30 results about "Amino sugar" patented technology

The invention relates to a process for producing an alcohol-free disinfectant comprising at least one polyaminosaccharide and at least one carboxylic acid, comprising the steps of: - mixing the polyaminosaccharide with the carboxylic acid to obtain a mixture of the polysaccharide and the carboxylic acid; - treating the mixture in a shear film mixer to obtain a homogeneous disinfectant.

The invention provides dandelion amino sugar as well as an extraction method and application thereof, and the extraction method comprises the following steps: putting dandelion leaves into an extraction kettle, conveying hot water into the extraction kettle, and pressurizing for subcritical extraction. According to the method, subcritical water is adopted to extract amino sugar in dandelion, the subcritical water not only has relatively strong dissolving capacity for polysaccharide, but also can promote full extraction of amino sugar, and water is adopted as an extraction solvent, so that environmental pollution is avoided. Meanwhile, the method has the advantages of high extraction yield, high efficiency and the like, and is expected to be applied to industrial extraction of taraxacum mongolicum amino sugar. In addition, the amino sugar obtained by the invention has a relatively strong ovarian improving function, specifically, the ovarian microenvironment can be improved, and the cyst nourishing rate can be increased.

The invention discloses C2-quaternary carbon amino sugar as well as a preparation method and application thereof. According to the preparation method, C2-position functionalized glyene is taken as a raw material, di-tert-butyldiaziridone is taken as a nitrogen source, and a double amination reaction of unsaturated bonds of sugar rings is realized by utilizing a copper-catalyzed nitrogen-nitrogen bond activation strategy, so that the C2-quaternary carbon amino sugar compound is constructed. In-vitro antifungal activity research results show that the C2-quaternary carbon amino sugar has certain inhibitory activity on tested fungi, and the compounds I-2 and I-3 show good broad-spectrum antibacterial biological activity and can be used as an agricultural bactericide. The C2-quaternary carbon amino sugar developed by the invention has the remarkable characteristics of simple and efficient synthesis method, cheap and easily available raw materials, mild reaction conditions and the like, and has a good application prospect.

The application discloses a non-natural sugar and a synthesis method and application thereof. At room temperature, hydroxyl groups of an amino sugar are fully trimethylsilyl-protected, amino groups on the sugar are selectively exposed, and after coupling and conversion of the amino groups at room temperature, a non-natural sugar with orthogonal groups and full trimethylsilyl protection is obtained. The non-natural sugar with orthogonal groups and full trimethylsilyl protection is removed from trimethylsilyl protection groups, and a non-natural sugar without protection groups is obtained. The application takes into account the advantages of existing non-natural sugars, ensures that the non-natural sugars can be efficiently utilized by cells, effectively avoids S side reactions with cysteine in proteins in the metabolic process of the non-natural sugars, and simultaneously realizes efficient metabolic labeling. In a cell test, the use concentration of 1,6-bisacylated non-natural sugar is one order of magnitude lower than that of non-natural sugar without protection groups.

The invention belongs to the technical field of bioengineering, and provides an engineering bacterium for producing an amino sugar intermediate as well as a construction method and application thereof, the engineering bacterium for producing the amino sugar intermediate inhibits synthesis of validamycin by knocking out genes on the basis of streptomyces hygroscopicus, and valilone synthetase is over-expressed. The engineering bacterium disclosed by the invention realizes high-yield effective alcohol amine through multiple modifications, and the yield reaches 513.8 mg / L.

1.The name of the design product: packaging bag (amino sugar glycosaminoglycan paste-new). 2.The use of the design product: for product packaging. 3.The design points of the design product: the combination of shape, pattern and color. 4.The picture or photo that best indicates the design points: front view. 5.The design for which protection is sought contains color. 6.The design product is a planar product, and the left view, right view, top view and bottom view are omitted.

