275 results about "Mitral valve leaflet" patented technology

The invention relates in some aspects to a device for use in anchoring an implant, including anchors, sutures, implants, clips, tools, lassos, and methods of anchoring among other methods. Anchors as disclosed herein could be utilized to secure a coaptation assistance device, an annuloplasty ring, an artificial valve, cardiac patch, sensor, pacemaker, or other implants. The implant could be a mitral valve ring or artificial mitral valve in some embodiments.

The invention relates to an anchor hook and methods of using the same for subannular anchoring of a transcatheter heart valve replacement, and in particular for an orthogonally delivered (side-delivered) transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the mitral or tricuspid valve from the inferior vena cava or superior vena cava, or trans-septally to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring a delivery catheter to bend 90 degrees during deployment.

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.

The invention relates to a real-time wear test device for a cardiovascular implant mitral valve / tricuspid valve, which comprises a plurality of test mechanisms, and each test mechanism comprises a first compliance adjusting module, a second compliance adjusting module, a liquid flowing pipeline and a driving module, a valve carrier module and a return pipe are connected between the second compliance adjusting module and the first compliance adjusting module; one end of the liquid flowing pipeline is communicated with the first compliance adjusting module, and the other end is connected with the driving module; test liquid sequentially flows through the liquid flowing pipeline, the first compliance adjusting module, the backflow pipe, the second compliance adjusting module and the valve carrier module and flows back into the first compliance adjusting module and the liquid flowing pipeline so as to perform circulating reciprocating motion. According to the invention, a test environment highly similar to human physiological conditions can be simulated, so that the credibility and the accuracy of test results of the mitral valve and the tricuspid valve are ensured, and a real and reliable basis is provided for evaluating the service life of the mitral valve and the tricuspid valve.

In various embodiments, provided herein are methods, devices and systems for transcatheter mitral valve replacement in a double-orifice mitral valve. These methods, devices and systems are used to treat patients with mitral valve disease, particularly those who have had failed edge-to-edge leaflet repair, or patients presently considered anatomically unsuitable for edge-to-edge leaflet repair alone.

A compressible and expandable stent assembly for implantation in a body lumen such as a mitral valve, the stent assembly including at least one stent barrel that is shaped and sized so that it allows for normal operation of adjacent heart structures. One or more stent barrels can be included in the stent assembly, where one or more of the stent barrels can include a cylinder with a tapered edge.

The invention provides a mitral valve replacement system in the technical field of medical instruments, and the mitral valve replacement system comprises a valve stent, a fixing ring and a shearing part, the fixing ring is arranged around the end face of the valve stent, and the shearing part is oppositely arranged on one side of the valve stent. The fixing ring surrounds the groove in the end face of the valve support to limit the moving direction of the valve support, so that the valve support is stably located at the native mitral valve ring, and the butterfly buckle is arranged on the valve support to buckle and clamp the native mitral valve leaflet. The fixing ring is tied and hooped at the groove in the end face of the valve support of the artificial heart valve, so that the artificial heart valve is stably positioned at the original mitral valve annulus, displacement of the artificial heart valve caused by external force factors such as blood flow impact force is prevented, and then the perivalvular leakage problem caused by displacement is avoided; the native mitral valve anterior leaflet is cut open through the cutting part, and then the cut native mitral valve anterior leaflet is buckled and clamped through the butterfly buckle, so that blood flowing through the native mitral valve anterior leaflet smoothly circulates, and the problem that the left ventricular outflow tract is obstructed is solved.

A mitral valve postoperative water test pipe comprises a water injection hose, a water inlet end threaded connector is fixed at one end of the water injection hose, a water outlet end piece is fixed at the other end of the water injection hose, an inner cavity is formed in the pipe wall of the water injection hose, a flexible metal piece is fixed in the inner cavity, and the axis of the flexible metal piece is parallel to the axis of the water injection hose. Compared with the prior art, the device has the technical effects that the device is provided with the metal piece, bending is not affected, the proper angle can be adjusted, meanwhile, the device can be shaped after being bent, the shape can be stably kept after being bent, and accurate detection of the state of the heart valve is facilitated.

