115 results about "Neoaortic valve" patented technology

The invention discloses an aortic valve function evaluation device which comprises a processor and a memory, and the memory stores programs or instructions capable of running on the processor. When the program or the instruction is executed by the processor, the following steps are realized: acquiring a first echocardiogram of a target object corresponding to a final systole and a second echocardiogram of a target object corresponding to a final diastole in a cardiac cycle, and acquiring medical record data of the target object; determining a first mask pattern corresponding to the first echocardiogram and a second mask pattern corresponding to the second echocardiogram according to the first echocardiogram, the second echocardiogram and an aortic valve segmentation model; determining an aortic valve morphological index of the target object according to the first mask pattern and the second mask pattern; determining aortic valve functional indexes of the target object according to the medical record data of the target object; and determining and outputting an aortic valve function evaluation result of the target object according to the first mask pattern, the second mask pattern, the aortic valve morphological index and the aortic valve functional index.

An assessment of basal cardiac fitness uses noninvasively obtained physiological measures to determine the presence of a basal physiological state and cardiometric measures to determine cardiac fitness. In the presence of preload independence and cardiac vagal control, cardiometric signals are acquired that are sensitive to cardiac function and include information indicative of the opening and closing of the individual's aortic valve. The cardiometric signals are analyzed by a cardiac fitness assessment system for the determination of basal cardiac fitness. The invention assures preload independence through the assessment of observational physiological parameters or the use of physiological parameters obtained following alterations in venous return. The invention assures the presence of cardiac vagal control by assessment of measured parameters, including the presence of respiratory sinus arrhythmia. The resulting test is specific for cardiac function without dependencies on physical activities associated with heart rate elevation or respiratory capabilities.

The application discloses an aortic valve guide wire and a use method thereof, which comprises a head section, a transition section and a support section connected in sequence along an axial direction; the head section is composed of a polymer and further comprises a deformation capsule, at least one closed unit embedded in the head section, and an internal sealing electric field sensitive viscoelastic fluid; a mesh cable is arranged on the surface of the deformation capsule and extends to the transition section; the transition section and the support section are provided with a conductive film on the surface, and the conductive film is connected with the mesh cable and used for applying a non-uniform electric field to the deformation capsule to generate a regional viscosity difference and drive the head section to bend in a direction.The electric field sensitive viscoelastic fluid built in the head section generates a regional viscosity difference under the action of the non-uniform electric field, and the difference is converted into a directional bending moment through the synergistic effect of the mesh cable and the conductive film, so that the head of the guide wire can quickly respond to an external electric signal and accurately deflect.

The subject of the invention is a delivery system for delivering a self-expanding endoluminal prosthesis to the patient's ascending aorta and aortic valve, the system comprising: - an inner tube (33), extending along a longitudinal Y axis of the delivery system (100), from an atraumatic distal tip (27) to a handle (37); - a metal tube (32), slide-fitted on the inner tube (33), and extending from the internal space of the distal tip (27) to a handle (37); - an outer tubular catheter shaft (22) slide-fitted on the metal tube (32), the catheter shaft (22) is brought out from the handle (37) and is terminated by a capsule (20), containing inside the radially compressed on the metal tube (32), self-expanding endoluminal prosthesis (1) having defined construction and covered at least partially by a coating (16), - the capsule (20) has closed position when is closed by the tip (27) and has open position when the capsule (20) and the tip (27) are displaced relative to each other; wherein the distal part of the metal tube (32) is equipped with receiving means (41, 42) on which the distal locking means (7) of prosthesis (1) are removably embedded and blocked in the inner space of the tip (27) and the delivery system (100) comprises also removable holding means (45, 45') retaining the proximal locking means (9) of the prosthesis (1), so that when the capsule (20) is in its fully open position, the prosthesis (1) is still maintained partially compressed, holding its crimping length.

An adjustable structure, comprising: a variable catheter (101) and an adjustment tube (103), wherein the variable catheter (101) is provided with a protrudable portion (102), which comprises an outer protruding side (1023) and an inner protruding side (1024), the height by which the outer protruding side (1023) can protrude being greater than the height by which the inner protruding side (1024) can protrude. A guidewire-assisted transvalvular device (100) comprising an adjustable structure. The lateral position of the distal end of the variable catheter (101) is controlled by means of adjusting the protruding height, so that the guidewire-assisted transvalvular device (100) can be stably fixed at the aortic valve orifice, making it convenient for a guidewire located inside the adjustment tube (103) to smoothly cross the aortic valve orifice so as to prepare for a subsequent TAVR procedure.

