66 results about "Spect imaging" patented technology

The invention discloses a time domain point-by-point imaging method, system and device for receiving and transmitting synthetic aperture sonar, and the method comprises the steps: calculating the synthetic aperture length and synthetic aperture time for any pixel in an imaging region; calculating the distance between the sonar and the pixel at the moment of transmitting the signal, and calculating the distance between the sonar and the pixel at the moment of receiving the signal to obtain an accurate two-way slant range process; calculating a reference echo signal corresponding to the pixel according to a two-way slant range process and related parameters of the signal; carrying out range-to-frequency domain conversion on the actually measured echo signal, carrying out range-to-frequency domain conversion on the reference echo signal, and carrying out conjugate multiplication processing on a conversion result; coherent accumulation is carried out on all conjugate multiplication results, and the result is used as an imaging result of the pixel; and for other pixels in the imaging area, repeatedly executing the steps to obtain imaging results of all pixels in the whole imaging area.

The invention relates to the technical field of small animal imaging, and particularly discloses a bimodal small animal molecular image imaging device which comprises a rack; the rotating bracket is rotationally mounted on the rack; the rotating assembly is installed on the rack and used for driving the rotating support to rotate relative to the rack; the CT imaging assembly is mounted on one side of the rotating bracket; the SPECT imaging assembly is installed on the other side of the rotating support, and the imaging center of the SPECT imaging assembly and the imaging center of the CT imaging assembly are coaxial with the rotating axis of the rotating support; the animal bed assembly is installed on the rack and used for bearing a small animal to be imaged and driving the small animal to be imaged to move towards or away from the rotating support along the rotating shaft of the rotating support; the method can effectively solve the problems of registration error, attenuation correction failure, image fusion quality reduction and quantitative analysis misalignment when the SPECT image and the CT image are fused due to alignment error of the SPECT imaging assembly and the CT imaging assembly.

Systems and techniques are described herein for foveated imaging. For instance, a method for foveated imaging is provided. The method may include determining a first region of interest within a first image based on a gaze of a user relative to the first image; clustering pixels of the first image into a one or more clusters of pixels based on a comparison of one or more characteristics of pixels of the first image; identifying a cluster of pixels from among the one or more clusters of pixels based on an intersection over union of the first region of interest and the cluster of pixels; generating a second region of interest based on the first region of interest and the cluster of pixels; and capturing a second image based on the second region of interest.

The invention provides a circuit board defect detection method and system based on deep learning, and the method comprises the steps: firstly obtaining a layered image set of a to-be-detected circuit board, which comprises a welding spot imaging layer, a line imaging layer and an element imaging layer; calling a pre-trained circuit board defect hierarchical detection model, inputting the hierarchical image set into a model defect pre-association layer, and generating a hierarchical defect association map which marks the position mapping relation of the same defect in different imaging layers; on the basis of the layered defect correlation map, extracting defect area exclusive features of each imaging layer to form a layered exclusive defect feature set, and inputting a model hierarchical feature enhancement layer to generate a hierarchical enhanced defect feature set. And finally, calling the model scene adaptive classification layer to carry out defect type matching, and generating a circuit board defect detection report containing defect types, hierarchical positions and association relationships in combination with the position mapping relationship, so that the circuit board defects can be comprehensively and accurately detected, and the detection efficiency and quality are improved.

Systems and techniques are described herein for foveated imaging. For instance, a method for foveated imaging is provided. The method may include determining a first region of interest within a first image based on a gaze of a user relative to the first image; clustering pixels of the first image into a one or more clusters of pixels based on a comparison of one or more characteristics of pixels of the first image; identifying a cluster of pixels from among the one or more clusters of pixels based on an intersection over union of the first region of interest and the cluster of pixels; generating a second region of interest based on the first region of interest and the cluster of pixels; and capturing a second image based on the second region of interest.

