit provided by the invention provides a new path for synthesizing long-chain zwitterionic polysaccharide PS A2.

The invention discloses a preparation method of voglibose, which comprises the following steps: by taking validamycin which is low in price and easy to obtain as a raw material, hydrolyzing and removing impurities to obtain validinol A, splitting C-N bonds of the validinol A to form a mixture of two quasi-six-membered amino sugars which are difficult to separate, and separating the two quasi-six-membered amino sugars to obtain the voglibose. The preparation method comprises the following steps: carrying out intramolecular cyclization on a selenium reagent loaded by a high polymer and pseudo-six-membered amino sugar (Va) containing double bonds to form a rigid lactone compound, and immobilizing the rigid lactone compound on resin through a carbon-selenium bond to form resin (VI); according to the process design, the problem of stereoselectivity during synthesis of the key intermediate validalylamine is solved, and separation of two quasi-six-membered amino sugars (Va) and (Vb) is realized, namely, the precursor quasi-six-membered amino sugars (Vb) of the validalylamine (XI) are separated through simple filtering and washing operations; cutting the resin (VI) through sodium borohydride, hydrolyzing, carrying out dehydration condensation on the resin (VI) and 1, 3-dihydroxyacetone, and hydrogenating to obtain voglibose; the method is short in route and low in cost. # imgabs0 #

The application relates to the technical field of agricultural fertilizers, and provides an amino sugar-oligosaccharide biofertilizer and a preparation method thereof. The amino sugar-oligosaccharide biofertilizer comprises 3-4 parts of amino sugar, 12-20 parts of seaweed oligosaccharide preparation liquid, 0.5-1 part of bacillus subtilis, 1-2 parts of trichoderma viride, 1-2 parts of aspergillus niger and 70-83 parts of base material. The seaweed oligosaccharide preparation liquid contained in the amino sugar-oligosaccharide biofertilizer is prepared by an acid enzymolysis-alkaline enzymolysis-biological fermentation three-step method, the content of seaweed oligosaccharide with a stable polymerization degree of 2-5 is high, the content of salicylic acid in crops can be effectively improved, the immune induction effect is obvious, the biocontrol and growth promotion effects of amino sugar and microorganisms are combined, the defense ability of crops against diseases is improved, and especially the growth and reproduction of pathogenic bacteria Pseudomonas syringae pv. tomato can be effectively inhibited, and the occurrence rate of bacterial spot disease of tomatoes can be reduced.

Compositions herein disclosed are conceived for the treatment and prevention of diseases caused by accumulation of heparan sulfate including mucopolysaccharidosis, Alzheimer's disease and cancers. These compositions include as active ingredient an iminosugar belonging to L-steric series and derivatives thereof. The L-iminosugars of this invention are able to reduce the levels of heparan sulfate in cells of patients affected by mucopolysaccharidosis and cancer, and to reduce the accumulation of amyloid plaques in a model of neurodegenerative disease. Therefore, the use of these compounds prevents the onset of symptoms associated with these diseases, thus improving the quality and length of life of patients suffering from diseases characterized by accumulation of heparan sulfate.

The invention provides a preparation method of a polymer conductive film, which comprises the following steps: (1) blending a polymer, a styrene-maleic anhydride copolymer and an organic solvent to prepare a polymer solution, and preparing a polymer film by adopting an immersion precipitation phase inversion method; (2) soaking the polymer membrane in an aqueous solution containing amino sugar to obtain a grafted membrane of which the membrane surface and the body both contain aldehyde groups; and (3) reducing silver or copper hydroxide in the silver ammonia solution or the potassium sodium tartrate solution of copper hydroxide into silver with a conductive effect or cuprous oxide nanoparticles with a semiconductor effect by the aldehyde group to form a continuous structure with nanoparticles on the surface and in the body, thereby obtaining the'polymer / inorganic nano material 'hybrid conductive film. The conductive film is stable and durable, has excellent conductivity and can be used for conductive thin films, electromagnetic shielding materials and the like, the preparation method of the film is simple and easy to amplify, the reaction process is easy to observe, application and popularization are easy, and good industrialization prospects are achieved.

The present invention relates to nanoparticles formed by a hollow polymeric wall, capable of transporting drugs and active substances, or contrast media, across cellular membranes and releasing them at sites of interest. The nanoparticles are formed by self-assembly of poly(isobutene-alt-maleic anhydride) functionalised with an aminosaccharide.

The invention belongs to the technical field of organic synthesis, and particularly relates to a method for synthesizing N, N-dimethyl aminoglycoside through halogen bond / hydrogen bond catalytic glycosylation. The invention develops a new glycosylation method, and N, N-dimethyl aminoglycoside is directly synthesized through halogen bond activation. Results show that under mild halogen bond activated glycosylation conditions, the N, N-dimethylamino glycosyl donor can be coupled with a wide range of receptors by using a specific catalyst, and the required N, N-dimethylamino glycoside can be provided with good to excellent yield and excellent stereoselectivity. The glycosylation reaction is carried out under mild conditions, conversion of various sugar substrates containing N, N-dimethylamine is promoted, and the yield is moderate to excellent. Results show that the halogen bond catalyst C5 and the N, N-dimethyl tertiary amine fragment have strong interaction to form a relatively stable complex, and intramolecular activation of the N, N-dimethyl amino glycosyl donor can be promoted.