The invention provides a delivery system. The delivery system comprises a sheath tube, a sheath core and a sheath core connector, the sheath core is nested in an inner cavity of the sheath tube, and the sheath core comprises a sheath core main body tube and two reference wires which are symmetrical about the center of the sheath core; the sheath core connector is arranged on the sheath core in a sleeving mode and comprises a fixing part at the near end and a rotating part at the far end, the fixing part is fixedly arranged on the sheath core body tube, and the rotating part can rotate relative to the sheath core. According to the conveying system, before the valve prosthesis is loaded into the sheathing canal, the sheath core connector rotating part can be rotated to circumferentially adjust the valve prosthesis to the optimal position, it is ensured that after the valve prosthesis is conveyed to the designated position, the connection part of the valve prosthesis is aligned with connection of a native aortic valve, and the release accuracy is improved.

This invention provides a bicuspid aortic valve implantable annuloplasty ring, comprising two symmetrically arranged semi-annular bodies. The two ends of the two semi-annular bodies are connected in a saddle shape by a connecting post, and the connecting post extends upward by a predetermined length, forming the highest point of the annuloplasty ring. At the connection point, the two semi-annular bodies form a first predetermined angle. The semi-annular bodies are made of flexible material, and the connecting post is made of rigid material. This invention can be conveniently implanted into the bicuspid aortic valve annuli and can be operated within the aorta, eliminating the need for dissection outside the vessel wall.

The invention belongs to the technical field of biological medicine research, and particularly relates to a cell in-vitro calcification inducer, an induction culture medium and application thereof, an aortic valve calcification in-vitro induction model and a modeling method thereof. The inducer provided by the invention is prepared from the following components in parts by weight: 2160.4 parts of beta-sodium glycerophosphate, 0.039 parts of dexamethasone, 50 parts of vitamin C and 34 parts of vitamin D. The invention further provides a culture medium formed by using the inducer and a method for modeling an aortic valve calcification in-vitro induction model by using the inducer. According to the method, osteogenic differentiation of the aortic valve interstitial cells can be stably induced within a short time, an efficient and repeatable standardized induction scheme is provided for in-vitro aortic valve calcification models and drug screening, and the method has a very good application prospect.

This invention discloses a method for predicting sudden cardiac death based on forensic autopsy data using machine learning and its forensic applications, belonging to the fields of machine learning, statistics, and forensic identification. This invention provides a method for screening independent predictors of forensic diagnosis of sudden cardiac death using LASSO regression and logistic regression. Using 10-fold cross-validation, the method selects the minimum lambda(λ) to identify 14 risk factors. Logistic regression ultimately identifies 9 independent predictors, including age, heart weight, left ventricular wall thickness, right ventricular wall thickness, interventricular septum thickness, aortic valve circumference, mitral valve circumference, liver weight, and left kidney weight. A nomogram and a web-based calculator are constructed for predicting sudden cardiac death in forensic practice, thereby determining sudden cardiac death using objective indicators. This method has not been reported worldwide.

The subject of the invention is a self-expanding, covered at least partially by a coating (16), endoluminal prosthesis, comprising: - a stent-valve part (1"), containing a metal frame (10) and an aortic valve (14) secured inside it, - a stent-graft part (1'), containing a metal frame (8, 8'), - an intermediate part (4), joining the stent-valve part (1") with the stent-graft part (1') and having less stiffness than the stent-valve part (1") and the stent-graft part (1'), wherein the stent graft part (1') comprises a tapered section (13) narrowing inwardly towards the intermediate part (4), the tapered section (13) is equipped with at least one branch (5', 5") covered by a coating (16).

Prosthetic valves are provided, e.g., for replacing a mitral or aortic valve of a patient, that includes an annular valve body including an inlet end, an outlet end, and one or more valve members for selectively opening and closing a passage between the inlet and outlet ends, a sewing cuff attached around an outer perimeter of the valve body, and a flexible skirt removably attached around the outer perimeter adjacent the sewing cuff. The prosthetic valve may be introduced into a patient's body, positioned adjacent a valve annulus, and the sewing cuff may be secured around a perimeter of the valve annulus. The skirt may be secured to tissue adjacent the valve annulus to further seal the prosthetic valve around the valve annulus, or the skirt may be removed from the valve body, e.g., if the annulus is sufficiently sealed by the sewing cuff.

A method of delivering a transcutaneous dual valve replacement (TDVR) device to a patient includes the steps of advancing a guide catheter into the heart of the patient, advancing a support wire through the guide catheter and across the mitral valve of the heart of the patient, removing the guide catheter, advancing a delivery sheath over the support wire and across both the aortic valve and the mitral valve of the heart of the patient, advancing the TDVR device over the support wire and through the delivery sheath, removing the delivery sheath, expanding a first segment of the TDVR device in the mitral valve and a second segment of the TDVR device in the aortic valve, and removing the support wire.