This application relates to a SPECT imaging system, imaging method, and SPECT imaging device. The SPECT imaging system includes multiple imaging modules and a data integration module. Each imaging module scans and images a local area of ​​the object under test, obtaining local imaging data. The data integration module is communicatively connected to the multiple imaging modules and integrates the multiple local imaging data to obtain a complete image. Each imaging module in this application can scan and image a local area of ​​the object under test, thereby obtaining corresponding local imaging data. Simultaneously, the data integration module integrates the multiple local imaging data to obtain a complete image. Since each imaging module includes a motion control unit and a probe, their scanning processes are relatively independent. When multiple areas need to be scanned, multiple imaging modules can perform scanning simultaneously, thus enabling parallel scanning of the object under test and improving scanning efficiency.

Compounds for targeting and agents for imaging, prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.

The application discloses a time-domain point-by-point imaging method, system and device of a transceiver combined synthetic aperture sonar, and the time-domain point-by-point imaging method comprises the following steps: for any pixel in an imaging area, calculating a synthetic aperture length and a synthetic aperture time; calculating a distance between a sonar at a signal transmitting time and the pixel, and calculating a distance between a sonar at a signal receiving time and the pixel to obtain an accurate two-way slant range history; according to the two-way slant range history and relevant parameters of the signal, calculating a reference echo signal corresponding to the pixel; performing distance domain transformation on a measured echo signal and a reference echo signal, and performing conjugate multiplication processing on the transformed results; coherently accumulating all the conjugate multiplication results as an imaging result of the pixel; and repeating the above steps for other pixels in the imaging area to obtain imaging results of all the pixels in the entire imaging area.

Optical system (21) for a metrology system (1) for measuring an object (2) in the form of a lithography mask, - with an object holder (14) for holding the object (2) in an object plane (13), - with a transmissive optical focusing component (11) arranged in the beam path of illumination light (4) between a light source (5) of the metrology system (1) and an object field (12) in the object plane (13), to generate an illumination focus (16) in the beam path of the illumination light (4) after the transmissive optical focusing component (11), - wherein the transmissive optical focusing component (11) has a focal length (f1) that is less than 5 mm, - with a detection device (6) for detecting the illumination light (4) in the beam path after the object field (12), - with an imaging optic (22) for imaging the illumination focus (16) generated by the transmissive optical focusing component (11) into a further illumination focus (16') in the area of ​​the object field (12).

Methods and systems are provided for calibrating a single photon emission computed tomography (SPECT) imaging system. In one example, a collimated line source for calibrating a SPECT system comprises a radioactive material aligned along a central axis of the collimated line source and a plurality of collimator plates arranged perpendicularly around the central axis, the collimator plates including a material that substantially absorbs photons striking the collimator plates. The collimator plates may absorb photons emitted by the radioactive material in non-perpendicular directions, which are not used for calibrating the SPECT imaging system, thereby reducing an amount of radiation released in an environment of the SPECT imaging system during calibration. Due to the reduced amount of radiation to which people in the environment are exposed, short time increments between patient examinations may be advantageously used to collect calibration data, reducing an overall amount of time used for calibration.

The invention discloses a myocardial amyloidosis quantitative analysis method based on SPECT imaging and related equipment, and relates to the field of wisdom medical device.The method comprises the steps that firstly, three-dimensional SPECT original data of N time phases of a target patient in the cardiac cycle are collected, a mu graph is generated based on low-dose CT for registration and attenuation correction, and a dynamic image is reconstructed; and then an MR structure sequence under synchronous electrocardio gating is obtained, and SPECT and MR space standardization and partial volume effect correction processing are completed. And unifying the cardiac cycle image form through affine and nonlinear transformation, and generating a high-quality enhanced SPECT image. Finally, radioactive counting information is extracted on the basis of three-dimensional segmentation, multiple myocardial quantitative indexes are calculated, comprehensive analysis of myocardial functions is achieved in combination with left ventricular functional parameters, and accurate image support is provided for non-invasive diagnosis and curative effect evaluation of myocardial amyloidosis.

