52 results about "Atrioventricular valve" patented technology

A device comprises an implantable blood pump receivable in a sheath for percutaneous delivery. The implantable blood pump comprises a collapsible impeller mounted in a collapsible impeller cage, and a drive device mounted in a housing. The housing is in connection between a first end of a catheter and the collapsible impeller cage. The drive device is adapted for rotating the collapsible impeller. A retractable support structure is adapted to extend from the catheter. The extended retractable support structure is adapted to engage with the wall of the aorta for allowing the implantable blood pump to be secured in the left ventricle. The collapsible impeller cage comprises an inlet and an outlet. The inlet is adapted to receive blood from the left ventricle. The outlet directs blood in the direction of the atrioventricular valve.

Method and systems are provided for characterizing blood flow in an atrioventricular valve of the human heart, the atrioventricular valve connecting an atrium with a corresponding ventricle of the heart, the ventricle being fluidly coupled to a particular vessel that transports blood outside the ventricle blood, which involve obtaining image data of the heart and identifying contours of the atrium and a region within the particular vessel within the image data. A time-density curve for the atrium can be calculated from the contour of the atrium and densitometric image data derived from the image data. A time-density curve for the region of the particular vessel can be calculated from the contour of the vessel region and the densitometric image data. Data that characterizes at least one regurgitation fraction related to the atrioventricular valve can be calculated from such time-density curves.

An implant for implantation at a native atrioventricular valve of a subject, includes a frame assembly, including a valve frame and an outer frame coupled to each other. The valve frame includes a tubular portion that circumscribes a longitudinal axis of the valve frame so as to define a lumen along the axis, and an upstream support portion including a plurality of arms. Each arm extends radially outward from the tubular portion to engage tissue in the atrium. The outer frame includes a ring that circumscribes the tubular portion, and a plurality of ventricular anchors that extend radially outward from the ring and are configured to anchor the implant to tissue of the ventricle. In an expanded state of the frame assembly, the implant defines a toroidal space between the plurality of ventricular anchors and the upstream support portion. Other embodiments are also described.

Methods and devices for reducing ventricle filling volume are disclosed. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to reduce ventricle filling volume or even blood pressure. When the heart is stimulated in a consistent way to reduce blood pressure, the cardiovascular system may over time adapt to the stimulation and revert back to the higher blood pressure. In some embodiments, the stimulation pattern may be configured to be inconsistent such that the adaptation response of the heart is reduced or even prevented. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to cause at least a portion of an atrial contraction to occur while the atrioventricular valve is closed. Such an atrial contraction may deposit less blood into the corresponding ventricle than when the atrioventricular valve is opened throughout an atrial contraction.

Systems for replacing the function of a native atrioventricular valve are described. The systems can include a prosthetic heart valve including a self-expanding frame and a plurality of leaflets. The systems can include a delivery catheter having an elongate shaft for advancing the prosthetic heart valve through a patient's vasculature to the native atrioventricular valve, the elongate shaft including a capsule along a distal end portion of the elongate shaft for maintaining the prosthetic heart valve in a compressed state. A tether assembly can extend through the elongate shaft of the delivery catheter and can include loop portions. A release assembly can include a plurality of flexible release tethers that are retractable for removal from the loop portions and thereby allowing the tether assembly to be released from the prosthetic heart valve.

Implant for improving coaptation of an atrioventricular valve in a human heart, the atrioventricular valve having a first and a second native leaflet, an anterolateral and posteromedial commissure between the first and the second native leaflet, and an annulus adjacent a wall of an atrium of the heart. The implant including a frame that includes a middle frame section that frames and supports an artificial central leaflet. The artificial central leaflet is configured to cover a middle region of the first native leaflet. The middle frame section includes a bend formed between a first region of the artificial central leaflet and a second region of the artificial central leaflet that forms a coaptation plane for coaptation with the second native leaflet. The frame further including two side frame sections extending at opposite sides of the middle frame section and configured to contact side regions of the first native leaflet.

