14 results about "Cannabinol" patented technology

The present disclosure relates to the preparation of synthetic cannabinol and homologs thereof having the structure of Formula (I), wherein, n is 1, 2, 3 or 4. The methods described herein provide for high yields and purity in a one-pot synthesis or high yields and purity without the need for lengthy column chromatography. The present disclosure also relates to solid forms of cannabinol.

Long-lasting biodegradable subcutaneous implant with prolonged release of pharmacologically active substance pre-concentrated in polymer for the treatment of epilepsy using from 10 to 1000 mg essential oil extracted from Cannabis sativa and / or Cannabis indica (full or broad spectrum), 10 to 500 mg natural or synthetic tetrahydrocannabidiol (THC) isolate, 10 to 500 mg natural or synthetic cannabidiol (CBD) isolate, proportional combination of broad spectrum essential oil and CBD isolate, proportional combination of full spectrum essential oil and natural or synthetic CBD isolate, or proportional combination of natural or synthetic THC isolate and CBD isolate in polymeric matrix for adjuvant treatment of epilepsy, chronic pain and anxiety.

Provided herein are methods and compositions for neuroprotection. The neuroprotective composition can be or include 4-chlorobutyl-cannabinol (4-chlorobutyl-CBN) or a derivative thereof and / or a pharmaceutically acceptable salt thereof. The neuroprotective composition can be used in the treatment of a neurodegenerative disease. The neuroprotective composition can be used to protect retinal neurons from degeneration in a subject in need thereof, such as for treatment of age-related macular degeneration.

The present invention generally relates to methods for producing (a) plant extract(s), preferably a Cannabis plant extract. In particular, the present invention relates to a method for producing a Cannabis plant extract comprising delta-9-tetrahydrocannabinol (THC) from a Cannabis plant comprising the following steps: (a) providing a Cannabis plant which comprises delta-9-tetrahydrocannabinol (THC) in a sufficient amount: (b) trimming and drying the flower material separated from the remaining plant material; and (c) treating the flower material of step (b) with a solvent and separating the Cannabis plant extract comprising delta-9-tetrahydrocannabinol (THC) from the flower material. Furthermore, the invention relates to a Cannabis plant extract comprising delta-9-tetrahydrocannabinol (THC) as produced by / obtainable by the methods described herein. Furthermore, the invention relates to the Cannabis plant extract as produced by / obtainable by the herein described methods for use in medicine. Moreover, the present invention relates to the Cannabis plant extract as produced by / obtainable by the herein described methods for use in the treatment and / or prevention of chronic cancer pain, somatic pain, visceral pain, central neuropathic pain, peripheral neuropathic pain and complex pain syndromes.

The present disclosure relates to polymorphs of D9-THC-naphthoylester for the preparation of D9-Tetrahydrocannabinol in high yields and high purity, methods of preparing the D9-Tetrahydrocannabinol, and compositions comprising the D9-Tetrahydrocannabinol.

Decarboxylated cannabis compositions and methods of making and using the same are provided. The methods produce a decarboxylated product that has more terpenes and cannabidiol preserved and less oxidation of tetrahydrocannabinol to cannabinol, compared to a decarboxylated product made by a traditional decarboxylation process.

In one aspect, the disclosure relates to substituted axially-chiral cannabinol analogs, methods of making same, pharmaceutical compositions comprising same, and methods of treating pain using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Provided is a method for preparing a cannabis oil composition, the method comprising the steps of eluting cannabinoids from dried cannabis plant material with a solvent to produce an eluate, filtering the eluate with a series of filters to produce a filtrate, evaporating the solvent by condensing from the filtrate with a distiller to extract the distillate, and purging the distillate via fractional distillation to remove residual solvent, thereby producing a cannabis extract. The method also includes the steps of performing a redox reaction of the cannabis extract for the complete removal of the water for creating CBN (Cannabinol) of various percentages depending on the timeframe in which the redox reaction is performed; and combining the cannabis extract with an essential oil or a carrier oil to produce the cannabis oil composition.