The invention provides a novel FAPI trimer compound based on a GalNAc (N-acetylgalactosamine) link chain, a preparation method of the FAPI trimer compound, a developing agent based on the FAPI trimer compound and a preparation method of a developing agent. The trimerization structure in the FAPI trimer compound molecule provided by the invention can improve the in-vivo dynamic characteristics of the compound and prolong the residence time of the compound in tumors; the imaging agent based on the FAPI trimer compound can improve the uptake and imaging effects in tumors, and has good application prospects in PET / SPECT imaging, preparation of drugs for diagnosing tumors expressed by FAP-q and drugs for marking therapeutic nuclide (177Lu or 90Y) to treat tumors expressed by FAP-q in the future.

A method for relaxation time determination includes delivering a series of radio frequency (RF) pulses in a sequence to a specimen having a magnetic resonance spin system. The pulses are separated by equal time intervals and the sequence has a duration comparable or greater than a spin-lattice relaxation time for the spin system. The method includes receiving a response after each RF pulse in the series. The response includes a free induction decay and spin echoes. The method includes generating a series of single point imaging (SPI) images from each response. Each SPI image of the series corresponds to an RF pulse in the series. The method includes converting SPI images to a spin-spin relaxation map and a spin-lattice relaxation map.

An optical lens assembly for image capturing includes six lenses. The six lenses are sequentially arranged along an optical path from an object side to an image side as a first lens, a second lens, a third lens, a fourth lens, a fifth lens, and a sixth lens. The six lenses respectively have an object side surface facing the object side direction and an image side surface facing the image side direction. The first lens object side surface is concave at a vicinity of an optical axis, and the first lens image side surface is convex at the vicinity of the optical axis. The third lens image side surface is concave at the vicinity of the optical axis. The sixth lens object side surface is convex at the vicinity of the optical axis. The sixth lens image side surface is concave at the vicinity of the optical axis, and the sixth lens image side surface is aspherical and has at least one inflection point. The total number of lenses in the optical lens assembly for image capturing is six. When certain conditions are met, the optical lens assembly for image capturing can simultaneously meet the requirements of miniaturization and high imaging quality. An image capturing device having the optical lens assembly for image capturing and an electronic device having the image capturing device are also disclosed.

A system for low-count quantitative single-photon emission computed tomography (LC-QSPECT) is provided. The system is programmed to a) store a computer tomography (CT) scan of a subject being examining including a plurality of defined volumes of interest (VOIs) of the subject being examined; b) model a system matrix based on the stored CT, wherein the model describes the probability that photons emitted from each of the defined VOIs are detected in different projection bins, wherein a plurality of projection bins are defined around the subject and the defined VOIs; c) adjust the model with analysis of stray-radiation noise around the subject; d) detect, by the one or more sensors, one or more photons being emitted by an alpha-particle-emitting isotope; and e) execute the adjusted model with the one or more detected photons as inputs to determine a source VOI of the detected photons.

This invention provides a dual-aperture multi-pinhole collimator, comprising: a collimator plate; and multiple pinholes of two different apertures spaced apart on the collimator plate. During a single imaging process, radioactive rays passing through the imaging fields of different apertures simultaneously form corresponding and non-overlapping projection responses on the detector. Of the two apertures, the first aperture is smaller than the second aperture. The first aperture is determined based on the desired system spatial resolution, and the second aperture is determined based on the desired detection efficiency. This invention also proposes a SPECT imaging system based on the aforementioned multi-pinhole collimator. Its imaging module obtains imaging results from the data required for tomographic reconstruction using an improved MLEM iterative algorithm. The improved MLEM iterative algorithm introduces weighting factors into the original MLEM iterative algorithm, weighting the projection data of the dual-aperture pinholes and the corresponding system transmission matrix elements respectively. This invention improves detection sensitivity while maintaining spatial resolution.

