161 results about "Amino sugar" patented technology

A topical skin rejuvenation preparation to relieve wrinkles, increase the skin's natural production of hyaluronic acid, reverse the lack of suppleness, hydrate from within, erase spider veins, reduce varicose veins, lighten aging dark blotches (“liver spots” / Lentigos, Senile Lentigines), decrease acne, and reduce under eye puffiness includes Glucosamine (2-amino-2-deoxy-alpha-D-glucose), a hexosamine (6 carbon amino sugar), including its derivative and precursor compounds: Glucosamine Sulfate, Glucosamine Hydrochloride, Glucose-6-Phosphate, Acetyl Glucosamine, Fructose-6-phosphate, Glucosamine-6-Phosphate, to increase production of Hyaluronic acid and collagen from Glucosamine Sulfate, its precursors and derivatives and to increase skin muscle tone by Dimethylaminoethanol (DMAE) while over coming deficiency it creates in each cell's production of PhosphatidylCholine, whose deficiency damages cell membranes, as well as mitochondrial and lysosome membranes.

A process for making a surfactant composition involving: (a) providing a starting mixture containing: (i) an aqueous alkali solution; (ii) at least one amino acid and / or a salt thereof; (iii) a fatty acid chloride; (iv) an acylatable surfactant precursor selected from the group consisting of a protein hydrolyzate, a polyamino acid, an aminosulfonic acid, an amino sugar, a nonionic surfactant, and mixtures thereof; and (v) up to about 15% by weight, based on the weight of the starting mixture, of a polyol component; (b) providing a stirring mechanism; and (c) reacting (ii) and (iii), with stirring, to form the surfactant composition.

Imino sugars, such as deoxynojirimycin (DNJ), are glucose analogues that selectively inhibit cellular α-glucosidase I and II (enzymes that process N-linked glycans in glycoprotein) and exhibit broad spectrum antiviral activities against many enveloped viruses. Previously we have reported a novel DNJ derivative, OSL-95II, with antiviral activity and reduced cytotoxicity. In order to develop imino sugars with more potent antiviral activity as well as improved toxicity profile, OSL-95II was modified by diversifying the nitrogen linked alkylated side chain. The antiviral activities were initially tested in bovine viral diarrhea virus (BVDV) infected MDBK cells, yielding several imino sugar derivatives with novel structure and superior antiviral activity and toxicity profile. Furthermore, these new compounds were shown to be active against Dengue virus (DV) and West Nile virus (WNV) infection in BHK cells where potent anti-DV activity having submicromolar EC50 values and SI of greater than 900. These compounds represent a new generation of iminio sugars and their analogues, having application in the clinical treatment of infection of DV and other members of flaviviridae.

A polishing agent of the invention comprises tetravalent metal hydroxide particles, a cationized polyvinyl alcohol, at least one type of saccharide selected from the group consisting of an amino sugar, a derivative of the amino sugar, a polysaccharide containing an amino sugar and a derivative of the polysaccharide, and water. The method for polishing a substrate of the invention comprises a step of polishing the silicon oxide film 1 (film to be polished), formed on the silicon substrate 2 having the silicon oxide film 1, by relatively moving the silicon substrate 2 and a polishing platen, in a state that the silicon oxide film 1 is pressed against a polishing pad on the polishing platen, while supplying the polishing agent of the invention between the silicon oxide film 1 and the polishing pad.

An object of the present invention is to provide a preventing agent or a treating agent for arthritis or to provide foods and drinks, additives for foods and drinks, feeds or additives for feeds for prevention or treatment of arthritis. In order to achieve the above object, the present invention provides a preventing or treating agent for arthritis or foods and drinks, additives for foods and drinks, feeds or additives for feeds for prevention or treatment of arthritis comprising plant belonging to the genus Hydrangea or an extract of the plant and amino sugar or a salt thereof and / or glycosaminoglycan or a salt thereof as active ingredients.

