109 results about "Mitral valve leaflet" patented technology

The application discloses a heart valve device and relates to the technical field of artificial heart valves, which comprises an outer valve frame and a valve leaflet assembly connected to the inside of the outer valve frame, and the outer valve frame is a ring-shaped grid frame; the outer valve frame comprises an inflow side grid frame and an outflow side grid frame arranged in sequence from an inflow end to an outflow end, and the inflow side grid frame and the outflow side grid frame form an annular recess for clamping a native valve ring on the outer periphery of the outer valve frame; the outflow side grid frame comprises a plurality of groups of grid support units connected in sequence along the circumferential direction and enclosed into a ring, and the grid support unit comprises an outer convex grid support and an inner concave grid support, and the outer surface of the inner concave grid support is arranged in a concave manner relative to the outer surface of the outer convex grid support. In this way, the anterior leaflet of the original mitral valve can be attached to the inner concave grid support, the extrusion of the outer valve frame on the anterior leaflet is reduced, the anterior leaflet is prevented from being extruded to the left ventricular outflow tract by the outer valve frame, and the outflow area of the left ventricular outflow tract is prevented from being reduced to cause obstruction.

A mitral valve prosthesis to be implanted in a heart, comprises an asymmetrical ring, the asymmetrical ring is dimensioned to mimic a native mitral annulus of a patient; an anterior flexible leaflet and a posterior flexible leaflet, said leaflets suspended from the asymmetrical ring and configured to substantially coapt with each other; and at least four sets of cords, each set of cords attached to the anterior or posterior leaflet on a first end and attached into a cap on a second end, the cap is configured to be attached onto papillary muscles of the heart on another end of the cap.

The application discloses a channel type mitral valve prosthesis implantation system, which comprises a plurality of deformable biological ring guide wires, the end of each of the biological ring guide wires is provided with a bendable hook, the hooks are used for forming a guideable channel, and the channel is annular in shape; a biological ring which is in the shape of a strip when freely stretched, two free ends of the biological ring are configured to be locked when a main body part of the biological ring is pushed along the channel to form a biological ring locking buckle; and a mitral valve prosthesis support which is fixed in the biological ring. The system is simple to operate, saves operation time, and enables safe and efficient completion of the operation.

The invention relates in some aspects to a device for use in anchoring an implant, including anchors, sutures, implants, clips, tools, lassos, and methods of anchoring among other methods. Anchors as disclosed herein could be utilized to secure a coaptation assistance device, an annuloplasty ring, an artificial valve, cardiac patch, sensor, pacemaker, or other implants. The implant could be a mitral valve ring or artificial mitral valve in some embodiments.

Methods and devices for transvascular prosthetic chordae tendinea implantation are disclosed. A catheter is advanced into the left atrium. From an atrium side, a leaflet connector carried by a distal end of the catheter can be anchored to a superior surface of a mitral valve leaflet. A needle is axially advanceable through the leaflet connector and through the leaflet. A leaflet anchor having a leaflet suture can be advanced out of the needle to secure the mitral valve leaflet to the leaflet suture. A ventricular anchor is anchored to the wall of the ventricle to secure the ventricular wall to a ventricle suture. The leaflet suture and the ventricle suture may be tensioned and connected by a suture lock to form an artificial chordae.

Procedures may be performed on the heart after the installation of a mitral valve fixation device. In order to prepare the heart for such procedures, the fixation device may be removed or disabled in minimally invasive ways (e.g., through an endovascular procedure), without requiring open access to the heart. The fixation device may be partitioned so that one portion may remain attached to each leaflet of the mitral valve. In another example, the leaflets may be cut along the edges of the distal element(s) of the fixation device, so as to cut the fixation device from the leaflet(s). Systems and devices for performing such procedures endovascularly are disclosed. Fixation devices with improved access to a release harness are also disclosed.

