62 results about "Right heart" patented technology

A catheter includes a catheter body, a pump assembly and a cannula. The pump assembly can be disposed at a distal end of the catheter body and has a distal portion. The cannula can be coupled to the distal end portion of the pump assembly and can include a proximal cannula portion and a distal cannula portion. The distal cannula portion has an approximately helical shape which can allow the cannula to be inserted into a patient's right heart and pump blood therethrough. In certain implementations, the distal tip of the helical shape has a slight bias relative to the main helix to further facilitate delivery of the device. In certain applications this bias is toward the central axis of the helix.

The invention discloses a method for noninvasive diagnosis of pulmonary arterial hypertension and a related device, and relates to the technical field of artery detection.The method comprises the steps that an echocardiogram result and right heart catheter pulmonary artery pressure data of a suspected pulmonary artery patient are obtained; the echocardiogram result is a tricuspid regurgitation spectrum; grading the quality of the tricuspid regurgitation spectrum based on a TR spectrum quality grading standard according to the regurgitation spectrum missing degree of the tricuspid regurgitation spectrum; according to the echocardiogram result and the right heart duct pulmonary artery pressure data, on the basis of the quality grading result of the tricuspid regurgitation spectrum, a personalized pulmonary artery hypertension diagnosis model suitable for different patients is constructed; according to the pulmonary arterial hypertension diagnosis model, on the basis of the echocardiogram result of the target pulmonary arterial patient, a pulmonary arterial hypertension diagnosis result of the target pulmonary arterial patient is obtained, and personalized accurate diagnosis can be carried out on different pulmonary arterial hypertension patients under the noninvasive condition.

The invention discloses a method for controlling the compaction degree of a left heart and a right heart in an extracorporeal circulation operation, which comprises the following steps of: in an in-vitro environment, mounting a peristaltic pump at a left heart inlet and a right heart inlet of an extracorporeal circulation device; a liquid inlet of the peristaltic pump is connected with a liquid inlet pump, and a liquid outlet of the peristaltic pump is connected with a liquid outlet pump; and finally, a first pressure measuring structure and a second pressure measuring structure are arranged on the sides, away from the peristaltic pump, of the liquid inlet pump and the liquid outlet pump correspondingly, and the pressure of the liquid inlet pump and the pressure of the liquid outlet pump are adjusted to be-20 mmHg. The negative pressure of the liquid inlet pump is adjusted through the first pressure measuring structure, and the negative pressure of the liquid outlet pump is adjusted through the second pressure measuring structure, so that the purpose of quantifying the adjusting mode is achieved, and the adjusting mode is accurate, rapid and high in reliability; the peristaltic pump can effectively avoid the occurrence of risks such as blood component damage, hemolysis, gas embolism and the like caused by reduction of the amount of blood conveyed by the pump, insufficient blood supply or direct interruption of blood circulation due to the condition that a pipe body connected with the peristaltic pump is shrunken or cannot be sucked during an operation.

The invention discloses a method for controlling left and right heart compaction degree before extracorporeal circulation operation, which comprises the following steps of: installing a peristaltic pump at a left and right heart inlet of an extracorporeal circulation device in an in-vitro environment; a liquid inlet of the peristaltic pump is connected with a liquid inlet pump, and a liquid outlet of the peristaltic pump is connected with a liquid outlet pump; and finally, a first pressure measuring structure and a second pressure measuring structure are arranged on the sides, away from the peristaltic pump, of the liquid inlet pump and the liquid outlet pump correspondingly, and the pressure of the liquid inlet pump and the pressure of the liquid outlet pump are adjusted to be-180 mmHg. The negative pressure of the liquid inlet pump is adjusted through the first pressure measuring structure, and the negative pressure of the liquid outlet pump is adjusted through the second pressure measuring structure, so that the purpose of quantifying the adjusting mode is achieved, the adjusting process for controlling the left and right heart compression degree before the extracorporeal circulation operation is visualized, the adjusting result is converted into the specific negative pressure values of the liquid inlet pump and the liquid outlet pump, and the accuracy of the operation is improved. The pressing degree reference for adjusting the left center and the right center is numeralized and standardized, the adjusting difference is avoided, experience and feeling are not needed, and the adjusting mode is fast and high in accuracy.

