Method for enriching cannabidiol

A cannabidiol enrichment technology, applied in chemical instruments and methods, preparation of organic compounds, bulk chemical production, etc., can solve the problems of insufficient purity of cannabidiol and high content of THC

Active Publication Date: 2017-08-04
YUNNAN HEMPSON BIO-TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The extraction methods of cannabidiol disclosed in the above two patents have improved the purity of cannabidiol to a certain extent, but the purity of cannabidiol is not high enough, and the content of tetrahydrocannabinol in cannabidiol is relatively high

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  • Method for enriching cannabidiol

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Embodiment 1

[0040] This embodiment provides a method for enriching cannabidiol, comprising the steps of:

[0041] S1. Dry the cannabis flower leaves at 120°C for 2 hours, crush them to 50 mesh, perform supercritical extraction with carbon dioxide under the conditions of 55°C and 30MPa for 2 hours, recover carbon dioxide, and obtain the initial extract of cannabis flowers and leaves;

[0042] S2. Dissolve the initial extract of cannabis flower leaves in 10 times the weight of ethanol, then cool the solution to 0°C, keep the temperature constant, let it stand for 12 hours, finely filter to remove impurities, and evaporate the solvent for later use;

[0043] S3, load pretreated D101 macroporous adsorption resin in the chromatographic column, first equilibrate with 1BV of phosphate buffer column, and then perform column equilibrium with 2BV of 10% (v / v) ethanol solution; step S2 The initial extract of cannabis flower leaves obtained by medium and fine filtration is dissolved in ethanol, and t...

Embodiment 2

[0055] This embodiment provides a method for enriching cannabidiol, comprising the steps of:

[0056] S1. Dry the cannabis flower leaves at 120°C for 4 hours, crush them to 60 mesh, perform supercritical extraction with carbon dioxide under the conditions of 40°C and 30MPa for 7 hours, recover carbon dioxide, and obtain the initial extract of cannabis flower leaves;

[0057] S2. Dissolve the initial extract of cannabis flower leaves in 10 times the weight of methanol, cool the solution to 0°C, keep the temperature constant, and let it stand for 12 hours, finely filter to remove impurities, evaporate the solvent, and set aside;

[0058] S3, load pretreated AB-8 macroporous adsorption resin into the chromatographic column, first equilibrate with 1BV of phosphate buffer column, and then use 2BV of methanol:water=15:85 (v / v) solution Carrying out column balance; dissolving the initial extract of cannabis flower leaves obtained by the fine filtration in step S2 with methanol, and l...

Embodiment 3

[0069] This embodiment provides a method for enriching cannabidiol, comprising the steps of:

[0070] S1. Dry the cannabis flower leaves at 120°C for 4 hours, crush them to 70 meshes, perform supercritical extraction with carbon dioxide under the conditions of 45°C and 30MPa for 9 hours, recover the carbon dioxide, and obtain the initial extract of cannabis flowers and leaves;

[0071] S2. Dissolve the initial extract of cannabis flower leaves in 10 times the weight of methanol, cool the solution to 0°C, keep the temperature constant, and let it stand for 12 hours, finely filter to remove impurities, evaporate the solvent, and set aside;

[0072] S3, load pretreated HPD-100A macroporous adsorption resin into the chromatographic column, first equilibrate with 1BV of phosphate buffer column, and then use 2BV of methanol:water=35:65 (v / v) solution Carrying out column balance; dissolving the primary extract of cannabis flower leaves obtained by fine filtration in step S2 with meth...

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Abstract

The invention belongs to the technical field of chemical industry, and particularly relates to a method for enriching cannabidiol. The method includes steps of S1, drying Cannabis sativa flower and leaf for 0.5-4 hours at 120 DEG C, and smashing until the particle size of the smashed material meets the requirement of over 50 meshes; performing carbon dioxide supercritical extraction for 1-9 hours under the conditions of 30-55 DEG C and 13-30 MPa, and recycling carbon dioxide to obtain initial extractive of Cannabis sativa flower and leaf; S2, dissolving the initial extractive of Cannabis sativa flower and leaf in ethanol or methanol, refining, filtering and removing impurities, distilling and drying the solvent for future use; S3, filling a chromatographic column with the pretreated filler, sampling by a wet method or a dry method, wherein the sampling amount is 3-15 wt%; S4, performing gradient elution or isocratic elution by one or mixture of water, methanol, ethanol, n-butyl alcohol, acetone or chloroform; collecting the dilution section with enriched cannabidiol. The method is simple in technique; content of cannabidiol is improved, and tetrahydrocannabinol content is reduced.

Description

technical field [0001] The invention belongs to the technical field of chemical industry, and in particular relates to a method for enriching cannabidiol. Background technique [0002] Marijuana (Cannabis sativa L.), also known as hemp or thread hemp, is a plant of the Moraceae family and the genus Cannabis. It is an annual erect herb with a height of 1 to 3 meters. Tetrahydrocannabinol (THC) and cannabidiol (CBD) components of other hemp species contained in cannabis are phenolic compounds that have not been isolated in other animals and plants, and have high medicinal value. Studies have shown that the abuse of THC will seriously endanger human health. If it is properly applied in medicine, it will have the functions of antiepileptic, antipsychotic, antidepressant, pain relief, reducing nausea caused by cancer chemotherapy and treating asthma. In recent years, scientists have also discovered that both tetrahydrocannabinol (THC) and cannabidiol (CBD) are powerful antioxid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/68C07C37/82C07C39/23
CPCC07C37/685C07C37/82C07C39/23Y02P20/54
Inventor 项伟刘绍兴顾文云吴玉金李泳霖
Owner YUNNAN HEMPSON BIO-TECH CO LTD
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