This invention discloses a method for predicting sudden cardiac death based on forensic autopsy data using machine learning and its forensic applications, belonging to the fields of machine learning, statistics, and forensic identification. This invention provides a method for screening independent predictors of forensic diagnosis of sudden cardiac death using LASSO regression and logistic regression. Using 10-fold cross-validation, the method selects the minimum lambda(λ) to identify 14 risk factors. Logistic regression ultimately identifies 9 independent predictors, including age, heart weight, left ventricular wall thickness, right ventricular wall thickness, interventricular septum thickness, aortic valve circumference, mitral valve circumference, liver weight, and left kidney weight. A nomogram and a web-based calculator are constructed for predicting sudden cardiac death in forensic practice, thereby determining sudden cardiac death using objective indicators. This method has not been reported worldwide.

A method of delivering a transcutaneous dual valve replacement (TDVR) device to a patient includes the steps of advancing a guide catheter into the heart of the patient, advancing a support wire through the guide catheter and across the mitral valve of the heart of the patient, removing the guide catheter, advancing a delivery sheath over the support wire and across both the aortic valve and the mitral valve of the heart of the patient, advancing the TDVR device over the support wire and through the delivery sheath, removing the delivery sheath, expanding a first segment of the TDVR device in the mitral valve and a second segment of the TDVR device in the aortic valve, and removing the support wire.

A transapical removal device that can be deployed in a catheter procedure to capture for removal or alteration a mitral valve clip or heart tissue, such as the anterior leaflet of the mitral valve, and methods of use are disclosed. The removal device includes a delivery catheter configured to be deployed near a mitral valve using a guide catheter. The delivery catheter has a snare head at the distal end, which assumes a collapsed state during movement of the delivery catheter through the guide catheter and deployed state for capturing a mitral valve clip or anterior leaflet. The snare head has one or more ablation delivery catheters configured to ablate tissue surrounding the pre-positioned mitral valve clip or anterior leaflet. In some arrangements within the scope of the present disclosure, the removal device includes a deployment mechanism for deploying a new transcatheter valve into the mitral valve.

A prosthetic heart valve includes an outer frame, a cover, an inner frame, and a valve structure. The outer frame includes a main body and an atrial flange. The main body includes a plurality of struts forming a plurality of circumferential rows of cells, a plurality of rows of barbs extending from junctions of the struts, the atrial flange extending radially outwardly and in an atrial direction from the inflow end of the main body. The atrial flange includes an oval shape corresponding to a shape of the patient's native mitral valve anatomy. The cover is disposed on a radially inner side of the atrial flange and on a radially outer side of the atrial flange. The inner frame is disposed within the outer frame and has a cylindrical shape. The valve structure is coupled to the inner frame and includes a plurality of leaflets.

A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

The invention provides a mitral valve clip operation simulator which comprises a bottom plate, and a first side of the bottom plate is provided with a first storage groove and a second storage groove; the first module is provided with an atrial septum simulation part and a mitral valve simulation part, and the first module is arranged on the bottom plate in the mode that the first module can be switched between an unfolded state and a folded state; the second module is provided with a lower cavity tube used for simulating the inferior vena cava, and the second module is arranged on the bottom plate in a mode of being capable of being switched between an unfolded state and a folded state; when the first module is in an unfolded state, the atrial septum simulation part and the mitral valve simulation part protrude out of the bottom plate, and the positions of the atrial septum simulation part and the mitral valve simulation part form an analogue simulation position; when the second module is in an unfolded state, the lower cavity tube protrudes out of the bottom plate to form a surgical instrument access path; when the first module is in the folded state, the first module is integrally contained in the first containing groove, and when the second module is in the folded state, the second module is integrally contained in the second containing groove.