A device for connecting artificial chordae tendineae to the leaflets of an atrioventricular valve, the device comprising: a neochord delivery system comprising a manipulable and pushable catheter that houses a neochord attached to a neochord puncture needle, the catheter being operable to push the puncture needle to puncture and pass the neochord through the papillary muscle of the ventricle; a retriever system comprising a catheter that houses a grasper that is operable to capture the neochord puncture needle after it passes through the papillary muscle and remove the neochord puncture needle and the neochord from the ventricle; and a tissue clamping system comprising a catheter that houses a distal tissue clamp and a proximal tissue clamp that can be deployed to clamp and hold the area of ​​the atrioventricular valve located therebetween so that the area can be punctured by the puncture needle to deliver the neochord through the leaflets and to the papillary muscle.

The present invention discloses a self-expanding atrioventricular valve prosthesis device, comprising: a main body portion, which is a frame structure, and the main body portion is implanted at the native valve annulus of the heart. The main body portion includes an inflow section, an outflow section and a transition section. The inflow section is located at the atrial end, the outflow section is located at the ventricular end, and the transition section is located between the inflow section and the outflow section; it further includes at least one artificial valve leaf, which is fixed to the transition section of the main body portion, and the artificial valve leaf is provided with a connecting portion; it further includes a chordae tendineae portion, one end of which is fixed, and the other end is connected to the artificial valve leaf through the connecting portion. The present invention restricts the movement range of the artificial valve leaf through the chordae tendineae portion, and the connecting portion prevents the chordae tendineae portion from tearing and stress concentration on the valve leaf, thereby increasing the durability of the artificial valve leaf.

To provide valve repair, e.g., repair of an atrioventricular valve of a patient.SOLUTION: The invention provides an apparatus comprising an implantable annuloplasty structure (1152), which comprises a primary body portion and a contracting member (226). A contracting member fastener (1560) can surround the contracting member, and comprise a clamping structure that is biased toward assuming a closed state to clamp the contracting member passed therethrough. A stop (1570) can be removably coupled to the fastener, and maintain the fastener in an open state. A contracting-member uptake tool (1502) can comprise static and dynamic cutting elements (1510, 1520) and graspers (1505) configured to pull the stop proximally so that the stop pushes and moves the dynamic cutting element onto the static cutting element in order to facilitate severing the contracting member. Other applications are also provided.SELECTED DRAWING: Figure 1

The application provides a valve anchoring device, a guide device and a method for anchoring a prosthetic valve, mainly comprising an anchoring structure and a positioning member, wherein the anchoring structure has a first anchoring member and a second anchoring member extending from both sides of a combination member, the positioning member is connectable to the combination member, the combination member passes through a commissure of a leaflet of a heart tissue, the positioning member is positioned at one side of a heart atrioventricular valve adjacent to an atrium, the first anchoring member and the second anchoring member are positioned at one side of the heart atrioventricular valve adjacent to a ventricle, and the first anchoring member and the second anchoring member are cooperatively matched to anchor the prosthetic valve, so that the prosthetic valve is positioned relative to a native valve of the heart tissue. Therefore, the anchoring effect of the prosthetic valve can be improved.

The present application provides a heart valve prosthesis, which has a first end and a second end opposite in a first direction; the heart valve prosthesis comprises a first support body, a second support body and an artificial valve leaflet; the first support body has a first edge and a second edge opposite in a second direction, which is perpendicular to the first direction; the second support body comprises a first segment, which is located on one side of the first support body and has a non-linear configuration; the first segment intersects the first edge at a first intersection point and intersects the second edge at a second intersection point; the second support body is connected with the first support body and allows the first segment to rotate relative to the first support body around a line connecting the first intersection point and the second intersection point; the artificial valve leaflet is connected with the edge of the second support body located on the side close to the first end and the first segment; the heart valve prosthesis has a contracted state and an expanded state; when the heart valve prosthesis switches from the contracted state to the expanded state, the first segment rotates and drives the middle part of the first segment to move in the direction close to the first end, and the distance between the middle part of the first segment and the first support body increases; when the heart valve prosthesis is in the expanded state, the area of the cross section of the artificial valve prosthesis perpendicular to the first direction first increases and then decreases along the first direction. The heart valve prosthesis can replace the native atrioventricular valve and / or the native arterial valve and has a larger effective valve orifice area.

