161 results about "Mitral valve flow" patented technology

The application discloses a heart valve device and relates to the technical field of artificial heart valves, which comprises an outer valve frame and a valve leaflet assembly connected to the inside of the outer valve frame, and the outer valve frame is a ring-shaped grid frame; the outer valve frame comprises an inflow side grid frame and an outflow side grid frame arranged in sequence from an inflow end to an outflow end, and the inflow side grid frame and the outflow side grid frame form an annular recess for clamping a native valve ring on the outer periphery of the outer valve frame; the outflow side grid frame comprises a plurality of groups of grid support units connected in sequence along the circumferential direction and enclosed into a ring, and the grid support unit comprises an outer convex grid support and an inner concave grid support, and the outer surface of the inner concave grid support is arranged in a concave manner relative to the outer surface of the outer convex grid support. In this way, the anterior leaflet of the original mitral valve can be attached to the inner concave grid support, the extrusion of the outer valve frame on the anterior leaflet is reduced, the anterior leaflet is prevented from being extruded to the left ventricular outflow tract by the outer valve frame, and the outflow area of the left ventricular outflow tract is prevented from being reduced to cause obstruction.

A mitral valve prosthesis to be implanted in a heart, comprises an asymmetrical ring, the asymmetrical ring is dimensioned to mimic a native mitral annulus of a patient; an anterior flexible leaflet and a posterior flexible leaflet, said leaflets suspended from the asymmetrical ring and configured to substantially coapt with each other; and at least four sets of cords, each set of cords attached to the anterior or posterior leaflet on a first end and attached into a cap on a second end, the cap is configured to be attached onto papillary muscles of the heart on another end of the cap.

The application discloses a channel type mitral valve prosthesis implantation system, which comprises a plurality of deformable biological ring guide wires, the end of each of the biological ring guide wires is provided with a bendable hook, the hooks are used for forming a guideable channel, and the channel is annular in shape; a biological ring which is in the shape of a strip when freely stretched, two free ends of the biological ring are configured to be locked when a main body part of the biological ring is pushed along the channel to form a biological ring locking buckle; and a mitral valve prosthesis support which is fixed in the biological ring. The system is simple to operate, saves operation time, and enables safe and efficient completion of the operation.

The invention relates in some aspects to a device for use in anchoring an implant, including anchors, sutures, implants, clips, tools, lassos, and methods of anchoring among other methods. Anchors as disclosed herein could be utilized to secure a coaptation assistance device, an annuloplasty ring, an artificial valve, cardiac patch, sensor, pacemaker, or other implants. The implant could be a mitral valve ring or artificial mitral valve in some embodiments.

A traditional Chinese medicine formula for treating blood vessel clogging belongs to the field of traditional Chinese medicine formulas, and comprises the following main raw materials: 29-31 parts of black pearl, 11-13 parts of codonopsis pilosula, 7-9 parts of saffron crocus, 8-10 parts of angelica sinensis, 190-210 parts of leek, 9-11 parts of pseudo-ginseng, 37-43 parts of hawthorn, 95-105 parts of astragalus membranaceus, 18-22 parts of kudzu vine root, 8-10 parts of peach kernel, 8-10 parts of prepared rehmannia root, 9-11 parts of radix rehmanniae, 11-13 parts of white paeony root, 3 parts of red ginseng, 9-11 parts of radix ophiopogonis, 14-16 parts of spina date seed, 11-13 parts of Chinese yam, 14-15 parts of schisandra chinensis, 9-11 parts of polygonum multiflorum, 7-9 parts of cinnamon, 18-21 , 13-15 parts of anise and 12-14 parts of rhizoma polygonati. The traditional Chinese medicine composition has an obvious improvement effect on coronary artery insufficiency, myocardial ischemia, mitral valve, tricuspid valve, aortic valve regurgitation, chronic heart failure, patients needing operation bypass stenting, angina pectoris, myocardial infarction sequelae, cerebral ischemia, cerebrovascular sequelae and other symptoms caused by cardiac insufficiency, the dosage is small, the effect is fast, the cure rate is high, relapse is not prone to occurring, and the traditional Chinese medicine composition is suitable for clinical application. The effects of tonifying qi and activating blood, dredging channels and relieving pain, eliminating phlegm and removing blood stasis, tonifying heart and soothing nerves and the like can be achieved.

