80 results about "Spect imaging" patented technology

The invention discloses a time domain point-by-point imaging method, system and device for receiving and transmitting synthetic aperture sonar, and the method comprises the steps: calculating the synthetic aperture length and synthetic aperture time for any pixel in an imaging region; calculating the distance between the sonar and the pixel at the moment of transmitting the signal, and calculating the distance between the sonar and the pixel at the moment of receiving the signal to obtain an accurate two-way slant range process; calculating a reference echo signal corresponding to the pixel according to a two-way slant range process and related parameters of the signal; carrying out range-to-frequency domain conversion on the actually measured echo signal, carrying out range-to-frequency domain conversion on the reference echo signal, and carrying out conjugate multiplication processing on a conversion result; coherent accumulation is carried out on all conjugate multiplication results, and the result is used as an imaging result of the pixel; and for other pixels in the imaging area, repeatedly executing the steps to obtain imaging results of all pixels in the whole imaging area.

The invention relates to the technical field of small animal imaging, and particularly discloses a bimodal small animal molecular image imaging device which comprises a rack; the rotating bracket is rotationally mounted on the rack; the rotating assembly is installed on the rack and used for driving the rotating support to rotate relative to the rack; the CT imaging assembly is mounted on one side of the rotating bracket; the SPECT imaging assembly is installed on the other side of the rotating support, and the imaging center of the SPECT imaging assembly and the imaging center of the CT imaging assembly are coaxial with the rotating axis of the rotating support; the animal bed assembly is installed on the rack and used for bearing a small animal to be imaged and driving the small animal to be imaged to move towards or away from the rotating support along the rotating shaft of the rotating support; the method can effectively solve the problems of registration error, attenuation correction failure, image fusion quality reduction and quantitative analysis misalignment when the SPECT image and the CT image are fused due to alignment error of the SPECT imaging assembly and the CT imaging assembly.

Systems and techniques are described herein for foveated imaging. For instance, a method for foveated imaging is provided. The method may include determining a first region of interest within a first image based on a gaze of a user relative to the first image; clustering pixels of the first image into a one or more clusters of pixels based on a comparison of one or more characteristics of pixels of the first image; identifying a cluster of pixels from among the one or more clusters of pixels based on an intersection over union of the first region of interest and the cluster of pixels; generating a second region of interest based on the first region of interest and the cluster of pixels; and capturing a second image based on the second region of interest.

In emission imaging, one, two, or a few topograms without a full CT scan are used to localize, such as through triangulation, and / or generate an attenuation map, such as based on model fitting. A limited radiation exposure, rather than a longer, larger full CT exposure, is needed to localize and / or provide attenuation correction for emission imaging, such as cardiac SPECT imaging.

The invention provides a circuit board defect detection method and system based on deep learning, and the method comprises the steps: firstly obtaining a layered image set of a to-be-detected circuit board, which comprises a welding spot imaging layer, a line imaging layer and an element imaging layer; calling a pre-trained circuit board defect hierarchical detection model, inputting the hierarchical image set into a model defect pre-association layer, and generating a hierarchical defect association map which marks the position mapping relation of the same defect in different imaging layers; on the basis of the layered defect correlation map, extracting defect area exclusive features of each imaging layer to form a layered exclusive defect feature set, and inputting a model hierarchical feature enhancement layer to generate a hierarchical enhanced defect feature set. And finally, calling the model scene adaptive classification layer to carry out defect type matching, and generating a circuit board defect detection report containing defect types, hierarchical positions and association relationships in combination with the position mapping relationship, so that the circuit board defects can be comprehensively and accurately detected, and the detection efficiency and quality are improved.

Systems and techniques are described herein for foveated imaging. For instance, a method for foveated imaging is provided. The method may include determining a first region of interest within a first image based on a gaze of a user relative to the first image; clustering pixels of the first image into a one or more clusters of pixels based on a comparison of one or more characteristics of pixels of the first image; identifying a cluster of pixels from among the one or more clusters of pixels based on an intersection over union of the first region of interest and the cluster of pixels; generating a second region of interest based on the first region of interest and the cluster of pixels; and capturing a second image based on the second region of interest.

