40 results about "Amino sugar" patented technology

The invention relates to a process for producing an alcohol-free disinfectant comprising at least one polyaminosaccharide and at least one carboxylic acid, comprising the steps of: - mixing the polyaminosaccharide with the carboxylic acid to obtain a mixture of the polysaccharide and the carboxylic acid; - treating the mixture in a shear film mixer to obtain a homogeneous disinfectant.

The utility model discloses filling equipment for preparing nicotinamide glucosamine oral liquid, which comprises a driving unit which comprises an electric conveying belt and a support plate fixedly connected to one side of the electric conveying belt, a filling unit which comprises a rectangular frame fixedly connected to the output end of the cross slide rail, and a driving unit which comprises a driving unit and a filling unit, the inner wall of the rectangular frame is rotationally connected with a threaded rod and a limiting rod, one side of the rectangular frame is rotationally connected with a rotating rod, the rotating rod penetrates through the rectangular frame and is fixedly connected with the threaded rod, and the outer wall of the limiting rod is slidably sleeved with a plurality of evenly-distributed movable plates. By rotating the threaded rod, the multiple movable plates can drive the multiple injection pipes to be away from or close to each other at equal intervals, so that the intervals among the multiple injection pipes can be adjusted according to the diameters of oral liquid bottles, and bottles with different diameters can be filled conveniently.

The invention provides a glucosamine and chondroitin sulfate pharmaceutical composition as well as a preparation method and application thereof, and belongs to the technical field of biological pharmaceutical preparations, the composition comprises sodium chondroitin sulfate, glucosamine sulfate, dimethyl sulfone, non-denatured type II collagen, frankincense extract and auxiliary materials in specific parts by mass, compared with the prior art, the composition provided by the invention has the advantages that by selecting the components, adding the composite synergist optionally and optimizing the ratio and synergistic effect of the components, the effects of the composition in promoting cartilage regeneration and inhibiting joint inflammation are remarkably improved, the anti-inflammatory and anti-oxidation effects are enhanced, and the bioavailability is also improved, so that a breakthrough progress is realized in the field of joint health.

The invention provides dandelion amino sugar as well as an extraction method and application thereof, and the extraction method comprises the following steps: putting dandelion leaves into an extraction kettle, conveying hot water into the extraction kettle, and pressurizing for subcritical extraction. According to the method, subcritical water is adopted to extract amino sugar in dandelion, the subcritical water not only has relatively strong dissolving capacity for polysaccharide, but also can promote full extraction of amino sugar, and water is adopted as an extraction solvent, so that environmental pollution is avoided. Meanwhile, the method has the advantages of high extraction yield, high efficiency and the like, and is expected to be applied to industrial extraction of taraxacum mongolicum amino sugar. In addition, the amino sugar obtained by the invention has a relatively strong ovarian improving function, specifically, the ovarian microenvironment can be improved, and the cyst nourishing rate can be increased.

The invention discloses C2-quaternary carbon amino sugar as well as a preparation method and application thereof. According to the preparation method, C2-position functionalized glyene is taken as a raw material, di-tert-butyldiaziridone is taken as a nitrogen source, and a double amination reaction of unsaturated bonds of sugar rings is realized by utilizing a copper-catalyzed nitrogen-nitrogen bond activation strategy, so that the C2-quaternary carbon amino sugar compound is constructed. In-vitro antifungal activity research results show that the C2-quaternary carbon amino sugar has certain inhibitory activity on tested fungi, and the compounds I-2 and I-3 show good broad-spectrum antibacterial biological activity and can be used as an agricultural bactericide. The C2-quaternary carbon amino sugar developed by the invention has the remarkable characteristics of simple and efficient synthesis method, cheap and easily available raw materials, mild reaction conditions and the like, and has a good application prospect.

The application discloses a non-natural sugar and a synthesis method and application thereof. At room temperature, hydroxyl groups of an amino sugar are fully trimethylsilyl-protected, amino groups on the sugar are selectively exposed, and after coupling and conversion of the amino groups at room temperature, a non-natural sugar with orthogonal groups and full trimethylsilyl protection is obtained. The non-natural sugar with orthogonal groups and full trimethylsilyl protection is removed from trimethylsilyl protection groups, and a non-natural sugar without protection groups is obtained. The application takes into account the advantages of existing non-natural sugars, ensures that the non-natural sugars can be efficiently utilized by cells, effectively avoids S side reactions with cysteine in proteins in the metabolic process of the non-natural sugars, and simultaneously realizes efficient metabolic labeling. In a cell test, the use concentration of 1,6-bisacylated non-natural sugar is one order of magnitude lower than that of non-natural sugar without protection groups.

