364 results about "Neoaortic valve" patented technology

Apparatus and methods are described including a ventricular assist device that includes a tube configured to traverse a subject's aortic valve. The tube defines a generally-cylindrical central portion, and a proximal conical portion that narrows from a proximal end of the central portion to a proximal end of the tube. The tube defines one or more blood inlet openings in a vicinity of a distal end of the tube, and one or more blood outlet openings that extend axially from the central portion of the tube at least partially into the proximal conical portion of the tube. A blood pump pumps blood into the tube from the subject's left ventricle through the one or more blood inlet openings, and from the tube into the aorta through the one or more blood outlet openings. Other applications are also described.

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's aorta. The device including a distal-tip element that defines a straight proximal portion, and a curved distal portion, the curved distal portion defining first and second curves with an elongated straight portion between the first and second curves. The distal-tip element is centered with respect to the aortic valve using the curved distal portion of the distal-tip element, to thereby guide the device through the subject's aortic valve atraumatically. A pump pumps blood through from the subject's left ventricle to the subject's aorta. Other applications are also described.

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's left ventricle. A tube is positioned such that a proximal portion of the tube traverses an aortic valve of the subject, and a distal portion of the tube is disposed within a left ventricle of the subject. A pump pumps blood through the tube from the subject's left ventricle to the subject's aorta such as to cause the proximal portion of the tube to be maintained in an open state, and to cause at least a portion of the tube to become curved. Other applications are also described.

The invention relates to the technical field of heart blood pumps, in particular to a passive ventricular auxiliary circulation device. Comprising a motor body shell, a stator and a rotor are arranged in the motor body shell, and one of the stator and the rotor comprises a coil; the axial flow channel shell is sleeved; the upper end of the axial flow channel shell is configured to face the aortic valve to the lower part of the ventricle, and a power supply configured to be operably coupled to the coil; and the controller is configured to be operated and coupled to the power supply to select and control the power supply to change the rotor to a certain rotating speed in a manual selection mode, then the rotor keeps working in a certain rotating speed mode, and corresponding auxiliary pressure output by the fluid outlet interface is configured at a different rotating speed. The device is controlled to be in a rotating speed state, and when systolic pressure smaller than normal systolic pressure is provided for cardiac pulsation of a heart failure patient, the normal systolic pressure is provided when the systolic pressure and auxiliary pressure are overlapped together, so that the heart failure patient maintains the normal systolic pressure.

The present invention discloses a presettable artificial biological aortic valve which comprises a valve seat (1), a valve leaflet stent (2) and three valve leaflets (3), wherein the valve seat (1) is a one-way limiting expandable annular metal seat; the head end of each seat body unit (4) is sequentially provided with a first rivet (7), a limiting protrusion (6) and a first long circular groove (5) from the outside to the inside; the tail end of each seat body unit (4) is sequentially provided with a second long circular groove (8), a second limiting hole (10) and a first limiting hole (9) matched with the limiting protrusion (6), and a second rivet (11) matched with the first long circular groove (5). The presettable artificial biological aortic valve has an original preset state and a normal use state after one-way limiting expansion.

A prosthetic aortic valve device, delivery system, interventional system, and related method are disclosed. The device includes an inner frame having relative compressed and expanded configurations; leaflets connected to the inner frame and cooperating with each other to control opening and closing of the blood flow passage; and a positioning mechanism arranged in a circumferential direction of the inner frame, the positioning mechanism including a fixed end connected to the inner frame and a free end extending towards the inflow end, the positioning mechanism being configured to be switchable among a loaded configuration, a transition configuration, and a released configuration.

The disclosure relates to heart have prostheses with the reduced need of pacemaker implantation and improved means for positioning the replacement heart valve. In one aspect of the present disclosure, the stent scaffold of the valve prosthesis includes axially extending locators. The locators may be positioned within the cusp of the native aortic valve. Placement of the locators within the cusps may prevent further proximal movement of the stent scaffold into the left ventricle. By adjusting the location of the proximal end of the locators with respect to the proximal end of the stent scaffold, infra-annular placement of the stent scaffold in the aortic annulus may be assured. In another aspect, means for visualizing the positioning of replacement heart valves at an implant site inside an individual's body is disclosed.