Disclosed in the present invention is a capturable and fixable mitral valve repair device. The present invention relates to the technical field of mitral valve repair devices. The capturable and fixable mitral valve repair device comprises an exposure structure. The exposure structure comprises a traction line, the traction line is fixedly connected to a traction ring by means of a lock-and-key structure, a coaxial rotating ring is arranged on one side of the traction ring, and an adjustable blade is arranged outside the rotating ring. Said device further comprises a capture structure. The capture structure penetrates through the exposure structure during the expansion and exposure of the exposure structure, and the capture structure is unfolded from a folded state to a capture state. Said device further comprises a traction rod. The exposure structure and the capture structure are both located on the traction rod. According to the present invention, by means of integrating the exposure structure and the capture structure into a whole by the traction rod, after completing the exposure in mitral valve repair surgery, the mitral valve can be rapidly captured according to an exposure result and pre-estimation. A capture position and a capture space can be adjusted by a doctor according to actual conditions, thereby reducing the duration and operation risks of the repair surgery.

Embodiments of prosthetic valves for implantation within a native mitral valve are provided. A preferred embodiment of a prosthetic valve includes a radially compressible main body and a one-way valve portion. The prosthetic valve further comprises at least one ventricular anchor coupled to the main body and disposed outside of the main body. A space is provided between an outer surface of the main body and the ventricular anchor for receiving a native mitral valve leaflet. The prosthetic valve preferably includes an atrial sealing member adapted for placement above the annulus of the mitral valve. Methods and devices for delivering and implanting the prosthetic valve are also described.

Systems and methods of atrioventricular valve replacement are provided. In various embodiments, an arch-like support structure is provided that is insertable and implantable into a heart and is positioned in the mitral annulus to replace a native mitral valve. The support structure is operable to support, and various systems comprise leaflet and chord structures operable to control and regular blood flow between chambers of the heart.

Mitral regurgitation can be reduced by creating one passageway between the right atrium and left ventricle in a portion of the tricuspid annulus just above the ventricular septum and another passageway through the outer wall of the left ventricle near at least one of the left ventricular papillary muscles. A support rod is positioned in the right atrium in contact with the septal portion of the tricuspid annulus, and a support plate is positioned adjacent to the second passageway and against the outer wall of the left ventricle. The support plate is pulled toward the support rod using a tether that extends between the first support plate and the support rod, passes through both passageways, and is under tension. The tension in the tether moves the root of the tendon closer to the mitral valve, which reduces mitral regurgitation.

The invention discloses an interventional valve ring device and an interventional valve device. The interventional valve ring device and the interventional valve device can be used for mitral valve and tricuspid valve lesions. The interventional valve ring device is mainly composed of a valve ring, a valve ring conveying system, a fixing nail and a fixing nail conveying system. The interventional valve is mainly composed of a fixing support, a supporting support, a supporting support covering film and valve leaflets. The interventional valve ring and the interventional valve enter the heart through the interventional delivery system and can pass through the apex of the heart, the femoral vein, the jugular vein or the subclavian vein, the right atrium or the left atrium. The interventional valve is fixed in the interventional valve ring, and a minimally invasive, safe and effective treatment method can be provided for a patient.

Guide wire apparatuses and methods. Guide wires may be utilized for guiding a delivery apparatus, for example a transcatheter mitral valve delivery apparatus to replace a native mitral valve. A guide wire may include a distal portion. The distal portion may define a central axis and comprise a distal tip. The distal portion may have an undeployed configuration in which the distal tip is contracted medially and centered on the central axis. The distal portion may have a deployed configuration in which the distal tip is expanded radially from the central axis such that, in multiple radial dimensions, the tip is thicker than a size of an opening between adjacent chordae tendineae of the mitral valve. The delivery apparatus may be configured to be passed along the wire to the mitral valve while the distal tip, in the deployed configuration, contacts the adjacent chordae tendineae without passing through the opening.

The invention relates to a mitral valve outer valve frame, a mitral valve frame assembly and a heart valve prosthesis. The invention relates to a ventricular atrial cavity which has a radial contraction state and a radial expansion state and comprises an atrial part, a ventricular part and a connecting frame, the atrial part and the ventricular part are connected through the connecting part, and the atrial part and the ventricular part are of a latticed structure and comprise frame units; the ventricular part comprises at least three protruding parts which are distributed at intervals in the circumferential direction, an avoiding space is formed between every two adjacent protruding parts, the area of the avoiding space is gradually increased in the direction from the inflow end to the outflow end, and due to the fact that an avoiding area formed between every two adjacent supporting pieces has small influence on the ventricular autologous structure, the ventricular autologous structure can be effectively improved. The avoiding area is aligned with the left ventricular outflow tract during anchoring, so that the problem that the left ventricular outflow tract is blocked due to deformation after the mitral valve outer valve frame is implanted is solved.