The application relates to the field of medical devices, in particular to a prosthesis capable of treating valve regurgitation, comprising a radially expandable stent body, the stent body comprising a plurality of diamond-shaped meshes, and at least three clamping members arranged at the outflow end of the stent body, used for positioning the aortic sinus and clamping the native valve leaflets; a sealing bag bulging outward is arranged on the stent body between adjacent clamping members, wherein the position of the sealing bag corresponds to the junction area of the aortic valve leaflets, and the sealing bag is attached to the tissue of the junction area of the aortic valve leaflets, and the configuration of the sealing bag is configured to guide the regurgitant blood to flow to the adjacent aortic sinuses on both sides when the blood regurgitates; in the application, the sealing bag guides the regurgitant blood to flow to the adjacent aortic sinuses in a diversion manner, so that blood regurgitation is avoided, and meanwhile, when the aorta pumps blood again, the blood in the aortic sinus is ejected, so that blood stasis is avoided.

The application provides an interventional ventricular auxiliary oxygen generation device, a blood flow channel crosses an aortic valve into a left ventricle from an ascending aorta, a blood inlet of the blood flow channel is located in the left ventricle, a blood outlet is located in the ascending aorta, a first conveying pipe and a second conveying pipe convey hydrogen peroxide and catalase into the left ventricle to generate oxygen and water through reaction, and a pumping unit pumps oxygen-rich blood in the left ventricle to the ascending aorta. The oxygen generation function is added to the ventricular auxiliary device, the oxygen-rich blood in the ventricle is pumped to the ascending aorta through the ventricular auxiliary device, which directly improves the myocardial hypoxia condition and helps the heart recover, and on the other hand, the oxygen-rich blood is pumped into the ascending aorta and directly participates in the systemic circulation, thereby directly and quickly improving the oxygen supply condition of the systemic circulation.

Systems and methods are provided for repairing a heart valve, such as a mitral, tricuspid or aortic valve, using an adjustable and removable implant that can be delivered to the heart through the apex in a simplified and non-invasive manner. The implant can include a prosthetic valve portion coupled to a proximal end of a shaft, and an anchor portion coupled to a distal end of the shaft. The prosthetic valve can be suspended within an opening of the heart valve while the anchor portion is affixed to the apex of the heart. When the implant is deployed, a distance between the prosthetic valve portion and the anchor portion can be adjusted, and / or the implant or a portion thereof can be rotated to thereby change the position of the prosthetic valve within the heart valve. This can allow correcting for post-implantation movements of the implant to mitigate potential complications.

The application belongs to the technical field of medical devices, and relates to a delivery system for a prosthetic valve, which comprises a guide wire, an ultrasonic probe and a processing module. The guide wire is used to build a delivery channel for a prosthetic valve to be delivered, and the end of the guide wire is provided with a guide wire head. The ultrasonic probe is arranged on the guide wire head, and is used to emit ultrasonic signals to the aorta and receive ultrasonic echo signals. The processing module is used to receive and respond to the ultrasonic echo signals, determine an aortic valve opening area according to the ultrasonic echo signals, output a first control instruction according to the aortic valve opening area and a current position of the guide wire head obtained in advance, and drive the guide wire head to move to the aortic valve opening area. The application reduces the difficulty of over-valve operation, shortens the operation time, avoids other surgical risks caused by long operation time, and has high safety.

The disclosure relates to heart valve prostheses with the reduced need of pacemaker implantation and / or improved means for positioning the replacement heart valve. A heart valve prosthesis is provided with a stent and at least one locator. The locator has an adapted design for positioning within a cusp of the native aortic valve for implantation at the native heart valve site. Placement of the locators within the cusps preferably prevents movement from the native heart valve site post-implantation, including proximal movement of the prosthesis into the left ventricle.

The application provides a catheter pump placement position judgment method, system, electronic equipment and medium. First, the catheter pump is started and controlled to operate at a predetermined rotating speed. Then, a current signal of a motor of the catheter pump and a pressure signal of a pressure sensor of the catheter pump within a predetermined time are acquired. The position of a blood outlet and a blood inlet of the catheter pump relative to an aortic valve can be judged based on the acquired current signal and pressure signal. The application only uses the data of the motor and the pressure sensor of the catheter pump, does not need to introduce other invasive measuring equipment, is beneficial to the doctor to quickly and accurately judge the placement position of the catheter pump, reduces the risk that the catheter pump cannot provide effective blood flow dynamics support due to the incorrect placement position of the catheter pump, and can directly and accurately reflect the state of the heart, greatly improving the safety of the operation.

