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Nicotine-containing chewing gum compositions

A technology for chewing gum and chewing gum base, which is applied in the field of producing the chewing gum product, and can solve the problems of unsatisfactory fast transmucosal absorption, slow release of nicotine and the like

Pending Publication Date: 2019-12-27
ENORAMA PHARMA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] However, typical nicotine chewing gums known to date have proven to be dosage forms that release nicotine relatively slowly and are therefore not ideal for promoting rapid transmucosal absorption

Method used

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  • Nicotine-containing chewing gum compositions
  • Nicotine-containing chewing gum compositions
  • Nicotine-containing chewing gum compositions

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] The invention relates to a stable nicotine-containing chewing gum composition and a preparation method thereof.

[0027] The present invention provides a stable nicotine-containing chewing gum product comprising at least one buffered gum core and at least one coating layer, wherein said buffering agent in the core is confined to the extragranular region.

[0028] The inventors have discovered that contact between the nicotine active and the buffering agent potentially compromises the stability of the composition; and by minimizing this contact, the present invention provides a new drug with better stability and release characteristics. and improved products.

[0029] Furthermore, the buffer in the core ensures that during chewing of the core of the chewing gum product, a suitable buffer or substance causes the pH of the saliva to increase, which results in increased transmucosal uptake of nicotine in the oral cavity. Furthermore, since the transmucosal uptake of nicoti...

Embodiment

[0094] Example: Chewing Gum Composition of Nicotine Ion Exchange Resin

[0095] 1) Preparation of buffered chewing gum centers:

[0096]

[0097] program:

[0098] a) manually dispersing the nicotine ion exchange resin in the mint flavor and adsorbing it on part of the gum base,

[0099] b) adding the colloidal silica to the mixer in step a) and kneading at a suitable speed for sufficient time to granulate,

[0100] c) mixing the remaining ingredients (except magnesium stearate) with the remainder of the gum base,

[0101] d) then blending the extragranular material obtained in step c) with the API-adsorbed particles of step (b),

[0102] e) The blend obtained in step d) is then lubricated and compressed.

[0103] II) Preparation of subcoatings:

[0104]

[0105] program:

[0106] f) dissolving xanthan gum in the required amount of purified water with constant stirring to obtain a clear viscous solution,

[0107] g) Add xylitol, talc and dye to the solution of ste...

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Abstract

The present invention relates to nicotine-containing chewing gum compositions and the method of preparing the same. The present invention provides improved and stable nicotine-containing chewing gum compositions for use in nicotine replacement therapy, which provide rapid nicotine release in the oral cavity and effectively satisfy the craving that most smokers experience.

Description

technical field [0001] The present application relates to a chewing gum product that delivers nicotine to a subject. The present application also provides a system for delivering nicotine, and a method for producing said chewing gum product. Background technique [0002] In recent years, with the recognition of the harmful effects of tobacco smoking, government agencies and various health groups and other concerned organizations have undertaken many activities and projects to disseminate information about the adverse health effects caused by tobacco smoking. Furthermore, and because of the recognition of this deleterious effect, there have been many programs involved in trying to reduce the incidence of smoking. [0003] Nicotine is an organic compound and is the main alkaloid of tobacco. Nicotine is the primary addictive ingredient in tobacco used in cigarettes, cigars, snuff and the like. However, nicotine is also an addictive drug, and smokers typically exhibit a stron...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/68A61K31/465A61P25/26
CPCA61K9/0058A61K9/2826A61K9/2886A61K31/465A61P25/26A61K47/551A61K47/10A61K47/12A61K47/36
Inventor 瓦尔马·鲁德拉朱叶尔丘里·拉杰什
Owner ENORAMA PHARMA AB
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