107 results about "Spect imaging" patented technology

The invention discloses a time domain point-by-point imaging method, system and device for receiving and transmitting synthetic aperture sonar, and the method comprises the steps: calculating the synthetic aperture length and synthetic aperture time for any pixel in an imaging region; calculating the distance between the sonar and the pixel at the moment of transmitting the signal, and calculating the distance between the sonar and the pixel at the moment of receiving the signal to obtain an accurate two-way slant range process; calculating a reference echo signal corresponding to the pixel according to a two-way slant range process and related parameters of the signal; carrying out range-to-frequency domain conversion on the actually measured echo signal, carrying out range-to-frequency domain conversion on the reference echo signal, and carrying out conjugate multiplication processing on a conversion result; coherent accumulation is carried out on all conjugate multiplication results, and the result is used as an imaging result of the pixel; and for other pixels in the imaging area, repeatedly executing the steps to obtain imaging results of all pixels in the whole imaging area.

The invention relates to the technical field of small animal imaging, and particularly discloses a bimodal small animal molecular image imaging device which comprises a rack; the rotating bracket is rotationally mounted on the rack; the rotating assembly is installed on the rack and used for driving the rotating support to rotate relative to the rack; the CT imaging assembly is mounted on one side of the rotating bracket; the SPECT imaging assembly is installed on the other side of the rotating support, and the imaging center of the SPECT imaging assembly and the imaging center of the CT imaging assembly are coaxial with the rotating axis of the rotating support; the animal bed assembly is installed on the rack and used for bearing a small animal to be imaged and driving the small animal to be imaged to move towards or away from the rotating support along the rotating shaft of the rotating support; the method can effectively solve the problems of registration error, attenuation correction failure, image fusion quality reduction and quantitative analysis misalignment when the SPECT image and the CT image are fused due to alignment error of the SPECT imaging assembly and the CT imaging assembly.

Systems and techniques are described herein for foveated imaging. For instance, a method for foveated imaging is provided. The method may include determining a first region of interest within a first image based on a gaze of a user relative to the first image; clustering pixels of the first image into a one or more clusters of pixels based on a comparison of one or more characteristics of pixels of the first image; identifying a cluster of pixels from among the one or more clusters of pixels based on an intersection over union of the first region of interest and the cluster of pixels; generating a second region of interest based on the first region of interest and the cluster of pixels; and capturing a second image based on the second region of interest.

In emission imaging, one, two, or a few topograms without a full CT scan are used to localize, such as through triangulation, and / or generate an attenuation map, such as based on model fitting. A limited radiation exposure, rather than a longer, larger full CT exposure, is needed to localize and / or provide attenuation correction for emission imaging, such as cardiac SPECT imaging.

The invention provides a circuit board defect detection method and system based on deep learning, and the method comprises the steps: firstly obtaining a layered image set of a to-be-detected circuit board, which comprises a welding spot imaging layer, a line imaging layer and an element imaging layer; calling a pre-trained circuit board defect hierarchical detection model, inputting the hierarchical image set into a model defect pre-association layer, and generating a hierarchical defect association map which marks the position mapping relation of the same defect in different imaging layers; on the basis of the layered defect correlation map, extracting defect area exclusive features of each imaging layer to form a layered exclusive defect feature set, and inputting a model hierarchical feature enhancement layer to generate a hierarchical enhanced defect feature set. And finally, calling the model scene adaptive classification layer to carry out defect type matching, and generating a circuit board defect detection report containing defect types, hierarchical positions and association relationships in combination with the position mapping relationship, so that the circuit board defects can be comprehensively and accurately detected, and the detection efficiency and quality are improved.

Systems and techniques are described herein for foveated imaging. For instance, a method for foveated imaging is provided. The method may include determining a first region of interest within a first image based on a gaze of a user relative to the first image; clustering pixels of the first image into a one or more clusters of pixels based on a comparison of one or more characteristics of pixels of the first image; identifying a cluster of pixels from among the one or more clusters of pixels based on an intersection over union of the first region of interest and the cluster of pixels; generating a second region of interest based on the first region of interest and the cluster of pixels; and capturing a second image based on the second region of interest.