A prosthetic cardiac valve includes a frame and plurality of prosthetic leaflets coupled to the frame so as to allow blood flow in one direction. An antenna is mechanically coupled to the frame, and includes a magnetic core and one or more coils wound about the magnetic core. At at least one location along a length of the magnetic core, a planar space bound by an outer perimeter of the magnetic core, in a plane perpendicular to a central longitudinal axis of the frame, has (a) a shorter dimension, which is measured along a ray that radiates radially outward from the central longitudinal axis and intersects a centroid defined by the planar space, and (b) a longer dimension, which is measured perpendicular to the shorter dimension in the plane, and is at least 150% of the shorter dimension. Other embodiments are also described.

A prosthetic cardiac valve (620) includes a frame (630) and a plurality of prosthetic leaflets (32) coupled to the frame (630) so as to allow blood flow in one direction. An antenna (28) is mechanically coupled to the frame (630) proximal of the prosthetic leaflets, and includes one or more prosthetic-valve coils (36). First and second proximal peaks (204 A, 204B) respectively defined by circumferentially adjacent first and second proximal- most stent cells (206A, 206B) of interconnected stent cells (192) of the frame (630) are located at respective first and second peak angular locations (208 A, 208B) about a central longitudinal axis (60) of the frame (630). The antenna (28) is mechanically coupled to the frame (630) such that a centroid (212) of the antenna (28) is at an antenna angular location (214) between the first and the second peak angular locations (208A, 208B), and a proximal-most point (216) of the antenna (28) is axially disposed between 5 mm proximal of and 5 mm distal of the first and the second proximal peaks (204 A, 204B). Other embodiments are also described.

Provided herein is a device for simultaneous intraoperative leak testing and visualisation of a heart valve seat, the device comprising an end cap configured to engage with and to sealingly close an opening of a tubular vascular graft, the end cap comprising a backing portion, a connector portion, a view port, and at least one fluid conduit element, the connector portion comprising a distal end dimensioned for placement inside of the opening, a first fastening element comprising an external thread, a second fastening element comprising an internal thread and configured to be rotated onto the first fastening element, and the external and internal threads are adapted such that the first and second fastening elements are fittingly engaged with the tubular vascular graft scalingly secured therebetween by less than one rotation of the second fastening element around the outer circumference.

The invention discloses a method for evaluating the dynamic change of the open form of an aortic valve based on 4D radiography, and the method comprises the following steps: 1, carrying out the three-dimensional modeling of the aortic valve based on a clinical image; 2, under the condition that it is guaranteed that morphological information of the three-dimensional model is not lost, the opening area AVA of the aortic valve under different time phases is obtained through a 4D image or the three-dimensional model; 3, according to the obtained AVA values in different time phases, drawing a systolic period AVA curve for describing open form change characteristics of the aortic valve in the systolic period, confirming an AV stable open period, and obtaining the average open area, the maximum open area and the minimum open area of the aortic valve in the AV stable open period; 4, calculating mutual differences according to the obtained average open area, the minimum open area and the maximum open area of the aortic valve in the AV stable open period; calculating the ratio of the open area to the maximum open area of the aortic valve under different time phases; 5, according to the result of the step 4, evaluating the opening degree change condition of the aortic valve in the systolic period.

A pigtail catheter may include an elongate shaft having a curled distal tip, a tubular sheath slidably disposed over the elongate shaft, and a compliant expandable member fixed to the elongate shaft and the tubular sheath. A transcatheter aortic valve replacement (TAVR) system may include the pigtail catheter, a TAVR delivery device comprising an elongate shaft having an implant holding portion proximate a distal end thereof, and a TAVR implant disposed within the holding portion in a collapsed configuration, the TAVR implant comprising an expandable framework including a lower crown disposed at an upstream end and an upper crown disposed downstream of 10 the lower crown. The compliant expandable member is configured to identify a downstream extent of a surgical aortic valve implant disposed within an ascending aorta prior to deploying the TAVR implant.

The ginsenoside F4 is found to be capable of effectively down-regulating the expression of osteogenic differentiation marker genes ALP and RUNX2 in valvular interstitial cells and inhibiting the osteogenic differentiation of the valvular interstitial cells, so that valve calcification is delayed or inhibited; the invention also provides a cell-tissue-individual three-dimensional culture system which can significantly improve osteogenic differentiation of valvular interstitial cells, human aortic valve tissue blocks and Apoe- / -male mouse aortic valves after being treated by ginsenoside F4, and further provides a new drug choice for prevention and treatment of calcified aortic valve diseases.