The invention belongs to the technical field of medicines, and discloses an application of a small molecule compound in preparation of a product for preventing and / or treating pulmonary arterial hypertension and complications thereof. The small molecule compound is 8-[[4-(cyclopropanecarbonyl) piperazine-1-yl] methyl]-1, 3-dimethyl-7-(3-methylbutyl) purine-2, 6-diketone, and the structural formula is as shown in a formula (I): # imgabs0. The small molecule compound and pharmaceutically acceptable salts thereof have a remarkable treatment effect on pulmonary arterial hypertension and complications thereof, and can be used for treating pulmonary arterial hypertension and complications thereof. The effects of preventing and / or treating the pulmonary arterial hypertension include the reduction of right heart hypertrophy, the reduction of right ventricular systolic pressure, right heart enlargement, right heart dysfunction, pulmonary vascular remodeling, pulmonary arterial intima thickness, increase of vascular myelization, pulmonary arterial smooth muscle cell proliferation and migration, the reduction of the right ventricular hypertrophy, the reduction of the right ventricular hypertrophy, the reduction of the right ventricular hypertrophy and the reduction of the right ventricular hypertrophy. The pulmonary arterial intima thickness and the vascular myelization level are improved, pulmonary vascular remodeling is reversed, and pulmonary artery smooth muscle cell proliferation and migration are inhibited.

The invention provides an automatic counting method and system for ultrasonic microbubbles in right heart acoustic radiography. The method comprises the following steps: acquiring a cardiac radiography image of a patient through high-resolution ultrasonic equipment; extracting a region of interest of the cardiac angiography image based on the cardiac vascular structure, and performing image registration operation on the cardiac angiography image by taking the region of interest as a reference point to obtain a registered image; carrying out pixel-by-pixel addition on two frames of pulse images with opposite phases in the registered image to obtain an enhanced image; determining the high-echo bright spots in the enhanced image as suspected microbubbles, and performing denoising processing according to the feature similarity to obtain real microbubbles; judging pathological conditions according to whether real microbubbles exist in the left atrium or not; if the real microbubbles exist in the left atrium, grading the abnormal blood flow according to the change data of the microbubbles in the left atrium and the right atrium. According to the method, through high-precision image registration, multi-modal feature analysis and dynamic parameter fusion technologies, the microbubble detection accuracy is improved, and quantitative grading of pathological conditions is achieved.

The invention belongs to the technical field of medicines, and discloses application of WZ3146 in preparation of products for preventing and / or treating pulmonary arterial hypertension and complications thereof. The WZ3146 and the pharmaceutically acceptable salt thereof have a remarkable treatment effect on pulmonary arterial hypertension and complications thereof, such as mean pulmonary arterial pressure, high right ventricular systolic pressure, right heart enlargement, right heart dysfunction, pulmonary vascular remodeling, pulmonary arterial intima thickness, increase of vascular myelization, pulmonary artery smooth muscle cell proliferation and migration and the like; the effects of preventing and / or treating pulmonary arterial hypertension comprise expanding the right heart, improving the pulmonary arterial intima thickness and the vascular myelization level, reversing pulmonary vascular remodeling and inhibiting pulmonary artery smooth muscle cell proliferation and migration.

The invention discloses a blood leakage rate measuring device and method and a clinical actual blood flow obtaining method. The blood leakage rate measuring device comprises a right heart simulator filled with liquid and a pulmonary artery simulator, a second pressure sensor and a first pressure sensor are installed at the bottom in the right heart simulator and the pulmonary artery simulator, the right heart simulator is communicated with the pulmonary artery simulator through a first pipeline and a second pipeline, and an auxiliary pump is installed on the first pipeline. The right heart auxiliary catheter penetrates through the right heart simulator, the valve assembly is arranged in liquid in the right heart simulator, the end cap is arranged in liquid in the pulmonary artery simulator, a second flow sensor is installed on the outer wall of the short tube part between the right heart simulator and the pulmonary artery simulator, and a first flow sensor is installed on the outer wall of the long tube part close to the extracorporeal membrane type cavity. According to the clinical actual blood flow obtaining method, the actual blood flow of the right heart auxiliary catheter can be accurately obtained through the obtained blood leakage rate.

