497 results about "Mitral valve flow" patented technology

The invention relates to an image detection method and device for a mitral valve, computer equipment, a computer readable storage medium and a computer program product. The method comprises the following steps: acquiring multiple frames of images including a heart, and performing multi-scale feature extraction on the multiple frames of images to obtain multi-scale image features of each frame of image; for each frame of image, determining a mitral valve area of the heart in each frame of image according to the multi-scale image features of the image; determining the area of a mitral valve opening in each frame of image based on the mitral valve area of the heart in each frame of image; and generating a detection result of the mitral valve membrane of the heart according to the area of the mitral valve opening in each frame of image. By adopting the method, the problems that a traditional manual measurement method is time-consuming and is easily influenced by subjective factors and the like can be solved, the efficiency and accuracy of mitral valve evaluation are also remarkably improved, professional requirements on operators are reduced, and the flexibility and practicability of clinical application are enhanced.

The invention relates in some aspects to a device for use in anchoring an implant, including anchors, sutures, implants, clips, tools, lassos, and methods of anchoring among other methods. Anchors as disclosed herein could be utilized to secure a coaptation assistance device, an annuloplasty ring, an artificial valve, cardiac patch, sensor, pacemaker, or other implants. The implant could be a mitral valve ring or artificial mitral valve in some embodiments.

The present disclosure provides systems and methods for a replacement mitral valve. The replacement valve may be made of a less rigid material thereby allowing the packed diameter of the replacement valve to be decreased. The less rigid replacement mitral valve may include a ventricular portion and a central portion. The ventricular portion may include a guide channel. A wire may be advanced into the guide channel. The wire in the guide channel may increase the stiffness on the ventricular side of the replacement valve. The increased stiffness may prevent the replacement valve from collapsing through a native valve annulus.

The invention relates to an anchor hook and methods of using the same for subannular anchoring of a transcatheter heart valve replacement, and in particular for an orthogonally delivered (side-delivered) transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the mitral or tricuspid valve from the inferior vena cava or superior vena cava, or trans-septally to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring a delivery catheter to bend 90 degrees during deployment.

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.

Procedures may be performed on the heart after the installation of a mitral valve fixation device. In order to prepare the heart for such procedures, the fixation device may be removed or disabled in minimally invasive ways (e.g., through an endovascular procedure), without requiring open access to the heart. The fixation device may be partitioned so that one portion may remain attached to each leaflet of the mitral valve. In another example, the leaflets may be cut along the edges of the distal element(s) of the fixation device, so as to cut the fixation device from the leaflet(s). Systems and devices for performing such procedures endovascularly are disclosed. Fixation devices with improved access to a release harness are also disclosed.

A split type precisely-anchorable transcatheter mitral valve system comprises a split transcatheter mitral valve anchoring stent (10) and a transcatheter artificial biological mitral valve (20), wherein the shape and structure of the transcatheter mitral valve anchoring stent (10) are matched with the mitral valve real structure after the patient image data is subjected to three-dimensional reconstruction, the transcatheter mitral valve anchoring stent (10) is firstly delivered to the mitral valve position of the patient to be released and deformed, and the transcatheter artificial biological mitral valve (20) is in personalized precise alignment and coaptation with tissues on the mitral valve position of the patient and under the petals; the transcatheter artificial biological mitral valve (20) is delivered into the transcatheter mitral valve anchoring stent (10) to be released, the transcatheter artificial biological mitral valve (20) is released and deformed and expanded to a functional state, the transcatheter mitral valve anchoring stent (10) is again deformed and combined with the expanded transcatheter artificial biological mitral valve (20), and meanwhile, the re-deformation of the transcatheter mitral valve anchoring stent (10) enables the mitral valve anchoring stent (10) to be anchored with the lower leaflet tissue in a preset combination. The split type accurately anchored transcatheter mitral valve system can realize accurate anchoring of transcatheter mitral valve personalized based on a system designed by three-dimensional reconstruction.

The invention discloses a lantern-shaped variable-diameter transcatheter artificial mitral valve stent, and belongs to the technical field of medical instruments. Comprising a lantern-shaped outer stent body and an outer stent covering film, the outer stent covering film is arranged close to an aorta side semi-open window, and the outer stent covering film is arranged close to the aorta side semi-open window. The grid lantern-shaped support body comprises an atrial side umbrella disc, a ventricular side variable diameter structure and a negative pressure suction cup which is connected with the atrial side umbrella disc and the ventricular side variable diameter structure and used for strengthening anchoring. The valve inner frame comprises a grid barrel-shaped inner frame body and an inner frame covering film, and the inner side of the inner frame body is connected with an artificial valve leaflet. By means of the lantern-shaped design of the outer stent and the valve ring suction cup for assisting anchoring, the problem that an artificial mitral valve replaced through a catheter is difficult to anchor is solved, and the problem that a left ventricular outflow tract is prone to being blocked after a covered stent is implanted is solved through the design that the single side of the dynamically-changeable valve outer stent is not covered with a film.