The invention relates to an S-4FB glucosamine modified carboxyl microsphere for latex immunoturbidimetry, a synthesis method and application. On the basis of carboxyl polystyrene microspheres, the S-4FB-glucosamine modified microspheres for latex immunoturbidimetric determination are obtained through glucosamine modification and S-4FB modification, the prepared S-4FB-glucosamine modified carboxyl microspheres have active groups and can be directly coupled with biomolecules with amino groups, operation is easy, convenient and efficient, coupling efficiency is high, and the S-4FB-glucosamine modified carboxyl microspheres have good application prospects. The anti-interference capability is strong, and the stability is good. When the S-4FB-glucosamine modified carboxyl microspheres are used as indicating microspheres for preparing a detection reagent, the repeatability, linearity, acceleration stability and kit correlation of the reagent are superior to those of unmodified carboxyl polystyrene microspheres. Therefore, the S-4FB-glucosamine modified carboxyl microspheres disclosed by the invention have a wide application prospect in the aspect of in-vitro detection.

A process for converting amino sugar to fructose and ammonia using one enzyme. Also provided are compositions and enzymes for converting amino sugar to fructose and ammonia.

The invention discloses a method for detecting a soil microbial marker-amino sugar by direct ion chromatography, and relates to the technical field of biomarker analysis, and the method comprises the following steps: adding a soil sample into a 6mol / L hydrochloric acid solution, and hydrolyzing at 105 DEG C for 8 hours; drying the hydrolysate with nitrogen, redissolving with ultrapure water, centrifuging, taking supernate, and filtering with a 0.22 mu m filter membrane to obtain a to-be-detected solution; the method comprises the following steps: injecting a to-be-detected solution into an ion chromatography system provided with an electrochemical detector, and carrying out gradient elution by adopting an anion exchange chromatographic column and taking a mixed solution of sodium hydroxide and sodium acetate as a mobile phase to realize separation and quantitative detection of glucosamine (GlcN), galactosamine (GalN), aminomannose (ManN) and muramic acid (Mur). A highly toxic derivatization step necessary for a traditional method is omitted, a sample can be directly injected through three-step purification after acid hydrolysis, and efficient separation of four amino sugars is realized by matching with a special ion chromatography system.

This present disclosure provides various diamine centered poly(amino acid)-saccharide-lipid conjugates. In various embodiments, the conjugates can safely be used as water solubility or bioavailability enhancers. In one aspect, the present disclosure provides a conjugate having the structural formula wherein B is a residue of a compound having three or four available binding positions, e.g., an alkylene diamine; S is a saccharide, for example, a residue of a mono-, di- or trisaccharide group, in which each saccharide unit is a sugar, a sugar alcohol, an amino sugar or a sugar acid; L is a lipophilic carrier residue selected from fatty acid residues (for example, residues of lauric acid, myristic acid, linoleic acid, palmitic acid, oleic acid and elaidic acid), steroid acid and sterol residues, and residues of retinoids carotenoids, tocopherols, and tocotrienols; Q is a residue of ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol or hexaethylene glycol; P is a residue of a polyaminoacid homopolymer; R2 is a terminal group selected from H, methyl, ethyl and maleimide; D is a secondary group that is as defined above for L or is a methyl-capped poly(ethylene glycol) residue; and d is 0, or d is 1.

The invention relates to novel silicon-based fluoride acceptor groups (SiFA groups) of the following formulae, as well as to compounds suitable for use in radiopharmacy comprising such groupswherein R1 and R2 are each a linear or branched C3 to C10 alkyl group and R3 is selected from (i) —OH or —O−, (ii) a sugar moiety or an amino sugar moiety, (iii) an amino acid moiety or an oligopeptide moiety, (iv) a PEG moiety; and from combinations of two or more of (ii), (iii) and (iv).

The present invention relates to a polysaccharide comprising pendant amides, methods of making thereof, and copolymers, nanoparticles, compositions, thermoplastics, and membranes comprising the polysaccharide.