The invention discloses an imaging display method and system for head-mounted display equipment, and relates to the technical field of display, and the system comprises an imaging display preparation module and an imaging display adjustment module. According to the method, the biological modeling of the target user is constructed, optimization is automatically carried out according to the vision condition, the head movement habit and the color preference of the user, and the display effect and the comfort degree are improved; by dividing the display screen and dynamically adjusting the display quality of the small area according to the sight focus point of the user, the highest definition of the core area can be always kept, and meanwhile, the display quality is properly reduced in the transition area and the edge area, so that the display effect and computing resources are balanced; by predicting the sight focus point and performing key imaging judgment, the equipment can position the visual attention area of the user in real time and optimize the displayed key area.

This application relates to a SPECT imaging system, imaging method, and SPECT imaging device. The SPECT imaging system includes multiple imaging modules and a data integration module. Each imaging module scans and images a local area of ​​the object under test, obtaining local imaging data. The data integration module is communicatively connected to the multiple imaging modules and integrates the multiple local imaging data to obtain a complete image. Each imaging module in this application can scan and image a local area of ​​the object under test, thereby obtaining corresponding local imaging data. Simultaneously, the data integration module integrates the multiple local imaging data to obtain a complete image. Since each imaging module includes a motion control unit and a probe, their scanning processes are relatively independent. When multiple areas need to be scanned, multiple imaging modules can perform scanning simultaneously, thus enabling parallel scanning of the object under test and improving scanning efficiency.

The invention relates to a technetium [99mTc]-labeled deuterated tropane derivative and application thereof, and belongs to the technical field of nuclear medicine. The invention provides a technetium [99mTc]-labeled deuterated tropane derivative, which can be specifically combined with a dopamine transporter, and can be used for preparing the technetium [99mTc]-labeled deuterated tropane derivative. The technetium [99mTc]-labeled deuterated tropane derivative has the advantages of good affinity to a dopamine transporter, high radioactive uptake of a target region (striatum) in a brain and high target / background ratio, and has an extremely high application prospect in the aspect of SPECT (Single Photon Emission Computed Tomography) imaging of the dopamine transporter.

A method includes accumulating counts for each pixel in a set of pixels of one or more gamma cameras of a SPECT imaging system from a plurality of imaging examinations and each energy peak of each isotope used in the plurality of imaging examinations to produce an energy spectrum for each of the pixels at each of the energy peaks of each of the isotopes, determining, for the pixels and for the energy peaks, an energy calibration factor that converts an energy detected by each of the pixels to an energy of a corresponding energy peak and populating an energy map with the factors, and determining, for the pixels and for the energy peaks, a uniformity calibration factor that converts a number of counts detected by each of the pixels to a predetermined number of counts for a corresponding energy peak and populating a uniformity map with the factors.

Compounds for targeting and agents for imaging, prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.

The utility model provides a naked eye aerial imaging device of a culture gallery, the top of the culture gallery is provided with a naked eye 3D display module used for displaying 3D images, the naked eye 3D display module comprises a first multi-point naked eye 3D display and a second multi-point naked eye 3D display which are mutually symmetrical; the negative refractive index optical element is used for respectively refracting 3D images formed by the first multi-point naked eye 3D display and the second multi-point naked eye 3D display to different 3D viewpoint positions and forming three-dimensional images at two positions in the air, the negative refractive index optical element comprises a first transparent substrate, a first optical waveguide layer, a second optical waveguide layer and a second transparent substrate which are attached in sequence. And the two multi-view imaging devices are respectively used for displaying the three-dimensional images at two positions, the two multi-view imaging devices are symmetrically arranged, and the two multi-view imaging devices and the negative refractive index optical element are arranged at an angle, so that a screen at the back can be hidden, and the three-dimensional display device looks more scientific and fantastic.