The invention belongs to the technical field of medical ultrasonic diagnosis auxiliary equipment, and discloses an electric right heart acoustic radiography foaming device which comprises a device body, the device body comprises a base, a mounting plate is fixedly arranged on the rear side of the base, a driving assembly is arranged on the front side of the mounting plate, and the driving assembly comprises fixing frames fixed to the upper side and the right side of the mounting plate; a stepping motor is fixedly arranged at the top of the fixing frame, a ball screw is fixedly arranged at the tail end of a main shaft of the stepping motor, a sliding block is spirally arranged on the outer side of the ball screw in a sleeving mode, and a connecting rod is fixedly arranged at the bottom of the sliding block, so that accurate controllability of power transmission and visual adjustment of parameters in the contrast agent injection process are achieved; specifically, key parameters such as injection speed and dosage can be accurately set through the operation panel, a traditional manual injection mode is replaced, and the stability of the foaming effect of the contrast agent is guaranteed.

The invention relates to the technical field of medical instruments, in particular to an intelligent catheter implanted right heart blood flow management system, a blood pumping impeller comprises a hub structure and a blade assembly fixed around the hub structure, and the near end of a hub is an annular concave curved surface used for guiding blood flow; the blade assembly comprises two symmetrical continuous blades with the same thickness, and the placement angles of the blades are gradually increased from the near end to the far end. The design structure that the segmented hub and the continuous blades are combined is adopted, all segments of the hub structure have different geometrical characteristics, the molded line of each continuous blade is formed by combining an arc and a straight line, and the design of a gradually-increased setting angle and a large wrap angle is matched with the design of a parabola at the far end of the hub, so that the shear stress and the flow dead zone are reduced, and the service life of the impeller is prolonged. Therefore, the risks of hemolysis and thrombus are reduced, the blood flow path is optimized under the miniaturized condition, the catheter implantation type miniature axial flow blood pump is more suitable for the blood flow flowing characteristic in the catheter implantation type miniature axial flow blood pump, and smooth transition from radial inflow to axial outflow of blood can be achieved.

The invention belongs to the technical field of medical treatment, particularly discloses an application of allicin in preparation of a medicine for improving right heart dysfunction caused by pulmonary arterial hypertension, and discloses an effect of the allicin in treatment of the right heart dysfunction caused by the pulmonary arterial hypertension. Compared with existing medicines (mainly for reducing pulmonary arterial pressure) for treating pulmonary arterial hypertension, allicin not only can reduce the pulmonary arterial pressure and relieve the symptoms of pulmonary arterial hypertension, but also can remarkably improve right heart dysfunction caused by pulmonary arterial hypertension, and the allicin is specifically shown as follows: (a) average pulmonary arterial pressure, pulmonary artery ejection time and pulmonary artery end diastolic inner diameter are reduced; the pulmonary artery acceleration time is prolonged; (b) the right ventricular systolic pressure, the right ventricular end-of-systolic free wall thickness, the right ventricular end-of-systolic free wall thickness, the right ventricular end-of-systolic inner diameter and the right heart hypertrophy index are reduced, and tricuspid valve displacement, stroke output and right heart discharge are increased; and (c) improving right ventricular and pulmonary vascular remodeling.

The invention discloses a pulmonary arterial hypertension recognition device and method based on multiple paths of electrocardio heart sound signals, and relates to the technical field of biomedicine, and the method comprises the steps: limiting an aortic valve closing candidate peak and a drop point of a pulmonary valve closing candidate peak in a time interval between a main peak anchor point time boundary of a double-anchoring split fragment set and an electrocardio fragment key turning point; adjacent beat backtracking replacement and multi-channel consistent voting retention are performed on candidate peaks of cross-beat hopping, and a physiological consistent split fragment set is generated; and according to the physiological consistency split fragment set, converging split sequences of multiple paths of heart sounds, and carrying out beat-level splicing and in-window consistency closing on the split sequences and right heart load related form entries of multiple paths of electrocardio, so as to generate a pulmonary arterial hypertension recognition and diagnosis set. According to the method, high-precision synchronization of multiple paths of electrocardiogram and heart sound signals is realized, equipment difference and noise interference are eliminated, the reliability of feature extraction is guaranteed, and the pulmonary arterial hypertension recognition stability is improved.

