294 results about "Neoaortic valve" patented technology

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's aorta. The device including a distal-tip element that defines a straight proximal portion, and a curved distal portion, the curved distal portion defining first and second curves with an elongated straight portion between the first and second curves. The distal-tip element is centered with respect to the aortic valve using the curved distal portion of the distal-tip element, to thereby guide the device through the subject's aortic valve atraumatically. A pump pumps blood through from the subject's left ventricle to the subject's aorta. Other applications are also described.

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's left ventricle. A tube is positioned such that a proximal portion of the tube traverses an aortic valve of the subject, and a distal portion of the tube is disposed within a left ventricle of the subject. A pump pumps blood through the tube from the subject's left ventricle to the subject's aorta such as to cause the proximal portion of the tube to be maintained in an open state, and to cause at least a portion of the tube to become curved. Other applications are also described.

The invention relates to the technical field of heart blood pumps, in particular to a passive ventricular auxiliary circulation device. Comprising a motor body shell, a stator and a rotor are arranged in the motor body shell, and one of the stator and the rotor comprises a coil; the axial flow channel shell is sleeved; the upper end of the axial flow channel shell is configured to face the aortic valve to the lower part of the ventricle, and a power supply configured to be operably coupled to the coil; and the controller is configured to be operated and coupled to the power supply to select and control the power supply to change the rotor to a certain rotating speed in a manual selection mode, then the rotor keeps working in a certain rotating speed mode, and corresponding auxiliary pressure output by the fluid outlet interface is configured at a different rotating speed. The device is controlled to be in a rotating speed state, and when systolic pressure smaller than normal systolic pressure is provided for cardiac pulsation of a heart failure patient, the normal systolic pressure is provided when the systolic pressure and auxiliary pressure are overlapped together, so that the heart failure patient maintains the normal systolic pressure.

The present invention discloses a presettable artificial biological aortic valve which comprises a valve seat (1), a valve leaflet stent (2) and three valve leaflets (3), wherein the valve seat (1) is a one-way limiting expandable annular metal seat; the head end of each seat body unit (4) is sequentially provided with a first rivet (7), a limiting protrusion (6) and a first long circular groove (5) from the outside to the inside; the tail end of each seat body unit (4) is sequentially provided with a second long circular groove (8), a second limiting hole (10) and a first limiting hole (9) matched with the limiting protrusion (6), and a second rivet (11) matched with the first long circular groove (5). The presettable artificial biological aortic valve has an original preset state and a normal use state after one-way limiting expansion.

The disclosure relates to heart have prostheses with the reduced need of pacemaker implantation and improved means for positioning the replacement heart valve. In one aspect of the present disclosure, the stent scaffold of the valve prosthesis includes axially extending locators. The locators may be positioned within the cusp of the native aortic valve. Placement of the locators within the cusps may prevent further proximal movement of the stent scaffold into the left ventricle. By adjusting the location of the proximal end of the locators with respect to the proximal end of the stent scaffold, infra-annular placement of the stent scaffold in the aortic annulus may be assured. In another aspect, means for visualizing the positioning of replacement heart valves at an implant site inside an individual's body is disclosed.

In some embodiments, a method includes providing a prosthetic heart valve including a collapsible and expandable stent having struts and a valve assembly coupled to the stent, the valve assembly having a plurality of leaflets and a cuff, providing a delivery device including a catheter extending between a proximal end and a distal end, an inflatable balloon, a handle coupled to the catheter, and a memory for storing data disposed within the handle, recording at least one of part-to-part noise factors and process variation factors and storing it in the memory, calculating an adjusted inflation parameter based on the at least one of part-to-part noise factor and process variation factor, advancing the delivery device to a native aortic valve of a patient while the prosthetic heart valve is disposed about the inflatable balloon, and inflating the balloon according to the adjusted inflation parameter.