This application relates to a SPECT imaging system, imaging method, and SPECT imaging device. The SPECT imaging system includes multiple imaging modules and a data integration module. Each imaging module scans and images a local area of ​​the object under test, obtaining local imaging data. The data integration module is communicatively connected to the multiple imaging modules and integrates the multiple local imaging data to obtain a complete image. Each imaging module in this application can scan and image a local area of ​​the object under test, thereby obtaining corresponding local imaging data. Simultaneously, the data integration module integrates the multiple local imaging data to obtain a complete image. Since each imaging module includes a motion control unit and a probe, their scanning processes are relatively independent. When multiple areas need to be scanned, multiple imaging modules can perform scanning simultaneously, thus enabling parallel scanning of the object under test and improving scanning efficiency.

A method includes accumulating counts for each pixel in a set of pixels of one or more gamma cameras of a SPECT imaging system from a plurality of imaging examinations and each energy peak of each isotope used in the plurality of imaging examinations to produce an energy spectrum for each of the pixels at each of the energy peaks of each of the isotopes, determining, for the pixels and for the energy peaks, an energy calibration factor that converts an energy detected by each of the pixels to an energy of a corresponding energy peak and populating an energy map with the factors, and determining, for the pixels and for the energy peaks, a uniformity calibration factor that converts a number of counts detected by each of the pixels to a predetermined number of counts for a corresponding energy peak and populating a uniformity map with the factors.

Compounds for targeting and agents for imaging, prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.

The utility model provides a naked eye aerial imaging device of a culture gallery, the top of the culture gallery is provided with a naked eye 3D display module used for displaying 3D images, the naked eye 3D display module comprises a first multi-point naked eye 3D display and a second multi-point naked eye 3D display which are mutually symmetrical; the negative refractive index optical element is used for respectively refracting 3D images formed by the first multi-point naked eye 3D display and the second multi-point naked eye 3D display to different 3D viewpoint positions and forming three-dimensional images at two positions in the air, the negative refractive index optical element comprises a first transparent substrate, a first optical waveguide layer, a second optical waveguide layer and a second transparent substrate which are attached in sequence. And the two multi-view imaging devices are respectively used for displaying the three-dimensional images at two positions, the two multi-view imaging devices are symmetrically arranged, and the two multi-view imaging devices and the negative refractive index optical element are arranged at an angle, so that a screen at the back can be hidden, and the three-dimensional display device looks more scientific and fantastic.

The application discloses a time-domain point-by-point imaging method, system and device of a transceiver combined synthetic aperture sonar, and the time-domain point-by-point imaging method comprises the following steps: for any pixel in an imaging area, calculating a synthetic aperture length and a synthetic aperture time; calculating a distance between a sonar at a signal transmitting time and the pixel, and calculating a distance between a sonar at a signal receiving time and the pixel to obtain an accurate two-way slant range history; according to the two-way slant range history and relevant parameters of the signal, calculating a reference echo signal corresponding to the pixel; performing distance domain transformation on a measured echo signal and a reference echo signal, and performing conjugate multiplication processing on the transformed results; coherently accumulating all the conjugate multiplication results as an imaging result of the pixel; and repeating the above steps for other pixels in the imaging area to obtain imaging results of all the pixels in the entire imaging area.

The invention provides a detector of an SPECT imaging system, the SPECT imaging system and an SPECT imaging method. The detector of the SPECT imaging system comprises a plurality of detector units, and the plurality of detector units are arranged in a first direction; each detector unit comprises a plurality of detector modules arranged in a second direction, the second direction is perpendicular to the first direction, each detector module comprises a scintillation crystal array, an SiPM detector array and a preprocessing device which are sequentially arranged in a third direction, and the third direction, the first direction and the second direction are perpendicular to one another; the scintillation crystal array comprises a plurality of scintillation crystal blocks arranged in an array, the SiPM detector array comprises a plurality of SiPM detector pixels arranged in an array, and the scintillation crystal blocks and the SiPM detector pixels are arranged in a one-to-one correspondence manner. According to the detector, the spatial uniformity is remarkably improved, and the imaging quality is further improved.

The present application discloses an imaging device, comprising: a position information acquisition module for obtaining position information of a target organ; an irradiation depth determination module for determining the irradiation depth of imaging rays from a detection point into the interior of a human body based on the position of the detection point and the target detection depth; a light source focus control module for determining the focus information of multiple light sources based on a preset magnification and irradiation depth; an irradiation module for controlling the multiple light sources to generate imaging rays to irradiate the detection point based on the focus information; an imaging module for obtaining first imaging information of a tomographic scan based on a first remaining imaging ray passing through the detected position of the target organ; and obtaining an image of the target organ based on the first imaging information. The imaging device provided in the embodiments of the present application is capable of performing microscopic imaging of a target organ using imaging rays.