The foldable blood pump for right heart assistance is small in intervention size, large in flow and small in blood damage and comprises an expandable and contractible pumping assembly, the near end of the pumping assembly is connected with an in-vitro driving unit through a flexible transmission unit, the pumping assembly comprises a foldable impeller and an expandable shell arranged on the periphery of the foldable impeller in a covering mode, and the expandable shell is connected with the foldable impeller. The thin film extends from the middle section of the expandable shell to the far side and extends to the catheter outside the expandable shell, the near section of the expandable shell forms a blood inflow port, and a blood outflow port is formed in the far end of the thin film. The impeller is of a foldable structure, large flow can be obtained at a low rotating speed, damage to cells in blood caused by too large rotating speed is reduced, the motor is externally arranged, and the temperature rise and fault risks of motor operation are effectively avoided. Meanwhile, an interventional artery passage is straight and short, abrasion and vibration of the shaft sleeve caused by bending of the flexible shaft are greatly reduced, power loss is reduced, power transmission efficiency is greatly improved, and controllability of the motor to the impeller and stability of power transmission are also improved.

The invention discloses application of scopalactone in treatment of pulmonary arterial hypertension, and relates to the technical field of medicinal chemistry. The scoparone is applied to preparation of the medicine for treating pulmonary arterial hypertension. The medicine comprises scopalactone, a pharmaceutically acceptable carrier, a diluent and an excipient, the medicine further comprises other medicines for treating the pulmonary arterial hypertension, and the other medicines for treating the pulmonary arterial hypertension are selected from a prostacyclin medicine, an endothelin receptor antagonist and a phosphodiesterase-5 inhibitor. The scopalactone is applied to preparation of the medicine for treating pulmonary arterial hypertension, right heart insufficiency caused by hypoxia can be remarkably reversed, and the right heart function is effectively improved by reducing the transverse diameter of the right ventricle and the transverse diameter of the right atrium and improving the indexes such as tricuspid valve ring plane contraction displacement; the average pulmonary arterial pressure and right ventricular systolic pressure can be obviously reduced, and hemodynamic parameters are improved; the area and thickness of a blood vessel wall can be remarkably reduced, the blood vessel structure is improved, and pulmonary arteriole reconstruction is relieved.

This invention discloses a method for controlling left and right ventricular compression before extracorporeal circulation. First, in an in vitro environment, peristaltic pumps are installed at the left and right ventricular inlets of the extracorporeal circulation device. Then, an inlet pump is connected to the inlet of the peristaltic pumps, and an outlet pump is connected to the outlet of the peristaltic pumps. Finally, a first pressure measuring structure and a second pressure measuring structure are respectively installed on the side of the inlet and outlet pumps away from the peristaltic pumps, and the pressure of both the inlet and outlet pumps is adjusted to -180 mmHg. The negative pressure of the inlet pump is adjusted by the first pressure measuring structure, and the negative pressure of the outlet pump is adjusted by the second pressure measuring structure, thereby quantifying the adjustment method. This visualizes the process of controlling left and right ventricular compression before extracorporeal circulation, converting the adjustment results into specific negative pressure values ​​for the inlet and outlet pumps. This makes the reference values ​​for adjusting left and right ventricular compression numerically and standardized, avoiding adjustment discrepancies, eliminating reliance on experience and intuition, and providing a quick and highly accurate adjustment method.

