Methods for nicotine replacement dosage determination

a nicotine replacement and dosage technology, applied in the direction of diagnostic recording/measuring, instruments, biocide, etc., can solve the problems of patient relapse, inability to accurately predict the nicotine replacement level of blood, and inability to stop the patient's medication

Inactive Publication Date: 2003-08-05
SACHS DAVID P L
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(1989) publication reported that nicotine transdermal replacement dosages adapted to previous daily cigarette consumption was no more effective than a standard dosage for achieving successful smoking cessation therapy.
Surprisingly, however, it is also observed herein that nicotine replacement levels of blood cannot be adequa

Method used

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  • Methods for nicotine replacement dosage determination
  • Methods for nicotine replacement dosage determination
  • Methods for nicotine replacement dosage determination

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Embodiment Construction

1. STUDY DESIGN

Subject Characteristics.

Subjects were smokers, aged 18 years or more, were eligible if they had smoked at least 10 cigarettes per day for a minimum of 3 years, were motivated to stop smoking completely, and were basically in good health. Exclusion criteria were severe or symptomatic cardiovascular disease, pregnancy or breast feeding, current regular use of psychotropic medications, current or past alcohol or other drug abuse, current use of smokeless tobacco, or chronic dermatological disorders such as psoriasis, urticaria, or chronic dermatitis.

Allocation to Treatment.

Subjects were sequentially and randomly assigned to receive one of three treatments based on a target percent cotinine replacement (% Cot Repl): 0% (placebo), 50%, or 100% cotinine replacement. In addition, subject enrollment was stratified by sex and nicotine dependency according to Table 1. Ninety-one subjects were assigned into the matrix shown in Table 1 with the "N" as shown.

Pharmacological Treatm...

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Abstract

A method for predicting nicotine replacement dosage to achieve a target nicotine serum concentration relies on measuring blood nicotine concentration prior to smoking cessation. At least two values corresponding to other patient characteristics, such as body mass, cumulative smoking, psychological dependence, age, and menopausal status, are also determined and used to predict expected blood nicotine concentrations based on nicotine replacement dosages. Such methods are useful in achieving target blood nicotine concentrations for smoking cessation and therapy.

Description

1. Field of the InventionThe present invention relates generally to methods for smoking cessation assistance, and more particularly to methods for determining and predicting dosages utilized in nicotine replacement therapy employed in conjunction with smoking cessation techniques.Cigarette smoking is a serious health concern in the United States and throughout the world, being a significant causative factor in several types of cancer, heart disease, and other disabilities. While the risk of these diseases can be greatly reduced by simply stopping smoking, tobacco dependency makes stopping very difficult for many patients. Thus, there is a continuing need to provide aids for use in smoking cessation therapy.Of particular interest to the present invention, a number of products have been commercially developed for providing nicotine replacement while a patient is undergoing smoking cessation and may suffer the symptoms of nicotine withdrawal. Such nicotine replacement can be achieved b...

Claims

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Application Information

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IPC IPC(8): A61K49/00G01N33/94
CPCA61K49/0008G01N33/94Y10T436/17Y10S436/816Y10S436/901
Inventor SACHS, DAVID P. L.
Owner SACHS DAVID P L
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