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The application discloses application of compound C-08 in improving ulcerative colitis and intestinal barrier function, and belongs to the technical field of medicines.The application screens the compound C-08, and verifies the improvement effect of the compound C-08 on ulcerative colitis, including the effect of improving ulcerative colitis and repairing intestinal barrier function; the compound C-08 can significantly inhibit the weight loss of a DSS-induced mouse, obviously down-regulate the expression of a colon proinflammatory factor IL1-beta, restore the colon length and reduce a disease activity index, and has the effect of improving ulcerative colitis, thereby providing a new target for the treatment of ulcerative colitis; the compound C-08 can promote the mRNA expression amount of intestinal tight junction to increase and tend to be normal, and has the effect of improving intestinal barrier dysfunction.