The application discloses an imaging lens system, which comprises eight lenses, and the eight lenses are sequentially arranged from the object side to the image side as a first lens, a second lens, a third lens, a fourth lens, a fifth lens, a sixth lens, a seventh lens and an eighth lens. The eight lenses respectively have an object side surface facing the object side direction and an image side surface facing the image side direction. The first lens has positive refractive power. The second lens has negative refractive power. At least one surface of at least one lens in the imaging lens system has at least one inflection point. The total number of the lenses in the imaging lens system is eight. When certain conditions are met, the imaging lens system can simultaneously meet the requirements of a large aperture and miniaturization.

This invention provides a label-free live cell screening system and method based on droplet microfluidics. The system includes: a microfluidic chip with fluorescence signal monitoring sites, imaging sites, and sorting sites; a fluorescence detection unit configured to excite and acquire fluorescence signals at the fluorescence signal monitoring sites; an imaging unit configured to acquire images of droplets at the imaging sites; a sorting unit configured to sort droplets encapsulating target cells at the sorting sites; and a signal processor that, when a droplet is detected passing through the fluorescence signal monitoring site based on the fluorescence signal, triggers the imaging unit to acquire images of the droplet at the imaging site; and when the signal processor determines, based on image analysis, that the droplet encapsulates a target cell, triggers the sorting unit to sort the droplet encapsulating the target cell at the sorting site. This invention utilizes fluorescence signals to monitor droplets, improving monitoring efficiency and accuracy, thereby significantly increasing the precision and throughput of droplet sorting.

The utility model relates to a lens focusing mechanism and a panel detection device, the lens focusing mechanism comprises a fixed seat, a lens module and a transmission assembly, the lens module is telescopically arranged on the fixed seat; the transmission assembly comprises a first gear and a plurality of second gears, the plurality of second gears are simultaneously engaged with the same tooth groove of the first gear, the installation directions of two adjacent second gears are opposite, the first gear is fixed on the lens module, and in the rotation process of the first gear, the first gear can drive the lens module to stretch out and draw back relative to the fixed seat. According to the lens focusing mechanism provided by the invention, the meshing gap between the second gear and the first gear can be adjusted to be small, the rotation adjustment precision of the first gear is improved, the telescopic distance of the lens module is finely adjusted, and the imaging quality of the lens module for each point of the measured workpiece is further ensured.

A detector for an SPECT imaging system, an SPECT probe, and an imaging system and method. The detector comprises: an SiPM detector array (1-2), a CsI crystal array (1-1), and a preprocessing circuit board (1-3). The CsI crystal array (1-1) comprises a plurality of strip-shaped crystals (3-1); each strip-shaped crystal (3-1) comprises at least one crystal light exit surface (3-2); and one crystal light exit surface (3-2) of each strip-shaped crystal (3-1) is coupled to the SiPM detector array (1-2). An electrical signal of each SiPM detector pixel (2-3) in the SiPM detector array (1-2) is independently outputted by means of a detector base plate (2-4) in the SiPM detector array (1-2). The preprocessing circuit board (1-3) combines electrical signals of all SiPM detector pixels (2-3) and outputs a number of signals equal to or fewer than the number of the SiPM detector pixels (2-3).

A method for calibrating the target pointing error of a multimode composite tracking and aiming system includes: (1) setting up an autocollimator in front of the multimode optical system and the field of view of the visible light camera, calibrating the multimode optical system and marking the zero point of the visible light camera; (2) placing a target at the maximum measurement distance of the multimode optical system and marking the position of the camera zero point in the target target; then rotating the azimuth and pitch axes of the high-precision turntable to zero, reading the imaging position of the laser emission point, and recording the system deviation of the target pointing; (3) controlling the azimuth and pitch axes of the high-precision turntable to swing to different angles, and measuring the deviation value between the tracking point of the visible light camera and the imaging position of the target laser illumination point; (4) substituting the measured value into the error calculation formula including the mirror installation deviation to form a multivariate equation system, solving for the mirror installation error of the multimode composite tracking and aiming system, and then combining the swing angles of the azimuth and pitch axes of the high-precision turntable to calculate the corresponding deviation value. The method of this invention can accurately calibrate the target pointing error of the multimode composite tracking and aiming system.

