218 results about "Neoaortic valve" patented technology

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's aorta. The device including a distal-tip element that defines a straight proximal portion, and a curved distal portion, the curved distal portion defining first and second curves with an elongated straight portion between the first and second curves. The distal-tip element is centered with respect to the aortic valve using the curved distal portion of the distal-tip element, to thereby guide the device through the subject's aortic valve atraumatically. A pump pumps blood through from the subject's left ventricle to the subject's aorta. Other applications are also described.

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's left ventricle. A tube is positioned such that a proximal portion of the tube traverses an aortic valve of the subject, and a distal portion of the tube is disposed within a left ventricle of the subject. A pump pumps blood through the tube from the subject's left ventricle to the subject's aorta such as to cause the proximal portion of the tube to be maintained in an open state, and to cause at least a portion of the tube to become curved. Other applications are also described.

The invention provides an adjustable structure, comprising: a variable catheter provided with a projecting portion; the protruding part comprises an outer protruding side and an inner protruding side, and the protruding height of the outer protruding side is larger than the protruding height of the inner protruding side. The invention further provides a guide wire assisted transvalvular device comprising the adjustable structure. The transverse position of the far end of the variable catheter is controlled by adjusting the protruding height, so that the valve crossing device can be stably fixed to the aortic valve opening, a guide wire located in the adjusting pipe can conveniently and smoothly cross the aortic valve opening, and preparation is made for a subsequent TAVA operation.

The present application relates to the field of medical devices, and specifically to an aortic valve auxiliary prosthesis for preventing regurgitation, comprising: a main body, which is configured to remain in place in the aorta at the surgical site; and three auxiliary leaflet segments configured to cooperate with the three free segments of the native leaflets of the aortic valve; the three auxiliary leaflet segments are fixed to the main body. The present invention allows the original native leaflets to be retained, and when the native valve is closed, the purpose of improving the prevention of regurgitation is achieved by overlapping and covering the free segments of the native valve, with significant therapeutic effects and stronger targeting. Since the native valve is retained, most of the impact force of blood when flowing is still on the native valve, the reliability requirements for the fixed positioning of the main body are low, and the morphological changes to the native valve are smaller.

The invention relates to the technical field of medical image processing, in particular to an aortic valve automatic segmentation method based on a multi-temporal CTA image. The method comprises the following steps: identifying a laminar flow dark area and a vortex bright area on a cross section of an aortic sinus area; according to the first feature size of the laminar flow dark area and the second feature size of the vortex bright area, the valve leaflet-sinus wall spacing is determined; determining a first deviation index according to the change trend of the valve leaflet-sinus wall spacing in the cardiac cycle; determining a second deviation index according to a difference characteristic between the CT value of the laminar flow dark area and the CT value of the eddy current bright area; if the first deviation index and the second deviation index both exceed the corresponding threshold values, judging that the data is in a to-be-corrected time phase; correcting the spacing by using the correction weight calculated by the second deviation index; and extracting key parameters of each time phase on the longitudinal section, and associating the corrected valve leaflet-sinus wall spacing to construct a valve three-dimensional dynamic model, thereby facilitating the three-dimensional dynamic model to output more accurate valve motion data.

The invention discloses an aortic valve function evaluation device which comprises a processor and a memory, and the memory stores programs or instructions capable of running on the processor. When the program or the instruction is executed by the processor, the following steps are realized: acquiring a first echocardiogram of a target object corresponding to a final systole and a second echocardiogram of a target object corresponding to a final diastole in a cardiac cycle, and acquiring medical record data of the target object; determining a first mask pattern corresponding to the first echocardiogram and a second mask pattern corresponding to the second echocardiogram according to the first echocardiogram, the second echocardiogram and an aortic valve segmentation model; determining an aortic valve morphological index of the target object according to the first mask pattern and the second mask pattern; determining aortic valve functional indexes of the target object according to the medical record data of the target object; and determining and outputting an aortic valve function evaluation result of the target object according to the first mask pattern, the second mask pattern, the aortic valve morphological index and the aortic valve functional index.