Apparatus and methods are described for treating a subject with a diseased atrioventricular valve. A docking element is implanted within the subject's atrium such that no portion of the docking element extends through the subject's atrioventricular valve. The docking becomes anchored to tissue of the atrium at least partially via ingrowth of the tissue of the atrium. The docking element includes a ring, which is implanted at the annulus of the atrioventricular valve, and a frame having a height of at least 15 mm, which extends upwardly from the ring. A prosthetic atrioventricular valve apparatus is placed at least partially inside the docking element subsequent to the ingrowth of the tissue of the atrium having occurred, and becomes anchored to the docking element, at least partially by radially expanding against the ring. Other applications are also described.

The invention provides a heart implant, a delivery assembly and a heart implant system.The heart implant comprises a valve prosthesis and an anchoring nail, the anchoring nail can nail the valve prosthesis on a native tissue of an atrioventricular valve, on one hand, anchoring of the valve prosthesis in the heart is achieved, the problems of falling, shifting, twisting and the like of the valve prosthesis are avoided, and the heart implant delivery efficiency is improved; on the other hand, the compression of the valve prosthesis on the native tissue of the heart is greatly reduced so as to solve a series of problems such as ventricular structure remodeling caused by the valve prosthesis anchored through radial force, and on the other hand, the fitting gap between the valve prosthesis and the native tissue can be reduced, the sealing performance of the perivalvular is improved, the perivalvular leakage is reduced, and the heart safety is improved. On the other hand, when the valve prosthesis is nailed on the valve ring of the atrioventricular valve through the anchoring nail, the valve prosthesis is allowed to have a small axial height, and therefore the height of the valve prosthesis below the valve is reduced, and blocking of the valve prosthesis to blood entering the ventricular outflow tract is reduced.

A heart valve prosthesis for replacing a native atrioventricular valve of the heart. The prosthesis includes a housing component that is configured to be radially expandable and compressible between a radially compressed state and a radially expanded state to engage structure of the native atrioventricular valve to fix the housing component relative to the native atrioventricular valve. The housing component includes a housing body and an annular sealing element connected to an atrial end of the housing body. The annular sealing element is made of polyester and is reinforced with wire. A valve component is configured to be radially expandable and compressible between a radially compressed state and a radially expanded state within the housing component. The valve component includes a valve body having a valve passage extending therethrough and three leaflets made from pericardium secured to the valve body.

Apparatus for use with an annuloplasty ring (20), and an atrioventricular valve of a heart of a mammalian subject. A plurality of chord-manipulation arms (26) each include a flexible material and a stiffening element (70), the stiffening elements being configured to provide desired shapes to the chord-manipulation arms (26), when the chord-manipulation arms are disposed in non-radially constrained configurations. The chord-manipulation arms (26) are configured to be deployed among chords of the atrioventricular valve, and subsequently, to cause a size of the valve annulus to decrease, by the chord-manipulation arms (26) being rotated such as to twist the native atrioventricular valve and pull the native atrioventricular valve radially inwards. The stiffening elements (70) are configured to be removed from the flexible material of the chord-manipulation arms and / or de-stiffened, such as to facilitate removal of the chord-manipulation arms (26) from among the chords. Other applications are also described.

The invention discloses a guiding sheath tube and a transcatheter atrioventricular valve repair system. The guiding sheath tube comprises a sheath tube body and an operating handle. The sheathing canal body comprises a main body section, a far-end section and a bending adjusting section located between the main body section and the far-end section, and the bending adjusting section comprises a first controllable section and a second controllable section which can be driven to bend. The operating handle comprises a first driving mechanism, a second driving mechanism and a third driving mechanism, the first driving mechanism is used for driving the first controllable section to bend, the second driving mechanism is used for driving the second controllable section to bend, and the third driving mechanism is used for driving the sheathing canal body to rotate. The guide sheath tube and the transcatheter atrioventricular valve repair system are flexible in operation and more suitable for complex atrioventricular valve repair operations.