The application discloses a time-domain point-by-point imaging method, system and device of a transceiver combined synthetic aperture sonar, and the time-domain point-by-point imaging method comprises the following steps: for any pixel in an imaging area, calculating a synthetic aperture length and a synthetic aperture time; calculating a distance between a sonar at a signal transmitting time and the pixel, and calculating a distance between a sonar at a signal receiving time and the pixel to obtain an accurate two-way slant range history; according to the two-way slant range history and relevant parameters of the signal, calculating a reference echo signal corresponding to the pixel; performing distance domain transformation on a measured echo signal and a reference echo signal, and performing conjugate multiplication processing on the transformed results; coherently accumulating all the conjugate multiplication results as an imaging result of the pixel; and repeating the above steps for other pixels in the imaging area to obtain imaging results of all the pixels in the entire imaging area.

The invention provides a detector of an SPECT imaging system, the SPECT imaging system and an SPECT imaging method. The detector of the SPECT imaging system comprises a plurality of detector units, and the plurality of detector units are arranged in a first direction; each detector unit comprises a plurality of detector modules arranged in a second direction, the second direction is perpendicular to the first direction, each detector module comprises a scintillation crystal array, an SiPM detector array and a preprocessing device which are sequentially arranged in a third direction, and the third direction, the first direction and the second direction are perpendicular to one another; the scintillation crystal array comprises a plurality of scintillation crystal blocks arranged in an array, the SiPM detector array comprises a plurality of SiPM detector pixels arranged in an array, and the scintillation crystal blocks and the SiPM detector pixels are arranged in a one-to-one correspondence manner. According to the detector, the spatial uniformity is remarkably improved, and the imaging quality is further improved.

The present application discloses an imaging device, comprising: a position information acquisition module for obtaining position information of a target organ; an irradiation depth determination module for determining the irradiation depth of imaging rays from a detection point into the interior of a human body based on the position of the detection point and the target detection depth; a light source focus control module for determining the focus information of multiple light sources based on a preset magnification and irradiation depth; an irradiation module for controlling the multiple light sources to generate imaging rays to irradiate the detection point based on the focus information; an imaging module for obtaining first imaging information of a tomographic scan based on a first remaining imaging ray passing through the detected position of the target organ; and obtaining an image of the target organ based on the first imaging information. The imaging device provided in the embodiments of the present application is capable of performing microscopic imaging of a target organ using imaging rays.

Optical system (21) for a metrology system (1) for measuring an object (2) in the form of a lithography mask, - with an object holder (14) for holding the object (2) in an object plane (13), - with a transmissive optical focusing component (11) arranged in the beam path of illumination light (4) between a light source (5) of the metrology system (1) and an object field (12) in the object plane (13), to generate an illumination focus (16) in the beam path of the illumination light (4) after the transmissive optical focusing component (11), - wherein the transmissive optical focusing component (11) has a focal length (f1) that is less than 5 mm, - with a detection device (6) for detecting the illumination light (4) in the beam path after the object field (12), - with an imaging optic (22) for imaging the illumination focus (16) generated by the transmissive optical focusing component (11) into a further illumination focus (16') in the area of ​​the object field (12).

The present invention provides a bivalent bispecific antibody targeting an EGFR and a c-MET and a radioactive label thereof. The research shows that the bivalent bispecific antibody provided by the present invention has good targeting affinity, and an antibody-radionuclide conjugate (taking 177Lu radioactive label as an example) of the bivalent bispecific antibody has an excellent SPECT imaging result, can be continuously accumulated in tumors over time, is more quickly removed in organs such as the liver and normal tissues, and can exhibit lower toxic and side effects. This also indirectly shows that the bivalent bispecific antibody provided by the present invention can clinically exhibit higher safety potential.

Methods and systems are provided for calibrating a single photon emission computed tomography (SPECT) imaging system. In one example, a collimated line source for calibrating a SPECT system comprises a radioactive material aligned along a central axis of the collimated line source and a plurality of collimator plates arranged perpendicularly around the central axis, the collimator plates including a material that substantially absorbs photons striking the collimator plates. The collimator plates may absorb photons emitted by the radioactive material in non-perpendicular directions, which are not used for calibrating the SPECT imaging system, thereby reducing an amount of radiation released in an environment of the SPECT imaging system during calibration. Due to the reduced amount of radiation to which people in the environment are exposed, short time increments between patient examinations may be advantageously used to collect calibration data, reducing an overall amount of time used for calibration.