The invention discloses a total synthesis method and application of furanose ring pyrrole spiroketal alkaloid, and belongs to the technical field of chemical synthesis and biological medicine. According to the method, D-glucose is used as a raw material and reacts with dibenzylamine, 1-dibenzylamino-1-deoxy-D fructose is prepared through an Amadori rearrangement reaction, 1-amino-1-deoxy-D fructose is prepared through direct hydrogenation debenzylation, or 2-hydroxyl of 1-dibenzylamino-1-deoxy-D fructose is protected by adding methyl and then debenzylation protection is carried out, and 1-amino-1-deoxy-D fructose is obtained. The preparation method comprises the following steps: preparing 1-amino-1-deoxy-2-methoxyl-D-fructose; and respectively carrying out Maillard condensation reaction on the two obtained amino sugars and dihydropyrone, and then completing spiro reaction under an acidic condition to obtain acorine B and pinosine C. The acorine B and pinosine C synthesized by the invention can obviously reduce the weight of an aged mouse, reduce the fat index, reduce lipid droplets in the liver and fat in thymus, reduce the number of aged cells and improve the proportion of T cells in immune cells, and have the potentials of reducing fat and resisting immune aging.

The invention belongs to the technical field of bioengineering, and provides an engineering bacterium for producing an amino sugar intermediate as well as a construction method and application thereof, the engineering bacterium for producing the amino sugar intermediate inhibits synthesis of validamycin by knocking out genes on the basis of streptomyces hygroscopicus, and valilone synthetase is over-expressed. The engineering bacterium disclosed by the invention realizes high-yield effective alcohol amine through multiple modifications, and the yield reaches 513.8 mg / L.

1.The name of the design product: packaging bag (amino sugar glycosaminoglycan paste-new). 2.The use of the design product: for product packaging. 3.The design points of the design product: the combination of shape, pattern and color. 4.The picture or photo that best indicates the design points: front view. 5.The design for which protection is sought contains color. 6.The design product is a planar product, and the left view, right view, top view and bottom view are omitted.

The invention relates to an S-4FB glucosamine modified carboxyl microsphere for latex immunoturbidimetry, a synthesis method and application. On the basis of carboxyl polystyrene microspheres, the S-4FB-glucosamine modified microspheres for latex immunoturbidimetric determination are obtained through glucosamine modification and S-4FB modification, the prepared S-4FB-glucosamine modified carboxyl microspheres have active groups and can be directly coupled with biomolecules with amino groups, operation is easy, convenient and efficient, coupling efficiency is high, and the S-4FB-glucosamine modified carboxyl microspheres have good application prospects. The anti-interference capability is strong, and the stability is good. When the S-4FB-glucosamine modified carboxyl microspheres are used as indicating microspheres for preparing a detection reagent, the repeatability, linearity, acceleration stability and kit correlation of the reagent are superior to those of unmodified carboxyl polystyrene microspheres. Therefore, the S-4FB-glucosamine modified carboxyl microspheres disclosed by the invention have a wide application prospect in the aspect of in-vitro detection.

A process for converting amino sugar to fructose and ammonia using one enzyme. Also provided are compositions and enzymes for converting amino sugar to fructose and ammonia.

The invention discloses a method for detecting a soil microbial marker-amino sugar by direct ion chromatography, and relates to the technical field of biomarker analysis, and the method comprises the following steps: adding a soil sample into a 6mol / L hydrochloric acid solution, and hydrolyzing at 105 DEG C for 8 hours; drying the hydrolysate with nitrogen, redissolving with ultrapure water, centrifuging, taking supernate, and filtering with a 0.22 mu m filter membrane to obtain a to-be-detected solution; the method comprises the following steps: injecting a to-be-detected solution into an ion chromatography system provided with an electrochemical detector, and carrying out gradient elution by adopting an anion exchange chromatographic column and taking a mixed solution of sodium hydroxide and sodium acetate as a mobile phase to realize separation and quantitative detection of glucosamine (GlcN), galactosamine (GalN), aminomannose (ManN) and muramic acid (Mur). A highly toxic derivatization step necessary for a traditional method is omitted, a sample can be directly injected through three-step purification after acid hydrolysis, and efficient separation of four amino sugars is realized by matching with a special ion chromatography system.