The invention provides sea cucumber polysaccharide capable of preventing and treating helicobacter pylori infection and a preparation method and application thereof, and belongs to the technical field of marine organism polysaccharide preparation. The sea cucumber polysaccharide comprises the following components: 35-44% of total sugar, 19-25% of sulfate group, 4.5-5.0% of protein, 3.0-3.5% of uronic acid, 4.0-4.7% of amino sugar, 7.0-9.0% of water and 20-25% of ash content, has the molecular weight of 16-1916 kDa, mainly contains fucose, mannose and galactose, and also contains a small amount of glucosamine, galactosamine, glucuronic acid and glucose. The sea cucumber polysaccharide has good anti-helicobacter pylori activity in vitro, and the minimum effective dose is 20 mg / mL; in vivo, the sea cucumber polysaccharide can reduce stomach inflammation response and helicobacter pylori colonization amount in the helicobacter pylori infection process, reduce the infection rate, and also can reduce the stomach inflammation level and the helicobacter pylori colonization amount after infection, that is, the obtained sea cucumber polysaccharide has prevention and treatment effects on helicobacter pylori infection. When the sea cucumber polysaccharide with good helicobacter pylori inhibitory activity is applied to the fields of food nutrition and pharmacy, the industrial additional value of sea cucumbers can be greatly improved.

The invention belongs to the technical field of bioengineering, and provides an engineering bacterium for producing an amino sugar intermediate as well as a construction method and application thereof, the engineering bacterium for producing the amino sugar intermediate inhibits synthesis of validamycin by knocking out genes on the basis of streptomyces hygroscopicus, and valilone synthetase is over-expressed. The engineering bacterium disclosed by the invention realizes high-yield effective alcohol amine through multiple modifications, and the yield reaches 318.8 mg / L.

The invention relates to sea urchin-derived glycopeptide as well as a preparation method and application thereof. The molecular weight of the glycopeptide is less than 3kDa, and the glycopeptide contains neutral sugar, amino sugar and tryptophan. The glycopeptide disclosed by the invention is small in molecular weight, easy to dissolve in water and capable of resisting gastrointestinal digestion; the traditional Chinese medicine composition has the effects of remarkably increasing white blood cells, protecting immune organs, relieving liver injury and other immunoregulation activities, and regulating intestinal flora; the compound is expected to be developed into drugs for improving or treating immune-related body dysfunction and / or prebiotics for regulating intestinal flora.

A method of treating or preventing an ocular disease in a subject comprising administering locally to an eye of the subject a nucleic acid (NA) molecule having an acetylated amino sugar moiety (CHO) (CHO-NA), wherein the NA is an inhibitor of at least one biological activity in the eye associated with the ocular disease and is effective in the treatment or prevention of the ocular disease. Also a composition comprising a CHO-NA for the treatment of an ocular disease. In embodiments, the CHO is an N-galactosamine moiety.

The invention discloses a surface glycosylation modified impregnation liquid and a preparation method thereof, an antibacterial fiber, an antibacterial fabric and application, and belongs to the technical field of antibiosis. According to the preparation method, a reactive main chain polymer and amino sugar are adopted, steeping liquor is prepared through step-by-step reaction or one-pot reaction, and then glycosylation modification is conducted on the surface of the nano-antibacterial fiber / fabric. On the basis of the nano antibacterial fiber, the fiber surface is subjected to glycosylation modification, the balance between the biological safety and the antibacterial activity of the nano antibacterial fiber material is realized, and the graphene fiber capable of selectively capturing and enriching pathogenic microorganisms such as bacteria and the like is obtained by utilizing the specific binding of a characteristic sugar chain to the bacteria; furthermore, the killing efficiency of the nano-antibacterial fiber on dispersed pathogenic microorganisms in the environment is greatly improved, the problem of space limitation of a nano-antibacterial material in contact antibiosis is effectively solved, and the material is suitable for preparing active bacterium targeting type drug-resistant bacterium infection wound dressings.

Provided are a cannabichromenic acid derivative, a method for preparing same, and a composition for cognitive function improvement comprising same, in which the cannabichromenic acid derivative exhibits acetylcholinesterase inhibitory activity and butyrylcholinesterase inhibitory activity, as well as inhibitory activity against monoamine oxidase B, therefore simultaneously treating a decrease in acetylcholine levels in brain tissue and a decrease in blood butyrylcholine levels, shown in patients with dementia, and providing a more effective cognitive function improvement treatment by preventing brain cell damage.