The invention provides a stepped ventricle auxiliary circulating pump device, relates to the technical field of heart blood pumps, and provides a structure that a heart blood pump is arranged in a heart chamber and below an aortic valve or a pulmonary valve, and a stepped motor and an axial flow channel are designed on the basis, so that a blood flow channel is formed between the motor and the axial flow channel; the blocking influence of the size of the motor above the aortic valve or the pulmonary valve on the blood circulation process can be effectively avoided, and the amount of blood pumped out of the aortic valve or the pulmonary valve is effectively increased.

An assessment of basal cardiac fitness uses noninvasively obtained physiological measures to determine the presence of a basal physiological state and cardiometric measures to determine cardiac fitness. In the presence of preload independence and cardiac vagal control, cardiometric signals are acquired that are sensitive to cardiac function and include information indicative of the opening and closing of the individual's aortic valve. The cardiometric signals are analyzed by a cardiac fitness assessment system for the determination of basal cardiac fitness. The invention assures preload independence through the assessment of observational physiological parameters or the use of physiological parameters obtained following alterations in venous return. The invention assures the presence of cardiac vagal control by assessment of measured parameters, including the presence of respiratory sinus arrhythmia. The resulting test is specific for cardiac function without dependencies on physical activities associated with heart rate elevation or respiratory capabilities.

The application discloses an aortic valve guide wire and a use method thereof, which comprises a head section, a transition section and a support section connected in sequence along an axial direction; the head section is composed of a polymer and further comprises a deformation capsule, at least one closed unit embedded in the head section, and an internal sealing electric field sensitive viscoelastic fluid; a mesh cable is arranged on the surface of the deformation capsule and extends to the transition section; the transition section and the support section are provided with a conductive film on the surface, and the conductive film is connected with the mesh cable and used for applying a non-uniform electric field to the deformation capsule to generate a regional viscosity difference and drive the head section to bend in a direction.The electric field sensitive viscoelastic fluid built in the head section generates a regional viscosity difference under the action of the non-uniform electric field, and the difference is converted into a directional bending moment through the synergistic effect of the mesh cable and the conductive film, so that the head of the guide wire can quickly respond to an external electric signal and accurately deflect.

The subject of the invention is a delivery system for delivering a self-expanding endoluminal prosthesis to the patient's ascending aorta and aortic valve, the system comprising: - an inner tube (33), extending along a longitudinal Y axis of the delivery system (100), from an atraumatic distal tip (27) to a handle (37); - a metal tube (32), slide-fitted on the inner tube (33), and extending from the internal space of the distal tip (27) to a handle (37); - an outer tubular catheter shaft (22) slide-fitted on the metal tube (32), the catheter shaft (22) is brought out from the handle (37) and is terminated by a capsule (20), containing inside the radially compressed on the metal tube (32), self-expanding endoluminal prosthesis (1) having defined construction and covered at least partially by a coating (16), - the capsule (20) has closed position when is closed by the tip (27) and has open position when the capsule (20) and the tip (27) are displaced relative to each other; wherein the distal part of the metal tube (32) is equipped with receiving means (41, 42) on which the distal locking means (7) of prosthesis (1) are removably embedded and blocked in the inner space of the tip (27) and the delivery system (100) comprises also removable holding means (45, 45') retaining the proximal locking means (9) of the prosthesis (1), so that when the capsule (20) is in its fully open position, the prosthesis (1) is still maintained partially compressed, holding its crimping length.