The invention relates to an anchor hook and methods of using the same for subannular anchoring of a transcatheter heart valve replacement, and in particular for an orthogonally delivered (side-delivered) transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the mitral or tricuspid valve from the inferior vena cava or superior vena cava, or trans-septally to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring a delivery catheter to bend 90 degrees during deployment.

A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.

Disclosed herein are embodiments of a delivery system which can be used to recapture and / or reposition a replacement valve, such as a replacement mitral valve, after initial deployment of the valve. Embodiments of the delivery system can involve a torqueing manifold that interacts with multiple tethers that are releasably coupled to eyelets of a replacement heart valve. Engagement pins may be configured to releasably retain one end of the tethers.

The present invention discloses a closure device for mitral valve leaflet repair, which relates to the technical field of mitral valve leaflet repair. The present invention includes an upper jaw assembly, one side of the upper jaw assembly is set to an opening shape, and a positioning clamp assembly is slidably connected to the inner wall of the opening. The end of the positioning clamp assembly is provided with an outer protrusion, and the top of the upper surface of the outer protrusion is provided with a hook-shaped groove. The present invention utilizes the continuous abutment and approach of the closure assembly to finally connect the port with the clamp arm, thereby forming an integrated structure between the closure assembly and the two clamp arms, so that the closure assembly is connected to the bottom of the mitral valve, and the first clamp arm and the second clamp arm are connected to the top of the mitral valve. Therefore, during the systole of the heart, the mitral valve is tightly closed, preventing blood from the left ventricle from flowing back to the left atrium, thereby ensuring that blood can be pumped from the left ventricle into the aorta in the correct direction, and the closure assembly can be closed without relying on external force. Compared with the existing technology, the external operating structure for controlling the turning is saved.

The application discloses a heart valve device and relates to the technical field of artificial heart valves, which comprises an outer valve frame and a valve leaflet assembly connected to the inside of the outer valve frame, and the outer valve frame is a ring-shaped grid frame; the outer valve frame comprises an inflow side grid frame and an outflow side grid frame arranged in sequence from an inflow end to an outflow end, and the inflow side grid frame and the outflow side grid frame form an annular recess for clamping a native valve ring on the outer periphery of the outer valve frame; the outflow side grid frame comprises a plurality of groups of grid support units connected in sequence along the circumferential direction and enclosed into a ring, and the grid support unit comprises an outer convex grid support and an inner concave grid support, and the outer surface of the inner concave grid support is arranged in a concave manner relative to the outer surface of the outer convex grid support. In this way, the anterior leaflet of the original mitral valve can be attached to the inner concave grid support, the extrusion of the outer valve frame on the anterior leaflet is reduced, the anterior leaflet is prevented from being extruded to the left ventricular outflow tract by the outer valve frame, and the outflow area of the left ventricular outflow tract is prevented from being reduced to cause obstruction.

A mitral valve prosthesis to be implanted in a heart, comprises an asymmetrical ring, the asymmetrical ring is dimensioned to mimic a native mitral annulus of a patient; an anterior flexible leaflet and a posterior flexible leaflet, said leaflets suspended from the asymmetrical ring and configured to substantially coapt with each other; and at least four sets of cords, each set of cords attached to the anterior or posterior leaflet on a first end and attached into a cap on a second end, the cap is configured to be attached onto papillary muscles of the heart on another end of the cap.