The invention provides a valve replacement system which is used for replacing a native atrioventricular valve and comprises a butt joint device, an anchoring device and a valve prosthesis. The docking device is configured to be positioned through the anchoring and locking device and provide an accommodating cavity; the anchoring and locking device comprises a plurality of anchoring pieces, a plurality of locking pieces and a plurality of flexible linear pieces, wherein the number of the locking pieces is the same as that of the anchoring pieces, and the number of the flexible linear pieces is the same as that of the anchoring pieces. In the deployment completion state, one end of a linear piece is correspondingly and fixedly connected with an anchoring piece, and the other end of the linear piece penetrates through the butt joint device and then is correspondingly and fixedly connected with a locking piece; at least one anchoring piece is anchored into ventricular tissue, and at least another anchoring piece is anchored into annulus tissue or atrial tissue; the linear piece is tensioned by the anchoring piece and the locking piece which are correspondingly located on the two opposite sides of the butt-joint device, so that the butt-joint device is pressed against the native valve ring to be positioned; the valve prosthesis is arranged in the containing cavity of the butt joint device in a penetrating mode and is reliably fixed by the butt joint device.

A method for treating a patient includes delivering a distal portion of an elongate medical device into a ventricle of a beating closed heart of a subject via a primary skin opening and a secondary puncture, utilizing the distal portion of the elongate medical device to engage a plurality of chordae tendineae extending from a first papillary muscle within the ventricle, at least a first one of the plurality of chordae tendineae attached to a first leaflet of an atrioventricular valve located between the ventricle and an adjacent atrium, and at least a second one of the plurality of chordae tendineae attached to a second leaflet of the atrioventricular valve, approximating the engaged plurality of chordae tendineae to increase an amount of closure possible between the first leaflet and the second leaflet, and locking the plurality of chordae tendineae in their approximated condition.

The application discloses a transcatheter atrioventricular valve treatment system comprising a valve repair device and a delivery device, the delivery device comprising a delivery catheter for delivering at least a portion of the valve repair device to or near an atrioventricular valve and an operating handle for controlling the delivery catheter, the delivery device also includes a fluid management system including a pressure monitoring channel disposed within the delivery catheter and extending therethrough from a proximal end to a distal end of the delivery catheter. According to the transcatheter atrioventricular valve treatment system, when the conveying catheter reaches the ventricle, the pressure of the ventricle can be monitored through the external pressure sensor, the pressure of the atrium can also be monitored when the conveying catheter passes through the heart part such as the atrium, more independent and accurate monitoring is provided through the pressure monitoring channel, and the treatment effect of the transcatheter atrioventricular valve treatment system is improved. And the influence of other fluid channels is avoided.

A method for treating a patient includes delivering a distal portion of an elongate medical device into a ventricle of a beating closed heart of a subject via a primary skin opening and a secondary puncture, utilizing the distal portion of the elongate medical device to engage a plurality of chordae tendineae extending from a first papillary muscle within the ventricle, at least a first one of the plurality of chordae tendineae attached to a first leaflet of an atrioventricular valve located between the ventricle and an adjacent atrium, and at least a second one of the plurality of chordae tendineae attached to a second leaflet of the atrioventricular valve, approximating the engaged plurality of chordae tendineae to increase an amount of closure possible between the first leaflet and the second leaflet, and locking the plurality of chordae tendineae in their approximated condition.

A method and apparatus for treatment of hypertension and heart failure by increasing vagal tone and secretion of endogenous atrial hormones by excitory pacing of the heart atria. Atrial pacing is done during the ventricular refractory period resulting in atrial contraction against closed AV valves, and atrial contraction rate that is higher than the ventricular contraction rate. Pacing results in the increased atrial wall stress. An implantable device is used to monitor ECG and pace the atria in a nonphysiologic manner.

Method and apparatus for treating prolapse of an atrioventricular valve. An implant (30) is delivered by catheter (32) into the heart, the implant configured to attach to a native chordae tendineae (20) and to shorten the functional length of the native chordae tendineae.

Devices and methods for reducing atrioventricular heart valve regurgitation. Some implementations include a compressible and expandable spacer with a proximal end and a distal end and sized to fit within coapt against the leaflets of the atrioventricular valve to reduce regurgitation therebetween. The spacer has a compressed delivery configuration and a radially expanded implant configuration. Supra-annular anchoring arms connect to the proximal end of the spacer via a malleable central mount extending axially from the spacer. The anchoring arms extend outward from a proximal end of the central mount sufficiently far to reach the atrioventricular annulus. Each anchoring arm terminates in a tissue anchor, wherein the central mount has one or more plastically-deformable components such that a position of the spacer relative to the atrioventricular annulus may be adjusted from leaflet contact therewith.