Optical system (21) for a metrology system (1) for measuring an object (2) in the form of a lithography mask, - with an object holder (14) for holding the object (2) in an object plane (13), - with a transmissive optical focusing component (11) arranged in the beam path of illumination light (4) between a light source (5) of the metrology system (1) and an object field (12) in the object plane (13), to generate an illumination focus (16) in the beam path of the illumination light (4) after the transmissive optical focusing component (11), - wherein the transmissive optical focusing component (11) has a focal length (f1) that is less than 5 mm, - with a detection device (6) for detecting the illumination light (4) in the beam path after the object field (12), - with an imaging optic (22) for imaging the illumination focus (16) generated by the transmissive optical focusing component (11) into a further illumination focus (16') in the area of ​​the object field (12).

The present invention provides a bivalent bispecific antibody targeting an EGFR and a c-MET and a radioactive label thereof. The research shows that the bivalent bispecific antibody provided by the present invention has good targeting affinity, and an antibody-radionuclide conjugate (taking 177Lu radioactive label as an example) of the bivalent bispecific antibody has an excellent SPECT imaging result, can be continuously accumulated in tumors over time, is more quickly removed in organs such as the liver and normal tissues, and can exhibit lower toxic and side effects. This also indirectly shows that the bivalent bispecific antibody provided by the present invention can clinically exhibit higher safety potential.

Methods and systems are provided for calibrating a single photon emission computed tomography (SPECT) imaging system. In one example, a collimated line source for calibrating a SPECT system comprises a radioactive material aligned along a central axis of the collimated line source and a plurality of collimator plates arranged perpendicularly around the central axis, the collimator plates including a material that substantially absorbs photons striking the collimator plates. The collimator plates may absorb photons emitted by the radioactive material in non-perpendicular directions, which are not used for calibrating the SPECT imaging system, thereby reducing an amount of radiation released in an environment of the SPECT imaging system during calibration. Due to the reduced amount of radiation to which people in the environment are exposed, short time increments between patient examinations may be advantageously used to collect calibration data, reducing an overall amount of time used for calibration.

According to an embodiment, an optical inspection apparatus includes an illumination portion, an imaging portion, and a processor. The illumination portion is configured to irradiate a first object point of an object with a light beam flux at one or more solid angles. The imaging portion is configured to acquire an image of the object according to illumination with the light beam flux. The processor causes the first object point to be irradiated with a light beam flux at a first solid angle by first illumination light, acquires a first captured image of the object with the first illumination light, causes the first object point to be irradiated with light beam fluxes at the third and fourth solid angles by second illumination light, acquires a second captured image of the object with the second illumination light, and acquires information regarding the object by the first and second captured images.

The invention discloses a myocardial amyloidosis quantitative analysis method based on SPECT imaging and related equipment, and relates to the field of wisdom medical device.The method comprises the steps that firstly, three-dimensional SPECT original data of N time phases of a target patient in the cardiac cycle are collected, a mu graph is generated based on low-dose CT for registration and attenuation correction, and a dynamic image is reconstructed; and then an MR structure sequence under synchronous electrocardio gating is obtained, and SPECT and MR space standardization and partial volume effect correction processing are completed. And unifying the cardiac cycle image form through affine and nonlinear transformation, and generating a high-quality enhanced SPECT image. Finally, radioactive counting information is extracted on the basis of three-dimensional segmentation, multiple myocardial quantitative indexes are calculated, comprehensive analysis of myocardial functions is achieved in combination with left ventricular functional parameters, and accurate image support is provided for non-invasive diagnosis and curative effect evaluation of myocardial amyloidosis.

The invention provides a novel FAPI trimer compound based on a GalNAc (N-acetylgalactosamine) link chain, a preparation method of the FAPI trimer compound, a developing agent based on the FAPI trimer compound and a preparation method of a developing agent. The trimerization structure in the FAPI trimer compound molecule provided by the invention can improve the in-vivo dynamic characteristics of the compound and prolong the residence time of the compound in tumors; the imaging agent based on the FAPI trimer compound can improve the uptake and imaging effects in tumors, and has good application prospects in PET / SPECT imaging, preparation of drugs for diagnosing tumors expressed by FAP-q and drugs for marking therapeutic nuclide (177Lu or 90Y) to treat tumors expressed by FAP-q in the future.

