72 results about "Pulmonary valve" patented technology

A percutaneously inserted bistable heart valve prosthesis is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve has an annular ring, a body member having a plurality of legs, each leg connecting at one end to the annular ring, claws that are adjustable from a first position to a second position by application of external force so as to allow ingress of surrounding heart tissue into the claws in the second position, and leaflet membranes connected to the annular ring, the body member and / or the legs, the leaflet membranes having a first position for blocking blood flow therethrough and a second position for allowing blood flow therethrough. The heart valve is designed such that upon removal of the external force the claws elastically revert to the first position so as to grip the heart tissue positioned within the claws, thereby holding the heart valve in place. The body member and claws may be integrated into a one-piece design. The heart valve may be used as a prosthesis for the mitral valve, aortic valve, pulmonary valve, or tricuspid valve by adapting the annular ring to fit in a respective mitral, aortic, pulmonary, or tricuspid valve opening of the heart.

A system for replacing a pulmonary valve includes a conduit having a lumen, a delivery catheter and a replacement valve device disposed on the delivery catheter. The replacement valve device includes a prosthetic valve connected to a valve support region of an expandable support structure. The valve support region includes a plurality of protective struts disposed between a first stent region and a second stent region. A method for replacing a pulmonary valve includes implanting a conduit and delivering a replacement valve device to the conduit. The replacement valve device includes a valve connected to a valve support region that includes a plurality of protective struts. The method also includes deploying the prosthetic valve device from a delivery catheter into the lumen, positioning the prosthetic valve device within the conduit lumen and expanding the prosthetic valve device into contact with the inner wall of the conduit.

A valve replacement system that can be used for treating abnormalities of the right ventricular outflow tract in a nonsymmetrical region of a vessel or conduit that includes a prosthetic valve device and a foundation structure. The foundation structure contacts a portion of the inner wall of a vessel or conduit, and undergoes a shape change resulting in a corresponding change in the wall of the vessel or conduit. As a result, the lumen of the conduit is made symmetrical, and is complementary to the exterior surface of the stented valve, and thereby, improves the functioning of the valve. Another embodiment of the invention includes a method for replacing a pulmonary valve that includes forming a symmetrical region in a lumen of a conduit and placing a stented valve in the symmetrical region.

A system for treating abnormalities of the right ventricular outflow tract includes a prosthetic valve device having a barrier material contacting at least a portion of the outer surface of the valve device. One embodiment of the invention includes a barrier member attached to the exterior surface of the valve device. Another embodiment includes a barrier material that is injected within the vascular system. Yet another embodiment of the invention includes a method for replacing a pulmonary valve that includes forming a barrier around the outer surface of a replacement valve and preventing blood flow around the replacement valve.

A system for treating abnormalities of the right ventricular outflow tract includes a prosthetic valve device having a barrier material contacting at least a portion of the outer surface of the valve device. One embodiment of the invention includes a barrier member attached to the exterior surface of the valve device. Another embodiment includes a barrier material that is injected within the vascular system. Yet another embodiment of the invention includes a method for replacing a pulmonary valve that includes forming a barrier around the outer surface of a replacement valve and preventing blood flow around the replacement valve.

The invention relates to a novel percutaneous aortic valve and pulmonary valve exchanger, which is a self-expand support with biological valve, formed by the support in special shape and made from nickel titanium alloy skeleton and the three-blade one-way opening valve formed by pig heart, wherein, the support has fixing and supporting functions, and the pig heart forms three valves fixed in the support. The invention has little hurt, high safety and reduced complication.

A tiny electrically powered hydrodynamic blood pump is disclosed which occupies one third of the aortic or pulmonary valve position, and pumps directly from the left ventricle to the aorta or from the right ventricle to the pulmonary artery. The device is configured to exactly match or approximate the space of one leaflet and sinus of valsalva, with part of the device supported in the outflow tract of the ventricular cavity adjacent to the valve. In the configuration used, two leaflets of the natural tri-leaflet valve remain functional and the pump resides where the third leaflet had been. When implanted, the outer surface of the device includes two faces against which the two valve leaflets seal when closed. To obtain the best valve function, the shape of these faces may be custom fabricated to match the individual patient's valve geometry based on high resolution three dimensional CT or MRI images. Another embodiment of the invention discloses a combined two leaflet tissue valve with the miniature blood pump supported in the position usually occupied by the third leaflet. Either stented or un-stented tissue valves may be used. This structure preserves two thirds of the valve annulus area for ejection of blood by the natural ventricle, with excellent washing of the aortic root and interface of the blood pump to the heart. In the aortic position, the blood pump is positioned in the non-coronary cusp. A major advantage of the transvalvular VAD is the elimination of both the inflow and outflow cannulae usually required with heart assist devices.