The present disclosure relates to the field of medical device technology, and specifically to a cardiac outflow tract valved patch, which includes a sinus wall support sheet and a valve leaflet; the lower edge of the valve leaflet is arc-shaped, and the lower edge of the valve leaflet is connected to the sinus wall support sheet, and a valve pocket is formed between the valve leaflet and the sinus wall support sheet; between the upper edge of the valve leaflet and the lower edge of the valve leaflet, an upper edge arm protrudes from the outside of the valve leaflet, and the end of the upper edge arm is used to connect to the sinus wall support sheet. After the heart is repaired with the cardiac outflow tract valved patch in this scheme, as the size of the cardiac outflow tract increases, the extension of the upper edge arm increases accordingly, so that the size of the opening of the valve pocket formed between the valve leaflet and the sinus wall support sheet also increases accordingly, thereby ensuring that the aortic valve will not be incompletely closed.

The invention provides an adjustable structure, comprising: a variable catheter provided with a projecting portion; the protruding part comprises an outer protruding side and an inner protruding side, and the protruding height of the outer protruding side is larger than the protruding height of the inner protruding side. The invention further provides a guide wire assisted transvalvular device comprising the adjustable structure. The transverse position of the far end of the variable catheter is controlled by adjusting the protruding height, so that the valve crossing device can be stably fixed to the aortic valve opening, a guide wire located in the adjusting pipe can conveniently and smoothly cross the aortic valve opening, and preparation is made for a subsequent TAVA operation.

The present application relates to the field of medical devices, and specifically to an aortic valve auxiliary prosthesis for preventing regurgitation, comprising: a main body, which is configured to remain in place in the aorta at the surgical site; and three auxiliary leaflet segments configured to cooperate with the three free segments of the native leaflets of the aortic valve; the three auxiliary leaflet segments are fixed to the main body. The present invention allows the original native leaflets to be retained, and when the native valve is closed, the purpose of improving the prevention of regurgitation is achieved by overlapping and covering the free segments of the native valve, with significant therapeutic effects and stronger targeting. Since the native valve is retained, most of the impact force of blood when flowing is still on the native valve, the reliability requirements for the fixed positioning of the main body are low, and the morphological changes to the native valve are smaller.

Disclosed herein are representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve. In one embodiment, for instance, a support structure and an expandable prosthetic valve are advanced through the aortic arch of a patient using a delivery system. The support structure is delivered to a position on or adjacent to the surface of the outflow side of the aortic valve (the support structure defining a support-structure interior). The expandable prosthetic valve is delivered into the aortic valve and into the support-structure interior. The expandable prosthetic heart valve is expanded while the expandable prosthetic heart valve is in the support-structure interior and while the support structure is at the position on or adjacent to the surface of the outflow side of the aortic valve, thereby causing one or more native leaflets of the aortic valve to be frictionally secured between the support structure and the expanded prosthetic heart valve.

The limiting expandable aortic valve pipeline comprises an aortic valve preliminary pipeline attached with a collagen fiber coating, and the aortic valve preliminary pipeline comprises a proximal pipeline, a valve connecting pipe and a telecentric pipeline. The invention also discloses a preparation method thereof. The limiting expandable aortic valve pipeline provided by the invention is used for replacing an aortic artificial blood vessel and a Bentall type operation of an aortic valve, and after the artificial bioprosthetic valve declines, the limiting expandable aortic valve pipeline provided by the invention provides a condition for embedding the artificial bioprosthetic valve with the same size as an original valve in an interventional manner, so that the limiting expandable aortic valve pipeline can be used for replacing the Bentall type operation of the aortic valve and the artificial bioprosthetic valve. In this way, after the bioprosthetic valve declines, the valve with the same size as the original valve can be placed in an interventional mode, and the patient does not need to open the chest to replace the bioprosthetic valve with the same size.

The invention relates to the technical field of medical image processing, in particular to an aortic valve automatic segmentation method based on a multi-temporal CTA image. The method comprises the following steps: identifying a laminar flow dark area and a vortex bright area on a cross section of an aortic sinus area; according to the first feature size of the laminar flow dark area and the second feature size of the vortex bright area, the valve leaflet-sinus wall spacing is determined; determining a first deviation index according to the change trend of the valve leaflet-sinus wall spacing in the cardiac cycle; determining a second deviation index according to a difference characteristic between the CT value of the laminar flow dark area and the CT value of the eddy current bright area; if the first deviation index and the second deviation index both exceed the corresponding threshold values, judging that the data is in a to-be-corrected time phase; correcting the spacing by using the correction weight calculated by the second deviation index; and extracting key parameters of each time phase on the longitudinal section, and associating the corrected valve leaflet-sinus wall spacing to construct a valve three-dimensional dynamic model, thereby facilitating the three-dimensional dynamic model to output more accurate valve motion data.