An apparatus (100), system and method for automated execution of a bubble test. The apparatus (100) comprises a container (110) for accommodating normal saline, a pipeline (120), a first syringe (160), a second syringe (170), a first valve (130), a second valve (140), and a third valve (100). By using the apparatus (100) to perform the bubble test, the accuracy of the results of the bubble test can be improved while the time for the bubble test is shortened. When the apparatus (100) is used to perform a right heart contrast test, the apparatus (100) can automatically draw normal saline, blood, and air, and the preparation and injection of a contrast agent are automatically carried out by means of the repeated pushing and pulling of the first syringe (160) and the second syringe (170). When the apparatus (100) is used to perform a left heart contrast test, normal saline and a left heart contrast agent can be manually or automatically mixed, then the contrast agent is uniformly mixed by using a uniform mixing apparatus or the left heart contrast agent is uniformly mixed by means of the repeated pushing and pulling of the first syringe (160) and the second syringe (170), so as to form microbubbles, and finally, the microbubble contrast agent is injected into a human body. The apparatus (100) can be used to perform not only the right heart contrast test but also the left heart contrast test, thereby greatly improving the utilization rate of the apparatus.

The present invention discloses a positioning device and method for a right heart catheterization pressure measurement transducer, belonging to the inspection and pressure measurement of right heart catheters in the technical field of electrocardiogram detection. The purpose is to solve the technical problems of cumbersome positioning and low positioning accuracy existing in the zero-point positioning of existing transducers. It includes: a bed surface, a mounting frame, a lifting lead screw, an RFID reader, a lower RFID tag, and an upper RFID tag; the RFID reader emits radio frequency signals, and the lower RFID tag and the upper RFID tag are activated and return response signals after receiving the signals; the RFID reader receives the response signals and calculates the distances between the lower RFID tag and the RFID reader, and between the upper RFID tag and the RFID reader respectively according to the time from sending the radio frequency signal to receiving the response signal, and calculates and determines the position of the fixing frame based on the distances between the RFID reader, the lower RFID tag, and the upper RFID tag pairwise. The entire positioning process only requires placing the RFID reader, greatly simplifying the procedure for zero-point positioning of the transducer, making the positioning process more convenient and with high positioning accuracy.

The invention relates to the technical field of medical equipment, and provides a right heart suction tube assembly. The right heart suction tube assembly comprises negative pressure equipment, a tube body, a diaphragm, a suction head, a first baffle and a second baffle. The tube body comprises a tube head end and a tube tail end; the interior of the tube body is divided into a first tube cavity and a second tube cavity by the diaphragm; the suction head is arranged at the tube head end; the first baffle is movably arranged in the first tube cavity, the first baffle comprises a first position and a second position, and when the right heart suction tube assembly works normally, the first baffle is located at the first position, and when the first baffle is located at the second position, the first baffle blocks the first tube cavity; the second baffle is movably arranged in the second tube cavity, the second baffle comprises a third position and a fourth position, and when the right heart suction tube assembly works normally, the second baffle is located at the third position, and when the second baffle is located at the fourth position, the second baffle blocks the second tube cavity. According to the right heart suction tube assembly, the phenomenon that the right heart suction tube assembly is completely blocked in an operation can be avoided.

A heart failure management system for a patient includes a plurality of sensors including at least one implantable pressure sensor positioned within the heart to capture synchronized left and right heart pressure waveforms, transmitted via one or more transmitters to a receiver. Control circuitry receives these waveforms and processes them using a machine learning medication dosage management model, trained on historical left and right heart pressure logs, volume status metrics (e.g., weight, fluid intake, symptoms), and / or ground truth dosage logs for certain heart failure treatment medications, such as a blood pressure reducing medication (e.g., ARNI) and an intravascular volume reducing medication (e.g., Lasix). The model can generate real-time dosage recommendations, systemic blood pressure, and volume load predictions in real-time, enabling precise, data-driven treatment adjustments aligned with clinical guidelines, supporting timely clinical decisions or automated medication dispensing to optimize patient outcomes and reduce hospitalization risks.