The present invention is an aqueous composition comprising at least one hydrophobic compound having at least one linkage of Formula I:—NHC(O)—X—  (I)wherein X is the residue of a cyclic or acyclic sugar alcohol which is substituted with at least one —R1; —C(O)R1; —(CH2CH2O)n(CH(CH3)CH2O)mR2; —(CH2CH2O)n(CH(CH3)CH2O)mC(O)R1; or mixtures thereof; where the cyclic or acyclic sugar alcohol is selected from a saccharide, reduced sugar, aminosaccharide, aldonic acid, or aldonic acid lactone; wherein each n is independently 0 to 20; each m is independently 0 to 20; m+n is greater than 0; each R1 is independently a linear or branched alkyl group having 5 to 29 carbons optionally comprising at least 1 unsaturated bond; each R2 is independently —H, a linear or branched alkyl group having 6 to 30 carbons optionally comprising at least 1 unsaturated bond, or mixtures thereof.

The invention relates to a hair-care composition containing an efficient anti-hair-loss compound agent. The hair-care composition comprises long-chain alcohol, a cationic surface active agent, a thickening agent, essence, a preservative, a chelating agent, water and an anti-hair-loss compound active matter, wherein the anti-hair-loss compound active matter accounts for 0.1 to 10 percent of weight of the composition and is a composition of hydrolyzed soy protein, amino acid, amino sugar, vitamin B complex, zinc salt, ginseng essence, May burdock root essence, organic silicon and polyquaternium. By virtue of the hair-care composition, the hair growth can be promoted, the ratio of a growing period to a resting period of hair is improved, forming of healthy scalp and healthy hair is promoted, and the hair loss speed of a hair loss patient is returned to be normal.

A polishing agent of the invention comprises tetravalent metal hydroxide particles, a cationized polyvinyl alcohol, at least one type of saccharide selected from the group consisting of an amino sugar, a derivative of the amino sugar, a polysaccharide containing an amino sugar and a derivative of the polysaccharide, and water. The method for polishing a substrate of the invention comprises a step of polishing the silicon oxide film 1 (film to be polished), formed on the silicon substrate 2 having the silicon oxide film 1, by relatively moving the silicon substrate 2 and a polishing platen, in a state that the silicon oxide film 1 is pressed against a polishing pad on the polishing platen, while supplying the polishing agent of the invention between the silicon oxide film 1 and the polishing pad.

An objective of the present invention is to provide methods for stabilizing proteins and methods for suppressing protein aggregation, which comprise the step of adding meglumine to the proteins. Another objective of the present invention is to provide agents for suppressing protein aggregation, which comprise meglumine. Still another objective of the present invention is to provide pharmaceutical compositions comprising antibody molecules stabilized by meglumine, methods for producing the pharmaceutical compositions, and kits comprising the pharmaceutical compositions.To achieve the objectives described above, the present inventors assessed the antibody-stabilizing effect of meglumine, an amino sugar. As a result, the inventors discovered that meglumine was useful as a stabilizer for antibody molecules and also as an excipient for freeze-dried preparations.

An object of the present invention is to provide a method for stabilizing a protein or a method for inhibiting aggregation of a protein, these methods including the step of adding meglumine to the protein. The present invention also provides a drug containing meglumine, which stabilizes protein, or a drug which inhibits protein aggregation. Furthermore, the object of the present invention is to provide a pharmaceutical composition containing an antibody molecule stabilized by meglumine, a method for preparing the pharmaceutical composition, and a kit containing the pharmaceutical composition. In order to solve the above-mentioned problems, the present inventors studied the antibody stability effect of a kind of amino sugar, meglumine. It was found that meglumine can be used as a stabilizer for antibody molecules and also as an excipient for lyophilized formulations.