The invention discloses an aortic valve function evaluation device which comprises a processor and a memory, and the memory stores programs or instructions capable of running on the processor. When the program or the instruction is executed by the processor, the following steps are realized: acquiring a first echocardiogram of a target object corresponding to a final systole and a second echocardiogram of a target object corresponding to a final diastole in a cardiac cycle, and acquiring medical record data of the target object; determining a first mask pattern corresponding to the first echocardiogram and a second mask pattern corresponding to the second echocardiogram according to the first echocardiogram, the second echocardiogram and an aortic valve segmentation model; determining an aortic valve morphological index of the target object according to the first mask pattern and the second mask pattern; determining aortic valve functional indexes of the target object according to the medical record data of the target object; and determining and outputting an aortic valve function evaluation result of the target object according to the first mask pattern, the second mask pattern, the aortic valve morphological index and the aortic valve functional index.

Disclosed are devices, systems, and methods for in vivo monitoring of biological fluid flow within anatomical structures, such as blood flow through heart valves (e.g., mitral, tricuspid, and / or aortic valves) or heart chambers. The disclosed devices, systems, and methods can continuously measure and evaluate blood flow back and forth at the inlet of a heart valve to determine cardiac function or dysfunction and / or to compile with other monitored data that can be used to measure or predict secondary factors.

The invention belongs to the technical field of cell mechanics biology experiment devices for health and rehabilitation engineering, and relates to a microfluidic device for endothelialization evaluation of a tissue engineering valve, which comprises a microfluidic chip, peripheral equipment, a signal acquisition and processing system and a feedback system. The biomechanical principle and the micro-fluidic chip technology are ingeniously combined, the control system, the mechanical loading device and the micro-fluidic chip are connected, a micro-fluidic endothelial cell culture cavity and a peripheral system are constructed, real-time accurate control over aortic valve blood flow is achieved through the PID control system, and the system is suitable for large-scale popularization and application. Shear stress applied to a tissue engineering valve endothelial cell culture area is generated, so that the real stress condition of the tissue engineering valve endothelial cells is simulated, and the method is used for analyzing and researching the influence rule of mechanical loading on the tissue engineering valve endothelial cells.

According to the anchoring piece, the restraining device, the conveying system and the conveying method, the anchoring piece adopts an anchoring clamp clamping mode, can adapt to more pathological structures, and can effectively treat aortic valve regurgitation (or aortic valve divalvular and tetravalvular deformity accompanied by aortic valve divalvular and tetravalvular deformity) patients; the protruding anchor is arranged to hang or carry the autologous valve leaflet, valve displacement is prevented, and the perivalvular leakage risk is reduced. The restraining device is provided with a restraining part, the anchoring part is sleeved with a restraining section of the restraining part in an annular shape, a scaling section is connected with the restraining section and arranged in the releasing pipe in a penetrating mode, and the restraining force of the restraining section on the anchoring part is controlled by controlling the scaling section so as to control the releasing speed of the anchoring part. The delivery system optimizes the structure and the function of the whole system, a lumen gap can be properly widened, emptying and water passing are facilitated, the delivery system has better control force when the artificial valve is released due to introduction of the restraining device, and it is guaranteed that when the anchoring piece reaches the lesion position, the anchoring piece is slowly placed, and the aorta and the sinus floor are prevented from being damaged.

The invention provides a stepped ventricle auxiliary circulating pump device, relates to the technical field of heart blood pumps, and provides a structure that a heart blood pump is arranged in a heart chamber and below an aortic valve or a pulmonary valve, and a stepped motor and an axial flow channel are designed on the basis, so that a blood flow channel is formed between the motor and the axial flow channel; the blocking influence of the size of the motor above the aortic valve or the pulmonary valve on the blood circulation process can be effectively avoided, and the amount of blood pumped out of the aortic valve or the pulmonary valve is effectively increased.