In some embodiments, a method includes providing a prosthetic heart valve including a collapsible and expandable stent having struts and a valve assembly coupled to the stent, the valve assembly having a plurality of leaflets and a cuff, providing a delivery device including a catheter extending between a proximal end and a distal end, an inflatable balloon, a handle coupled to the catheter, and a memory for storing data disposed within the handle, recording at least one of part-to-part noise factors and process variation factors and storing it in the memory, calculating an adjusted inflation parameter based on the at least one of part-to-part noise factor and process variation factor, advancing the delivery device to a native aortic valve of a patient while the prosthetic heart valve is disposed about the inflatable balloon, and inflating the balloon according to the adjusted inflation parameter.

The invention belongs to the field of biological medicines, and particularly relates to a method for inhibiting osteogenic differentiation of human aortic valve interstitial cells (hVICs), namely, N-acetyltransferase 10 (NAT10) is silenced in vivo and in vitro by a biological method, and the NAT10 is over-silenced in a mouse body by adeno-associated viruses according to the method, so that the result shows that the mouse aortic valve calcification can be inhibited by the silencing of the NAT10, and the osteogenic differentiation of the human aortic valve interstitial cells (hVICs) can be inhibited. NAT10 is silenced in hVICs through adenovirus, and it is found that NAT10 silencing can inhibit osteogenic differentiation of hVICs, so that valve calcification is delayed or inhibited. The invention further provides a method for preventing and treating aortic valve calcification by inhibiting the NAT10 protein expression level, and a new non-surgical treatment scheme is provided for preventing and treating calcified aortic valve diseases.

The present disclosure relates to the field of medical device technology, and specifically to a cardiac outflow tract valved patch, which includes a sinus wall support sheet and a valve leaflet; the lower edge of the valve leaflet is arc-shaped, and the lower edge of the valve leaflet is connected to the sinus wall support sheet, and a valve pocket is formed between the valve leaflet and the sinus wall support sheet; between the upper edge of the valve leaflet and the lower edge of the valve leaflet, an upper edge arm protrudes from the outside of the valve leaflet, and the end of the upper edge arm is used to connect to the sinus wall support sheet. After the heart is repaired with the cardiac outflow tract valved patch in this scheme, as the size of the cardiac outflow tract increases, the extension of the upper edge arm increases accordingly, so that the size of the opening of the valve pocket formed between the valve leaflet and the sinus wall support sheet also increases accordingly, thereby ensuring that the aortic valve will not be incompletely closed.

A prosthetic aortic valve that uses actuating arms and grippers to attach to leaflets, reducing device migration and sizing issues. It involves excising diseased leaflets prior to implantation, ensuring blood flow to coronary arteries, and offers optical visualization. The valve features replaceable leaflets and a streamlined frame. Innovative left atrial appendage devices, embolic protection devices, intra-cardiac echocardiography devices, and steerable catheter devices are introduced. Provided herein are atraumatic, cinchable mitral valve annular repair devices, noninvasive methods that modify body calcium with electromagnetic energy, and systems for optical visualization in vascular interventions by displacing blood with clear fluid.

The invention provides an adjustable structure, comprising: a variable catheter provided with a projecting portion; the protruding part comprises an outer protruding side and an inner protruding side, and the protruding height of the outer protruding side is larger than the protruding height of the inner protruding side. The invention further provides a guide wire assisted transvalvular device comprising the adjustable structure. The transverse position of the far end of the variable catheter is controlled by adjusting the protruding height, so that the valve crossing device can be stably fixed to the aortic valve opening, a guide wire located in the adjusting pipe can conveniently and smoothly cross the aortic valve opening, and preparation is made for a subsequent TAVA operation.

The present application relates to the field of medical devices, and specifically to an aortic valve auxiliary prosthesis for preventing regurgitation, comprising: a main body, which is configured to remain in place in the aorta at the surgical site; and three auxiliary leaflet segments configured to cooperate with the three free segments of the native leaflets of the aortic valve; the three auxiliary leaflet segments are fixed to the main body. The present invention allows the original native leaflets to be retained, and when the native valve is closed, the purpose of improving the prevention of regurgitation is achieved by overlapping and covering the free segments of the native valve, with significant therapeutic effects and stronger targeting. Since the native valve is retained, most of the impact force of blood when flowing is still on the native valve, the reliability requirements for the fixed positioning of the main body are low, and the morphological changes to the native valve are smaller.

Disclosed herein are representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve. In one embodiment, for instance, a support structure and an expandable prosthetic valve are advanced through the aortic arch of a patient using a delivery system. The support structure is delivered to a position on or adjacent to the surface of the outflow side of the aortic valve (the support structure defining a support-structure interior). The expandable prosthetic valve is delivered into the aortic valve and into the support-structure interior. The expandable prosthetic heart valve is expanded while the expandable prosthetic heart valve is in the support-structure interior and while the support structure is at the position on or adjacent to the surface of the outflow side of the aortic valve, thereby causing one or more native leaflets of the aortic valve to be frictionally secured between the support structure and the expanded prosthetic heart valve.