A method for relaxation time determination includes delivering a series of radio frequency (RF) pulses in a sequence to a specimen having a magnetic resonance spin system. The pulses are separated by equal time intervals and the sequence has a duration comparable or greater than a spin-lattice relaxation time for the spin system. The method includes receiving a response after each RF pulse in the series. The response includes a free induction decay and spin echoes. The method includes generating a series of single point imaging (SPI) images from each response. Each SPI image of the series corresponds to an RF pulse in the series. The method includes converting SPI images to a spin-spin relaxation map and a spin-lattice relaxation map.

An optical lens assembly for image capturing includes six lenses. The six lenses are sequentially arranged along an optical path from an object side to an image side as a first lens, a second lens, a third lens, a fourth lens, a fifth lens, and a sixth lens. The six lenses respectively have an object side surface facing the object side direction and an image side surface facing the image side direction. The first lens object side surface is concave at a vicinity of an optical axis, and the first lens image side surface is convex at the vicinity of the optical axis. The third lens image side surface is concave at the vicinity of the optical axis. The sixth lens object side surface is convex at the vicinity of the optical axis. The sixth lens image side surface is concave at the vicinity of the optical axis, and the sixth lens image side surface is aspherical and has at least one inflection point. The total number of lenses in the optical lens assembly for image capturing is six. When certain conditions are met, the optical lens assembly for image capturing can simultaneously meet the requirements of miniaturization and high imaging quality. An image capturing device having the optical lens assembly for image capturing and an electronic device having the image capturing device are also disclosed.

A system for low-count quantitative single-photon emission computed tomography (LC-QSPECT) is provided. The system is programmed to a) store a computer tomography (CT) scan of a subject being examining including a plurality of defined volumes of interest (VOIs) of the subject being examined; b) model a system matrix based on the stored CT, wherein the model describes the probability that photons emitted from each of the defined VOIs are detected in different projection bins, wherein a plurality of projection bins are defined around the subject and the defined VOIs; c) adjust the model with analysis of stray-radiation noise around the subject; d) detect, by the one or more sensors, one or more photons being emitted by an alpha-particle-emitting isotope; and e) execute the adjusted model with the one or more detected photons as inputs to determine a source VOI of the detected photons.

This invention provides a dual-aperture multi-pinhole collimator, comprising: a collimator plate; and multiple pinholes of two different apertures spaced apart on the collimator plate. During a single imaging process, radioactive rays passing through the imaging fields of different apertures simultaneously form corresponding and non-overlapping projection responses on the detector. Of the two apertures, the first aperture is smaller than the second aperture. The first aperture is determined based on the desired system spatial resolution, and the second aperture is determined based on the desired detection efficiency. This invention also proposes a SPECT imaging system based on the aforementioned multi-pinhole collimator. Its imaging module obtains imaging results from the data required for tomographic reconstruction using an improved MLEM iterative algorithm. The improved MLEM iterative algorithm introduces weighting factors into the original MLEM iterative algorithm, weighting the projection data of the dual-aperture pinholes and the corresponding system transmission matrix elements respectively. This invention improves detection sensitivity while maintaining spatial resolution.

The application discloses an imaging lens system, which comprises eight lenses, and the eight lenses are sequentially arranged from the object side to the image side as a first lens, a second lens, a third lens, a fourth lens, a fifth lens, a sixth lens, a seventh lens and an eighth lens. The eight lenses respectively have an object side surface facing the object side direction and an image side surface facing the image side direction. The first lens has positive refractive power. The second lens has negative refractive power. At least one surface of at least one lens in the imaging lens system has at least one inflection point. The total number of the lenses in the imaging lens system is eight. When certain conditions are met, the imaging lens system can simultaneously meet the requirements of a large aperture and miniaturization.

The invention provides an SPECT imaging device and a swing-type acquisition tomography method. The device comprises an SPECT scanning frame, and the SPECT scanning frame comprises a main rotating motor, a first large probe, a second large probe, a first small probe and a second small probe; the main rotating motor is used for synchronously driving the first large probe, the second large probe, the first small probe and the second small probe to swing back and forth around the bed according to a preset angle; wherein the first large probe and the second large probe are used for covering and scanning to obtain longitudinal data of a human body, and the first small probe and the second small probe are used for assisting in scanning to obtain transverse data of the human body; in the reciprocating swing process, all the probes can advance and retreat in the radial direction of the SPECT scanning frame in the same plane and translate left and right in the second direction perpendicular to the radial direction, so that a parallelogram imaging area which is always close to the outline formed by a bed and a human body is defined, and plane and cross-sectional image data can be obtained through single-time small-angle scanning.