This present disclosure provides various diamine centered poly(amino acid)-saccharide-lipid conjugates. In various embodiments, the conjugates can safely be used as water solubility or bioavailability enhancers. In one aspect, the present disclosure provides a conjugate having the structural formula wherein B is a residue of a compound having three or four available binding positions, e.g., an alkylene diamine; S is a saccharide, for example, a residue of a mono-, di- or trisaccharide group, in which each saccharide unit is a sugar, a sugar alcohol, an amino sugar or a sugar acid; L is a lipophilic carrier residue selected from fatty acid residues (for example, residues of lauric acid, myristic acid, linoleic acid, palmitic acid, oleic acid and elaidic acid), steroid acid and sterol residues, and residues of retinoids carotenoids, tocopherols, and tocotrienols; Q is a residue of ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol or hexaethylene glycol; P is a residue of a polyaminoacid homopolymer; R2 is a terminal group selected from H, methyl, ethyl and maleimide; D is a secondary group that is as defined above for L or is a methyl-capped poly(ethylene glycol) residue; and d is 0, or d is 1.

The invention relates to novel silicon-based fluoride acceptor groups (SiFA groups) of the following formulae, as well as to compounds suitable for use in radiopharmacy comprising such groupswherein R1 and R2 are each a linear or branched C3 to C10 alkyl group and R3 is selected from (i) —OH or —O−, (ii) a sugar moiety or an amino sugar moiety, (iii) an amino acid moiety or an oligopeptide moiety, (iv) a PEG moiety; and from combinations of two or more of (ii), (iii) and (iv).

The present invention relates to a polysaccharide comprising pendant amides, methods of making thereof, and copolymers, nanoparticles, compositions, thermoplastics, and membranes comprising the polysaccharide.

The invention belongs to the technical field of polysaccharide vaccine vector synthesis, and relates to a pentasaccharide repeating unit and decasaccharide repeating unit compound of zwitterionic polysaccharide PS A2 and a synthesis method thereof. The PS A2 pentasaccharide repeating unit is successfully synthesized through a [2 + 2 + 1] strategy, and the technical problems of construction of a mannoheptaose C6-position ether bond, determination of a side chain methyl configuration, efficient construction of a 1, 2-cis-glucosidic bond, synthesis of multiple amino sugars and the like in the synthesis process are solved. The pentasaccharide repeating unit is coupled with other compounds and can be used for researching the potential anticancer effect of the PS A2. The pentasaccharide repeating units with different chiral methyl groups on the side chains provided by the invention can be used for subsequently performing activity screening on the two pentasaccharide repeating units to compare the influence of different methyl chirality on antigenicity, so that a foundation is laid for bacteroides fragilis sugar vaccines; the decasaccharide repeating unit provided by the invention provides a new path for synthesizing long-chain zwitterionic polysaccharide PS A2.

The application relates to the technical field of agricultural fertilizers, and provides an amino sugar-oligosaccharide biofertilizer and a preparation method thereof. The amino sugar-oligosaccharide biofertilizer comprises 3-4 parts of amino sugar, 12-20 parts of seaweed oligosaccharide preparation liquid, 0.5-1 part of bacillus subtilis, 1-2 parts of trichoderma viride, 1-2 parts of aspergillus niger and 70-83 parts of base material. The seaweed oligosaccharide preparation liquid contained in the amino sugar-oligosaccharide biofertilizer is prepared by an acid enzymolysis-alkaline enzymolysis-biological fermentation three-step method, the content of seaweed oligosaccharide with a stable polymerization degree of 2-5 is high, the content of salicylic acid in crops can be effectively improved, the immune induction effect is obvious, the biocontrol and growth promotion effects of amino sugar and microorganisms are combined, the defense ability of crops against diseases is improved, and especially the growth and reproduction of pathogenic bacteria Pseudomonas syringae pv. tomato can be effectively inhibited, and the occurrence rate of bacterial spot disease of tomatoes can be reduced.