An assessment of basal cardiac fitness uses noninvasively obtained physiological measures to determine the presence of a basal physiological state and cardiometric measures to determine cardiac fitness. In the presence of preload independence and cardiac vagal control, cardiometric signals are acquired that are sensitive to cardiac function and include information indicative of the opening and closing of the individual's aortic valve. The cardiometric signals are analyzed by a cardiac fitness assessment system for the determination of basal cardiac fitness. The invention assures preload independence through the assessment of observational physiological parameters or the use of physiological parameters obtained following alterations in venous return. The invention assures the presence of cardiac vagal control by assessment of measured parameters, including the presence of respiratory sinus arrhythmia. The resulting test is specific for cardiac function without dependencies on physical activities associated with heart rate elevation or respiratory capabilities.

The utility model provides an anchoring device and a transcatheter artificial aortic valve system. The anchoring device is of an integrated structure and comprises an anchoring valve ring support at the telecentric end and an anchoring foot at the proximal end. The anchoring valve ring support is of a cylindrical net-shaped structure. The number of the anchoring feet is three, the anchoring feet are distributed on the periphery of the proximal end of the anchoring valve ring support, the anchoring feet have an abduction angle relative to the axis of the anchoring valve ring support, and each anchoring foot is of a C-shaped hollow structure. According to the anchoring device and the transcatheter artificial aortic valve system, after the anchoring device is released through a catheter, the anchoring foot is embedded into the aortic sinus bottom corresponding to the aorta root, the native valve is extruded between the anchoring foot and the artificial aortic valve, and a first anchoring state is formed; after the artificial aortic valve is expanded, the artificial aortic valve is tightly attached to the anchoring valve ring support and the aortic valve ring to form a second anchoring state; double anchoring provides a stable and reliable supporting effect for the artificial aortic valve.

The application discloses an aortic valve guide wire and a use method thereof, which comprises a head section, a transition section and a support section connected in sequence along an axial direction; the head section is composed of a polymer and further comprises a deformation capsule, at least one closed unit embedded in the head section, and an internal sealing electric field sensitive viscoelastic fluid; a mesh cable is arranged on the surface of the deformation capsule and extends to the transition section; the transition section and the support section are provided with a conductive film on the surface, and the conductive film is connected with the mesh cable and used for applying a non-uniform electric field to the deformation capsule to generate a regional viscosity difference and drive the head section to bend in a direction.The electric field sensitive viscoelastic fluid built in the head section generates a regional viscosity difference under the action of the non-uniform electric field, and the difference is converted into a directional bending moment through the synergistic effect of the mesh cable and the conductive film, so that the head of the guide wire can quickly respond to an external electric signal and accurately deflect.

The invention discloses a valve stent, an aortic valve and a mitral valve, and the valve stent comprises a valve stent which is of a latticed annular stent structure formed by cutting a metal tube; the outer frame is of a latticed or semi-latticed annular support structure formed by cutting a metal pipe, the outer frame wraps the outer side of the valve frame and is connected with the valve frame, and a first positioning unit is integrally formed on the outer frame; the first positioning unit comprises a plurality of supporting legs arranged in the circumferential direction of the outer frame, and the supporting legs are obtained by outwards bending and forming two adjacent edges in the grids or half grids of the outer frame in the circumferential direction, so that when the outer frame is implanted into the implantation position of the inner side of the autologous valve leaflet, the first positioning unit can be supported on the inner side of the autologous valve ring; the valve support is limited to move in the direction opposite to the heart blood flow direction. When the valve support is anchored through the outer support, the valve support provided with the outer support can still have the small radial size, and the implanting difficulty of the valve and the requirement for a conveying system are lowered.

