The invention discloses a composite
probiotic preparation capable of improving sensitivity of low-
dose nicotine and reducing usage amount of
nicotine, and belongs to the crossing field of microbial technology and biological
medicine. The compound
probiotic preparation only improves the sensitivity of mice to low-concentration
nicotine, does not improve the preference of the mice to the existing preference concentration, prevents aggravated
smoking addiction, enables individuals to reach the satisfaction of smoking at ordinary times under the condition of low dosage of nicotine, and has the advantages of being simple in preparation process, low in cost and the like. The formulations may be used in combination with products in
nicotine replacement therapy or alone. The compound
probiotic preparation disclosed by the invention can be used for preparing functional foods, health-care products and medicines capable of improving the sensitivity of the low-concentration nicotine, and has a very wide application prospect.