31 results about "Mitral valve leaflet" patented technology

The application discloses a heart valve device and relates to the technical field of artificial heart valves, which comprises an outer valve frame and a valve leaflet assembly connected to the inside of the outer valve frame, and the outer valve frame is a ring-shaped grid frame; the outer valve frame comprises an inflow side grid frame and an outflow side grid frame arranged in sequence from an inflow end to an outflow end, and the inflow side grid frame and the outflow side grid frame form an annular recess for clamping a native valve ring on the outer periphery of the outer valve frame; the outflow side grid frame comprises a plurality of groups of grid support units connected in sequence along the circumferential direction and enclosed into a ring, and the grid support unit comprises an outer convex grid support and an inner concave grid support, and the outer surface of the inner concave grid support is arranged in a concave manner relative to the outer surface of the outer convex grid support. In this way, the anterior leaflet of the original mitral valve can be attached to the inner concave grid support, the extrusion of the outer valve frame on the anterior leaflet is reduced, the anterior leaflet is prevented from being extruded to the left ventricular outflow tract by the outer valve frame, and the outflow area of the left ventricular outflow tract is prevented from being reduced to cause obstruction.

A mitral valve prosthesis to be implanted in a heart, comprises an asymmetrical ring, the asymmetrical ring is dimensioned to mimic a native mitral annulus of a patient; an anterior flexible leaflet and a posterior flexible leaflet, said leaflets suspended from the asymmetrical ring and configured to substantially coapt with each other; and at least four sets of cords, each set of cords attached to the anterior or posterior leaflet on a first end and attached into a cap on a second end, the cap is configured to be attached onto papillary muscles of the heart on another end of the cap.

Methods and devices for transvascular prosthetic chordae tendinea implantation are disclosed. A catheter is advanced into the left atrium. From an atrium side, a leaflet connector carried by a distal end of the catheter can be anchored to a superior surface of a mitral valve leaflet. A needle is axially advanceable through the leaflet connector and through the leaflet. A leaflet anchor having a leaflet suture can be advanced out of the needle to secure the mitral valve leaflet to the leaflet suture. A ventricular anchor is anchored to the wall of the ventricle to secure the ventricular wall to a ventricle suture. The leaflet suture and the ventricle suture may be tensioned and connected by a suture lock to form an artificial chordae.

This invention discloses a method for predicting sudden cardiac death based on forensic autopsy data using machine learning and its forensic applications, belonging to the fields of machine learning, statistics, and forensic identification. This invention provides a method for screening independent predictors of forensic diagnosis of sudden cardiac death using LASSO regression and logistic regression. Using 10-fold cross-validation, the method selects the minimum lambda(λ) to identify 14 risk factors. Logistic regression ultimately identifies 9 independent predictors, including age, heart weight, left ventricular wall thickness, right ventricular wall thickness, interventricular septum thickness, aortic valve circumference, mitral valve circumference, liver weight, and left kidney weight. A nomogram and a web-based calculator are constructed for predicting sudden cardiac death in forensic practice, thereby determining sudden cardiac death using objective indicators. This method has not been reported worldwide.

A method of delivering a transcutaneous dual valve replacement (TDVR) device to a patient includes the steps of advancing a guide catheter into the heart of the patient, advancing a support wire through the guide catheter and across the mitral valve of the heart of the patient, removing the guide catheter, advancing a delivery sheath over the support wire and across both the aortic valve and the mitral valve of the heart of the patient, advancing the TDVR device over the support wire and through the delivery sheath, removing the delivery sheath, expanding a first segment of the TDVR device in the mitral valve and a second segment of the TDVR device in the aortic valve, and removing the support wire.