The invention provides a close-range valve-pump integrated ventricular auxiliary circulating pump device, and relates to the technical field of heart blood pumps, the close-range valve-pump integrated ventricular auxiliary circulating pump device comprises a ventricular auxiliary circulating pump device, the ventricular auxiliary circulating pump device is connected in series with a heart artery tube, and the ventricular auxiliary circulating pump device is arranged in a heart chamber and below an aortic valve or a pulmonary artery valve; the ventricular auxiliary circulating pump device comprises an axial flow channel and a power part located in the axial flow channel. The upper end of the axial flow channel is provided with a radially outward turnup part, the turnup part faces the lower surface of the aortic valve or the pulmonary valve and is sewn at the aortic root or the pulmonary artery root, the turnup part serves as a mounting plane, and the power part is provided with an impeller rotating in the axial direction of the axial flow channel. The plane of the outlet of the impeller and the plane where the flanging part is located are the same plane, and direct adjacent maximum pressure of the ventricular auxiliary circulating pump device is provided for the aortic valve or the pulmonary valve.

A catheter device is disclosed comprising; an elongate sheath (503) with a lumen and a distal end for positioning at a heart valve (6), an embolic protection device (200) for temporarily positioning in the aortic arch for deflection of embolic debris from the ascending aorta to the descending aorta, said embolic protection device is connectable to a transluminal delivery unit (130) extending proximally from a connection point (131), and having: a frame with a periphery, a blood permeable unit within said periphery for preventing embolic particles from passing therethrough with a blood flow downstream an aortic valve into side vessels of said aortic arch to the brain of a patient, and at least one tissue apposition sustaining unit (300, 350) extending from said catheter, into said aortic arch, and being attached to said embolic protection device at a sustaining point (502), for application of a stabilization force offset to said connection point at said embolic protection device, such as at said periphery, and for providing said stabilization force towards an inner wall of said aortic arch, away from said heart, and in a direction perpendicular to a longitudinal extension of said periphery, when said catheter device is positioned in said aortic arch, such that tissue apposition of said periphery to an inner wall of said aortic arch is supported by said force for improving stability and peripheral sealing. In addition related methods are disclosed.

The present invention provides a close-range valve pump integrated ventricular assist circulation pump device, which relates to the field of cardiac blood pump technology and includes: a ventricular assist circulation pump device, which is connected in series with the cardiac artery tube, and the ventricular assist circulation pump device is arranged in the ventricle and below the aortic valve or the pulmonary valve; the ventricular assist circulation pump device includes an axial flow channel and a power unit located in the axial flow channel; the upper end of the axial flow channel is provided with a radially outward flange portion, the flange portion faces the lower surface of the aortic valve or the pulmonary valve and is sutured to the aortic root or the pulmonary artery root, the flange portion serves as an installation plane, the power unit has an impeller rotating in the axial direction of the axial flow channel, and the impeller outlet plane is in the same plane as the plane where the flange portion is located, providing the ventricular assist circulation pump device with a maximum pressure directly adjacent to the aortic valve or the pulmonary valve.

The present invention provides an auxiliary occlusion device for aortic valve regurgitation. The auxiliary occlusion device comprises a positioning mechanism and an auxiliary occlusion member disposed proximal to the positioning mechanism. When the positioning mechanism is released, it is secured within the aorta, positioning the auxiliary occlusion member between the aortic valves. The auxiliary occlusion device can assist the aortic valve in occluding the gap between the aorta and the left ventricle in the presence of aortic valve regurgitation, thereby reducing or preventing blood backflow through the aortic valve. Furthermore, the auxiliary occlusion device does not obstruct blood flow in the aorta during ventricular contraction.

The invention belongs to the technical field of medical instruments, and particularly relates to a full-catheter aortic root repair system and an implantation method.The full-catheter aortic root repair system comprises an aortic valve ring, an arch-shaped cambered surface is arranged on the upper surface of the aortic valve ring, a through hole is formed in the upper surface of the arch-shaped cambered surface, and a branch vein frame is fixedly installed in the through hole in the top of the arch-shaped cambered surface; the grid end of the frame body, the kidney-shaped frame block and the aortic valve ring are tightly connected, the positioning side lugs and the branch pulse frame are cooperatively positioned, it is ensured that the system stably fixes and supports valve leaflets at the root of the aorta to be matched with the deformation cavity A, normal aortic valve opening and closing can be accurately simulated, one-way flow of blood is guaranteed, and the branch pulse frame can be accurately aligned with a coronary artery opening; meanwhile, during the operation, the shape of the containing membrane flap can be adjusted through angiography monitoring in combination with a control silk thread, accurate covering and sealing of a lesion area are achieved, complications such as perivalvular leakage are effectively reduced, and the treatment effect of aorta root diseases and long-term prognosis of patients are remarkably improved.