The invention belongs to the technical field of polysaccharide vaccine vector synthesis, and relates to a pentasaccharide repeating unit and decasaccharide repeating unit compound of zwitterionic polysaccharide PS A2 and a synthesis method thereof. The PS A2 pentasaccharide repeating unit is successfully synthesized through a [2 + 2 + 1] strategy, and the technical problems of construction of a mannoheptaose C6-position ether bond, determination of a side chain methyl configuration, efficient construction of a 1, 2-cis-glucosidic bond, synthesis of multiple amino sugars and the like in the synthesis process are solved. The pentasaccharide repeating unit is coupled with other compounds and can be used for researching the potential anticancer effect of the PS A2. The pentasaccharide repeating units with different chiral methyl groups on the side chains provided by the invention can be used for subsequently performing activity screening on the two pentasaccharide repeating units to compare the influence of different methyl chirality on antigenicity, so that a foundation is laid for bacteroides fragilis sugar vaccines; the decasaccharide repeating unit provided by the invention provides a new path for synthesizing long-chain zwitterionic polysaccharide PS A2.

The application relates to the technical field of agricultural fertilizers, and provides an amino sugar-oligosaccharide biofertilizer and a preparation method thereof. The amino sugar-oligosaccharide biofertilizer comprises 3-4 parts of amino sugar, 12-20 parts of seaweed oligosaccharide preparation liquid, 0.5-1 part of bacillus subtilis, 1-2 parts of trichoderma viride, 1-2 parts of aspergillus niger and 70-83 parts of base material. The seaweed oligosaccharide preparation liquid contained in the amino sugar-oligosaccharide biofertilizer is prepared by an acid enzymolysis-alkaline enzymolysis-biological fermentation three-step method, the content of seaweed oligosaccharide with a stable polymerization degree of 2-5 is high, the content of salicylic acid in crops can be effectively improved, the immune induction effect is obvious, the biocontrol and growth promotion effects of amino sugar and microorganisms are combined, the defense ability of crops against diseases is improved, and especially the growth and reproduction of pathogenic bacteria Pseudomonas syringae pv. tomato can be effectively inhibited, and the occurrence rate of bacterial spot disease of tomatoes can be reduced.

The present invention relates to nanoparticles formed by a hollow polymeric wall, capable of transporting drugs and active substances, or contrast media, across cellular membranes and releasing them at sites of interest. The nanoparticles are formed by self-assembly of poly(isobutene-alt-maleic anhydride) functionalised with an aminosaccharide.

The invention belongs to the technical field of bioengineering, and provides an engineering bacterium for producing an amino sugar intermediate as well as a construction method and application thereof, the engineering bacterium for producing the amino sugar intermediate inhibits synthesis of validamycin by knocking out genes on the basis of streptomyces hygroscopicus, and valilone synthetase is over-expressed. The engineering bacterium disclosed by the invention realizes high-yield effective alcohol amine through multiple modifications, and the yield reaches 318.8 mg / L.

The invention relates to sea urchin-derived glycopeptide as well as a preparation method and application thereof. The molecular weight of the glycopeptide is less than 3kDa, and the glycopeptide contains neutral sugar, amino sugar and tryptophan. The glycopeptide disclosed by the invention is small in molecular weight, easy to dissolve in water and capable of resisting gastrointestinal digestion; the traditional Chinese medicine composition has the effects of remarkably increasing white blood cells, protecting immune organs, relieving liver injury and other immunoregulation activities, and regulating intestinal flora; the compound is expected to be developed into drugs for improving or treating immune-related body dysfunction and / or prebiotics for regulating intestinal flora.

The present disclosure provides PEG-saccharide-lipid conjugates centered around various diamines. In various embodiments, these conjugates can be safely used as water-soluble or bioavailability enhancers. In one aspect, the present disclosure provides a PEG-saccharide-lipid conjugate having the following structural formula. JPEG2026528703000080.jpg27170Here The number average value of m ranges from 2 to 10. S is a monosaccharide, disaccharide or trisaccharide group, and each sugar unit is a sugar, sugar alcohol, amino sugar or sugar acid. L is -C(O)-R 1 where R 1 is an alkanoyl or alkenoyl group having an average carbon number of 6 to 22, and / or a steroid acyl group. P is -(CH2-CH2-O)nR 2 where "n" has a number average value in the range of 5 to 50 (e.g., 8 to 45), and R 2 is hydrogen and / or an alkane and has a number average carbon number in the range of 0 to 4.