This invention provides an apparatus for repairing heart valves and a method for implanting anchors and repairing heart valves. The apparatus includes: a body; a component attached to the body at a first end and having a plurality of positioning cords extending laterally across a space between the component and away from a second end of the component opposite to the first end; a tube suspended from the plurality of positioning cords; and an adjustment cord extending through the tube. The method includes: implanting at least one annular anchor into the mitral valve annulus of a heart valve; implanting papillary anchors through each papillary muscle of the heart; delivering and positioning the apparatus for repairing the heart valve within the heart valve using at least one annular anchor and papillary anchors; and adjusting the apparatus to adjust the degree of atrial displacement of the mitral valve leaflets during ventricular systole.

Procedures may be performed on the heart after the installation of a mitral valve fixation device. In order to prepare the heart for such procedures, the fixation device may be removed or disabled in minimally invasive ways (e.g., through an endovascular procedure), without requiring open access to the heart. The fixation device may be partitioned so that one portion may remain attached to each leaflet of the mitral valve. In another example, the leaflets may be cut along the edges of the distal element(s) of the fixation device, so as to cut the fixation device from the leaflet(s). Systems and devices for performing such procedures endovascularly are disclosed. Fixation devices with improved access to a release harness are also disclosed.

The invention belongs to the technical field of medical instruments, and particularly relates to an artificial mitral valve suture-free automatic implantation device which comprises a catheter, one end of the catheter is fixedly connected with an opening and closing puncture mechanism, the inner wall of the catheter is fixedly connected with a pushing mechanism, a groove is formed in the outer surface of the catheter, and a filling solvent bag is installed in the groove; through the arranged opening and closing puncture mechanism, the opening and closing puncture head enters the human body with the minimum incision and then is expanded after entering the human body, the initial puncture point is extremely small, direct injury to tissues such as blood vessels and cardiac muscle can be reduced, the path of the automatically expanded needle head is more regular, important blood vessels, nerves or cardiac muscle tissues can be avoided, the accidental injury risk is reduced, and the working efficiency is improved. According to traditional implantation, a puncture channel possibly needs to be expanded in advance, an open-close type needle head is automatically expanded after entering, an additional expansion step is not needed, traction and extrusion on surrounding tissue are reduced, and the possibility of hematoma and infection after an operation is reduced.

This invention discloses a method for predicting sudden cardiac death based on forensic autopsy data using machine learning and its forensic applications, belonging to the fields of machine learning, statistics, and forensic identification. This invention provides a method for screening independent predictors of forensic diagnosis of sudden cardiac death using LASSO regression and logistic regression. Using 10-fold cross-validation, the method selects the minimum lambda(λ) to identify 14 risk factors. Logistic regression ultimately identifies 9 independent predictors, including age, heart weight, left ventricular wall thickness, right ventricular wall thickness, interventricular septum thickness, aortic valve circumference, mitral valve circumference, liver weight, and left kidney weight. A nomogram and a web-based calculator are constructed for predicting sudden cardiac death in forensic practice, thereby determining sudden cardiac death using objective indicators. This method has not been reported worldwide.

A method of delivering a transcutaneous dual valve replacement (TDVR) device to a patient includes the steps of advancing a guide catheter into the heart of the patient, advancing a support wire through the guide catheter and across the mitral valve of the heart of the patient, removing the guide catheter, advancing a delivery sheath over the support wire and across both the aortic valve and the mitral valve of the heart of the patient, advancing the TDVR device over the support wire and through the delivery sheath, removing the delivery sheath, expanding a first segment of the TDVR device in the mitral valve and a second segment of the TDVR device in the aortic valve, and removing the support wire.