Disclosed are methods, compounds and compositions useful for treatment of a patient with valvular dysfunction. The invention relates to using stem cells, modified stem cells, derivatives thereof, and agents stimulatory to stem cells in order to substantially ameliorate, and in some cases induce a therapeutic benefit, to a patient suffering from a dysfunction of the mitral, aortic, tricuspid, or pulmonary valve. In some embodiments the invention treats the valve dysfunction itself, whereas in other embodiments treatment of associated cardiac structures is performed. Furthermore, in other embodiments the invention permits physiological compensation for the valve dysfunction, prolonging the time until surgical intervention is needed.

A pulmonary valve replacement system having a vascular conduit and a prosthetic valve device including a valve operably connected to a support structure. The prosthetic valve device is positioned within the vascular conduit. A conduit support includes a substantially circular cross-section. The conduit support is positioned adjacent to and reinforces the vascular conduit. In one embodiment, the pulmonary valve replacement system includes a catheter and an inflatable member operably attached to the catheter. The prosthetic valve device is disposed on the inflatable member. The invention provides a method for replacing a pulmonary valve including providing a vascular conduit positioned at a treatment site. The vascular conduit includes a conduit support positioned adjacent the vascular conduit. A prosthetic valve device is deployed within the vascular conduit via catheter. The prosthetic valve device includes a valve operably connected to a support structure. The vascular conduit is supported with the conduit support.

A percutaneously inserted bistable heart valve prosthesis is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve has an annular ring, a body member having a plurality of legs, each leg connecting at one end to the annular ring, claws that are adjustable from a first position to a second position by application of external force so as to allow ingress of surrounding heart tissue into the claws in the second position, and leaflet membranes connected to the annular ring, the body member and / or the legs, the leaflet membranes having a first position for blocking blood flow therethrough and a second position for allowing blood flow therethrough. The heart valve is designed such that upon removal of the external force the claws elastically revert to the first position so as to grip the heart tissue positioned within the claws, thereby holding the heart valve in place. The body member and claws may be integrated into a one-piece design. The heart valve may be used as a prosthesis for the mitral valve, aortic valve, pulmonary valve, or tricuspid valve by adapting the annular ring to fit in a respective mitral, aortic, pulmonary, or tricuspid valve opening of the heart.

In an implantable medical device and a method for the operation thereof, acoustic energy is sensed in a subject in whom the device is implanted, and signals indicative of heart sounds of the heart of the patient are produced over predetermined periods of a cardiac cycle, during successive cardiac cycles. A signal corresponding to the second heart sound (S2) is extracted from the sensed signal, and the respective durations of successive second heart sound signals are determined. An optimization procedure is implemented that includes controlling delivery of pacing pulses based on the determined durations of successive second heart sounds, to determined a combination of stimulation intervals, including at least the AV interval and the VV interval, that causes a substantially synchronized closure of the aortic and pulmonary valves.

There is provided an artificial cardiac or heart valve, more particularly a flexible leaflet heart valve used to replace natural aortic or pulmonary valves of the heart in which the leaflet geometry is defined by a parabolic function and a method of manufacturing said artificial cardiac valves. In addition, there is provided leaflets which have geometry defined by a parabolic function.

A method for diagnosing pulmonary hypertension from phase-contrast magnetic resonance (MR) images includes providing a time series of one or more magnetic resonance (MR) flow images of a patient's mediastinum during one or more cardiac cycles, segmenting the pulmonary artery within each image of the times series of images, identifying the anterior wall and pulmonary valve within the segmented pulmonary artery, analyzing blood flow during a diastolic phase of the one or more cardiac cycles to determine a relative duration of blood flow, tstreamlines, during the diastolic phase, analyzing blood flow during a latter portion of a systolic phase and a subsequent diastolic phase of the one or more cardiac cycles to detect the presence and duration tvortex of a vortex, and diagnosing the presence of pulmonary hypertension from tstreamlines and tvortex.

A prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement is described herein. A sewing ring for use with the prosthetic tissue valve is also described. The valve can have a circumference that is a predetermined distance larger than the circumference of an annulus in a defective valve. The valve can be substantially planar in an unstressed position before attachment at the annulus and substantially non-planar upon attachment in a biased position at the annulus. Methods are provided for placing the valve as described herein in the biased position within the annulus of the defective valve.

There is provided an artificial cardiac or heart valve, more particularly a flexible leaflet heart valve used to replace natural aortic or pulmonary valves of the heart in which the leaflet geometry is defined by a parabolic function and a method of manufacturing said artificial cardiac valves. In addition, there is provided leaflets which have geometry defined by a parabolic function.

A prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement is described herein. A sewing ring for use with the prosthetic tissue valve is also described. The valve can have a circumference that is a predetermined distance larger than the circumference of an annulus in a defective valve. The valve can be substantially planar in an unstressed position before attachment at the annulus and substantially non-planar upon attachment in a biased position at the annulus. Methods are provided for placing the valve as described herein in the biased position within the annulus of the defective valve.

The invention provides a trileaflet semi-lunar prosthetic tissue valve for aortic, pulmonary, mitral, or tricuspid valve replacement. The valve is planar before attachment at an annulus of a valvular lumen, and non-planar upon attachment at the annulus of the defective valve. A sewing ring having a circumference greater than the annular circumference of annulus of the valve being replaced is also described and the sewing ring is placed at the approximate position of the annulus of the defective valve in a non-planar configuration.

The invention relates to a pulmonary valve stent with an anchor mechanism, which comprises a valve suture section (1) and an artificial valve (2), wherein the artificial valve (2) is connected with the valve suture section (1), and the valve suture section (1) is positioned at a right ventricular outflow tract or a main pulmonary artery (10) after being released. The pulmonary valve stent further comprises the anchor mechanism (3), wherein the near end of the anchor mechanism (3) is connected with the far end of the valve suture section (1) by a transition connecting rod (4), and the anchor mechanism (3) is positioned in a pulmonary artery branching vessel (30) after being released. According to the pulmonary valve stent, as the anchor mechanism is placed in the pulmonary artery branching vessel and connected with the valve suture section positioned at the right ventricular outflow tract or the main pulmonary artery by the transition connecting rod, the stability of the valve stent can be improved significantly, and displacement of the pulmonary valve stent is avoided.

The invention relates to an anti-displacement pulmonary valve stent which comprises a valve suture section (1) and an artificial valve (2), wherein the artificial valve (2) is connected with the valve suture section (1); and after the valve suture section (1) is released, the valve suture section (1) is located on an outflow tract of a right ventricle or a main pulmonary artery (10). The anti-displacement pulmonary valve stent further comprises a limiting mechanism (3), wherein a bottom end part of the limiting mechanism (3) is connected with a far end of the valve suture section (1); and after a top end part (31) of the limiting mechanism is released, the top end part is propped against an intersection (30) of the main pulmonary artery and a branch pulmonary artery. According to the anti-displacement pulmonary valve stent, the limiting mechanism is arranged at the far end of the pulmonary valve stent, and is propped against an inner wall of a blood vessel at the intersection of the main pulmonary artery and the branch pulmonary artery after the limiting mechanism is released, and the valve stent can be limited axially, so that the stability of the pulmonary valve stent is improved, and the displacement of the pulmonary valve stent is avoided.

The invention belongs to the field of biomedical engineering and particularly relates to an intrusive assisted circulation device used in the department of cardiac surgery. The device is characterized in that a magnetic drive mode is adopted for power transmission. The device is divided into two parts, namely an invitro driving device and an auxiliary device capable of being implanting into a human body through percutaneous coronary intervention, wherein an invitro driving device main body is a rotating magnetic field generation device capable of generating a rotating magnetic field which is strong enough; the auxiliary device implanted into the human body is internally provided with a minitype axial flow pump; a high-energy magnet is embedded in an impeller of the minitype axial flow pump, and is driven to rotate by the rotating magnetic field so as to push blood to flow; and the pump is implanted into the part, crossing over an aortic valve or pulmonic valve, of a heart, so as to play a role in assisting the heart to pump blood, thus effectively relieving the cardiac muscle load and assisting heart recovery.

The invention discloses a pulmonary artery support and a pulmonary artery valve replacement device with the same. The pulmonary artery support comprises a tubular support net rack, an inflow section and an outflow section, wherein the inflow section and the outflow section are connected to two axial ends of the support net rack and are radially expanded to form flareouts; the part, adjacent to the outflow section, of the support network rack is provided with a plurality of first cells distributed in the circumferential direction; the outflow section is composed of a plurality of positioning strips which are sequentially distributed in the circumferential direction of the support network rack; the middle of each positioning strip is bent toward the outflow direction; two ends of each positioning strip are connected with the top points of two separated first cells. The pulmonary artery valve replacement device comprises the pulmonary artery support, and a prosthesis valve fixed in the pulmonary artery support. The pulmonary artery support disclosed by the invention is unlikely to cause damage to blood vessels and has little blocking effect on blood flow.