The invention provides a mitral valve clamp device for preventing a control rod from being broken. The mitral valve clamp device comprises a handle shell; the flexible sheath tube extends from the handle shell to the far end; a control rod extending through the flexible sheath tube, the distal end of the control rod being detachably connected to the valve clip; and a control mechanism connected to the handle housing. Wherein the control mechanism comprises a movable element, a fixed element and a limiting pin, the fixed element comprises a stepped interface, and the limiting pin is provided with a circumferential boss. When the valve clamp clamps the mitral valve leaflet, traction force generated on the valve clamp can be transmitted to the fixing element through the control rod so as to pull the fixing element to axially move towards the far end relative to the limiting pin and the moving element until the circumferential boss abuts against the step interface to lock the limiting pin. Therefore, the limiting pin is prevented from being pulled out in advance before the traction force is released, the huge risk that the control rod is broken due to torsion is finally avoided, the success rate of an operation is increased, and huge damage to the valve leaflet is further avoided.

The application provides a method for fixing an interventional valve on a mitral valve, which comprises the following steps: driving a plurality of fixing nails into the left atrial side wall above the mitral valve; and connecting a fixing disc on the atrial septum through a connecting line to form a plurality of fixing lines above the mitral valve. The fixing method can form a plurality of fixing lines above the mitral valve, and the fixing lines can provide stable fixing support for the interventional valve implanted below, thereby effectively solving the problem that the current interventional mitral valve is difficult to be stably anchored, and the method for fixing the interventional valve on the mitral valve is simple and convenient to operate.

Improved features of medical devices. Implants that may include self-expanding portions and portions that are expandable with an inflatable body. A portion expandable with an inflatable body may dock with a portion that is self-expanding. A portion expandable with an inflatable body may be coupled to a portion that is self-expanding. Delivery apparatuses for deployment of both a self-expanding portion and a portion expandable with an inflatable body may be disclosed.

The invention relates to a device (1) for placing an artificial mitral valve chorda (30), the device comprising: - a central body (10); - two end portions (12, 14) arranged on either side of the central body (10), each comprising a through-opening (122, 142) and comprising two jaws (124, 144) defining the corresponding opening (122, 142); it being possible for each end portion (12, 14) to be placed in two distinct configurations: - a first configuration in which the jaws are in a closed position, in which position an artificial chorda strand passing through the corresponding opening (122, 142) cannot pass between the corresponding jaws (124, 144); - a second configuration in which the jaws are in an open position, in which position an artificial chorda strand passing through the corresponding opening (122, 142) can pass between the corresponding jaws.

The mitral valve forming ring is provided with a discontinuous peripheral shape surrounding a center hole and provided with an opening, the mitral valve forming ring comprises a front section and a rear section which are oppositely arranged and a pair of junction narrowing sections located at the junction of the front section and the rear section, the curvature radius of the front section is larger than that of the rear section, and the curvature radius of the front section is larger than that of the rear section. The junction narrowing section is locally arranged in a manner of protruding outwards in the circumferential direction; the junction narrowing section can enable the junction area to be narrowed so as to increase the involution area of the anterior valve leaflet and the posterior valve leaflet in the junction area. According to the mitral valve forming ring with the opening, regurgitation of a junction area is accurately inhibited through a differentiated strengthening structure, and the postoperative residual regurgitation rate is reduced; the limitation that an existing product is single in indication is broken through, clinical coverage of all disease causes and multiple disease types can be achieved, and the method is suitable for repairing various complex mitral valve lesions; the bionic physiological structure design is optimized, the biocompatibility and the long-term stability after implantation are improved, postoperative complications are reduced, and the prognosis of patients is improved.