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.

The invention discloses a steady-state leakage and forward flow testing device for a heart valve, and relates to the technical field of medical instrument inspection. The device comprises a reservoir, a pipeline, and a driving device, a regulating valve, a front-end flow meter, a front-end valve mounting channel and a rear-end valve mounting channel which are sequentially mounted on the pipeline, and the two ends of the pipeline are communicated with the reservoir. The heating and temperature control system ensures that the liquid temperature meets the requirement of a new edition standard, the valve installation channel with the inner diameter of 70 mm is suitable for a large-size mitral valve, and differential pressure sensor interfaces are arranged in front of and behind the valve ring of the artificial heart valve, so that the requirement of the new standard for the position of a sensor is met; according to the device, flexible selection of pressure values under different blood pressure states is achieved by adjusting the rotating speed of a driving device (a magnetic pump), accurate measurement and automation of the leakage amount are achieved through a high-precision flow meter, and the whole design aims at improving the accuracy and repeatability of testing and ensuring the quality and safety of an artificial heart valve.

A valve fixation device may comprise a unitary elongate member that is biased towards a closed configuration wherein at least a pair of tissue engaging surfaces of the elongate member are held adjacent to each other by a bias force. The bias force is at least equal to a valve leaflet grasping force, enabling the fixation device to grasp and retain leaflets as part of cardiac treatment. A delivery tool including a spreader may independently translate the tissue engaging surfaces to enable cardiac leaflets to be captured and retained by and / or between the tissue engaging surfaces. The valve fixation device may include at least two arms, each of which may be independently controlled to grasp and capture opposing leaflets of a valve, such as the anterior and posterior leaflets of a mitral valve, to reduce the size of the valve opening and improve cardiac performance.

The invention relates to a real-time wear test device for a cardiovascular implant mitral valve / tricuspid valve, which comprises a plurality of test mechanisms, and each test mechanism comprises a first compliance adjusting module, a second compliance adjusting module, a liquid flowing pipeline and a driving module, a valve carrier module and a return pipe are connected between the second compliance adjusting module and the first compliance adjusting module; one end of the liquid flowing pipeline is communicated with the first compliance adjusting module, and the other end is connected with the driving module; test liquid sequentially flows through the liquid flowing pipeline, the first compliance adjusting module, the backflow pipe, the second compliance adjusting module and the valve carrier module and flows back into the first compliance adjusting module and the liquid flowing pipeline so as to perform circulating reciprocating motion. According to the invention, a test environment highly similar to human physiological conditions can be simulated, so that the credibility and the accuracy of test results of the mitral valve and the tricuspid valve are ensured, and a real and reliable basis is provided for evaluating the service life of the mitral valve and the tricuspid valve.

A system to treat heart failure with preserved ejection fraction (HFpEF) is described. The system comprises a blood pumping device (120) configured for implantation in a left ventricle (31) of a heart of a subject, in which the blood pumping device is configured to draw blood from a left atrium (30) into the left ventricle (31) of the heart through a mitral valve (34) upon activation, an anchoring assembly (122) for anchoring the blood pumping device to the heart, and a connector (125) rigidly connecting the anchoring assembly (122) to the blood pumping device (120) in a spaced-apart relationship to allow the blood pumping device to be positioned in the left ventricle and the anchoring assembly to be anchored at an anatomical location in or adjacent to the heart and distant to the left ventricle, wherein the system is configured for percutaneous delivery to the heart.

A prosthetic aortic valve that uses actuating arms and grippers to attach to leaflets, reducing device migration and sizing issues. It involves excising diseased leaflets prior to implantation, ensuring blood flow to coronary arteries, and offers optical visualization. The valve features replaceable leaflets and a streamlined frame. Innovative left atrial appendage devices, embolic protection devices, intra-cardiac echocardiography devices, and steerable catheter devices are introduced. Provided herein are atraumatic, cinchable mitral valve annular repair devices, noninvasive methods that modify body calcium with electromagnetic energy, and systems for optical visualization in vascular interventions by displacing blood with clear fluid.

