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Bird's nest acid skin whitening and brightening nano composition as well as preparation method and application thereof

A nano-composition and bird's nest acid technology, which is applied in skin care preparations, pharmaceutical formulas, cosmetic preparations, etc., can solve the problems of few types of whitening active ingredients, insignificant whitening effect, and reduced whitening effect, so as to reduce skin irritation Sexuality, increase skin penetration, and improve whitening effect

Active Publication Date: 2022-03-01
WUHAN BEST CARRIER NANO TECH +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The second, blocking melanin transport
Since the existing whitening active ingredients are directly added into the product system, there are many defects such as low solubility and poor compatibility with other components, and they are easy to oxidize and deteriorate and crystallize during the product placement process, which also makes the existing whitening active ingredients There are fewer types of whitening active ingredients in whitening products, the mechanism is single, and the whitening effect is not significant
And because of the skin's own barrier, it is difficult for whitening active ingredients to penetrate the stratum corneum and enter the base layer of the skin to play a role, greatly reducing the whitening effect

Method used

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  • Bird's nest acid skin whitening and brightening nano composition as well as preparation method and application thereof
  • Bird's nest acid skin whitening and brightening nano composition as well as preparation method and application thereof
  • Bird's nest acid skin whitening and brightening nano composition as well as preparation method and application thereof

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preparation example Construction

[0079] The present invention provides a preparation method of the above-mentioned bird's nest acid whitening and brightening nano composition, comprising the following steps:

[0080]Mix part of sialic acid, part of carnosine, tranexamic acid, glutathione and part of water to obtain the inner water phase;

[0081] mixing undecylenoyl phenylalanine, salicylic acid, liquid lipids, emulsifiers, co-emulsifiers and polyols to obtain an oil phase;

[0082] mixing and emulsifying the internal water phase and the oil phase to obtain a water-in-oil internal system;

[0083] Mixing remaining sialic acid, remaining carnosine and remaining water to obtain an external aqueous phase;

[0084] mixing and emulsifying the water-in-oil internal system and the external water phase to obtain a water-in-oil-in-water bicontinuous system;

[0085] Micronizing the water-in-oil-in-water bicontinuous system to obtain a micron-scale dispersion;

[0086] The micron-scale dispersion is subjected to nan...

Embodiment 1

[0105] According to the mass percentage, add 0.08% bird's nest acid, 6% carnosine, 0.5% tranexamic acid, and 1% glutathione to 10.4% purified water, heat and dissolve in a water bath at 20°C to obtain the inner water phase;

[0106] 18% undecylenoyl phenylalanine, 2% salicylic acid, 10% olive oil, 10% caprylic capric triglyceride, 10% lecithin, 10% polyglyceryl-10 myristate, 12 Mix %PPG-1-PEG-9 lauryl glycol ether and 5% propylene glycol, heat and dissolve in a water bath at 20°C to obtain an oil phase;

[0107] Add the internal water phase dropwise to the oil phase at a rate of 1 drop / second and stir continuously at 20°C and a rotation rate of 200r / min to obtain an internal water-in-oil system;

[0108] Add 0.02% bird's nest acid and 2% carnosine to 3% purified water, heat and dissolve in a water bath at 20°C to obtain the outer water phase;

[0109] (Specifically, add 0.08g bird’s nest acid, 6g carnosine, 0.5g tranexamic acid, and 1g glutathione to 10.4g purified water, hea...

Embodiment 2

[0118] Add 12% bird's nest acid, 15% carnosine, 3% tranexamic acid, and 10% glutathione to 30% purified water, heat and dissolve in a water bath at 50°C to obtain an inner water phase;

[0119] Mix 6% undecylenoyl phenylalanine, 3% salicylic acid, 1% wheat germ oil, 1% polyglyceryl-10 oleate, 2% oleth-12, 1% glycerin, 50 ℃ water bath to heat and dissolve to obtain an oil phase;

[0120] Add the inner water phase dropwise to the oil phase at a rate of 6 drops / second and keep stirring at 50°C and a rotation rate of 600r / min to obtain an inner water-in-oil system;

[0121] Add 3% sialic acid and 5% carnosine to 8% purified water, heat and dissolve in a water bath at 50°C to obtain the outer water phase;

[0122] Add the water-in-oil internal system dropwise to the external water phase at a rate of 6 drops / second and stir continuously at 50°C and a rotation rate of 600r / min to obtain a water-in-oil-in-water bicontinuous system;

[0123] The water-in-oil-in-water bicontinuous sys...

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Abstract

The invention provides a sialic acid skin whitening and brightening nano composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. According to the nano composition provided by the invention, active ingredients, namely sialic acid, undecylenoyl phenylalanine, carnosine, glutathione, tranexamic acid and salicylic acid, with different whitening mechanisms are jointly entrapped in the nano composition according to a melanin formation principle, so that the effect of synergistically improving the whitening effect is achieved, the sialic acid, the undecylenoyl phenylalanine, the carnosine and the glutathione have a synergistic effect, so that the effect of blocking melanogenesis is achieved; tranexamic acid is used as a protease inhibitor and plays a role in blocking melanin transport; salicylic acid plays a role in accelerating cuticle shedding and melanin metabolism. The whitening active components are used, the components have a good compatibility effect, the whitening active components are prepared into the nano composition, and the stability, the solubility and the whitening effect of the active components can be effectively improved.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a nano composition of bird's nest acid for whitening and skin brightening, a preparation method and application thereof. Background technique [0002] If you want to whiten, you must eradicate the culprit that affects whitening--melanin. Different whitening active ingredients can achieve whitening effects from different angles. According to the principle of melanin formation, the whitening mechanism can be divided into the following three types: [0003] The first is to block melanin production. The tyrosinase contained in melanocytes can oxidize tyrosine into polysaccharides, and then go through a series of metabolic processes in the middle to produce melanin. The active ingredients of antioxidants can reduce the oxidation products in the process of melanin production, and block the production of melanin by continuously reducing the oxidation products. In addition, antioxid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/368A61K8/44A61K8/49A61K8/60A61Q19/02
CPCA61K8/4946A61K8/64A61K8/44A61K8/368A61K8/60A61Q19/02A61K2800/782A61K2800/5922A61K2800/413Y02A50/30
Inventor 刘卫李翔宇陈家玲肖敏陈丹胡雄沈慧慧雷俊华
Owner WUHAN BEST CARRIER NANO TECH
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