Various arrangements for measuring blood pressure using radar are presented herein. Radio frequency (RF) signals may be emitted and RF reflection signals can be received in response. The RF reflection signals can be analyzed at a first distance range and a second distance range to identify a first time of a pulse pressure wave at an aortic valve of a user and a second time of the pulse pressure wave at an extremity of the user, respectively. A pulse transmit time (PTT) of the pulse pressure wave from the aortic valve of the user to the extremity of the user using the first time and the second time can be determined. Using the PTT, a blood pressure of the user can then be determined.

An adjustable structure, comprising: a variable catheter (101) and an adjustment tube (103), wherein the variable catheter (101) is provided with a protrudable portion (102), which comprises an outer protruding side (1023) and an inner protruding side (1024), the height by which the outer protruding side (1023) can protrude being greater than the height by which the inner protruding side (1024) can protrude. A guidewire-assisted transvalvular device (100) comprising an adjustable structure. The lateral position of the distal end of the variable catheter (101) is controlled by means of adjusting the protruding height, so that the guidewire-assisted transvalvular device (100) can be stably fixed at the aortic valve orifice, making it convenient for a guidewire located inside the adjustment tube (103) to smoothly cross the aortic valve orifice so as to prepare for a subsequent TAVR procedure.

The invention provides a delivery system. The delivery system comprises a sheath tube, a sheath core and a sheath core connector, the sheath core is nested in an inner cavity of the sheath tube, and the sheath core comprises a sheath core main body tube and two reference wires which are symmetrical about the center of the sheath core; the sheath core connector is arranged on the sheath core in a sleeving mode and comprises a fixing part at the near end and a rotating part at the far end, the fixing part is fixedly arranged on the sheath core body tube, and the rotating part can rotate relative to the sheath core. According to the conveying system, before the valve prosthesis is loaded into the sheathing canal, the sheath core connector rotating part can be rotated to circumferentially adjust the valve prosthesis to the optimal position, it is ensured that after the valve prosthesis is conveyed to the designated position, the connection part of the valve prosthesis is aligned with connection of a native aortic valve, and the release accuracy is improved.

This invention provides a bicuspid aortic valve implantable annuloplasty ring, comprising two symmetrically arranged semi-annular bodies. The two ends of the two semi-annular bodies are connected in a saddle shape by a connecting post, and the connecting post extends upward by a predetermined length, forming the highest point of the annuloplasty ring. At the connection point, the two semi-annular bodies form a first predetermined angle. The semi-annular bodies are made of flexible material, and the connecting post is made of rigid material. This invention can be conveniently implanted into the bicuspid aortic valve annuli and can be operated within the aorta, eliminating the need for dissection outside the vessel wall.

The invention belongs to the technical field of biological medicine research, and particularly relates to a cell in-vitro calcification inducer, an induction culture medium and application thereof, an aortic valve calcification in-vitro induction model and a modeling method thereof. The inducer provided by the invention is prepared from the following components in parts by weight: 2160.4 parts of beta-sodium glycerophosphate, 0.039 parts of dexamethasone, 50 parts of vitamin C and 34 parts of vitamin D. The invention further provides a culture medium formed by using the inducer and a method for modeling an aortic valve calcification in-vitro induction model by using the inducer. According to the method, osteogenic differentiation of the aortic valve interstitial cells can be stably induced within a short time, an efficient and repeatable standardized induction scheme is provided for in-vitro aortic valve calcification models and drug screening, and the method has a very good application prospect.