The limiting expandable aortic valve pipeline comprises an aortic valve preliminary pipeline attached with a collagen fiber coating, and the aortic valve preliminary pipeline comprises a proximal pipeline, a valve connecting pipe and a telecentric pipeline. The invention also discloses a preparation method thereof. The limiting expandable aortic valve pipeline provided by the invention is used for replacing an aortic artificial blood vessel and a Bentall type operation of an aortic valve, and after the artificial bioprosthetic valve declines, the limiting expandable aortic valve pipeline provided by the invention provides a condition for embedding the artificial bioprosthetic valve with the same size as an original valve in an interventional manner, so that the limiting expandable aortic valve pipeline can be used for replacing the Bentall type operation of the aortic valve and the artificial bioprosthetic valve. In this way, after the bioprosthetic valve declines, the valve with the same size as the original valve can be placed in an interventional mode, and the patient does not need to open the chest to replace the bioprosthetic valve with the same size.

The invention relates to the technical field of medical image processing, in particular to an aortic valve automatic segmentation method based on a multi-temporal CTA image. The method comprises the following steps: identifying a laminar flow dark area and a vortex bright area on a cross section of an aortic sinus area; according to the first feature size of the laminar flow dark area and the second feature size of the vortex bright area, the valve leaflet-sinus wall spacing is determined; determining a first deviation index according to the change trend of the valve leaflet-sinus wall spacing in the cardiac cycle; determining a second deviation index according to a difference characteristic between the CT value of the laminar flow dark area and the CT value of the eddy current bright area; if the first deviation index and the second deviation index both exceed the corresponding threshold values, judging that the data is in a to-be-corrected time phase; correcting the spacing by using the correction weight calculated by the second deviation index; and extracting key parameters of each time phase on the longitudinal section, and associating the corrected valve leaflet-sinus wall spacing to construct a valve three-dimensional dynamic model, thereby facilitating the three-dimensional dynamic model to output more accurate valve motion data.

The invention discloses an aortic valve function evaluation device which comprises a processor and a memory, and the memory stores programs or instructions capable of running on the processor. When the program or the instruction is executed by the processor, the following steps are realized: acquiring a first echocardiogram of a target object corresponding to a final systole and a second echocardiogram of a target object corresponding to a final diastole in a cardiac cycle, and acquiring medical record data of the target object; determining a first mask pattern corresponding to the first echocardiogram and a second mask pattern corresponding to the second echocardiogram according to the first echocardiogram, the second echocardiogram and an aortic valve segmentation model; determining an aortic valve morphological index of the target object according to the first mask pattern and the second mask pattern; determining aortic valve functional indexes of the target object according to the medical record data of the target object; and determining and outputting an aortic valve function evaluation result of the target object according to the first mask pattern, the second mask pattern, the aortic valve morphological index and the aortic valve functional index.

Disclosed are devices, systems, and methods for in vivo monitoring of biological fluid flow within anatomical structures, such as blood flow through heart valves (e.g., mitral, tricuspid, and / or aortic valves) or heart chambers. The disclosed devices, systems, and methods can continuously measure and evaluate blood flow back and forth at the inlet of a heart valve to determine cardiac function or dysfunction and / or to compile with other monitored data that can be used to measure or predict secondary factors.

An aortic valve simulation device and an extracorporeal circulation simulation system comprise an inlet flange, an artificial valve and an outlet flange, the artificial valve is clamped between the inlet flange and the outlet flange and used for simulating an active valve, and a catheter pump can penetrate into a first flow channel of the inlet flange from the outlet flange. Therefore, the relative position of the catheter pump and the aortic valve is reflected. The artificial valve comprises at least two valve leaflets, and a gap is formed between every two adjacent valve leaflets, so that the valve leaflets on the artificial valve are mutually independent, do not interfere with each other and are easier to open or close; meanwhile, a supporting rod is arranged at one end, facing the artificial valve, of the inner side wall of the inlet flange, the gap can be blocked, and simulation of the one-way valve characteristic of the aortic valve is achieved. According to the aortic valve simulation device, the valve leaflets on the artificial valve are easier to open or close, the trans-valve pressure of the aortic valve simulation device is reduced, the valve opening pressure difference is lower, and the left ventricular pressure and aortic pressure waveforms can be more perfectly reproduced when the cardiovascular state of the human body is simulated when a catheter pump assists.