The present invention provides a pharmaceutical composition that, despite containing rebamipide, exhibits excellent transparency and high stability. [Solution] A pharmaceutical composition containing rebamipide, amino sugar, a solubilizer, a buffer, and an organic acid.

This invention discloses a method and system for measuring soil microbial nitrogen pumps, belonging to the field of soil biogeochemistry and agricultural ecological environment monitoring technology. The method involves applying nitrogen to a soil-crop system... 15 N-labeled nitrogen fertilizer, combined with in-situ closed sampling, membrane sample mass spectrometry (MIMS) detection, and amino sugar compound specificity. 15 This invention analyzes nitrogen emissions, simultaneously measuring the fluxes and isotopic characteristics of N2 emissions, NH3 volatilization, and N2O emissions, as well as nitrogen uptake by plants, residual nitrogen in the soil, and nitrogen fixed by microorganisms. Finally, it constructs a microbial nitrogen pump efficiency (MNUE) index to characterize the intensity and efficiency of soil microbial nitrogen pumps. This invention enables comprehensive accounting of multiple nitrogen fluxes under near-real-field conditions, accurately distinguishing the contributions of fertilizer-source and soil-source nitrogen to gaseous nitrogen emissions. It is applicable to anaerobic ecosystems such as flooded paddy fields and wetlands, providing a systematic and operable technical solution for the quantitative study of soil microbial nitrogen pumps.

This invention discloses a method for preparing a fluorescent probe specifically for the detection of D-aminomannose (D-ManN) and a rapid detection and analysis method. A novel chiral crown ether fluorescent probe (S)-Q8 is designed and synthesized based on a binaphthol backbone, achieving for the first time specific and selective fluorescent recognition of D-ManN. This probe has a short synthetic route and is simple to operate. Under excitation light at a wavelength of 285 nm, (S)-Q8 reacts with D-ManN and produces a significant fluorescence enhancement signal at 365 nm. This fluorescence signal is not interfered with by other structurally similar amino sugars, chiral amino acids, or chiral sugars. This invention achieves rapid and specific quantitative analysis of D-ManN in complex environments by developing a chiral crown ether-based fluorescent probe (S)-Q8.

1. The name of the design product: label (Jian Lida amino sugar plus chondroitin calcium tablets). 2. The use of the design product: for the external packaging of products. 3. The design points of the design product: in the pattern. 4. The picture or photo that best indicates the design points: front view. 5. The design product is a flat product, omitting rear view, left view, right view, top view, bottom view.

A method of treating or preventing an ocular disease in a subject comprising administering locally to an eye of the subject a nucleic acid (NA) molecule having an acetylated amino sugar moiety (CHO) (CHO-NA), wherein the NA is an inhibitor of at least one biological activity in the eye associated with the ocular disease and is effective in the treatment or prevention of the ocular disease. Also a composition comprising a CHO-NA for the treatment of an ocular disease. In embodiments, the CHO is an N-galactosamine moiety.

The invention relates to the field of health food, in particular to glucosamine-chondroitin-sika deer bone glue polypeptide composite milk powder which comprises 80-95 wt% of whole milk powder, 2-5 wt% of glucosamine-chondroitin-sika deer bone glue polypeptide microcapsules, 6-10 wt% of whey protein powder and 0.5 wt% of composite vitamins and composite minerals. Through a microcapsule embedding technology, active components of the microcapsule can be effectively reserved, and the microcapsule can cooperate with calcium in the milk powder to increase the bone mineral density of human bones.

Provided herein are compounds of Formula (I) (i.e., compounds of R1-L-R2) or a pharmaceutically acceptable salt thereof, wherein R1 is a substituted or unsubstituted sugar, substituted or unsubstituted amino sugar, or substituted or unsubstituted deoxy sugar; L is a linker; and R2 is DNA-interacting agent (e.g., intercalating agent). Further provided are compositions, kits, methods, and uses comprising Formula (I). The compounds, compositions, kits, methods, and uses provided herein can be used for (i) delivering a compound or DNA (e.g., a plasmid) to a subject, and / or (ii) treating and / or prevention a disease or disorder.