A transapical removal device that can be deployed in a catheter procedure to capture for removal or alteration a mitral valve clip or heart tissue, such as the anterior leaflet of the mitral valve, and methods of use are disclosed. The removal device includes a delivery catheter configured to be deployed near a mitral valve using a guide catheter. The delivery catheter has a snare head at the distal end, which assumes a collapsed state during movement of the delivery catheter through the guide catheter and deployed state for capturing a mitral valve clip or anterior leaflet. The snare head has one or more ablation delivery catheters configured to ablate tissue surrounding the pre-positioned mitral valve clip or anterior leaflet. In some arrangements within the scope of the present disclosure, the removal device includes a deployment mechanism for deploying a new transcatheter valve into the mitral valve.

Embodiments of prosthetic valves for implantation within a native mitral valve are provided. A preferred embodiment of a prosthetic valve includes a radially compressible main body and a one-way valve portion. The prosthetic valve further comprises at least one ventricular anchor coupled to the main body and disposed outside of the main body. A space is provided between an outer surface of the main body and the ventricular anchor for receiving a native mitral valve leaflet. The prosthetic valve preferably includes an atrial sealing member adapted for placement above the annulus of the mitral valve. Methods and devices for delivering and implanting the prosthetic valve are also described.

Systems and methods of atrioventricular valve replacement are provided. In various embodiments, an arch-like support structure is provided that is insertable and implantable into a heart and is positioned in the mitral annulus to replace a native mitral valve. The support structure is operable to support, and various systems comprise leaflet and chord structures operable to control and regular blood flow between chambers of the heart.

Improved features of medical devices. Implants that may include self-expanding portions and portions that are expandable with an inflatable body. A portion expandable with an inflatable body may dock with a portion that is self-expanding. A portion expandable with an inflatable body may be coupled to a portion that is self-expanding. Delivery apparatuses for deployment of both a self-expanding portion and a portion expandable with an inflatable body may be disclosed.

A separate, precisely anchorable transcatheter bicuspid valve system includes a separate transcatheter bicuspid valve anchor stent (10) and a transcatheter bicuspid bioprosthetic valve (20), the anchor stent shape and structure of the transcatheter bicuspid valve anchor stent (10) matching the true structure of the bicuspid valve after three-dimensional reconstruction based on the patient's image data, the transcatheter bicuspid valve anchor stent (10) is first pre-assembled and pre-assembled for release, deformation, and individual alignment and coaptation with the supravalvular and subvalvular tissues of the patient's bicuspid valve into the bicuspid valve position of the patient. The transcatheter bicuspid valve anchor stent 10 is then delivered to the valve base 10 for delivery to the valve base 10, and the transcatheter bicuspid valve prosthesis 20 is delivered into the transcatheter bicuspid valve anchor stent 10 and released, the transcatheter bicuspid valve prosthesis 20 is released and deformed to expand to a functional state, and the transcatheter bicuspid valve anchor stent 10 is again deformed to couple with the expanded transcatheter bicuspid valve 20, and at the same time, the transcatheter bicuspid valve anchor stent 10 is again deformed to complete the preset coupling between the transcatheter bicuspid valve anchor stent 10 and the valve base tissue for anchoring. The separate, precise anchoring transcatheter bicuspid valve system is designed based on three-dimensional reconstruction, and can realize individual precise anchoring of the transcatheter bicuspid valve.

This invention proposes a mitral valve capture mechanism for transcatheter interventional therapy, comprising: a capture unit, sleeved outside a control rod and located behind a clamping device, comprising: a base with an axially extending through-hole for the control rod to pass through, the front end of which is connected to a plurality of circumferentially distributed shape memory alloy units; a rigid unit, correspondingly arranged and connected to the shape memory alloy units, comprising an anterior rigid plate and a posterior rigid plate, wherein the anterior and posterior rigid plates do not contact each other, nor does the posterior rigid plate contact the base; a limiting ring, located in front of the shape memory alloy units and connected to the anterior rigid plate; a first cable control unit and a second cable control unit. This invention can effectively solve the problem of valve floating due to blood flow during mitral valve edge-to-edge repair, leading to clamping failure.