The application discloses an image processing method based on compensation of dynamic SPECT imaging information deviation, which comprises the following steps: acquiring a first projection image dynamically collected by a double-probe SPECT camera, extracting effective radioactivity counts of a target organ, analyzing information continuity and consistency according to dynamic frames and rotation angles to obtain information quality parameters, determining dynamic frames and probe rotation angles with information defects based on the information quality parameters and a preset threshold, generating a first reconstructed image by using effective radioactivity counts of non-defect angles, and then obtaining a second projection image by using the first reconstructed image to compensate for defect angles. The image processing method based on compensation of dynamic SPECT imaging information deviation can repair information defects in the projection image, improve SPECT image quality and subsequent analysis accuracy, and provide reliable image data support for medical diagnosis.

An RGD polypeptide-containing composition and use thereof. The composition contains 1-3 parts by weight of a compound of formula I, 50-200 parts by weight of TPPTS, 2-250 parts by weight of Tricine, and a succinate buffer system, and the amount of the succinate buffer system is such that the pH of the composition is 4.0-7.0. The composition has excellent integrity and stability, and can be used for preparing SPECT imaging agents for tumor diagnosis.

The invention provides a measurement system for infinitesimal displacement, and the system comprises a laser transmitting module which is used for transmitting an original laser beam; the light beam shaping module is used for shaping the original laser beam and outputting a vortex light beam and a plane wave reference light beam; the focusing module is used for superposing the vortex light beam and the plane wave reference light beam to construct a measurement focal field, and the measurement focal field comprises a longitudinal optical singular point; the imaging acquisition module is used for acquiring a real image of a longitudinal optical singular point in a measurement focal field; and the data processing module is electrically connected with the imaging acquisition module and is used for determining the displacement of the focusing module according to the real image. The unique advantages that the spatial scale of a longitudinal optical singular point is infinitely small and the phase gradient is steep are fully utilized, optical diffraction limit restriction caused by the fact that a traditional optical metering method depends on a structured light field or an interference effect is avoided, and the precision of a displacement reference datum is improved.

The invention discloses a star point imaging quality evaluation method, which comprises the following steps of: installing imaging equipment in a test environment, performing star point imaging to obtain a test image, and calculating standard values of a circle fitting degree score and an energy concentration degree score by using a qualified star point image or a newly collected star point image; calculating a circle fitting degree score and an energy concentration degree score of the test image, comparing the scores with a standard value, if the scores are both greater than the standard value, determining that the test star point image is qualified, otherwise, determining that the test star point image is unqualified; according to the method, the indexes of the circle fitting degree score and the energy concentration degree score are calculated from the dimensions of the shape and the brightness and compared with the indexes of the qualified image, the evaluation conclusion of the image to be detected is obtained, and the difference of subjective evaluation is avoided.

The invention relates to the technical field of SPECT image reconstruction, and particularly provides a multi-bed SPECT image reconstruction method, electronic equipment and a storage medium, the method comprises the following steps: obtaining multi-bed projection data of an SPECT imaging system, the multi-bed projection data comprises projection data sets corresponding to different beds, each projection data set comprises a plurality of two-dimensional projection images, and each projection data set comprises a plurality of two-dimensional projection images; each two-dimensional projection image corresponds to a detector geometric parameter set and a voxel space coordinate set; acquiring a position vector corresponding to each bed; adjusting a detector geometric parameter set according to the position vector, and then obtaining a system global transmission matrix based on the adjusted detector geometric parameter set and the voxel space coordinate set; reconstructing the multi-bed projection data based on the system global transmission matrix; reconstructing the multi-bed projection data based on the system global transmission matrix; according to the method, a global unified modeling and reconstruction mode can be adopted to replace a mode of first bed-based reconstruction and then splicing.