According to an embodiment, an optical inspection apparatus includes an illumination portion, an imaging portion, and a processor. The illumination portion is configured to irradiate a first object point of an object with a light beam flux at one or more solid angles. The imaging portion is configured to acquire an image of the object according to illumination with the light beam flux. The processor causes the first object point to be irradiated with a light beam flux at a first solid angle by first illumination light, acquires a first captured image of the object with the first illumination light, causes the first object point to be irradiated with light beam fluxes at the third and fourth solid angles by second illumination light, acquires a second captured image of the object with the second illumination light, and acquires information regarding the object by the first and second captured images.

The invention discloses a myocardial amyloidosis quantitative analysis method based on SPECT imaging and related equipment, and relates to the field of wisdom medical device.The method comprises the steps that firstly, three-dimensional SPECT original data of N time phases of a target patient in the cardiac cycle are collected, a mu graph is generated based on low-dose CT for registration and attenuation correction, and a dynamic image is reconstructed; and then an MR structure sequence under synchronous electrocardio gating is obtained, and SPECT and MR space standardization and partial volume effect correction processing are completed. And unifying the cardiac cycle image form through affine and nonlinear transformation, and generating a high-quality enhanced SPECT image. Finally, radioactive counting information is extracted on the basis of three-dimensional segmentation, multiple myocardial quantitative indexes are calculated, comprehensive analysis of myocardial functions is achieved in combination with left ventricular functional parameters, and accurate image support is provided for non-invasive diagnosis and curative effect evaluation of myocardial amyloidosis.

The invention relates to the field of nuclear medicine, in particular to an imaging probe based on radionuclide labeling and application. The imaging probe based on radionuclide labeling provided by the invention comprises lanthanide nanocrystals, an amphiphilic block copolymer self-assembled by the lanthanide nanocrystals, and radionuclide ions labeled on the nanocrystals, and the imaging probe simultaneously realizes time-gated intensity imaging, life imaging and SPECT (Single Photon Emission Computed Tomography) imaging. The imaging probe based on radionuclide labeling is provided for the first time, the radionuclide labeling rate as high as 99.6% is achieved, the imaging probe not only supports time gating intensity imaging with high signal-to-background ratio, but also supports life imaging and SPECT imaging, and in-vivo biological distribution and metabolism tracking of radioactive nanoparticles are achieved.

The invention provides a novel FAPI trimer compound based on a GalNAc (N-acetylgalactosamine) link chain, a preparation method of the FAPI trimer compound, a developing agent based on the FAPI trimer compound and a preparation method of a developing agent. The trimerization structure in the FAPI trimer compound molecule provided by the invention can improve the in-vivo dynamic characteristics of the compound and prolong the residence time of the compound in tumors; the imaging agent based on the FAPI trimer compound can improve the uptake and imaging effects in tumors, and has good application prospects in PET / SPECT imaging, preparation of drugs for diagnosing tumors expressed by FAP-q and drugs for marking therapeutic nuclide (177Lu or 90Y) to treat tumors expressed by FAP-q in the future.

A method for relaxation time determination includes delivering a series of radio frequency (RF) pulses in a sequence to a specimen having a magnetic resonance spin system. The pulses are separated by equal time intervals and the sequence has a duration comparable or greater than a spin-lattice relaxation time for the spin system. The method includes receiving a response after each RF pulse in the series. The response includes a free induction decay and spin echoes. The method includes generating a series of single point imaging (SPI) images from each response. Each SPI image of the series corresponds to an RF pulse in the series. The method includes converting SPI images to a spin-spin relaxation map and a spin-lattice relaxation map.