The utility model relates to a kind of mitral valve leaflet cutting device and system, the device includes: remote control, remote control is equipped with the guide groove of inclination extension along axial direction;Main body, the distal end of main body is fixed with remote control;Clamping arm, the distal end of clamping arm is equipped with limit boss, limit boss is slidably matched in guide groove, the proximal end of clamping arm is used to clamp and fix mitral valve leaflet;Moving part, moving part is slidably set on the outer periphery of main body, its distal end is pivotally connected with clamping arm, the axial movement of moving part is used to drive limit boss to move along guide groove, so that clamping arm can rotate around the pivot joint of it and main body, to realize opening and closing;Tool bit, tool bit is axially movably arranged in main body, tool bit can reciprocate along the axial direction of main body when clamping arm fixes mitral valve leaflet, to cut mitral valve leaflet.

The present invention relates to mitral valve repair and replacement devices and methods. An implant and method for repairing and / or replacing the function of a native mitral valve, in various embodiments, is configured to reduce or eliminate mitral regurgitation and residual mitral valve leakage. A coiled anchor with a central turn that reduces in size after implantation is used to approximate the native mitral annulus size and reshape the native mitral annulus to reduce valve leakage. A clip can be further applied to the native valve leaflets to reduce the size of the native mitral annulus and reduce leakage therethrough. An artificial heart valve can be implanted in the coiled anchor to replace and further improve the function of the valve. In some cases, an artificial valve can be implanted in the clipped valve, with the clip detached from one of the native valve leaflets to provide space for the artificial valve to expand.

A device for providing cardiac treatment at the left atrium of a patient's heart. The device includes a retention body and a prosthetic valve. The retention body has a shape that can be manipulated between a collapsed state and a normal or expanded state. First and second openings are defined at one side of the retention body, and a lower opening is defined at an opposite side. The prosthetic valve is carried by the retention body at the lower opening. The retention body is configured to engage a substantial portion of an interior surface of the left atrium, securing the prosthetic valve at a desired location relative to a native mitral valve (e.g., within the mitral valve or slightly spaced from the mitral valve). The first and second openings are sized and shaped so as to permit blood flow from the pulmonary veins into the interior region.

A mitral valve prosthesis is percutaneously and / or transapically deployed in at least two stages. In a first stage, a mitral annular ring platform adapted for percutaneous delivery is delivered to and anchored in the mitral valve annulus. In the second stage, a valved-stent mitral valve prosthetic device adapted for percutaneously delivery is delivered to the mitral valve annulus for mounting in the mitral annular ring platform. This approach provides a consistent platform for accepting valved-stent mitral valve prosthetic devices from different vendors to be used.

Embodiments of prosthetic valves for implantation within a native mitral valve are provided. A preferred embodiment of a prosthetic valve includes a radially compressible main body and a one-way valve portion. The prosthetic valve further comprises at least one ventricular anchor coupled to the main body and disposed outside of the main body. A space is provided between an outer surface of the main body and the ventricular anchor for receiving a native mitral valve leaflet. The prosthetic valve preferably includes an atrial sealing member adapted for placement above the annulus of the mitral valve. Methods and devices for delivering and implanting the prosthetic valve are also described.

A mitral valve clip includes a stud, a lock, and two arms. The stud includes a shank, and the lock includes a frame relative to which the stud is translatable and into which the shank extends. The lock is able to prevent movement of the stud relative to the lock in at least one direction by locking engagement of the shank. The two arms are connected to the lock and the stud such that an angle between the arms depends on a location of the stud relative to the lock. The locking engagement of the shank that prevents movement of the stud relative to the lock in the at least one direction is only possible when the angle between the arms is below a predefined locking threshold.

