The invention discloses a biomedical skin care product and a preparation method thereof. The raw materials of the biomedical skin care product include: honey, marine fish skin collagen oligomer skin powder, modified dietary fiber, fruit and vegetable powder, sheep placenta, collagen, active Stem cells, Mexican yam, centella asiatica, white pomegranate, rose, ground peach blossom, polygonatum odoratum, motherwort, alpine snow lotus, aloe, saffron; modified dietary fiber raw materials by weight include inulin, apple fiber, oat fiber, wheat Fiber, Rice Bran, Bran. The present invention can be used externally for skin care, and can also be taken orally. It has remarkable curative effect, quick effect and simple application method. The purpose of removing wrinkles, firming skin, eliminating skin texture, reducing swelling and blood stasis, relieving fatigue, tightening the skin around the eyes, diluting eye bags, reducing wrinkles, and beautifying appearance has no side effects and dependence.