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Nicotine replacement therapy products comprising synthetic nicotine

A technology for nicotine, products, used in the field of nicotine replacement therapy products containing synthetic nicotine

Active Publication Date: 2018-10-23
NEXT GENERATION LABS LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pollutants, although sometimes in low concentrations, do enter the human system when using traditional NRT products

Method used

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  • Nicotine replacement therapy products comprising synthetic nicotine
  • Nicotine replacement therapy products comprising synthetic nicotine
  • Nicotine replacement therapy products comprising synthetic nicotine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0098] The following examples are provided for illustrative purposes only and are not intended to limit the scope of any embodiments of the invention.

Synthetic example 1

[0099] Synthesis example 1-R, the synthesis of S nicotine

[0100]To a stirred solution of 1-vinyl-2-pyrrolidone (2) in dry THF was added 1 equivalent of potassium hydride under nitrogen atmosphere. The reaction mixture was stirred at room temperature for about 20 minutes, then ethyl nicotinate (1 equiv) was added and the resulting mixture was stirred at 65 degrees Celsius for 24 hours. The reaction was cooled, then acidified using 5% HCl, then concentrated hydrochloric acid was added, and the resulting solution was refluxed for 48 hours. The pH was adjusted to 13 using sodium hydroxide, and the aqueous and organic layers of the resulting biphasic solution were separated 3 times using the same volume of dichloromethane. The combined separated extracts were dried over sodium sulfate, filtered, and the solvent was evaporated to give an amorphous material. The amorphous material was dissolved in 3 parts of ethanol, then palladium on carbon (about 10%) was added, and the resul...

Synthetic example 2

[0101] Synthetic example 2-R, the synthesis of S nicotine

[0102] To a stirred solution of 1-vinyl-2-pyrrolidone (2) in dry THF / DMF (3 / 1 ) was added 1.2 equivalents of sodium hydride under nitrogen atmosphere. The reaction mixture was stirred at room temperature for about 20 minutes, then ethyl nicotinate (1 equiv) was added and the resulting mixture was stirred at 65 degrees Celsius for 24 hours. The reaction was cooled, then acidified using 5% HCl, then concentrated hydrochloric acid was added, and the resulting mixture was refluxed for 48 hours. The pH was adjusted to 6 with sodium hydroxide, then excess dichloromethane was added and the layers were separated. The aqueous layer was extracted twice with excess dichloromethane, and the extracts were combined, washed with water, and dried over sodium sulfate. The solution was then filtered and the solvent was removed using vacuum to give a brown solid. This solid was dissolved in ethanol (about 5 to about 10 parts), then...

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Abstract

A composition suitable for use in nicotine replacement therapy products includes a nicotine product that includes a synthetic nicotine that is substantially free of one or more contaminants and / or impurities normally associated with tobacco-derived nicotine. For example, the synthetic nicotine is substantially free of one or more of nicotine-1'-N-oxide, nicotyrine, nornicotyrine, 2',3-bipyridyl, cotinine, anabasine, and / or anatabine. The composition further comprises one or more pharmaceutically acceptable excipients, additives and / or carriers. The nicotine replacement therapy products may include any number of such products, including transdermal nicotine delivery patches, nicotine gums, synthetic chewing tobacco, synthetic snuff, and synthetic strips (e.g., dissolvable synthetic tobacco). Additionally, a method of treating nicotine addiction includes administering a nicotine replacement composition, e.g., via a nicotine replacement therapy product, to a user.

Description

[0001] Cross References to Related Applications [0002] This application claims priority and benefit to US Provisional Application No. 62 / 273,296, filed December 30, 2015, the entire contents of which are incorporated herein by reference. Background technique [0003] Nicotine replacement therapy (NRT) products are devices and compositions that typically include strategically administered forms of nicotine delivery. The product is intended to help users stop smoking addiction. Many nicotine replacement therapy products include nicotine strength designed to reduce the craving for nicotine. tobacco products. Smoking cessation programs use these therapies to replace the physical demand for nicotine in tobacco products, while using other means to reduce the psychological demand for tobacco product use. The uses of NRT products vary from smoking cessation devices and compositions to recreational products. Improve the user's entertainment experience, or reduce the socially unde...

Claims

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Application Information

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IPC IPC(8): A24B15/16A24D1/18A24F47/00A24B15/00A24F40/10
CPCA61K9/0058A61K9/006A61K9/7023C07D401/04A61P25/34A61K31/465A24F40/10A24B15/165A24F42/10A24F40/20A61M11/00
Inventor M·阿诺德
Owner NEXT GENERATION LABS LLC
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