The application discloses a kind of heart mitral valve medical image segmentation model, training method, segmentation method and equipment.The segmentation model is improved based on DoubleU-Net architecture, and the two independent and serial U-Net networks contain encoder and decoder;Use EfficientNetB7 network as the feature extraction encoder of front-end U-Net network;Two U-Net networks are sequentially introduced into multi-core residual convolution (MKRC) module, hollow space convolution pyramid pooling (ASPP) module and mixed triple attention (TAG) module after extracting features;The input end of the decoder introduces triple attention gate (TAM) module.The segmentation model training uses hybrid loss function, combines binary cross-entropy loss and Dice loss, balances the class imbalance problem and improves the segmentation precision.The application can automatically and accurately segment heart and related vascular structures, thereby solving the technical problems that accurate and efficient heart mitral valve image segmentation is difficult in the prior art.

The application discloses a channel type mitral valve prosthesis implantation system, which comprises a plurality of deformable biological ring guide wires, the end of each of the biological ring guide wires is provided with a bendable hook, the hooks are used for forming a guideable channel, and the channel is annular in shape; a biological ring which is in the shape of a strip when freely stretched, two free ends of the biological ring are configured to be locked when a main body part of the biological ring is pushed along the channel to form a biological ring locking buckle; and a mitral valve prosthesis support which is fixed in the biological ring. The system is simple to operate, saves operation time, and enables safe and efficient completion of the operation.

The present invention discloses devices and methods for treating or repairing regurgitant heart valves such as the mitral valve and / or the tricuspid valve. Exemplary valvuloplasty devices can be placed in the coronary sinus to re-shape the mitral valve and reduce mitral regurgitation as well as tricuspid regurgitation. The present disclosure also provides improved techniques for cardiac pacing.

A suturing catheter for reducing mitral insufficiency by applying suturing points percutaneously is provided. The suturing catheter has a catheter body provided with a distal end and at least one internal lumen, at least one U-folded suture filament with two free ends, each provided with a suture needle, a pair of stylets, each provided with a catch needle, the suture and catch needles being provided with a connecting portion that allows a catch needle to mechanically engage with a suture needle, and a lever having a stapling arm, from which the suture needles protrude. The stapling arm, together with the catheter body, from which the catch needles protrude, defines a catch zone for a flap of a mitral valve. An opposite operating arm, together with the catheter body, defines an operating zone of the lever.

The invention relates in some aspects to a device for use in anchoring an implant, including anchors, sutures, implants, clips, tools, lassos, and methods of anchoring among other methods. Anchors as disclosed herein could be utilized to secure a coaptation assistance device, an annuloplasty ring, an artificial valve, cardiac patch, sensor, pacemaker, or other implants. The implant could be a mitral valve ring or artificial mitral valve in some embodiments.

A traditional Chinese medicine formula for treating blood vessel clogging belongs to the field of traditional Chinese medicine formulas, and comprises the following main raw materials: 29-31 parts of black pearl, 11-13 parts of codonopsis pilosula, 7-9 parts of saffron crocus, 8-10 parts of angelica sinensis, 190-210 parts of leek, 9-11 parts of pseudo-ginseng, 37-43 parts of hawthorn, 95-105 parts of astragalus membranaceus, 18-22 parts of kudzu vine root, 8-10 parts of peach kernel, 8-10 parts of prepared rehmannia root, 9-11 parts of radix rehmanniae, 11-13 parts of white paeony root, 3 parts of red ginseng, 9-11 parts of radix ophiopogonis, 14-16 parts of spina date seed, 11-13 parts of Chinese yam, 14-15 parts of schisandra chinensis, 9-11 parts of polygonum multiflorum, 7-9 parts of cinnamon, 18-21 , 13-15 parts of anise and 12-14 parts of rhizoma polygonati. The traditional Chinese medicine composition has an obvious improvement effect on coronary artery insufficiency, myocardial ischemia, mitral valve, tricuspid valve, aortic valve regurgitation, chronic heart failure, patients needing operation bypass stenting, angina pectoris, myocardial infarction sequelae, cerebral ischemia, cerebrovascular sequelae and other symptoms caused by cardiac insufficiency, the dosage is small, the effect is fast, the cure rate is high, relapse is not prone to occurring, and the traditional Chinese medicine composition is suitable for clinical application. The effects of tonifying qi and activating blood, dredging channels and relieving pain, eliminating phlegm and removing blood stasis, tonifying heart and soothing nerves and the like can be achieved.