The invention discloses a first-aid device for relieving SAM symptoms, which comprises a guide puncture sheathing canal, a first-aid device is arranged in the guide puncture sheathing canal, the first-aid device comprises a hollow sheathing canal of which the top end is an inclined plane, a channel is formed in the wall of the hollow sheathing canal, a jacking component is mounted in the hollow sheathing canal, and a propelling component is arranged at the bottom end of the hollow sheathing canal. The bottom end of the jacking assembly is connected with the top end of the pushing assembly, a main supporting strip and an auxiliary supporting strip of the jacking assembly can open and close the elastic umbrella cover, the pushing assembly is used for pushing the jacking assembly forwards to enable the jacking assembly to stretch out of the top end of the hollow sheathing canal to open the elastic umbrella cover, an anti-falling plate is further arranged at the bottom end of the hollow sheathing canal, and the pushing assembly is inserted into the anti-falling plate. The device is reasonable in structure and easy and convenient to operate, is applied to the first-aid operation of the SAM symptom patient, and can be used for rapidly jacking up the mitral valve anterior lobe to be separated from the ventricular septum, widening the left ventricular outflow tract and win time for the subsequent treatment of the patient.

A transapical removal device that can be deployed in a catheter procedure to capture for removal or alteration a mitral valve clip or heart tissue, such as the anterior leaflet of the mitral valve, and methods of use are disclosed. The removal device includes a delivery catheter configured to be deployed near a mitral valve using a guide catheter. The delivery catheter has a snare head at the distal end, which assumes a collapsed state during movement of the delivery catheter through the guide catheter and deployed state for capturing a mitral valve clip or anterior leaflet. The snare head has one or more ablation delivery catheters configured to ablate tissue surrounding the pre-positioned mitral valve clip or anterior leaflet. In some arrangements within the scope of the present disclosure, the removal device includes a deployment mechanism for deploying a new transcatheter valve into the mitral valve.

A replacement heart valve prosthesis can be delivered to or within an existing prosthesis through a valve-in-valve delivery procedure. The existing prosthesis can be a prosthetic heart valve or other device that is implanted at a target site, such as an aortic or mitral valve of the heart. The methods provided herein can allow a surgeon to position a replacement prosthesis within or adjacent to an existing prosthesis and permit the replacement prosthesis to expand into engagement against the existing prosthesis. Thereafter, the surgeon can adjust components of the replacement prosthesis, including the position of separate anchor and frame components in order to ensure accurate and secure placement of the replacement prosthesis at the target site.

A mitral valve prosthesis is percutaneously and / or transapically deployed in at least two stages. In a first stage, a mitral annular ring platform adapted for percutaneous delivery is delivered to and anchored in the mitral valve annulus. In the second stage, a valved-stent mitral valve prosthetic device adapted for percutaneously delivery is delivered to the mitral valve annulus for mounting in the mitral annular ring platform. This approach provides a consistent platform for accepting valved-stent mitral valve prosthetic devices from different vendors to be used.

A prosthetic heart valve includes an outer frame, a cover, an inner frame, and a valve structure. The outer frame includes a main body and an atrial flange. The main body includes a plurality of struts forming a plurality of circumferential rows of cells, a plurality of rows of barbs extending from junctions of the struts, the atrial flange extending radially outwardly and in an atrial direction from the inflow end of the main body. The atrial flange includes an oval shape corresponding to a shape of the patient's native mitral valve anatomy. The cover is disposed on a radially inner side of the atrial flange and on a radially outer side of the atrial flange. The inner frame is disposed within the outer frame and has a cylindrical shape. The valve structure is coupled to the inner frame and includes a plurality of leaflets.

A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

The invention provides a mitral valve clip operation simulator which comprises a bottom plate, and a first side of the bottom plate is provided with a first storage groove and a second storage groove; the first module is provided with an atrial septum simulation part and a mitral valve simulation part, and the first module is arranged on the bottom plate in the mode that the first module can be switched between an unfolded state and a folded state; the second module is provided with a lower cavity tube used for simulating the inferior vena cava, and the second module is arranged on the bottom plate in a mode of being capable of being switched between an unfolded state and a folded state; when the first module is in an unfolded state, the atrial septum simulation part and the mitral valve simulation part protrude out of the bottom plate, and the positions of the atrial septum simulation part and the mitral valve simulation part form an analogue simulation position; when the second module is in an unfolded state, the lower cavity tube protrudes out of the bottom plate to form a surgical instrument access path; when the first module is in the folded state, the first module is integrally contained in the first containing groove, and when the second module is in the folded state, the second module is integrally contained in the second containing groove.