The invention belongs to the technical field of cell mechanics biology experiment devices for health and rehabilitation engineering, and relates to a microfluidic device for endothelialization evaluation of a tissue engineering valve, which comprises a microfluidic chip, peripheral equipment, a signal acquisition and processing system and a feedback system. The biomechanical principle and the micro-fluidic chip technology are ingeniously combined, the control system, the mechanical loading device and the micro-fluidic chip are connected, a micro-fluidic endothelial cell culture cavity and a peripheral system are constructed, real-time accurate control over aortic valve blood flow is achieved through the PID control system, and the system is suitable for large-scale popularization and application. Shear stress applied to a tissue engineering valve endothelial cell culture area is generated, so that the real stress condition of the tissue engineering valve endothelial cells is simulated, and the method is used for analyzing and researching the influence rule of mechanical loading on the tissue engineering valve endothelial cells.

The utility model discloses an aortic valve balloon dilatation pressure pump which comprises a needle cylinder, a piston rod, a piston, a sealing ring, a pressure gauge, a rotary knob, a sleeve, a locking piece, a connecting plate and a rotating shaft. An opening groove is concavely formed in the outer side wall of the upper end of the locking piece, short shafts are convexly arranged on the two side walls of the upper end of the connecting plate respectively, first through holes are concavely formed in the two side walls of the upper end of the locking piece respectively, the short shafts are rotatably embedded in the first through holes respectively, and second through holes are concavely formed in the two side walls of the second containing groove respectively. A third through hole is concavely formed in the side wall of the lower end part of the connecting plate, the rotating shaft sequentially penetrates through the second through hole, the upper end part of the through groove and the third through hole, a wedge-shaped surface is arranged on the inner peripheral wall of the upper end part of the through groove, and the rotating shaft can slide along the wedge-shaped surface. According to the technical scheme, the pressure pump outputs high pressure and adjusts the pressure more conveniently and quickly.

According to the anchoring piece, the restraining device, the conveying system and the conveying method, the anchoring piece adopts an anchoring clamp clamping mode, can adapt to more pathological structures, and can effectively treat aortic valve regurgitation (or aortic valve divalvular and tetravalvular deformity accompanied by aortic valve divalvular and tetravalvular deformity) patients; the protruding anchor is arranged to hang or carry the autologous valve leaflet, valve displacement is prevented, and the perivalvular leakage risk is reduced. The restraining device is provided with a restraining part, the anchoring part is sleeved with a restraining section of the restraining part in an annular shape, a scaling section is connected with the restraining section and arranged in the releasing pipe in a penetrating mode, and the restraining force of the restraining section on the anchoring part is controlled by controlling the scaling section so as to control the releasing speed of the anchoring part. The delivery system optimizes the structure and the function of the whole system, a lumen gap can be properly widened, emptying and water passing are facilitated, the delivery system has better control force when the artificial valve is released due to introduction of the restraining device, and it is guaranteed that when the anchoring piece reaches the lesion position, the anchoring piece is slowly placed, and the aorta and the sinus floor are prevented from being damaged.

The invention provides a stepped ventricle auxiliary circulating pump device, relates to the technical field of heart blood pumps, and provides a structure that a heart blood pump is arranged in a heart chamber and below an aortic valve or a pulmonary valve, and a stepped motor and an axial flow channel are designed on the basis, so that a blood flow channel is formed between the motor and the axial flow channel; the blocking influence of the size of the motor above the aortic valve or the pulmonary valve on the blood circulation process can be effectively avoided, and the amount of blood pumped out of the aortic valve or the pulmonary valve is effectively increased.

The utility model belongs to the technical field of medical instruments, and particularly discloses a novel aortic valve support and an artificial valve. The novel aortic valve stent is made of memory metal wires, is of a grid cylindrical structure and comprises an inflow end stent, a connecting part stent and an outflow end stent. The connecting part bracket comprises an interval side bracket, an interval opposite side bracket and other side wall brackets; the grid area and the metal wire width of the interval side support and the interval opposite side support are larger than those of the other side wall supports, and the metal wire thickness and the deformation amount compliance are smaller than those of the other side wall supports. The artificial valve comprises a novel aortic valve support, axial positioning metal, valve leaflets and an anti-regurgitation skirt edge, wherein the valve leaflets and the anti-regurgitation skirt edge are made of polymer materials. The problems of perivalvular regurgitation, abnormal heart conduction and short service life of the existing artificial valve can be solved.