The invention relates to the technical field of medical treatment, and particularly discloses a classification detection system for lung cancer and pulmonary embolism, which is used for solving the problem that in the prior art, texture features related to lung cancer and pulmonary embolism are not extracted, and a model does not divide a focus area, so that an embolism position cannot be quickly found out when a film is read by using the model. According to the method, a healthy lung X-ray image set is acquired and summarized into a first lung image set, a lung cancer combined embolism lung X-ray image set is acquired and summarized into a second lung image set, embolism features are extracted according to the first lung image set and the second lung image set, and an embolism area is positioned and marked according to the embolism features; according to the method, extraction and analysis of the vascular sparseness and right cardiac shadow increase features are integrated, the embolism area is positioned in combination with machine learning, and the detection efficiency and accuracy of lung cancer combined pulmonary embolism are greatly improved.

According to one aspect of the disclosure, a method of advancing a delivery catheter to a heart of a patient includes advancing a guidewire through the vasculature of the patient until the guidewire reaches a target treatment site in or adjacent to the heart. A dilator may be positioned within the delivery catheter so that a distal tip of the dilator extends beyond a distal end of the delivery catheter. The dilator may be advanced through the vasculature of the patient directly over the guidewire while simultaneously advancing the delivery catheter through the vasculature until the distal tip of the dilator reaches the target treatment site. While maintaining the distal tip of the dilator substantially stationary relative to the target treatment site, the delivery catheter may be advanced over the dilator until the distal end of the delivery catheter is positioned at the target treatment site.

The invention discloses an endothelium targeted controlled-release antithrombotic drug intelligent monitoring biodegradable heart occluder, and relates to the field of medical instruments, the heart occluder comprises an occluder main body and a sheathing canal for regulating and controlling the occluder main body, the occluder main body is composed of a double-disc-shaped biological skeleton, a fixed deformation body and a biological flow blocking film, the double-disc-shaped biological skeleton is composed of two attaching discs which are mutually symmetrical to form a left center disc face and a right center disc face, a support outer disc is arranged on the side surfaces of the attaching discs in a surrounding mode, and a double-layer antithrombotic drug controlled release layer is arranged on the surface of the support outer disc; the two attaching plates are tightly connected with the fixed deformation body, an ultrasonic blood flow sensor is arranged in the fixed deformation body, an impedance sensor is arranged at the position, located on one side of the ultrasonic blood flow sensor, in the fixed deformation body, and the biological flow blocking films are arranged on the surfaces of the opposite sides of the two attaching plates respectively. The plugging device is periodically degraded in the body of a patient to reduce complications caused by foreign matter retention, and aiming at thrombus formation on the surface of the plugging device, middle and low doses of antithrombotic drugs are locally controlled, so that whole-body adverse reactions caused by long-term oral administration of the antithrombotic drugs after the plugging operation are reduced. Thrombus risk and occluder endothelialization process are dynamically monitored to assist in repair and regeneration of heart tissue.

The invention provides a right heart failure detection method and device.The method comprises the steps that a first pumping flow curve is obtained, and the first pumping flow curve is a pumping flow curve within a target period when a ventricular assist device operates at a target rotating speed; determining at least one target parameter according to the first pumping flow curve; and if the at least one target parameter meets the preset condition, determining that the right heart failure exists. The target parameters capable of measuring the state of the right heart are obtained from the pumping flow curve of the ventricular assist device implanted into the left heart in real time, whether the current ventricular assist device causes the right heart failure or not is determined through comparison, and real-time detection of the right heart failure is achieved.

The present invention discloses a device and method for accurately adjusting the compression tightness of the left and right hearts during extracorporeal circulation, and relates to the technical field of medical devices. The device for accurately adjusting the compression tightness of the left and right hearts during extracorporeal circulation comprises a first connector, a sterile saline bag, a first pipeline, a first flow stopper, a second connector, and a second pipeline; the first connector is suitable for being installed on the liquid inlet pipeline of a roller pump; the liquid outlet end of the sterile saline bag is connected to the first connector through the first pipeline; the first flow stopper is suitable for being arranged on the liquid inlet pipeline of the roller pump and clamping the blood inlet end of the first connector; the second connector is suitable for being installed on the liquid outlet pipeline of the roller pump, and the second connector is detachably connected to the pulmonary membrane through the second pipeline; the second flow stopper is suitable for being arranged on the liquid outlet pipeline of the roller pump and clamping the bleeding end of the second connector. The present invention provides a device and method for accurately adjusting the compression tightness of the left and right hearts during extracorporeal circulation, which greatly improves the accuracy and convenience of adjusting the compression tightness of the left and right hearts during extracorporeal circulation.