The invention discloses a safety improved pulmonary artery stent and a pulmonary artery valve replacement device. The safety improved pulmonary artery stent comprises a pipe-shaped supporting net stent and two flaring sections which are connected with two axial ends of the supporting net stent; every flaring section is connected with an end portion of the supporting net stent through a fixing part; one ends of the flaring sections, which are back to the supporting net stent, is provided with a plurality of wave crests which are provided with smooth edges. The pulmonary artery valve replacement device comprises the safety improved pulmonary artery stent and a prosthesis valve which is arranged inside the pulmonary artery stent. According to the safety improved pulmonary artery stent, the flaring sections are connected with the supporting net stent through the fixing parts, namely, the flaring sections and the supporting net stent are connected in a detachable mode, the safety is improved, the utilization is flexible, and meanwhile machining difficulty is reduced.

The invention provides a trileaflet semi-lunar prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement. The valve is planar before attachment at an annulus of a valvular lumen, and non-planar upon attachment at the annulus of the defective valve. A sewing ring having a circumference greater than the annular circumference of annulus of the valve being replaced is also described and the sewing ring is placed at the approximate position of the annulus of the defective valve in a non-planar configuration.

The invention discloses a pulmonary artery valve replacement device and a support thereof. The support comprises a valve fixing part, the top edge of the valve fixing part and a support part used for supporting a left pulmonary artery or / and right pulmonary artery are connected through a transitional section, and both the valve fixing part and the support part are of cylindrical structures. The transitional section is provided with a transitional arc surface fittingly contacting with the inner wall of blood vessels. The pulmonary artery valve replacement device comprises a pulmonary artery valve support, an artificial valve is arranged in the valve fixing part, and the valve fixing part is provided with a tectorial membrane below the artificial valve. The pulmonary artery valve support and the pulmonary artery valve replacement device can solve two problems that backflow of pulmonary artery valve and restenosis of pulmonary artery after pulmonary artery valve operation at the same time and are high in stability, operation risk of support displacement is avoided, damage of blood vessels are less prone to causing, stenosis of pulmonary artery branches is solved and repeated implanting of multiple supports is not needed.

The invention belongs to the field of interventional therapy, and relates to a balloon catheter for ultrasound-guided percutaneous pulmonary valve balloon dilatation. The balloon catheter comprises a catheter and two balloons which are arranged on the outer side of the catheter, the balloons are connected with the catheter in a sleeving mode to achieve sealing, and the two balloons comprises a guiding balloon and a working balloon in sequence; three tunnels which are parallel in the length direction of the catheter and are independent from one to another, each balloon is correspondingly and only connected to the outer side of each tunnel opening located on the side wall in a sealing and sleeving mode, and therefore inflatable sealed spaces which are independent and non-interfering are formed. According to the dilatation used by the balloon catheter, ultrasound can be effectively used for guiding, and the harm brought by radioactive ray guiding in the prior art can be avoided. The double-balloon design is beneficial for reducing the diameter of the catheter and reducing complications of femoral vein injury, and suitable for an underweight patient. Spacing of 1-5 cm exists between the guiding balloon and the working balloon to enable the guiding balloon to play a role in positioning, and when the guiding balloon is located nearby an opening of a left pulmonary artery, the working balloon is exactly located on a pulmonary valve ring.

The present invention relates to medical techniques and can be used in heart surgery for the replacement of the damaged natural aortal and mitral human heart valves and also tricuspid and lung artery valves. A heart valve prosthesis comprises an annular body with a pair of flanges, and a closing element in the form of two or three flaps mounted by means of bearings into the body's recesses with freedom to be rotated. The body has a constant height on a greater portion of a ring circle, and ledges the number of which is equal to that of the flaps. The ledges are provided with flap rotation limiters. In the preferable embodiment, the ledges are W-shaped while their interior surface from the side of the direct flow of blood is inclined to the central axis of the body. The flaps have ascending and descending surfaces oriented to the direct and reverse flows of blood, respectively, a side edge and an edge for joining the other flap. The descending surface of a flap is flat and the ascending surface thereof is spherically concave. The flaps have the minimal thickness on an axis of symmetry at the joining edge. In the event when a closing element comprises three flaps, each of them has two joining edges obliquely converging toward the body's central axis. Also, the axes of rotation of the flaps will be arranged relative to each other at an angle of 60° thereby to form the sides of an equilateral triangle. For the valve with two flaps the flange facing the direct flow of blood is thickened. Recesses for bearings enter into the thickened flange, said recesses having a lateral cylindrical surface and a concave bottom. The recesses for bearings can be configured as a triad of blind holes being in communication, which is comprised of one central and two side holes. And the radius and depth of the central hole are greater than the radii and depths of the side holes.