This invention discloses a method for predicting sudden cardiac death based on forensic autopsy data using machine learning and its forensic applications, belonging to the fields of machine learning, statistics, and forensic identification. This invention provides a method for screening independent predictors of forensic diagnosis of sudden cardiac death using LASSO regression and logistic regression. Using 10-fold cross-validation, the method selects the minimum lambda(λ) to identify 14 risk factors. Logistic regression ultimately identifies 9 independent predictors, including age, heart weight, left ventricular wall thickness, right ventricular wall thickness, interventricular septum thickness, aortic valve circumference, mitral valve circumference, liver weight, and left kidney weight. A nomogram and a web-based calculator are constructed for predicting sudden cardiac death in forensic practice, thereby determining sudden cardiac death using objective indicators. This method has not been reported worldwide.

The subject of the invention is a self-expanding, covered at least partially by a coating (16), endoluminal prosthesis, comprising: - a stent-valve part (1"), containing a metal frame (10) and an aortic valve (14) secured inside it, - a stent-graft part (1'), containing a metal frame (8, 8'), - an intermediate part (4), joining the stent-valve part (1") with the stent-graft part (1') and having less stiffness than the stent-valve part (1") and the stent-graft part (1'), wherein the stent graft part (1') comprises a tapered section (13) narrowing inwardly towards the intermediate part (4), the tapered section (13) is equipped with at least one branch (5', 5") covered by a coating (16).

Prosthetic valves are provided, e.g., for replacing a mitral or aortic valve of a patient, that includes an annular valve body including an inlet end, an outlet end, and one or more valve members for selectively opening and closing a passage between the inlet and outlet ends, a sewing cuff attached around an outer perimeter of the valve body, and a flexible skirt removably attached around the outer perimeter adjacent the sewing cuff. The prosthetic valve may be introduced into a patient's body, positioned adjacent a valve annulus, and the sewing cuff may be secured around a perimeter of the valve annulus. The skirt may be secured to tissue adjacent the valve annulus to further seal the prosthetic valve around the valve annulus, or the skirt may be removed from the valve body, e.g., if the annulus is sufficiently sealed by the sewing cuff.

The invention relates to the field of medical instruments, in particular to a prosthesis capable of treating valve regurgitation, which comprises a stent main body capable of expanding in the radial direction, the stent main body comprises a plurality of rhombic grids and at least three clamping pieces arranged at the outflow end of the stent main body, and the clamping pieces are used for positioning aortic sinus and clamping autologous valve leaflets; a sealing bag bulging outwards is arranged on the stent body between the adjacent clamping pieces, the position of the sealing bag corresponds to the junction area of the aortic valve leaflet, the sealing bag is attached to the tissue of the junction area of the aortic valve leaflet, and the structure of the sealing bag is configured in a way that when blood regurgitates, the sealing bag can seal the tissue of the junction area of the aortic valve leaflet. The regurgitated blood is guided to be shunted to the two sides into the adjacent aortic sinus; the sealing bag enables backflow blood to flow into the adjacent aortic sinus in a guiding and shunting mode, backflow of the blood is avoided, meanwhile, when blood is pumped next time on the aorta, the blood in the aortic sinus is ejected out, and thrombus caused by blood deposition is avoided.

A method of delivering a transcutaneous dual valve replacement (TDVR) device to a patient includes the steps of advancing a guide catheter into the heart of the patient, advancing a support wire through the guide catheter and across the mitral valve of the heart of the patient, removing the guide catheter, advancing a delivery sheath over the support wire and across both the aortic valve and the mitral valve of the heart of the patient, advancing the TDVR device over the support wire and through the delivery sheath, removing the delivery sheath, expanding a first segment of the TDVR device in the mitral valve and a second segment of the TDVR device in the aortic valve, and removing the support wire.