The present invention discloses a method for quantitatively measuring the volume of atrioventricular valve regurgitation by M-mode PISA. Three target cardiac ultrasound images are received, the first image is the continuous wave Doppler spectral image of the atrioventricular valve regurgitation jet, the second image is the M-mode PISA color image, and the third image is the M-mode PISA grayscale image. The time curve of the PISA radius is obtained from the second and third images, and the value r of the PISA radius at each time point is calculated. (t) , the velocity-time curve of the regurgitation jet is obtained from the first image, and the velocity V at each time point is calculated. (t) , the aliasing velocity V is extracted from the metadata of the target cardiac ultrasound image. a , the instantaneous flow rate, total regurgitation volume, regurgitation orifice area at each time point, and average regurgitation orifice area are calculated. By automatically tracing the M-mode PISA contour and the continuous wave Doppler boundary of the regurgitation jet and calculating the total regurgitation volume, it can assist doctors in quickly and accurately quantifying the severity of atrioventricular valve regurgitation.

Method and apparatus for treating prolapse of an atrioventricular valve. An implant (30) is delivered by catheter (32) into the heart, the implant configured to attach to a native chordae tendineae (20) and to shorten the functional length of the native chordae tendineae.

A heart valve prosthesis for replacing a native atrioventricular valve of the heart. The prosthesis includes a housing component that is configured to be radially expandable and compressible between a radially compressed state and a radially expanded state to engage structure of the native atrioventricular valve. The housing component includes a housing body. A valve component is configured to be radially expandable and compressible between a radially compressed state and a radially expanded state within the housing component. The valve component includes a valve body. The valve body has an atrial end that protrudes beyond an atrial end of the housing body and has a diameter that is greater than a diameter of a ventricular end of the valve body such that the atrial end of the valve body expands into an atrium of the heart.

An assembly for the tricuspid orifice of a human heart has an external frame connected to an internal stent carrying a tricuspid valve bioprosthesis and a sealing skirt. The external frame is configured to hold its position in the native tricuspid annulus. The internal stent is connected to the external frame by one or more fixing strands. The sealing skirt covers the interstitial space existing between the external frame and the internal stent. Developments are described which include the use of a deformable region of the frame, various alternative embodiments of the sealing skirt, the use of a frame composed of multiple sub-sections, the use of fixing strands between the stent and the frame and of fixing elements for fixing the assembly to the native tissue, the use of sensors and / or actuators, and also the use of a stent in the inferior vena cava. Method aspects are also described.

A system for replacing the function of a native atrioventricular valve includes a prosthetic heart valve and a steerable delivery catheter. A capsule or sheath is provided along a distal end portion of the delivery catheter to maintain the prosthetic heart valve in a compressed state during advancement through the vascular system. A tether assembly includes an attachment tether adapted to extend through the delivery catheter and pass through an opening in the prosthetic heart valve. A release assembly includes a release tether for securing the attachment tether to the prosthetic heart valve. The release tether is retractable to detach the attachment tether from the prosthetic heart valve. The prosthetic heart valve can be released from the capsule and, while attached to the tether assembly, can expand and operate as a one-way valve. The prosthetic heart valve can then be detached from the tether assembly after confirming proper deployment.

Method and apparatus for treating prolapse of an atrioventricular valve. An implant (30) is delivered by catheter (32) into the heart, the implant configured to attach to a native chordae tendineae (20) and to shorten the functional length of the native chordae tendineae.

Devices for anchoring catheter systems, such as an atrioventricular heart valve regurgitation reduction system with a coapting element or spacer positioned within the atrioventricular valve leaflets. The spacer may be anchored above the atrioventricular valve with a rail that extends up into the subclavian vein, with tethers that attach to anchors around the annulus, or with a tether that connects to a stent expanded within an adjacent blood flow passage. The spacer may also be anchored below the atrioventricular valve with a rail that terminates in a tissue anchor within the ventricle, with tethers that attach to anchors around ventricle, or with a tether that connects to a stent expanded within an adjacent blood flow passage. The spacer may also be stabilized by a harness extending across the valve annulus or may be self-anchoring with an array of struts that extend into contact with the surrounding tissue.