An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are moveable from a closed position to an open position. The clasps are also moveable from an open position to a closed position. The clasps include a fixed arm and a plurality of movable arms. The implantable prosthetic device can be used to repair a native valve, such as a native mitral valve.

A method, for use at a mitral valve of a heart of a subject, is provided which includes advancing a transluminal sheath into a femoral vein of the subject, through an inferior vena cava of the subject, into a right atrium of the subject, and transseptally into a left atrium of the subject. A surrounding-sheath is advanced out of a distal end of the transluminal sheath, into the left atrium, and toward a commissure of the mitral valve. An anchor is implanted by advancing the anchor out of the surrounding-sheath into a left ventricle of the subject, such that the anchor helically wraps around left ventricular mitral valve tissue. The surrounding-sheath is then extracted from the heart and then, a guide wire is advanced through the transluminal sheath. Other embodiments are also described.

In various embodiments, provided herein are methods, devices and systems for transcatheter mitral valve replacement in a double-orifice mitral valve. These methods, devices and systems are used to treat patients with mitral valve disease, particularly those who have had failed edge-to-edge leaflet repair, or patients presently considered anatomically unsuitable for edge-to-edge leaflet repair alone.

The invention relates to the technical field of medical imaging, and provides an automatic measurement method, system and equipment for the cardiac muscle full segment thickness of an echocardiogram, and the method comprises the steps: determining a sector rectangular frame in an ultrasonic video stream through employing a deep learning target detection model, so as to determine a cutting region; cutting the ultrasonic video stream based on the cutting area, and scaling the cut ultrasonic cardiac image to a target size in an equal proportion; performing feature extraction on the echocardiography image through a feature extraction module and generating a feature map; cardiac muscle segmentation is completed through the cardiac muscle segmentation module, and mitral valve endpoint recognition is completed through the mitral valve endpoint recognition module; based on the data obtained by the myocardial segmentation module and the mitral valve endpoint identification module, a post-processing module is adopted to calculate and visually output a myocardial full segment thickness result at the end of diastole or end of systole; the cardiac muscle full segment thickness can be effectively measured, the accuracy and repeatability of cardiac function parameter measurement can be improved, and the medical examination process is optimized.

Disclosed are devices, systems, and methods for in vivo monitoring of biological fluid flow within anatomical structures, such as blood flow through heart valves (e.g., mitral, tricuspid, and / or aortic valves) or heart chambers. The disclosed devices, systems, and methods can continuously measure and evaluate blood flow back and forth at the inlet of a heart valve to determine cardiac function or dysfunction and / or to compile with other monitored data that can be used to measure or predict secondary factors.

The invention relates to a heart valve regurgitation drum and optional closure disk and / or tubular stent to manage and provide levels of intentional regurgitation within an orthogonally delivered transcatheter prosthetic heart valve having a first inner flow control component / valve, a second inner regurgitation control component, and an outer annular support frame having compressible wire cells that facilitate folding flat along the z-axis and compressing the valve vertically along the y-axis, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the tricuspid valve from the inferior vena cava or superior vena cava, or trans-atrially to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring delivery and deployment from a catheter at an acute angle of approach.

A compressible and expandable stent assembly for implantation in a body lumen such as a mitral valve, the stent assembly including at least one stent barrel that is shaped and sized so that it allows for normal operation of adjacent heart structures. One or more stent barrels can be included in the stent assembly, where one or more of the stent barrels can include a cylinder with a tapered edge.

The invention provides a mitral valve replacement system in the technical field of medical instruments, and the mitral valve replacement system comprises a valve stent, a fixing ring and a shearing part, the fixing ring is arranged around the end face of the valve stent, and the shearing part is oppositely arranged on one side of the valve stent. The fixing ring surrounds the groove in the end face of the valve support to limit the moving direction of the valve support, so that the valve support is stably located at the native mitral valve ring, and the butterfly buckle is arranged on the valve support to buckle and clamp the native mitral valve leaflet. The fixing ring is tied and hooped at the groove in the end face of the valve support of the artificial heart valve, so that the artificial heart valve is stably positioned at the original mitral valve annulus, displacement of the artificial heart valve caused by external force factors such as blood flow impact force is prevented, and then the perivalvular leakage problem caused by displacement is avoided; the native mitral valve anterior leaflet is cut open through the cutting part, and then the cut native mitral valve anterior leaflet is buckled and clamped through the butterfly buckle, so that blood flowing through the native mitral valve anterior leaflet smoothly circulates, and the problem that the left ventricular outflow tract is obstructed is solved.