The utility model discloses a first-aid device used for relieving SAM symptoms, which comprises a lead puncture sheath tube, a first-aid device is arranged in the lead puncture sheath tube, the first-aid device comprises a hollow sheath tube with an inclined top end, a channel is arranged on the tube wall of the hollow sheath tube, a jacking component is mounted in the hollow sheath tube, and a propelling component is arranged at the bottom end of the hollow sheath tube. The bottom end of the jacking assembly is connected with the top end of the pushing assembly, a main supporting strip and an auxiliary supporting strip of the jacking assembly can open and close the elastic umbrella cover, the pushing assembly is used for pushing the jacking assembly forwards to enable the jacking assembly to stretch out of the top end of the hollow sheathing canal to open the elastic umbrella cover, an anti-falling plate is further arranged at the bottom end of the hollow sheathing canal, and the pushing assembly is inserted into the anti-falling plate. The device is reasonable in structure and easy and convenient to operate, is applied to the first-aid operation of the SAM symptom patient, and can be used for rapidly jacking up the mitral valve anterior lobe to be separated from the ventricular septum, widening the left ventricular outflow tract and win time for the subsequent treatment of the patient.

The invention relates to constriction devices and methods for deploying a laterally delivered prosthetic heart valve in a native annulus. The present invention relates to anchoring channels and subannulus anchors for transcatheter heart valve replacement (A61F2 / 2412), and in particular for transcatheter prosthetic heart valves with orthogonal delivery of an annulus support frame having a compressible wire unit, the compressible wire unit facilitates rolling and folding of the valve in a longitudinal direction or orthogonal to a central axis of the flow control member, allowing delivery and deployment of a very large diameter valve from the inferior vena cava or superior vena cava to the tricuspid valve, or trans-atrial delivery and deployment to the mitral valve, or delivery and deployment of a very large diameter valve from the inferior vena cava or superior vena cava to the tricuspid valve. The valve has a height of about 5 mm to 60 mm and a diameter of about 25 mm to 80 mm without the need for an over-diameter catheter and without the need for delivery and deployment from the catheter at an acute access angle.

Methods and devices for transvascular prosthetic chordae tendinea implantation are disclosed. A catheter is advanced into the left atrium. From an atrium side, a leaflet connector carried by a distal end of the catheter can be anchored to a superior surface of a mitral valve leaflet. A needle is axially advanceable through the leaflet connector and through the leaflet. A leaflet anchor having a leaflet suture can be advanced out of the needle to secure the mitral valve leaflet to the leaflet suture. A ventricular anchor is anchored to the wall of the ventricle to secure the ventricular wall to a ventricle suture. The leaflet suture and the ventricle suture may be tensioned and connected by a suture lock to form an artificial chordae.

This invention provides an apparatus for repairing heart valves and a method for implanting anchors and repairing heart valves. The apparatus includes: a body; a component attached to the body at a first end and having a plurality of positioning cords extending laterally across a space between the component and away from a second end of the component opposite to the first end; a tube suspended from the plurality of positioning cords; and an adjustment cord extending through the tube. The method includes: implanting at least one annular anchor into the mitral valve annulus of a heart valve; implanting papillary anchors through each papillary muscle of the heart; delivering and positioning the apparatus for repairing the heart valve within the heart valve using at least one annular anchor and papillary anchors; and adjusting the apparatus to adjust the degree of atrial displacement of the mitral valve leaflets during ventricular systole.

The invention relates to anchor channels and subannular anchors for a transcatheter heart valve replacement, and in particular for an orthogonally delivered transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the tricuspid valve from the inferior vena cava or superior vena cava, or trans-atrially to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring delivery and deployment from a catheter at an acute angle of approach.