The invention discloses a pulmonary arterial hypertension recognition device and method based on multiple paths of electrocardio heart sound signals, and relates to the technical field of biomedicine, and the method comprises the steps: limiting an aortic valve closing candidate peak and a drop point of a pulmonary valve closing candidate peak in a time interval between a main peak anchor point time boundary of a double-anchoring split fragment set and an electrocardio fragment key turning point; adjacent beat backtracking replacement and multi-channel consistent voting retention are performed on candidate peaks of cross-beat hopping, and a physiological consistent split fragment set is generated; and according to the physiological consistency split fragment set, converging split sequences of multiple paths of heart sounds, and carrying out beat-level splicing and in-window consistency closing on the split sequences and right heart load related form entries of multiple paths of electrocardio, so as to generate a pulmonary arterial hypertension recognition and diagnosis set. According to the method, high-precision synchronization of multiple paths of electrocardiogram and heart sound signals is realized, equipment difference and noise interference are eliminated, the reliability of feature extraction is guaranteed, and the pulmonary arterial hypertension recognition stability is improved.

The invention discloses application of H-151 in preparation of drugs for preventing and treating calcified aortic valve diseases, relates to the technical field of biological medicines, and is characterized in that the invention provides application of an STING inhibitor H-151 or pharmaceutically acceptable salts thereof in preparation of drugs for preventing and / or treating calcified aortic valve diseases. The invention reveals for the first time that H-151 can inhibit the increase of the expression level of osteogenic differentiation markers ALP and RUNX2 in aortic valve interstitial cells induced by an osteogenic culture medium in an in-vitro experiment, and inhibit osteogenic differentiation and calcium salt deposition of the aortic valve interstitial cells; in addition, aortic valve thickening, fibrosis and calcium salt deposition of mice induced by an aortic valve injury model are inhibited in vivo. Based on the biological effect, the application of H-151 in developing the medicine for treating the calcified aortic valve disease is provided for the first time, and a new technical path and a new medicine choice are provided for preventing and treating the calcified aortic valve disease.

The invention belongs to the technical field of aortic valve and ascending aorta pathological assessment, and particularly relates to an aortic valve and ascending aorta in-vitro assessment method, system and equipment and a medium, which are applied to a test system based on an aortic valve and ascending aorta entity model customized by a patient. The method comprises the following steps: in a simulation test process of an aortic valve and ascending aorta entity model of a patient, acquiring a PIV velocity field, a multi-point pressure time sequence and a flow time sequence through a flow meter, a pressure sensor and a high-frequency camera which are pre-arranged in the aortic valve and ascending aorta entity model; calculating a corresponding time domain-frequency domain mechanical index according to the time domain-frequency domain mechanical index; calculating a corresponding period consistency index according to the test period of the simulation test; and integrating all the time domain-frequency domain mechanical indexes and the period consistency indexes, and evaluating the conditions of the aortic valve and the ascending aorta of the patient according to the time domain-frequency domain mechanical indexes and the period consistency indexes, so as to serve as a basis for preoperative decision making and instrument evaluation.

Systems, devices and methods are provided for supporting cardiac function. A device comprises a catheter having a shaft with a distal end portion configured for advancing through an aortic valve to a left ventricle of a patient and an impeller coupled to the distal end portion of the catheter. One or more inlets are positioned distal of the impeller and coupled to an internal lumen within the catheter to draw blood from the left ventricle through the inlets and into the internal lumen. One or more outlets positioned proximal of the impeller and coupled to the internal lumen to pump the blood through the outlets and into the aorta. The device further includes an extracorporeal motor coupled to a proximal end portion of the catheter and a drive member extending through the catheter shaft and coupling the impeller with the motor to rotate the impeller. The motor may comprise a non-contact motor that generates a magnetic field to rotate the drive member.

A catheter apparatus includes a first catheter, a housing configured to contain a laceration device in the retracted configuration, and a distal attachment device. In aspects, the first catheter can be within the outer catheter, and the housing can be movably attached to the outer catheter and surround a portion of the first catheter. In aspects, the housing can be within the first catheter, and the laceration device can extend beyond the first catheter in a deployed configuration. Methods of ameliorating septal hypertrophy of a heart include positioning a distal end of a first catheter at a first location proximate an aortic valve and extending the first catheter towards an apex of a left ventricle. Methods include anchoring the distal end to a second location proximate the apex. Methods include activating a laceration device to lacerate a portion of the septal wall between the apex and the aortic valve.