This invention provides a label-free live cell screening system and method based on droplet microfluidics. The system includes: a microfluidic chip with fluorescence signal monitoring sites, imaging sites, and sorting sites; a fluorescence detection unit configured to excite and acquire fluorescence signals at the fluorescence signal monitoring sites; an imaging unit configured to acquire images of droplets at the imaging sites; a sorting unit configured to sort droplets encapsulating target cells at the sorting sites; and a signal processor that, when a droplet is detected passing through the fluorescence signal monitoring site based on the fluorescence signal, triggers the imaging unit to acquire images of the droplet at the imaging site; and when the signal processor determines, based on image analysis, that the droplet encapsulates a target cell, triggers the sorting unit to sort the droplet encapsulating the target cell at the sorting site. This invention utilizes fluorescence signals to monitor droplets, improving monitoring efficiency and accuracy, thereby significantly increasing the precision and throughput of droplet sorting.

The utility model relates to a lens focusing mechanism and a panel detection device, the lens focusing mechanism comprises a fixed seat, a lens module and a transmission assembly, the lens module is telescopically arranged on the fixed seat; the transmission assembly comprises a first gear and a plurality of second gears, the plurality of second gears are simultaneously engaged with the same tooth groove of the first gear, the installation directions of two adjacent second gears are opposite, the first gear is fixed on the lens module, and in the rotation process of the first gear, the first gear can drive the lens module to stretch out and draw back relative to the fixed seat. According to the lens focusing mechanism provided by the invention, the meshing gap between the second gear and the first gear can be adjusted to be small, the rotation adjustment precision of the first gear is improved, the telescopic distance of the lens module is finely adjusted, and the imaging quality of the lens module for each point of the measured workpiece is further ensured.

A detector for an SPECT imaging system, an SPECT probe, and an imaging system and method. The detector comprises: an SiPM detector array (1-2), a CsI crystal array (1-1), and a preprocessing circuit board (1-3). The CsI crystal array (1-1) comprises a plurality of strip-shaped crystals (3-1); each strip-shaped crystal (3-1) comprises at least one crystal light exit surface (3-2); and one crystal light exit surface (3-2) of each strip-shaped crystal (3-1) is coupled to the SiPM detector array (1-2). An electrical signal of each SiPM detector pixel (2-3) in the SiPM detector array (1-2) is independently outputted by means of a detector base plate (2-4) in the SiPM detector array (1-2). The preprocessing circuit board (1-3) combines electrical signals of all SiPM detector pixels (2-3) and outputs a number of signals equal to or fewer than the number of the SiPM detector pixels (2-3).

A single photon emission computed tomography (SPECT) imaging system includes a detector configured to receive photons emitted by a radiopharmaceutical in an examination region and convert the received photons to measured projection data and a collimator with septa spatially arranged with respect to each other and the detector to provide channels to pass photons that traverse the channels and absorb photons that impinge the septa. A first sub-set of the photons emitted by the radiopharmaceutical traverse the channels without impinging the septa and are directly received by the detector. A second sub-set of the photons emitted by the radiopharmaceutical traverse the septa and are received by the detector. The SPECT imaging system further includes a reconstructor configured to discard scatter photons and the second sub-set of photons traversing the septa, and iteratively reconstruct an image based on the first subset of photons that are directly received by the detector.

A method for calibrating the target pointing error of a multimode composite tracking and aiming system includes: (1) setting up an autocollimator in front of the multimode optical system and the field of view of the visible light camera, calibrating the multimode optical system and marking the zero point of the visible light camera; (2) placing a target at the maximum measurement distance of the multimode optical system and marking the position of the camera zero point in the target target; then rotating the azimuth and pitch axes of the high-precision turntable to zero, reading the imaging position of the laser emission point, and recording the system deviation of the target pointing; (3) controlling the azimuth and pitch axes of the high-precision turntable to swing to different angles, and measuring the deviation value between the tracking point of the visible light camera and the imaging position of the target laser illumination point; (4) substituting the measured value into the error calculation formula including the mirror installation deviation to form a multivariate equation system, solving for the mirror installation error of the multimode composite tracking and aiming system, and then combining the swing angles of the azimuth and pitch axes of the high-precision turntable to calculate the corresponding deviation value. The method of this invention can accurately calibrate the target pointing error of the multimode composite tracking and aiming system.