A separate, precisely anchorable transcatheter bicuspid valve system includes a separate transcatheter bicuspid valve anchor stent (10) and a transcatheter bicuspid bioprosthetic valve (20), the anchor stent shape and structure of the transcatheter bicuspid valve anchor stent (10) matching the true structure of the bicuspid valve after three-dimensional reconstruction based on the patient's image data, the transcatheter bicuspid valve anchor stent (10) is first pre-assembled and pre-assembled for release, deformation, and individual alignment and coaptation with the supravalvular and subvalvular tissues of the patient's bicuspid valve into the bicuspid valve position of the patient. The transcatheter bicuspid valve anchor stent 10 is then delivered to the valve base 10 for delivery to the valve base 10, and the transcatheter bicuspid valve prosthesis 20 is delivered into the transcatheter bicuspid valve anchor stent 10 and released, the transcatheter bicuspid valve prosthesis 20 is released and deformed to expand to a functional state, and the transcatheter bicuspid valve anchor stent 10 is again deformed to couple with the expanded transcatheter bicuspid valve 20, and at the same time, the transcatheter bicuspid valve anchor stent 10 is again deformed to complete the preset coupling between the transcatheter bicuspid valve anchor stent 10 and the valve base tissue for anchoring. The separate, precise anchoring transcatheter bicuspid valve system is designed based on three-dimensional reconstruction, and can realize individual precise anchoring of the transcatheter bicuspid valve.

This invention proposes a mitral valve capture mechanism for transcatheter interventional therapy, comprising: a capture unit, sleeved outside a control rod and located behind a clamping device, comprising: a base with an axially extending through-hole for the control rod to pass through, the front end of which is connected to a plurality of circumferentially distributed shape memory alloy units; a rigid unit, correspondingly arranged and connected to the shape memory alloy units, comprising an anterior rigid plate and a posterior rigid plate, wherein the anterior and posterior rigid plates do not contact each other, nor does the posterior rigid plate contact the base; a limiting ring, located in front of the shape memory alloy units and connected to the anterior rigid plate; a first cable control unit and a second cable control unit. This invention can effectively solve the problem of valve floating due to blood flow during mitral valve edge-to-edge repair, leading to clamping failure.

1. The name of the design product: surgical retractor. 2. The use of the design product: the design product is used for the exposure of the mitral valve in the clinical center. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

Methods and devices for transvascular prosthetic chordae tendinea implantation are disclosed. A catheter is advanced into the left atrium. From an atrium side, the catheter can be anchored to a superior surface of a mitral valve leaflet and a leaflet anchor can be advanced into the mitral valve leaflet to secure the mitral valve leaflet to a leaflet suture. A ventricular anchor is anchored to the wall of the ventricle to secure the ventricular wall to a ventricle suture. The leaflet suture and the ventricle suture may be tensioned and connected by a suture lock to form an artificial chorda.

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets, to inhibit prolapse into the left atrium. At least one marginal chordae is severed, to permit leaflet closure against the band.

The present invention provides a valve material having synergistic anti-coagulation and anti-calcification functions and a preparation method therefor. The preparation method comprises the following steps: performing glutaraldehyde cross-linking treatment on an animal-derived biological valve material; immersing the treated valve material in a blocking solution containing an amine compound for 0.5-6 h, thereby blocking the remaining aldehyde groups after glutaraldehyde cross-linking; then placing the valve material into a reaction solution containing an anticoagulant and a cross-linking agent, and performing cross-linking treatment for 6-24 h at 4° C.-37° C.; and finally washing and obtaining the valve material, and storing the valve material in a mixed solvent of glutaraldehyde or isopropyl alcohol / glycerol. The method can effectively solve the problem of calcification and thrombosis caused by residual aldehyde groups in a valve material prepared by the existing method. The valve material prepared by the present method can be used as a valve material required for aortic valve, pulmonary valve, venous valve, mitral valve and tricuspid valve replacement.