The application discloses a mitral valve clamping device, which is implanted through a heart apex, and comprises an upper clamping assembly and a lower clamping assembly. The upper clamping assembly comprises a flexible clamping sheet and a first supporting piece, and the first supporting piece is connected with a distal end of the flexible clamping sheet. The lower clamping assembly comprises a first clamping arm, a second clamping arm and a second supporting piece. One end of the first clamping arm and one end of the second clamping arm are rotatably connected to form a first connecting part, and the first connecting part is connected with the second supporting piece. The second supporting piece is connected with a proximal end of the flexible clamping sheet. The flexible clamping sheet can be in a straight state and a folded state. When the flexible clamping sheet is in the folded state, a first clamping surface and a second clamping surface can be formed. The first clamping surface cooperates with the first clamping arm, and the second clamping surface cooperates with the second clamping arm to jointly clamp the mitral valve. The application further provides a mitral valve clamping system comprising the above-mentioned mitral valve clamping device.

This disclosure relates to transcatheter delivery systems, cardiac therapeutic devices (e.g., implants), and related methods for deploying the cardiac therapeutic devices to the heart. For example, some embodiments described herein can provide improved transcatheter delivery in an efficient, repeatable, and effective manner for structural heart intervention devices at the tricuspid valve and the mitral valve.

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. An improved protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.

The application discloses a mitral valve orifice area detection method based on artificial intelligence, relates to the technical field of intelligent analysis of ultrasonic images, and comprises the following steps: collecting a mitral valve ultrasonic continuous frame sequence for standardized pretreatment, forming a sliding window frame sequence according to a fixed length and a step length, inputting the sliding window frame sequence into a phase embedding neural network to obtain a phase embedding vector sequence; calculating an interframe similarity based on the phase embedding vector sequence, determining a cardiac cycle boundary according to the interframe similarity and intercepting a complete cardiac cycle, calculating an open phase score in the complete cardiac cycle, selecting a most open phase frame of the valve orifice according to the open phase score, and intercepting a short time sequence segment with the most open phase frame of the valve orifice as the center. The application realizes consistent selection of the most open phase frame of the mitral valve orifice of different individuals and under different imaging quality conditions through automatic and stable positioning of a key phase of the cardiac cycle, thereby reducing artificial frame selection difference and repeated measurement fluctuation.

An AI-based automatic 3D image segmentation method for mitral valve structure includes the following steps: First, the original 3D dataset of the heart structure is acquired, labeled, and normalized and segmented. Then, the image data is denoised and enhanced to expand the training data and improve the model's robustness. Subsequently, a 3D encoder-decoder architecture is constructed, combining a multi-scale feature fusion module and a strategy of progressively increasing the kernel size to optimize image detail preservation and the recognition of subtle mitral valve structures. In model design, a composite scaling strategy is used to adjust the model's depth, width, and kernel size. A composite loss function is introduced during model training. Finally, a deep supervision mechanism is introduced at different decoding stages, and the model's performance on multiple datasets is evaluated using five-fold cross-validation. This invention achieves high-precision and high-efficiency automatic 3D image segmentation of the mitral valve structure, possessing significant clinical application value.

The application relates to a method and device for determining the thickness of the interventricular septum, a computer device and a storage medium. The method comprises the following steps: acquiring a heart scan image, performing image segmentation on the heart scan image by using an image segmentation model, and determining a segmentation mask of a target detection region in the heart scan image; converting the segmentation mask of the target detection region by using a moving cube algorithm, and determining target three-dimensional point cloud data corresponding to each segmentation mask; determining key point position information of a heart key point according to the target three-dimensional point cloud data and a key point detection model; determining the position information of a three-dimensional section of a left ventricular interventricular septum region according to the key point position information; the three-dimensional section comprises a mitral valve horizontal short-axis section, a left ventricular long-axis section and a four-chamber heart section; and determining the thickness of the interventricular septum of the left ventricular interventricular septum region according to the position information of the three-dimensional section. The above scheme improves the accuracy of the determined thickness of the interventricular septum.