This invention discloses a radiotracer targeting pan-KRAS mutant proteins, its preparation method, and its applications. The tracer uses small molecule ligands that specifically recognize multiple KRAS mutant proteins as targeting modules, and is coupled to diagnostic radionuclides through an optimized linkage system. This tracer is independent of specific mutation sites and can broadly and specifically bind to multiple high-frequency KRAS mutant subtypes, including G12C, G12D, and G12V. Based on PET / SPECT imaging, this tracer enables rapid, non-invasive, systemic, visualized, and quantitative assessment of KRAS mutant protein expression load in living tumors, overcoming the invasiveness, spatiotemporal limitations, and tumor heterogeneity challenges of traditional biopsies. It provides a novel molecular imaging tool for accurate companion diagnosis of KRAS-mutant tumors, screening of patients benefiting from pan-KRAS inhibitors, and monitoring efficacy, possessing significant clinical translational value.

A multi-view on-orbit geometric calibration system for agile imaging satellite: in view of the problem that imaging parameters change during the launch and on-orbit operation of agile imaging satellite, affecting the high-precision positioning of images, a rigorous imaging geometric model is constructed according to the collinear imaging principle, and the on-orbit geometric calibration of agile satellite imaging parameters is carried out through the internal and external step-by-step calibration strategy. The change of imaging angle of agile satellite causes the change of image imaging height, and the influence of atmospheric refraction is intensified, so that the imaging image calibration coefficient of the nadir point of the agile satellite is directly used for the geometric calibration of the inclined imaging image, and the uncontrolled positioning precision is reduced. By establishing the relationship between the change of imaging angle and the compensation of external calibration coefficient, the external calibration coefficient of the inclined imaging image is compensated, and the problem of the decline of uncontrolled positioning precision caused by the change of imaging height and the intensified influence of atmospheric refraction on the inclined imaging image is relieved. The present application can effectively realize the on-orbit geometric calibration of agile imaging satellite, and provide support for the subsequent high-precision geometric processing of images.

The invention discloses a human motion monitoring system, method and device and a storage medium. In the human motion monitoring system, an image acquisition module acquires N continuous frames of images of a human body on a diagnostic bed through multiple cameras. The image processing module extracts each frame of human body ROI, determines a single frame and integrates ROI area features. And the state recognition module judges the shielding state of each camera based on the characteristics. The motion detection module dynamically determines a human body motion energy value for an unshielded or semi-shielded camera. And the alarm module gives an alarm when a preset condition is met by combining the shielding state and the human body motion energy value. The scheme adopts pure visual analysis, does not depend on internal data of SPECT equipment, has the advantages of flexible deployment and strong compatibility, can effectively identify the occlusion state and accurately detect the motion of the patient, is beneficial to reducing motion artifacts in SPECT imaging, and ensures the imaging quality.

This application relates to a camera module, its manufacturing method, and an electronic device. The camera module includes: an optical path reversing component; a lens assembly disposed on the optical path reversing component; a photosensitive component disposed on the optical path reversing component, with the photosensitive component and the lens assembly located on the same side of the optical path reversing component; a spacer disposed on the optical path reversing component, with a portion of the spacer located between the optical path reversing component and the lens assembly, and a portion located between the optical path reversing component and the photosensitive component; and a light-shielding layer located between the lens assembly and the photosensitive component, the light-shielding layer sealing the gap between the lens assembly and the photosensitive component and abutting against the spacer. This application isolates the light-incident space and the light-exit space through the spacer and the light-shielding layer, preventing blemishes from moving from the light-incident space into the light-exit space, thereby reducing the probability of blemish imaging in the camera module.