Disclosed are methods of transseptal crossing to permit introduction of large bore catheters into to the left atrium, such as to deploy left atrial appendage closure devices or to repair or replace a mitral valve. The method may include the steps of providing a single pass, large bore transseptal crossing system, having a tubular access cannula and an energy delivery wire movably extending through the tubular access cannula. A first electrode tip on the energy delivery wire is brought into contact with a fossa ovalis and energized. The energy delivery wire and cannula are advanced into the left atrium. A large bore sheath is advanced directly over the access cannula and into the left atrium. The cannula and energy delivery wire are removed, and a large bore index procedure catheter may be advanced through the large bore sheath and into the left atrium.

A mitral valve postoperative water test pipe comprises a water injection hose, a water inlet end threaded connector is fixed at one end of the water injection hose, a water outlet end piece is fixed at the other end of the water injection hose, an inner cavity is formed in the pipe wall of the water injection hose, a flexible metal piece is fixed in the inner cavity, and the axis of the flexible metal piece is parallel to the axis of the water injection hose. Compared with the prior art, the device has the technical effects that the device is provided with the metal piece, bending is not affected, the proper angle can be adjusted, meanwhile, the device can be shaped after being bent, the shape can be stably kept after being bent, and accurate detection of the state of the heart valve is facilitated.

Methods and devices for transvascular prosthetic chordae tendinea implantation are disclosed. A catheter is advanced into the left atrium, through the mitral valve, and into the left ventricle. A ventricular anchor is deployed from the catheter and into a wall of the left ventricle, leaving a ventricular suture attached to the ventricular anchor and extending proximally through the catheter. A leaflet anchor is deployed to secure a mitral valve leaflet to a leaflet suture, with the leaflet suture extending proximally through the catheter. The leaflet suture is secured to the ventricular suture to limit a range of travel of the leaflet in the direction of the left atrium. Also disclosed is an assembled in situ mitral valve leaflet restraint, having a neo papillary muscle and a neo chordae tendinea.

The invention provides a mitral valve leaflet length automatic measurement method based on 3D-to-2D morphological transformation. The method comprises the following steps: firstly, acquiring three-dimensional medical image data of the heart of a patient, and extracting six partitions of a mitral valve and related heart structures; an orthogonal plane is calculated by fitting a mitral valve structure point set, and a cKDTree algorithm is used to determine a connected area of each partition, and a corresponding projection plane is established. And then extracting the contour of the projection point set through an Alpha shape algorithm, correcting the contour into a linear three-dimensional point set, and finally calculating the length of the valve leaflet of each partition. According to the method, the accuracy, consistency and efficiency of measurement are improved through an automation technology, personal errors are reduced, the method is suitable for various three-dimensional medical image data, and a more reliable basis is provided for clinical diagnosis and treatment of mitral valve diseases.

The invention relates to an anchor hook and methods of using the same for subannular anchoring of a transcatheter heart valve replacement, and in particular for an orthogonally delivered (side-delivered) transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the mitral or tricuspid valve from the inferior vena cava or superior vena cava, or trans-septally to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring a delivery catheter to bend 90 degrees during deployment.

A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.

The invention discloses a valve stent, an aortic valve and a mitral valve, and the valve stent comprises a valve stent which is of a latticed annular stent structure formed by cutting a metal tube; the outer frame is of a latticed or semi-latticed annular support structure formed by cutting a metal pipe, the outer frame wraps the outer side of the valve frame and is connected with the valve frame, and a first positioning unit is integrally formed on the outer frame; the first positioning unit comprises a plurality of supporting legs arranged in the circumferential direction of the outer frame, and the supporting legs are obtained by outwards bending and forming two adjacent edges in the grids or half grids of the outer frame in the circumferential direction, so that when the outer frame is implanted into the implantation position of the inner side of the autologous valve leaflet, the first positioning unit can be supported on the inner side of the autologous valve ring; the valve support is limited to move in the direction opposite to the heart blood flow direction. When the valve support is anchored through the outer support, the valve support provided with the outer support can still have the small radial size, and the implanting difficulty of the valve and the requirement for a conveying system are lowered.

Systems and methods of valve quantification are disclosed. In one embodiment, a method of mitral valve quantification is provided. The method includes generating a 3-D heart model, defining a 3-D mitral valve annulus, fitting a plane through the 3-D mitral valve annulus, measuring the distance between at least two papillary muscle heads, defining an average diameter of at least one cross section around the micro valve annulus, and determining a size of an implant to be implanted.