Compositions herein disclosed are conceived for the treatment and prevention of diseases caused by accumulation of heparan sulfate including mucopolysaccharidosis, Alzheimer's disease and cancers. These compositions include as active ingredient an iminosugar belonging to L-steric series and derivatives thereof. The L-iminosugars of this invention are able to reduce the levels of heparan sulfate in cells of patients affected by mucopolysaccharidosis and cancer, and to reduce the accumulation of amyloid plaques in a model of neurodegenerative disease. Therefore, the use of these compounds prevents the onset of symptoms associated with these diseases, thus improving the quality and length of life of patients suffering from diseases characterized by accumulation of heparan sulfate.

The invention provides a preparation method of a polymer conductive film, which comprises the following steps: (1) blending a polymer, a styrene-maleic anhydride copolymer and an organic solvent to prepare a polymer solution, and preparing a polymer film by adopting an immersion precipitation phase inversion method; (2) soaking the polymer membrane in an aqueous solution containing amino sugar to obtain a grafted membrane of which the membrane surface and the body both contain aldehyde groups; and (3) reducing silver or copper hydroxide in the silver ammonia solution or the potassium sodium tartrate solution of copper hydroxide into silver with a conductive effect or cuprous oxide nanoparticles with a semiconductor effect by the aldehyde group to form a continuous structure with nanoparticles on the surface and in the body, thereby obtaining the'polymer / inorganic nano material 'hybrid conductive film. The conductive film is stable and durable, has excellent conductivity and can be used for conductive thin films, electromagnetic shielding materials and the like, the preparation method of the film is simple and easy to amplify, the reaction process is easy to observe, application and popularization are easy, and good industrialization prospects are achieved.

The present invention relates to nanoparticles formed by a hollow polymeric wall, capable of transporting drugs and active substances, or contrast media, across cellular membranes and releasing them at sites of interest. The nanoparticles are formed by self-assembly of poly(isobutene-alt-maleic anhydride) functionalised with an aminosaccharide.

The invention belongs to the technical field of bioengineering, and provides an engineering bacterium for producing an amino sugar intermediate as well as a construction method and application thereof, the engineering bacterium for producing the amino sugar intermediate inhibits synthesis of validamycin by knocking out genes on the basis of streptomyces hygroscopicus, and valilone synthetase is over-expressed. The engineering bacterium disclosed by the invention realizes high-yield effective alcohol amine through multiple modifications, and the yield reaches 318.8 mg / L.

The invention relates to sea urchin-derived glycopeptide as well as a preparation method and application thereof. The molecular weight of the glycopeptide is less than 3kDa, and the glycopeptide contains neutral sugar, amino sugar and tryptophan. The glycopeptide disclosed by the invention is small in molecular weight, easy to dissolve in water and capable of resisting gastrointestinal digestion; the traditional Chinese medicine composition has the effects of remarkably increasing white blood cells, protecting immune organs, relieving liver injury and other immunoregulation activities, and regulating intestinal flora; the compound is expected to be developed into drugs for improving or treating immune-related body dysfunction and / or prebiotics for regulating intestinal flora.

A method of treating or preventing an ocular disease in a subject comprising administering locally to an eye of the subject a nucleic acid (NA) molecule having an acetylated amino sugar moiety (CHO) (CHO-NA), wherein the NA is an inhibitor of at least one biological activity in the eye associated with the ocular disease and is effective in the treatment or prevention of the ocular disease. Also a composition comprising a CHO-NA for the treatment of an ocular disease. In embodiments, the CHO is an N-galactosamine moiety.

The present disclosure provides PEG-saccharide-lipid conjugates centered around various diamines. In various embodiments, these conjugates can be safely used as water-soluble or bioavailability enhancers. In one aspect, the present disclosure provides a PEG-saccharide-lipid conjugate having the following structural formula. JPEG2026528703000080.jpg27170Here The number average value of m ranges from 2 to 10. S is a monosaccharide, disaccharide or trisaccharide group, and each sugar unit is a sugar, sugar alcohol, amino sugar or sugar acid. L is -C(O)-R 1 where R 1 is an alkanoyl or alkenoyl group having an average carbon number of 6 to 22, and / or a steroid acyl group. P is -(CH2-CH2-O)nR 2 where "n" has a number average value in the range of 5 to 50 (e.g., 8 to 45), and R 2 is hydrogen and / or an alkane and has a number average carbon number in the range of 0 to 4.