Disclosed in the present invention is a capturable and fixable mitral valve repair device. The present invention relates to the technical field of mitral valve repair devices. The capturable and fixable mitral valve repair device comprises an exposure structure. The exposure structure comprises a traction line, the traction line is fixedly connected to a traction ring by means of a lock-and-key structure, a coaxial rotating ring is arranged on one side of the traction ring, and an adjustable blade is arranged outside the rotating ring. Said device further comprises a capture structure. The capture structure penetrates through the exposure structure during the expansion and exposure of the exposure structure, and the capture structure is unfolded from a folded state to a capture state. Said device further comprises a traction rod. The exposure structure and the capture structure are both located on the traction rod. According to the present invention, by means of integrating the exposure structure and the capture structure into a whole by the traction rod, after completing the exposure in mitral valve repair surgery, the mitral valve can be rapidly captured according to an exposure result and pre-estimation. A capture position and a capture space can be adjusted by a doctor according to actual conditions, thereby reducing the duration and operation risks of the repair surgery.

Embodiments of prosthetic valves for implantation within a native mitral valve are provided. A preferred embodiment of a prosthetic valve includes a radially compressible main body and a one-way valve portion. The prosthetic valve further comprises at least one ventricular anchor coupled to the main body and disposed outside of the main body. A space is provided between an outer surface of the main body and the ventricular anchor for receiving a native mitral valve leaflet. The prosthetic valve preferably includes an atrial sealing member adapted for placement above the annulus of the mitral valve. Methods and devices for delivering and implanting the prosthetic valve are also described.

The invention discloses a stent system for preventing obstruction of a left ventricular outflow tract and an implantation method, and the stent system comprises a stent assembly which is provided with a main body stent, an anchoring part and a control part, and the main body stent is a hollow cylindrical stent formed by a plurality of rhombic grids; one side of the lower end of the main body support is connected with an anchoring part which is of a strip-shaped structure and is tightly attached to the outer wall of one side of the main body support in a natural form, one end of the anchoring part is movably connected with the main body support, and the other free end is connected with the control part to swing under the action of the control part to get away from or get close to the main body support; the conveying assembly is detachably connected with the main body stent and used for conveying the whole stent assembly to a designated position in a human body to achieve implantation, at least three connecting pieces are arranged at the upper end of the main body stent, and the conveying assembly is detachably connected with the connecting pieces at the central point over the main body stent. The stent is implanted in the left ventricular outflow tract in advance to open the mitral valve anterior lobe of the left ventricular outflow tract, and then transcatheter mitral valve replacement is carried out, so that obstruction of the left ventricular outflow tract is avoided.

Systems and methods of atrioventricular valve replacement are provided. In various embodiments, an arch-like support structure is provided that is insertable and implantable into a heart and is positioned in the mitral annulus to replace a native mitral valve. The support structure is operable to support, and various systems comprise leaflet and chord structures operable to control and regular blood flow between chambers of the heart.

Mitral regurgitation can be reduced by creating one passageway between the right atrium and left ventricle in a portion of the tricuspid annulus just above the ventricular septum and another passageway through the outer wall of the left ventricle near at least one of the left ventricular papillary muscles. A support rod is positioned in the right atrium in contact with the septal portion of the tricuspid annulus, and a support plate is positioned adjacent to the second passageway and against the outer wall of the left ventricle. The support plate is pulled toward the support rod using a tether that extends between the first support plate and the support rod, passes through both passageways, and is under tension. The tension in the tether moves the root of the tendon closer to the mitral valve, which reduces mitral regurgitation.

The invention relates to the technical field of image processing, and discloses an evaluation index detection method and device for evaluating the stenosis degree of a mitral valve orifice, and the method comprises the steps: obtaining a first target echocardiography image which is an image of the horizontal section of a para-sternum minor-axis mitral valve; inputting the first target echocardiography image into a target detection model, and determining a first region of interest where a mitral valve opening is located in the first target echocardiography image and first target information corresponding to the first region of interest, the first target information comprises a center point coordinate of the detection frame and size information of the detection frame; according to the first target information, segmenting the first region of interest by using a mitral valve orifice segmentation model to obtain a mask image of the mitral valve orifice; and according to the number of pixels contained in the mask image of the mitral valve orifice, determining the area of a mitral valve orifice region in a first region of interest where the mitral valve orifice is located.