The subject of the invention is a delivery system for delivering a self-expanding endoluminal prosthesis to the patient's ascending aorta and aortic valve, the system comprising: - an inner tube (33), extending along a longitudinal Y axis of the delivery system (100), from an atraumatic distal tip (27) to a handle (37); - a metal tube (32), slide-fitted on the inner tube (33), and extending from the internal space of the distal tip (27) to a handle (37); - an outer tubular catheter shaft (22) slide-fitted on the metal tube (32), the catheter shaft (22) is brought out from the handle (37) and is terminated by a capsule (20), containing inside the radially compressed on the metal tube (32), self-expanding endoluminal prosthesis (1) having defined construction and covered at least partially by a coating (16), - the capsule (20) has closed position when is closed by the tip (27) and has open position when the capsule (20) and the tip (27) are displaced relative to each other; wherein the distal part of the metal tube (32) is equipped with receiving means (41, 42) on which the distal locking means (7) of prosthesis (1) are removably embedded and blocked in the inner space of the tip (27) and the delivery system (100) comprises also removable holding means (45, 45') retaining the proximal locking means (9) of the prosthesis (1), so that when the capsule (20) is in its fully open position, the prosthesis (1) is still maintained partially compressed, holding its crimping length.

A bilateral mechanical circulatory support system is described. The bilateral mechanical circulatory support system includes a first heart pump configured to be positioned across an aortic valve of a patient, the first heart pump including a first pressure sensor and a second pressure sensor, a second heart pump configured to be positioned across a pulmonary valve of the patient, the second heart pump including a third pressure sensor and a fourth pressure sensor, and at least one controller. The at least one controller is configured to control operation of the first heart pump and the second heart pump, the at least one controller configured to receive pressure signals from the first pressure sensor, the second pressure sensor, the third pressure sensor, and the fourth pressure sensor. The system further includes a display configured to display one or more waveforms or values based, at least in part, on the pressure signals.

The invention provides a close-range valve-pump integrated ventricular auxiliary circulating pump device, and relates to the technical field of heart blood pumps, the close-range valve-pump integrated ventricular auxiliary circulating pump device comprises a ventricular auxiliary circulating pump device, the ventricular auxiliary circulating pump device is connected in series with a heart artery tube, and the ventricular auxiliary circulating pump device is arranged in a heart chamber and below an aortic valve or a pulmonary artery valve; the ventricular auxiliary circulating pump device comprises an axial flow channel and a power part located in the axial flow channel. The upper end of the axial flow channel is provided with a radially outward turnup part, the turnup part faces the lower surface of the aortic valve or the pulmonary valve and is sewn at the aortic root or the pulmonary artery root, the turnup part serves as a mounting plane, and the power part is provided with an impeller rotating in the axial direction of the axial flow channel. The plane of the outlet of the impeller and the plane where the flanging part is located are the same plane, and direct adjacent maximum pressure of the ventricular auxiliary circulating pump device is provided for the aortic valve or the pulmonary valve.

The invention belongs to the technical field of medical instruments, and relates to a delivery system and method for an artificial valve, the system comprises a guide wire used for building a delivery passage for the artificial valve to be delivered, and the end part of the guide wire is provided with a guide wire head; the ultrasonic probe is arranged on the guide wire head and is used for transmitting an ultrasonic signal to the aorta and receiving an ultrasonic echo signal; the processing module is used for receiving and responding to the ultrasonic echo signal, determining an aortic valve opening area according to the ultrasonic echo signal, and outputting a first control instruction according to the aortic valve opening area and the pre-acquired current position of the guide wire head; the mechanical device receives and responds to the first control instruction while bearing the guide wire, and drives the guide wire head to move to the aortic valve opening area. According to the invention, the valve passing operation difficulty is reduced, the operation time is shortened, other operation risks possibly caused by too long operation time are avoided, and the safety is higher.

A valve stent and an artificial valve. The valve stent (100) comprises: a stent main body (110), a plurality of first support arms (120), and at least one second support arm (130). The plurality of first support arms are arranged in a circumferential direction of the stent main body. One end of each of the first support arms is connected to an outflow end (112) of the stent main body, and the other end (121) of each of the first support arms is arranged outside the stent main body and extends toward the direction of an inflow end (111) of the stent main body. One end of the second support arm is connected to the outflow end of the stent main body, and the other end (131) of the second support arm is arranged outside the stent main body. The stent main body is used for placement at an aortic valve. A native valve leaflet (11) is accommodated between the stent main body and the first support arms, and the other end of each of the first support arms is used for extending into a corresponding aortic sinus to provide anchoring. In each aortic sinus, at least one first support arm is arranged, and the second support arm is used for expanding an aortic wall. When a pure aortic regurgitation valve is replaced, the valve stent can provide stable and reliable anchoring by means of the first support arms and the second support arm, can be prevented from interfering and blocking the coronary artery ostia by means of the second support arm, and can expand the aortic wall during delivery.

