The invention discloses skin cream with effects of removing acnes, eliminating acne marks and whitening and a preparation method of the skin cream. The skin cream comprises the following components: glycerin, tocopherol, phytosterol / octyl dodecyl lauryl glutamate, hydrogenated coconut oil, glyceryl stearate, cholesterol polyether-24, behenyl alcohol, stearyl glycyrrhetinate, eucalyptus globulus leaf oil, undecylenoyl phenylalanine, a dutchmanspipe root extract, a ceriops tagal extract, an irkutsk anemone rhizome extract, growth factor-containing lipidosome, a plant seed superfine powder, a sodium acrylate / sodium acrylate dimethyl taurine copolymer, phenoxyethanol, ethylhexylglycerin and the balance of deionized water. The skin cream contains multiple natural active ingredients, can effectively penetrate into skin tissues, can cooperatively achieve the effects of regulating blain muscles, inhibiting acne regeneration, flattening acne scars and fading acne marks, has an excellent effectof treating the acnes, and also has an excellent whitening effect.