The application discloses a fluorescent probe for identifying D-galactosamine, a preparation method and an identification method, and belongs to the technical field of chemical analysis and detection. The fluorescent probe takes BINOL as a skeleton, and the steps of the fluorescent probe are as follows: sequentially synthesizing intermediates (R)-2, (R)-3 and (R)-4, then dissolving (R)-4 in a mixed solution of anhydrous ethanol and dichloromethane, adding hydrochloric acid and reacting overnight, separating water phase and organic phase after quenching, removing the solvent under reduced pressure, and purifying the yellow solid product (R)-5 through a silica gel column to obtain the fluorescent probe. The fluorescent probe is simple in preparation, low in cost, can identify D-galactosamine (D-GalN) from a plurality of amino sugars and amino acids in acetonitrile, and has the advantages of simple operation, high sensitivity and convenient post-processing.

The present invention discloses unnatural sugars, their synthesis methods, and applications. Protecting the hydroxyl groups of amino sugars with tris(trimethylsilyl)silane at room temperature selectively exposes the amino groups of the sugars, and then converting them by coupling at room temperature yields unnatural sugars bearing orthogonal functional groups protected by tris(trimethylsilyl)silane. Removal of the trimethylsilane protecting group from unnatural sugars bearing orthogonal functional groups protected by tris(trimethylsilyl)silane yields unprotected unnatural sugars. Taking into account the advantages of existing unnatural sugars, the present invention not only ensures efficient cell utilization of unnatural sugars, but also effectively avoids side reactions with protein cysteines during the metabolism of unnatural sugars, thereby achieving efficient metabolic labeling. In cell experiments, the concentration of 1,6-diacylated unnatural sugars used was one order of magnitude lower than that of unprotected unnatural sugars.

The present application belongs to the field of environmental monitoring, and discloses a method for tracing the source of organic carbon in wetlands, specifically a method for tracing the source of organic carbon in wetlands, comprising the following steps: (1) collection of sediment samples; (2) determination of the content of biomarkers in the sediment samples, wherein the biomarkers include n-alkanes and amino sugars; (3) based on the determination results of step (2), analyzing the contribution of plant carbon sources and microbial carbon sources to soil organic carbon. The present application combines two biomarkers, n-alkanes and amino sugars, and based on different markers and total carbon content, a calculation process is proposed, which realizes the analysis and comparison of six biological source carbon inputs, i.e. wetland plant sources (herbaceous plants, algal plants, woody plants and aquatic plants) and microbial source carbon (fungal residue carbon and bacterial residue carbon), thereby realizing carbon source tracing in different dimensions.

1. The name of the design product: packaging bag (amino sugar glycosaminoglycan medicine patch). 2. The use of the design product: medicine patch packaging bag. 3. The design points of the design product: the combination of patterns and colors. 4. The picture or photo that best indicates the design points: front view. 5. The design for which protection is sought includes color. 6. The design product is a thin product, and the left view is omitted; the design product is a thin product, and the right view is omitted; the design product is a thin product, and the top view is omitted; the design product is a thin product, and the bottom view is omitted.

The invention discloses a high-sensitivity rapid detection and analysis method of amino sugar, which realizes high-selectivity and high-sensitivity fluorescent recognition of D-galactosamine (D-GalN) by designing and synthesizing a novel chiral fluorescent probe (R)-L10 based on a binaphthol skeleton. The probe is short in synthesis route, simple and convenient to operate and high in yield. Under exciting light of 430 nm, the fluorescent probe reacts with D-GalN to generate a specific fluorescence enhancement signal at 550 nm, and the fluorescent probe is not interfered by amino sugar, chiral amino acid or chiral carbohydrate with similar structures. The method can realize quantitative analysis of D-GalN in the soil extract and real-time fluorescence imaging in cells, has the advantages of good stability, rapid response and strong specificity, and provides an effective tool for detection of D-galactosamine in a complex environment. The fluorescent probe (R)-L10 disclosed by the invention realizes specific fluorescent recognition of 0-30 equivalent of D-galactosamine, is high in detection stability, and can realize determination of the content of D-galactosamine in soil and cells.