Methods and systems are provided for assessing an area of interest in the circulatory system of a subject. The method comprises: obtaining (210) a temporal sequence of ultrasound image frames of the area of interest; obtaining (220, 320) one or more trained models; inputting (250, 350) the temporal sequence of ultrasound image frames into the one or more trained models; and analysing (260, 360) the temporal sequence of ultrasound image frames, using the one or more trained models, to produce output data characterising a condition of the area of interest, wherein the output data characterises an extent of atherosclerosis or calcification of the area of interest, and wherein the area of interest is the aortic valve. An associated training method for training the one or more models is also provided.

The application discloses an interventional system with interception function, which comprises an interventional delivery system and an artificial implant loaded on the interventional delivery system, the artificial implant being an aortic valve with a first mark and comprising a stent and valve leaflets; the interventional delivery system comprises a catheter assembly, a control handle for controlling the catheter assembly, and an interception device connected to the control handle, the interception device being a filter for capturing blood clots or a deflection device for guiding blood clots, wherein the delivery channels of the interception device and the artificial implant are independently configured with pipe fittings or utilize a multi-lumen tube structure; the interventional delivery system has a third mark, and when the artificial implant is loaded on the interventional delivery system, the circumferential relative position between the first mark and the third mark is adjusted based on deviation information, wherein the deviation information is obtained by comparing the position information of each sinus of a native aortic valve with reference information. The interventional system with interception function can effectively deflect and capture blood clots and the like generated in the body, thereby reducing the risk.

The utility model discloses a kind of delivery sheaths, it is related to medical instrument technical field, including sheath tube, sheath tube has sheath tube distal end first curved section, sheath tube distal end second curved section, sheath tube distal end third curved section and sheath tube main body section in turn from the distal end of sheath tube to the proximal end of sheath tube on sheath tube, the center line of sheath tube distal end first curved section and the center line of sheath tube distal end second curved section are on first plane, the center line of sheath tube distal end third curved section and the center line of sheath tube main body section are on second plane, the included angle between second plane and first plane is greater than 0 and less than 90 °;The center line of sheath tube distal end third curved section can be parallel with the center line of aortic arch, the outlet on sheath tube distal end first curved section can be directly opposite aortic valve orifice;The utility model can effectively avoid blood vessel or valve injury.

Sensors for catheter pumps are disclosed herein. The catheter pump can include a catheter assembly comprising a catheter and a cannula coupled to a distal portion of the catheter. The cannula can have a proximal port for permitting the flow of blood therethrough. The catheter assembly can include a sensor to be disposed near the proximal port. A processing unit can be programmed to process a signal detected by the sensor. The processing unit can comprise a computer-readable set of rules to evaluate the signal to determine a position of the cannula relative to an aortic valve of a patient.

The invention relates to an aortic valve related event risk prediction method and system based on multi-time-point data, and the method comprises the following steps: collecting multi-time-point baseline data parameters and longitudinal follow-up visit data of a patient, carrying out the preprocessing, and extracting related features; constructing a medical constraint matrix based on the related features, and calculating a time attenuation weight matrix; carrying out medical constraint guided feature screening by adopting an improved random forest algorithm, carrying out layered constraint feature sampling based on a medical constraint matrix and a time decay weight matrix when nodes of each decision tree are constructed, and selecting key features from related features through iteration; calculating a fusion weight based on the time attenuation weight matrix, the medical constraint matrix and the feature reliability; and performing weighted fusion on the key features based on the fusion weight to obtain an aortic valve related event risk prediction result. Compared with the prior art, the aortic valve related event risk prediction method can integrate multi-time-point and multi-modal data, and has the advantages of accurate aortic valve related event risk prediction and the like.

Systems and methods for evaluating a proposed valve-in-valve procedure for a patient in which a replacement transcatheter aortic valve will be deployed within a first bioprosthetic aortic valve. The methods include selecting predetermined benchmark measurements of a valve-in-valve combination. Images of anatomy of the patient are received. Anatomical measurements of the first bioprosthetic valve are obtained from the received images. The predetermined benchmark measurements and the anatomical measurements are reviewed. Based, at least in part, upon the review, risks of a valve-in-valve procedure for the patient are evaluated. The methods of the present disclosure can be used on baseline scans of a patient without a first bioprosthetic valve implanted; under these circumstances, dimensions of the first valve are determined by benchmark measurements. Where methods of the present disclosure are used on post-first implant scans, then the dimensions of the first valve are determined from the post-implant scans.