The present application relates to the technical field of medical image processing, and in particular to an aortic valve automatic segmentation method based on multi-phase CTA images. The method identifies the laminar flow dark area and the vortex light area on the cross section of the aortic sinus region; determines the leaflet-sinus wall distance according to the first characteristic size of the laminar flow dark area and the second characteristic size of the vortex light area; determines the first deviation index according to the change trend of the leaflet-sinus wall distance in the cardiac cycle; determines the second deviation index according to the difference characteristics between the CT value of the laminar flow dark area and the CT value of the vortex light area; if the first deviation index and the second deviation index both exceed the corresponding threshold, it is determined that the data is in the phase to be corrected; corrects the distance by using the correction weight calculated by the second deviation index; extracts the key parameters of each phase on the longitudinal section, associates the corrected leaflet-sinus wall distance to construct a three-dimensional dynamic model of the valve, and thus the three-dimensional dynamic model outputs more accurate valve motion data.

The application relates to the field of medical devices, in particular to a prosthesis capable of treating valve regurgitation, comprising a radially expandable stent body, the stent body comprising a plurality of diamond-shaped meshes, and at least three clamping members arranged at the outflow end of the stent body, used for positioning the aortic sinus and clamping the native valve leaflets; a sealing bag bulging outward is arranged on the stent body between adjacent clamping members, wherein the position of the sealing bag corresponds to the junction area of the aortic valve leaflets, and the sealing bag is attached to the tissue of the junction area of the aortic valve leaflets, and the configuration of the sealing bag is configured to guide the regurgitant blood to flow to the adjacent aortic sinuses on both sides when the blood regurgitates; in the application, the sealing bag guides the regurgitant blood to flow to the adjacent aortic sinuses in a diversion manner, so that blood regurgitation is avoided, and meanwhile, when the aorta pumps blood again, the blood in the aortic sinus is ejected, so that blood stasis is avoided.

The application provides an interventional ventricular auxiliary oxygen generation device, a blood flow channel crosses an aortic valve into a left ventricle from an ascending aorta, a blood inlet of the blood flow channel is located in the left ventricle, a blood outlet is located in the ascending aorta, a first conveying pipe and a second conveying pipe convey hydrogen peroxide and catalase into the left ventricle to generate oxygen and water through reaction, and a pumping unit pumps oxygen-rich blood in the left ventricle to the ascending aorta. The oxygen generation function is added to the ventricular auxiliary device, the oxygen-rich blood in the ventricle is pumped to the ascending aorta through the ventricular auxiliary device, which directly improves the myocardial hypoxia condition and helps the heart recover, and on the other hand, the oxygen-rich blood is pumped into the ascending aorta and directly participates in the systemic circulation, thereby directly and quickly improving the oxygen supply condition of the systemic circulation.

The present disclosure generally relates to implantable medical devices, and, in some embodiments, to a prosthetic aortic implant. Such implantable devices may be useful in the treatment of acute aortic dissections (AADs). related systems and methods are also provided. In some embodiments, the prosthetic aortic implant comprises an expandable support structure and at least a first portion sized and configured to be positioned within an ascending portion of a native aorta of a subject. In some embodiments, the first portion comprises a non-porous layer and a porous layer. In some embodiments, the first portion is sized and configured to engage an aortic root of the native aorta. In some embodiments, the prosthetic aortic implant is designed and configured to engage with and / or receive an aortic valve implant.

Systems and methods are provided for repairing a heart valve, such as a mitral, tricuspid or aortic valve, using an adjustable and removable implant that can be delivered to the heart through the apex in a simplified and non-invasive manner. The implant can include a prosthetic valve portion coupled to a proximal end of a shaft, and an anchor portion coupled to a distal end of the shaft. The prosthetic valve can be suspended within an opening of the heart valve while the anchor portion is affixed to the apex of the heart. When the implant is deployed, a distance between the prosthetic valve portion and the anchor portion can be adjusted, and / or the implant or a portion thereof can be rotated to thereby change the position of the prosthetic valve within the heart valve. This can allow correcting for post-implantation movements of the implant to mitigate potential complications.