The invention discloses an interventional valve ring device and an interventional valve device. The interventional valve ring device and the interventional valve device can be used for mitral valve and tricuspid valve lesions. The interventional valve ring device is mainly composed of a valve ring, a valve ring conveying system, a fixing nail and a fixing nail conveying system. The interventional valve is mainly composed of a fixing support, a supporting support, a supporting support covering film and valve leaflets. The interventional valve ring and the interventional valve enter the heart through the interventional delivery system and can pass through the apex of the heart, the femoral vein, the jugular vein or the subclavian vein, the right atrium or the left atrium. The interventional valve is fixed in the interventional valve ring, and a minimally invasive, safe and effective treatment method can be provided for a patient.

Methods, devices and systems for anchoring and / or sealing a heart valve prosthesis and, in particular, a mitral valve prosthesis (202). Inflatable elements (204, 206) are used to seal and anchor the mitral valve prosthesis (202) and / or other elements associated with repairing a native mitral valve.

An implantable prosthetic device includes a connecting portion, flaps, and connectors. The flaps are movable from a closed position to an open position. The connectors are also movable from a closed position to an open position. The implantable prosthetic device can be used to repair a natural valve, such as a natural mitral valve.

Guide wire apparatuses and methods. Guide wires may be utilized for guiding a delivery apparatus, for example a transcatheter mitral valve delivery apparatus to replace a native mitral valve. A guide wire may include a distal portion. The distal portion may define a central axis and comprise a distal tip. The distal portion may have an undeployed configuration in which the distal tip is contracted medially and centered on the central axis. The distal portion may have a deployed configuration in which the distal tip is expanded radially from the central axis such that, in multiple radial dimensions, the tip is thicker than a size of an opening between adjacent chordae tendineae of the mitral valve. The delivery apparatus may be configured to be passed along the wire to the mitral valve while the distal tip, in the deployed configuration, contacts the adjacent chordae tendineae without passing through the opening.

The invention relates to a mitral valve outer valve frame, a mitral valve frame assembly and a heart valve prosthesis. The invention relates to a ventricular atrial cavity which has a radial contraction state and a radial expansion state and comprises an atrial part, a ventricular part and a connecting frame, the atrial part and the ventricular part are connected through the connecting part, and the atrial part and the ventricular part are of a latticed structure and comprise frame units; the ventricular part comprises at least three protruding parts which are distributed at intervals in the circumferential direction, an avoiding space is formed between every two adjacent protruding parts, the area of the avoiding space is gradually increased in the direction from the inflow end to the outflow end, and due to the fact that an avoiding area formed between every two adjacent supporting pieces has small influence on the ventricular autologous structure, the ventricular autologous structure can be effectively improved. The avoiding area is aligned with the left ventricular outflow tract during anchoring, so that the problem that the left ventricular outflow tract is blocked due to deformation after the mitral valve outer valve frame is implanted is solved.

The invention provides a mitral valve clamp device for preventing a control rod from being broken. The mitral valve clamp device comprises a handle shell; the flexible sheath tube extends from the handle shell to the far end; a control rod extending through the flexible sheath tube, the distal end of the control rod being detachably connected to the valve clip; and a control mechanism connected to the handle housing. Wherein the control mechanism comprises a movable element, a fixed element and a limiting pin, the fixed element comprises a stepped interface, and the limiting pin is provided with a circumferential boss. When the valve clamp clamps the mitral valve leaflet, traction force generated on the valve clamp can be transmitted to the fixing element through the control rod so as to pull the fixing element to axially move towards the far end relative to the limiting pin and the moving element until the circumferential boss abuts against the step interface to lock the limiting pin. Therefore, the limiting pin is prevented from being pulled out in advance before the traction force is released, the huge risk that the control rod is broken due to torsion is finally avoided, the success rate of an operation is increased, and huge damage to the valve leaflet is further avoided.

The application provides a method for fixing an interventional valve on a mitral valve, which comprises the following steps: driving a plurality of fixing nails into the left atrial side wall above the mitral valve; and connecting a fixing disc on the atrial septum through a connecting line to form a plurality of fixing lines above the mitral valve. The fixing method can form a plurality of fixing lines above the mitral valve, and the fixing lines can provide stable fixing support for the interventional valve implanted below, thereby effectively solving the problem that the current interventional mitral valve is difficult to be stably anchored, and the method for fixing the interventional valve on the mitral valve is simple and convenient to operate.