The present invention relates to pharmaceuticals, foods and drinks, food additives, animal feeds and feed additives comprising an N-acylated hydroxyproline derivative or a salt thereof, and an amino sugar or a salt thereof and / or a glycosaminoglycan or a salt thereof as active ingredients, use of an Nacylated hydroxyproline derivative or a salt thereof for the production of an arthritis preventing or treating agent, and a method for preventing or treating arthritis which comprises administering an N-acylated hydroxyproline derivative or a salt thereof, and an amino sugar or a salt thereof and / or a glycosaminoglycan or a salt thereof.

Described are various compounds and methods for the treatment of disorders arising from aberrant protein folding, including in particular lysosomal storage diseases. In particular, polyhydroxylated alkaloids and imino sugars which are pharmacoperones of an enzyme and which do not bind to a catalytic site of said enzyme are described.

A polymer composition with (A) a first poly(meth)acrylate polymer or urethane polymer; and (B) a second poly(meth)acrylate polymer or urethane polymer which has a residue X incorporated therein, where X is the residue of a cyclic or acyclic sugar alcohol which is substituted with at least one —R1; —C(O)R1; —(CH2CH2O)n(CH(CH3)CH2O)mR2; —(CH2CH2O)n(CH(CH3)CH2O)mC(O)R1; or mixtures thereof; where the cyclic or acyclic sugar alcohol is selected from a saccharide, reduced sugar, aminosaccharide, aldonic acid, or aldonic acid lactone; wherein each n is independently 0 to 20; each m is independently 0 to 20; m+n is greater than 0; each R1 is independently a linear or branched alkyl group having 5 to 29 carbons optionally comprising at least 1 unsaturated bond; and each R2 is independently —H, a linear or branched alkyl group having 6 to 30 carbons optionally comprising at least 1 unsaturated bond, or mixtures thereof.

An object of the present invention is to provide a pharmaceutical composition containing rebamipide, which is unnecessary to be re-dispersed, has an enough transparency, and exhibits neutral to weakly acidic pH not to injure the keratoconjunctiva of a patient suffering from dry eye. The present pharmaceutical composition comprises (1) rebamipide, (2) an amino sugar, and (3) an buffer agent, which has no inorganic cation.

The core structure of pentaerythritol has been used as a replacement for one or both sugars in lipid A, leading to the generation of a series of lipid A analogs. These lipid A analogs may further differ from lipid A with respect to, e.g., the number, nature and location of negatively charged groups, and the number, nature and location of the lipid chains. The lipid A analogs may be lipid A agonists useful as immunostimulatory agents, or lipid A antagonists useful in the treatment of septic shock. In a like manner, a residue of pentaerythritylamine may be used as a replacement for an amino sugar residue in a carbohydrate ligand having a biological activity of interest, generating a series of ligand analogs. These are useful, e.g., as haptens, inhibitors of bacterial-host cell adhesion, etc.

The object of the present invention is to provide a composition which exerts a higher effect on recovering health from articular disorders than that attained by amino sugars and glycosaminoglycans. The present invention solves the object by providing an agent for treating articular disorders, comprising an amino sugar and trehalose as effective ingredients.

The present invention relates to recombinant strains of Vibrio spp, which are unable to utilize the amino sugar N-acetylglucosamine (GlcNAc) as a sole carbon source. This inability to utilize GlcNAc severely impairs the colonization property of the recombinants. The present invention also provides compositions comprising these recombinant strains for use in pharmaceuticals and in providing immunity.

The invention discloses an alveolar bone repair material and a preparation method and application thereof. The alveolar bone repair material is a powdery, granular or massive composite formed by bone meal, metal salt and amino sugar, wherein the mass part ratio of bone meal, metal salt and amino sugar is 10:(0.01-20):(0.1-100). The composite adopts a multi-layered structure taking bone meal as the core, and comprises bone meal, metal salt, amino sugar and metal salt from the inside out. Bone meal, calcium, zinc, magnesium, manganese, strontium metal element, glycosaminoglycan, amino-oligosaccharide and amino-monosaccharide all have bone guiding and promoting functions. Therefore, the alveolar bone repair material has better bone guiding and promoting functions, and can serve as a bone filler in alveolar bone repair and bone defect repair to quicken formation of new bones, to increase bone weight and to promote bone defect repair.