Procedures may be performed on the heart after the installation of a mitral valve fixation device. In order to prepare the heart for such procedures, the fixation device may be removed or disabled in minimally invasive ways (e.g., through an endovascular procedure), without requiring open access to the heart. The fixation device may be partitioned so that one portion may remain attached to each leaflet of the mitral valve. In another example, the leaflets may be cut along the edges of the distal element(s) of the fixation device, so as to cut the fixation device from the leaflet(s). Systems and devices for performing such procedures endovascularly are disclosed. Fixation devices with improved access to a release harness are also disclosed.

The invention belongs to the technical field of medical instruments, and particularly relates to an artificial mitral valve suture-free automatic implantation device which comprises a catheter, one end of the catheter is fixedly connected with an opening and closing puncture mechanism, the inner wall of the catheter is fixedly connected with a pushing mechanism, a groove is formed in the outer surface of the catheter, and a filling solvent bag is installed in the groove; through the arranged opening and closing puncture mechanism, the opening and closing puncture head enters the human body with the minimum incision and then is expanded after entering the human body, the initial puncture point is extremely small, direct injury to tissues such as blood vessels and cardiac muscle can be reduced, the path of the automatically expanded needle head is more regular, important blood vessels, nerves or cardiac muscle tissues can be avoided, the accidental injury risk is reduced, and the working efficiency is improved. According to traditional implantation, a puncture channel possibly needs to be expanded in advance, an open-close type needle head is automatically expanded after entering, an additional expansion step is not needed, traction and extrusion on surrounding tissue are reduced, and the possibility of hematoma and infection after an operation is reduced.

The present invention discloses a mitral valve repair device that can capture and fix, and the present invention relates to the technical field of mitral valve repair devices. The mitral valve repair device that can capture and fix includes an exposure structure. The exposure structure includes a stretching line, and the stretching line is fixedly connected with a traction ring by a key-lock structure. A coaxial rotating ring is arranged on one side of the traction ring, and adjustable blades are arranged on the outer side of the rotating ring. It further includes a capture structure. When the exposure structure is expanded and exposed, the capture structure penetrates through the exposure structure, and the capture structure unfolds from the closed state to the capture state. It further includes a traction rod, and both the exposure structure and the capture structure are located on the traction rod. By integrating the exposure structure and the capture structure into one body by the traction rod, the present invention can quickly capture the mitral valve according to the exposure result and the prior estimation after the exposure of the mitral valve repair surgery is completed. Both the capture position and the capture space can be adjusted by the doctor according to the actual situation, reducing the time and operation risk of the repair surgery.

This invention discloses a method for predicting sudden cardiac death based on forensic autopsy data using machine learning and its forensic applications, belonging to the fields of machine learning, statistics, and forensic identification. This invention provides a method for screening independent predictors of forensic diagnosis of sudden cardiac death using LASSO regression and logistic regression. Using 10-fold cross-validation, the method selects the minimum lambda(λ) to identify 14 risk factors. Logistic regression ultimately identifies 9 independent predictors, including age, heart weight, left ventricular wall thickness, right ventricular wall thickness, interventricular septum thickness, aortic valve circumference, mitral valve circumference, liver weight, and left kidney weight. A nomogram and a web-based calculator are constructed for predicting sudden cardiac death in forensic practice, thereby determining sudden cardiac death using objective indicators. This method has not been reported worldwide.

A method of delivering a transcutaneous dual valve replacement (TDVR) device to a patient includes the steps of advancing a guide catheter into the heart of the patient, advancing a support wire through the guide catheter and across the mitral valve of the heart of the patient, removing the guide catheter, advancing a delivery sheath over the support wire and across both the aortic valve and the mitral valve of the heart of the patient, advancing the TDVR device over the support wire and through the delivery sheath, removing the delivery sheath, expanding a first segment of the TDVR device in the mitral valve and a second segment of the TDVR device in the aortic valve, and removing the support wire.