The present disclosure relates to a surgical procedure training system. The system comprises a patient body part simulator (2), such as a replica of a heart (5) or a part thereof, such as a mitral valve (6,7). Further, an image acquisition system (3) directed at the patient body part simulator is provided. The system also comprises an image processing system (700) configured to convert images from the image acquisition system (3) into emulation images corresponding with a specific imaging technique, from a group comprising echoscopy and / or echocardiography, as deployed during an actual surgical procedure on the patient body part; and an image display (4) presenting to a training surgeon images from the image acquisition system (3) and converted by the image processing system (700) into the images corresponding with the specific imaging technique.

The application relates to the technical field of medical devices, and provides a medical suturing device, which comprises a delivery tube structure, the delivery tube structure is provided with a first through channel arranged along an axial direction of the delivery tube structure, and a first end of the delivery tube structure is provided with a receiving cavity; a fixing mechanism, the fixing mechanism comprises a fixing assembly, an anti-rotation piece and a fixing assembly control rod piece, the fixing assembly is rotatably arranged in the receiving cavity, the anti-rotation piece is rotatably arranged on the fixing assembly, the anti-rotation piece is used for fixing an artificial chordae tendinea, a rotation limiting structure for limiting the anti-rotation piece is arranged on a cavity wall of the receiving cavity, a first end of the fixing assembly control rod piece is connected with the fixing assembly, and when the fixing assembly control rod piece drives the fixing assembly to rotate around the axis of the delivery tube structure, the anti-rotation piece is limited by the rotation limiting structure and cannot rotate around the axis of the delivery tube structure; when the medical suturing device is applied to mitral valve posterior leaflet chordae tendinea implantation surgery, the artificial chordae tendinea can be prevented from being damaged, and the durability of the artificial chordae tendinea is ensured.

To provide improved devices and methods for treating mitral valve regurgitation. [Solution] The implantable artificial spacer device comprises an inflatable spacer having a plurality of inflatable members, and a frame, the frame may include one or more anchors and one or more clasps. The inflatable spacer may be configured to be positioned between the natural valve leaflets of the heart. The implantable artificial spacer may be positioned in a symmetrical or asymmetrical configuration. The inflatable spacer may be inflatable between a non-inflatable configuration and an inflatable configuration.

The present application relates to a multi-part replacement heart valve prosthesis. The replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an inner valve frame and an outer sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of a native mitral annulus. The sealing frame can be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors are coupled to the outlet end of the valve frame. The anchors extend radially outward to be disposed behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the outer sealing frame. The prosthesis is collapsible for delivery into the heart by a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart upon release from the delivery catheter.

A system and method for non-invasive identification of fiducials points of the events of the cardiac cycle, including but not limited to mitral valve closing (MC), aortic value opening (AO), aortic value closing (AC), mitral valve opening (MO), rapid systolic ejection (RE), rapid diastolic filling (RF), atrial systole (AS), isovolumic movement (IM), and isovolumic contraction (IC); additionally tricuspid valve closing (TC), pulmonic value opening (PO), tricuspid value closing (TC), pulmonic valve opening (MO). The system includes a device with multiple accelerometers, physiological electrical sensor, microcontroller for measuring and converting analog to digital signals and time deterministic synchronous sensor capture. The method includes seismocardiograph waveform fiducial detectors for peaks and troughs, phase detectors for mechanical and electrical signals, a heartbeat onset detector and one or more microprocessors to perform signal processing operations. Serving as a powerful, non-invasive system or method for quantifying myocardial performance.

The present application discloses an annuloplasty device comprising a detachable and elastic elongated displacement unit for insertion into a coronary sinus (CS) adjacent to a mitral valve, a proximal reversibly deployable portion reversibly deployable to a deployed state for positioning against a tissue wall at an entrance of the CS, a distal anchoring portion movable relative to the proximal deployable portion in a longitudinal direction of the displacement unit to an activated state in which a shape of the annulus is modified to a modified shape, a stent arranged around the displacement unit and movable relative to the displacement unit in the longitudinal direction for insertion into the CS, and wherein the stent is releasably connected to the delivery device and radially arranged between the displacement unit and the proximal deployable portion in a radial direction.