The present invention provides a pharmaceutical composition that, despite containing rebamipide, exhibits excellent transparency and high stability. [Solution] A pharmaceutical composition containing rebamipide, amino sugar, a solubilizer, a buffer, and an organic acid.

The invention relates to chitosan hemostatic gel and a preparation method thereof. The chitosan hemostatic gel is prepared from the following raw materials: a hydrophobic group modified chitosan derivative, unmodified chitosan, an acidic pH regulator, an organic solvent, a metal ion chelating agent and the balance of water. The chitosan gel realizes the functions of quickly stopping bleeding, resisting bacteria, improving mechanical strength and the like through a synergistic mechanism of palmitic acyl chitosan and unmodified chitosan. The hydrophobic group modified chitosan derivative is inserted into an erythrocyte membrane phospholipid layer through a hydrophobic effect, membrane surface charge balance is destroyed, surface protonated amino groups are induced to be combined with fibrinogen, an endogenous blood coagulation pathway is activated so as to improve the hemostasis efficiency, the hydrophobic group is used as a physical cross-linking point to be combined with a hydrogen bond network of an unmodified chitosan main chain, and the hemostasis efficiency is improved. And the natural amino sugar unit can promote the activation of blood platelets and activate a double blood coagulation mechanism, so that the hemostasis efficiency is further improved.

This invention discloses a method and system for measuring soil microbial nitrogen pumps, belonging to the field of soil biogeochemistry and agricultural ecological environment monitoring technology. The method involves applying nitrogen to a soil-crop system... 15 N-labeled nitrogen fertilizer, combined with in-situ closed sampling, membrane sample mass spectrometry (MIMS) detection, and amino sugar compound specificity. 15 This invention analyzes nitrogen emissions, simultaneously measuring the fluxes and isotopic characteristics of N2 emissions, NH3 volatilization, and N2O emissions, as well as nitrogen uptake by plants, residual nitrogen in the soil, and nitrogen fixed by microorganisms. Finally, it constructs a microbial nitrogen pump efficiency (MNUE) index to characterize the intensity and efficiency of soil microbial nitrogen pumps. This invention enables comprehensive accounting of multiple nitrogen fluxes under near-real-field conditions, accurately distinguishing the contributions of fertilizer-source and soil-source nitrogen to gaseous nitrogen emissions. It is applicable to anaerobic ecosystems such as flooded paddy fields and wetlands, providing a systematic and operable technical solution for the quantitative study of soil microbial nitrogen pumps.

This invention discloses a method for preparing a fluorescent probe specifically for the detection of D-aminomannose (D-ManN) and a rapid detection and analysis method. A novel chiral crown ether fluorescent probe (S)-Q8 is designed and synthesized based on a binaphthol backbone, achieving for the first time specific and selective fluorescent recognition of D-ManN. This probe has a short synthetic route and is simple to operate. Under excitation light at a wavelength of 285 nm, (S)-Q8 reacts with D-ManN and produces a significant fluorescence enhancement signal at 365 nm. This fluorescence signal is not interfered with by other structurally similar amino sugars, chiral amino acids, or chiral sugars. This invention achieves rapid and specific quantitative analysis of D-ManN in complex environments by developing a chiral crown ether-based fluorescent probe (S)-Q8.

1. The name of the design product: label (Jian Lida amino sugar plus chondroitin calcium tablets). 2. The use of the design product: for the external packaging of products. 3. The design points of the design product: in the pattern. 4. The picture or photo that best indicates the design points: front view. 5. The design product is a flat product, omitting rear view, left view, right view, top view, bottom view.

A method of treating or preventing an ocular disease in a subject comprising administering locally to an eye of the subject a nucleic acid (NA) molecule having an acetylated amino sugar moiety (CHO) (CHO-NA), wherein the NA is an inhibitor of at least one biological activity in the eye associated with the ocular disease and is effective in the treatment or prevention of the ocular disease. Also a composition comprising a CHO-NA for the treatment of an ocular disease. In embodiments, the CHO is an N-galactosamine moiety.