The application discloses a pulmonary arterial hypertension recognition device and method based on multiple ECG and PCG signals, and relates to the technical field of biomedicine. The device comprises the following steps: limiting the landing points of the aortic valve closing candidate peak and the pulmonary valve closing candidate peak in the main peak anchor point time boundary and the ECG segment key turning point time interval of the double-anchored split segment set, performing adjacent beat backtracking replacement and multi-channel consistent voting reservation on the candidate peak of the cross-beat jump, and generating a physiological consistency split segment set; according to the physiological consistency split segment set, gathering the split sequence of the multiple PCGs, and performing beat-level splicing and window-in-consistency closure on the right heart load related morphological items of the multiple ECGs, and generating a pulmonary arterial hypertension recognition diagnosis set. The application realizes high-precision synchronization of multiple ECG and PCG signals, eliminates device differences and noise interference, guarantees the reliability of feature extraction, and improves the stability of pulmonary arterial hypertension recognition.

The present invention concerns the field of diagnostics. In particular. It relates to a method for assessing a heart valve disease or disorder comprising the steps of a) determining the amount of a BMPlO-type peptide in a sample of said subject, and b) comparing the amount determined in step a) to a reference, whereby the heart valve disease or disorder is assessed. Further, the invention concerns computer-implemented methods of the aforementioned methods as well as devices and kits for carrying out said methods. Yet, the present invention contemplates the general use of a BMPlO-type peptide in a sample of a subject or a detection agent for a BMPlO-type peptide to be applied in said sample for assessing a heart valve disease or disorder.

The invention relates to the technical field of medicines, and relates to application of licochalcone B as a Furin enzyme inhibitor. In particular to application of licochalcone B in preparation of drugs for preventing, relieving and / or treating diseases related to Furin enzyme activity increase. The application shows that the licochalcone B has a certain inhibition effect on Furin enzyme activity, has a good pharmacodynamic effect on hypoxia-induced pulmonary arterial hypertension and monocrotaline-induced pulmonary arterial hypertension, can obviously reduce right ventricular systolic pressure, improve right heart remodeling and pulmonary artery blood flow, inhibit pulmonary artery blood vessel remodeling, and can be used for treating pulmonary arterial hypertension. In addition, the Furinase signal channel in the lung tissue of the pulmonary arterial hypertension disease can be obviously reduced. Licochalcone B has good application and development prospects, and is an ideal compound for treating pulmonary arterial hypertension and complications thereof.

The invention provides a control method and device for a double-ventricle auxiliary system. The method comprises the following steps: acquiring a first parameter and a second parameter in a first period; adjusting the rotating speed of the first ventricular assist device or the second ventricular assist device according to the first parameter and the second parameter; acquiring a third parameter in a second period; and adjusting the rotating speed of the first ventricular assist device or the second ventricular assist device according to the third parameter, so that the cardiac function state of the target user is kept normal. The rotating speed of the ventricular assist device is adjusted according to the obtained physiological parameters of the user in the first period, so that the left ventricle of the user is in the normal operation state, and then the rotating speed of the ventricular assist device is adjusted by obtaining the adjusted physiological parameters of the user in the second period; the left heart and the right heart of the user are in a normal operation state, so that systemic circulation and pulmonary circulation of the user are kept balanced, the pumping effect of the double-ventricle auxiliary system is improved, and the heart failure symptom of the user is improved.

1. The name of the design product: silicone mold (heart double-pasted candle). 2. The use of the design product: silicone mold for making heart double-pasted candle by dripping glue. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: assembly 1 perspective view 1. 5. Other circumstances that need to be explained: in the design, component 1 is a left heart candle, and component 2 is a right heart candle.