A catheter device is disclosed comprising; an elongate sheath (503) with a lumen and a distal end for positioning at a heart valve (6), an embolic protection device (200) for temporarily positioning in the aortic arch for deflection of embolic debris from the ascending aorta to the descending aorta, said embolic protection device is connectable to a transluminal delivery unit (130) extending proximally from a connection point (131), and having: a frame with a periphery, a blood permeable unit within said periphery for preventing embolic particles from passing therethrough with a blood flow downstream an aortic valve into side vessels of said aortic arch to the brain of a patient, and at least one tissue apposition sustaining unit (300, 350) extending from said catheter, into said aortic arch, and being attached to said embolic protection device at a sustaining point (502), for application of a stabilization force offset to said connection point at said embolic protection device, such as at said periphery, and for providing said stabilization force towards an inner wall of said aortic arch, away from said heart, and in a direction perpendicular to a longitudinal extension of said periphery, when said catheter device is positioned in said aortic arch, such that tissue apposition of said periphery to an inner wall of said aortic arch is supported by said force for improving stability and peripheral sealing. In addition related methods are disclosed.

The present invention provides a close-range valve pump integrated ventricular assist circulation pump device, which relates to the field of cardiac blood pump technology and includes: a ventricular assist circulation pump device, which is connected in series with the cardiac artery tube, and the ventricular assist circulation pump device is arranged in the ventricle and below the aortic valve or the pulmonary valve; the ventricular assist circulation pump device includes an axial flow channel and a power unit located in the axial flow channel; the upper end of the axial flow channel is provided with a radially outward flange portion, the flange portion faces the lower surface of the aortic valve or the pulmonary valve and is sutured to the aortic root or the pulmonary artery root, the flange portion serves as an installation plane, the power unit has an impeller rotating in the axial direction of the axial flow channel, and the impeller outlet plane is in the same plane as the plane where the flange portion is located, providing the ventricular assist circulation pump device with a maximum pressure directly adjacent to the aortic valve or the pulmonary valve.

The present invention provides an auxiliary occlusion device for aortic valve regurgitation. The auxiliary occlusion device comprises a positioning mechanism and an auxiliary occlusion member disposed proximal to the positioning mechanism. When the positioning mechanism is released, it is secured within the aorta, positioning the auxiliary occlusion member between the aortic valves. The auxiliary occlusion device can assist the aortic valve in occluding the gap between the aorta and the left ventricle in the presence of aortic valve regurgitation, thereby reducing or preventing blood backflow through the aortic valve. Furthermore, the auxiliary occlusion device does not obstruct blood flow in the aorta during ventricular contraction.

The invention belongs to the technical field of medical instruments, and particularly relates to a full-catheter aortic root repair system and an implantation method.The full-catheter aortic root repair system comprises an aortic valve ring, an arch-shaped cambered surface is arranged on the upper surface of the aortic valve ring, a through hole is formed in the upper surface of the arch-shaped cambered surface, and a branch vein frame is fixedly installed in the through hole in the top of the arch-shaped cambered surface; the grid end of the frame body, the kidney-shaped frame block and the aortic valve ring are tightly connected, the positioning side lugs and the branch pulse frame are cooperatively positioned, it is ensured that the system stably fixes and supports valve leaflets at the root of the aorta to be matched with the deformation cavity A, normal aortic valve opening and closing can be accurately simulated, one-way flow of blood is guaranteed, and the branch pulse frame can be accurately aligned with a coronary artery opening; meanwhile, during the operation, the shape of the containing membrane flap can be adjusted through angiography monitoring in combination with a control silk thread, accurate covering and sealing of a lesion area are achieved, complications such as perivalvular leakage are effectively reduced, and the treatment effect of aorta root diseases and long-term prognosis of patients are remarkably improved.