The present invention relates to a modified-release solid oral pharmaceutical composition, which is in the form of an enteric-coated capsule, wherein said capsule comprises cannabidiol (CBD), tetrahydrocannabinol (THC) and an emulsifier, and wherein the capsule optionally further comprises one or more cannabis terpenes. The solid oral pharmaceutical composition provided herein has a particularly advantageous modified release profile as well as an improved oral bioavailability as compared to conventional formulations of CBD and THC.

The invention relates to a method for destroying tetrahydrocannabinol (THC), in particular to a method and a system for destroying tetrahydrocannabinol based on photocatalytic oxidation. According to the invention, nano titanium dioxide (TiO2) is used as a catalyst, active oxygen free radicals are generated under the excitation of ultraviolet rays with specific wavelength, and the THC molecular structure is decomposed. The multi-stage reaction system is adopted, raw material pretreatment, solvent dissolution and dispersion, photocatalytic degradation reaction and tail gas purification modules are integrated, tetrahydrocannabinol is decomposed on a production line, the supervision pressure in production is relieved, the degradation rate of tetrahydrocannabinol reaches 99% or above, degradation products are carbon dioxide, water and trace inert organic acid, and high efficiency and environment friendliness are achieved. The method is suitable for innocent treatment of hemp processing waste, law enforcement inspection products or medical waste, and is simple to operate, high in practicability and suitable for industrial popularization and application.

The present invention pertains to composition of a cannabis flavored improvement modification. to Liquors, Spirits and Distilled Beverages with formulation concentrates of various strengths of content.The cannabis flavored improvement to liquors, spirits & distilled beverages begin with the process of using the cannabis plant and any of its extracted oils. Extracting the cannabis hashish or cannabis concentrate from Cannabis plant is the process of isolating the active ingredients: cannabin, cannabindon, cannabinine, and cannabinol using vegetable oil as solvent and mixing it with the concentrates of distilled or separation of the product of fermented grains, seeds, roots, fruits, vegetables or other sugars with a total alcohol content around 40%.The object of the cannabis flavored improvement to liquors, spirits & distilled beverages have the advantage that such consumption will bring a refreshing effect as well as a cooling effect with intense stimulation and enjoyable taste experience. The present invention represents a new composition, method of preparation and applications, beyond the prior art of any to liquors, spirits & distilled beverages.

In one aspect, the disclosure relates to substituted axially-chiral cannabinol analogs, methods of making same, pharmaceutical compositions comprising same, and methods of treating pain using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

A method of preparing cannabinol (CBN) and hexahydrocannabinol (HHC) including contacting delta-8-tetrahydrocannabinol (Δ8-THC) with a supported noble metal catalyst under conditions suitable for the dehydrogenation of at least a portion of the Δ8-THC and aromatization of at least a portion of the Δ8-THC to form a product comprising HHC and / or, CBN. Also, a method of preparing CBN and HHC comprising contacting Δ8-THC with a supported noble metal catalyst under conditions suitable for the dehydrogenation of at least a portion of the Δ8-THC and aromatization of at least a portion of the Δ8-THC to form a product comprising HHC and / or CBN; contacting the product with (i) an acetylating agent and (ii) a proton donor under conditions suitable for formation of an acetylated product; and separating the acetylated product to recover an acetylated CBN, an acetylated HHC or combinations thereof.

The invention discloses a preparation and quantitative analysis method of a 9-tetrahydrocannabinol cis-trans isomer. The invention provides a preparation method of (+ / -)-9-trans-THC or (+ / -)-9-cis-THC. The preparation method comprises the following steps: separating a mixture of (+ / -)-9-trans-THC and (+ / -)-9-cis-THC by adopting chromatography; the separation conditions of the chromatography are as follows: a chromatographic column is a C18 chromatographic column; the mobile phase is acetonitrile and water; the volume ratio of the acetonitrile to the water is (7: 3)-(3: 1). The (+ / -)-9-trans-THC and (+ / -)-9-cis-THC prepared by the method disclosed by the invention are high in purity, and the quantitative analysis method provided by the invention realizes accurate quantification under the condition of no standard reference substance, and also has the advantages of no damage to samples, simple preparation, high analysis speed, good accuracy, good repeatability and the like.