The present invention is directed to stabilized compositions comprising at least one macrocyclic lactone, or derivative thereof, in combination with levamisole, and an amino sugar stabilizing agent, optionally an additional antiparasitic agent, and a method for treating or controlling a parasitic infection or infestation in an animal by administering said composition.

The invention discloses an amino sugar thiazole derivative as well as a synthetic method thereof. When synthesis is carried out, glucosamine hydrochloride is taken as a raw material, and benzyl ether protection is carried out on hydroxy, so that the selective reaction of amino is realized, a novel intermediate glycosyl thiourea-N-(1,3,4,6-tetra-0-benzyl-2-deoxygenation- beta-D-glucopyranose-2-group) thiocarbamide is synthesized, and glycosyl thiazole-N-(1,3,4,6-tetra-0-benzyl-beta-D-glucopyranose-2-group)-2-amido-4-substituted thiazole is synthesized by cyclizing the novel intermediate glycosyl thiourea-N-(1,3,4,6-tetra-0-benzyl-2-deoxygenation beta-D-glucopyranose-2-group) thiocarbamide with 1-bromine-2-substituted ethyl ketone. The synthetic method disclosed by the invention has the advantages of easiness and safety for operation, wide application scope, low cost of the raw material, easiness for raw material obtaining, easiness and convenience for post-processing and high yield, is a fast high-efficiency synthetic method and has a wide application prospect on the aspect of preparing an acetylcholinesterase resistant drug because the synthesized compound has high inhibiting effect on acetylcholinesterase.

The present invention provides a process for the synthesis of substituted arylureidophenoxymethylpropionic acid and related compounds including bifunctional and tetrafunctional derivatives. The compounds are useful for inhibiting the formation of AGEs (Aminaglycation end products).

The invention relates to a fresh fillet compounding fresh-keeping agent. The fresh-keeping agent mainly comprises the following raw material components in parts by weight: 15-20 parts of amino sugar Maillard series reaction products, 0.1-1.0 part of spice essential oil, 0.5-1.5 parts of plant polyphenols, 0.05-0.8 part of pimaricin and 1-2 parts of sodium chloride. The compounding fresh-keeping agent synthesizes the characteristics of all the components and uses the synergetic effects of the components, so that the compounding fresh-keeping agent has favorable oxidation resistance and broad-spectrum bacterial inhibition, can notably restrain the growth of various microorganisms, can delay the corruption of fillets, has the effects of color protection, whitening and water retention on the fresh fillets, concurrently has certain efficacy of dispelling fishy smell, and can effectively improve the organoleptic quality of the fillets; and in addition, the compounding fresh-keeping agent also has a seasoning function, gives unique fragrant and pungent flavor to the fillets, is appropriate in the degree of saltness and conforms to the consumption taste of the public. The invention further provides a fillet cold storage fresh keeping method, so that the shelf life of the fillets can be significantly prolonged. The compounding fresh-keeping agent disclosed by the invention is low in cost, simple in production technology and convenient to use, and industrialized popularization is facilitated.

Aminoside tetracyclic anthraquinones represented by formula (I) and (II). Peptides are introduced to connect tetracyclic anthraquinones and fatty acid to enable selective absorption and release of the anticancer agents. In addition, aminosaccharide and tetracyclic moieties are introduced into the branched chain to improve water-solubility. The compounds of formula (I) and (II) are pharmaceutically active components useful for treating diseases that are cured by aminoside tetracyclic anthraquinones, including cancer.

The invention discloses a glucosamine intermediate tobacco flavor with a roasted and nutty aroma and its preparation and application. The preparation method includes: (1) taking amino acids and reducing sugars according to the proportion, adding water to dissolve them into a solution, and adjusting the pH to 6-8, the resulting solution is placed in a Maillard reactor to perform the Maillard reaction to obtain the Maillard reaction solution; (2) The Maillard reaction solution is evaporated simultaneously in a negative pressure environment of 80-100°C And react 15-60min; Obtain product deoxyaminosugar solid. The invention adds the prepared amino sugar compound to the cigarette, which can significantly improve the aroma of the cigarette, enhance the smoking taste of the cigarette, round and smoke, and have obvious roasted and nutty aromas, which are harmonious with the aroma of flue-cured tobacco cigarettes Good, the application effect is ideal.

The invention belongs to the field of analysis and detection, and relates to a method for extracting and detecting frisee polyphenols (levan). An inventor adopts a GracePure<TM> SPE C18-Max column produced by GRACE Company to filter a sample in the extraction of frisee plant samples. The column can remove the polar matters from a water solution, nearly cannot absorb sugar, and can effectively reduce the detection background. A common HPLC (high performance liquid chromatography) instrument is adopted, but a PREVAIL Carbohydrate ES special sugar column produced by the GRACE Company is adopted and has good sugar separation function. The sugar column is an amino sugar column bonded by polystyrene and divinylbenzene, so the problem of disturbing other amino columns is avoided, the chemical degradation is avoided, and the stability is realized at room temperature and under the gradient elution condition; an ELSD (evaporative light-scattering detector) is used for the sugar detection, and one complete set of extraction and detection flow of the polyphenols (levan) of the frisee plant samples is firstly established.

The present invention provides a food for improving arthritis comprising proanthocyanidins (A) and a mucopolysaccharide and / or an amino sugar (B). Preferably, the proanthocyanidins contain at least 20 wt % of OPCs.

The present invention discloses certain derivatives of artemisinin and the active principles contained in Artemisia annua extracts with amino acids, peptides, and amino sugars, and isomers and salts thereof (formula I). The compounds of the present invention possess wide-spectrum antibacterial and antifungal biological activity suitable for topical or oral application for the treatment of infections and topical ailments in mammals, including acne, rosacea, topical wounds, infections, dandruff, skin disfigurements caused by infection, skin discoloration, age spots, wrinkles, excess facial oil, and veterinary problems including canine infections;

The invention relates to a main material for constructing a tillage layer of newly rectified cultivated land, a construction method of the tillage layer and application. The main material for constructing the tillage layer of the newly rectified cultivated land comprises peat materials, active organic materials and biological activators; the peat materials include herbal peat, woody peat and / or humus soil; the active organic materials are natural plant organic materials rich in polysaccharide / organic acid / amino sugar; the biological activators comprise amino acid bacteria and bacillus which promote degradation of all the active organic materials to form soil organic matter, facilitate formation of a good agglomeration structure of the soil and activate rapid circulation of the system. Thetillage layer is rapidly constructed by engineering, a traditional mode is subverted, a lengthy cultivation and ripening process formed by the high-quality tillage layer can be simplified into one-time engineering operation, geotechnical cultivation of the newly rectified cultivated land is improved in a short time, and crop yields and benefits are continuously ensured.

The invention discloses a preparation method of a nitrogen and chlorine double-doped fluorescent carbon quantum dot. The preparation method comprises the steps of with amino sugar hydrochloride or amino acid hydrochloride as raw materials, simultaneously supplying a carbon source, a nitrogen source and a chlorine source, dissolving the raw material into ultrapure water, stirring so as to obtain asettled solution, carrying out hydrothermal reaction, cooling a synthesized product, filtering, and carrying out centrifugation and dialysis, so as to obtain the water-soluble nitrogen and chlorine double-doped fluorescent carbon quantum dot. By utilizing a one-step reaction, the required raw material is few, byproducts are few, and the method has the characteristics of high efficiency, economy and the like. The carbon quantum dot prepared by virtue of the carbon quantum dot has stable fluorescent property and low toxin, can be applied to the detection of Fe<3+> and simultaneously has wide application prospect in the aspects of fluorescent ink, sewage treatment and the like.