The present invention discloses an AIE-SPECT dual-modality imaging agent and its preparation method and application. It is based on a polymer-modified organic small molecule structure, adds a radionuclide with a SPECT imaging effect, forms nanoparticles through self-assembly, and chelates radionuclide ions to synthesize an AIE nanomaterial with both SPECT and fluorescence dual-modality imaging characteristics. The nanomaterial can produce near-infrared second-zone fluorescence under light irradiation in a specific wavelength range, and can produce a photothermal effect, so the nanomaterial can be used for tumor fluorescence imaging and photothermal therapy; at the same time, since the radionuclide can release beta rays, the nanomaterial can be used for tumor radiotherapy. The nanomaterial is uniformly dispersed in an aqueous solution, with an average particle size of 9.5nm, and can passively target tumors through the enhanced penetration and retention (EPR) effect, so it can be used as a tumor imaging agent and therapeutic drug.

An optical lens assembly for image capturing includes six lenses. The six lenses are sequentially arranged along an optical path from an object side to an image side as a first lens, a second lens, a third lens, a fourth lens, a fifth lens, and a sixth lens. The six lenses respectively have an object side surface facing the object side direction and an image side surface facing the image side direction. The first lens object side surface is concave at a vicinity of an optical axis, and the first lens image side surface is convex at the vicinity of the optical axis. The third lens image side surface is concave at the vicinity of the optical axis. The sixth lens object side surface is convex at the vicinity of the optical axis. The sixth lens image side surface is concave at the vicinity of the optical axis, and the sixth lens image side surface is aspherical and has at least one inflection point. The total number of lenses in the optical lens assembly for image capturing is six. When certain conditions are met, the optical lens assembly for image capturing can simultaneously meet the requirements of miniaturization and high imaging quality. An image capturing device having the optical lens assembly for image capturing and an electronic device having the image capturing device are also disclosed.

A system for low-count quantitative single-photon emission computed tomography (LC-QSPECT) is provided. The system is programmed to a) store a computer tomography (CT) scan of a subject being examining including a plurality of defined volumes of interest (VOIs) of the subject being examined; b) model a system matrix based on the stored CT, wherein the model describes the probability that photons emitted from each of the defined VOIs are detected in different projection bins, wherein a plurality of projection bins are defined around the subject and the defined VOIs; c) adjust the model with analysis of stray-radiation noise around the subject; d) detect, by the one or more sensors, one or more photons being emitted by an alpha-particle-emitting isotope; and e) execute the adjusted model with the one or more detected photons as inputs to determine a source VOI of the detected photons.

The utility model discloses an SPECT multi-parallel-hole collimator, a collimator device and a detection device. The SPECT multi-parallel-hole collimator comprises three collimator positions, a calibration position, a first collimator position and a second collimator position which are transversely and continuously arranged, or the first collimator position, the second collimator position, or the zero collimator position, the first collimator position, and the second collimator position. The utility model relates to an SPECT (Single Photon Emission Computed Tomography) multi-parallel-hole collimator device, which comprises two SPECT multi-parallel-hole collimators which are oppositely arranged in parallel. The two PECT multi-parallel-hole collimators which are oppositely arranged in parallel further comprise a set of transverse guide rails, collimator transmission pieces and transmission mechanisms. A single photon emission computed tomography (SPECT) detection device comprises a multi-parallel-hole collimator device and two opposite detectors, each detector is fixed in a detector frame, and a transverse guide rail is fixed on the inner side of the detector frame. The utility model relates to an SPECT imaging method, which utilizes an SPECT detection device to implement detection and comprises a debugging step and a testing step.

This invention provides a dual-aperture multi-pinhole collimator, comprising: a collimator plate; and multiple pinholes of two different apertures spaced apart on the collimator plate. During a single imaging process, radioactive rays passing through the imaging fields of different apertures simultaneously form corresponding and non-overlapping projection responses on the detector. Of the two apertures, the first aperture is smaller than the second aperture. The first aperture is determined based on the desired system spatial resolution, and the second aperture is determined based on the desired detection efficiency. This invention also proposes a SPECT imaging system based on the aforementioned multi-pinhole collimator. Its imaging module obtains imaging results from the data required for tomographic reconstruction using an improved MLEM iterative algorithm. The improved MLEM iterative algorithm introduces weighting factors into the original MLEM iterative algorithm, weighting the projection data of the dual-aperture pinholes and the corresponding system transmission matrix elements respectively. This invention improves detection sensitivity while maintaining spatial resolution.

Methods and systems are provided for improving the quality of an image generated by a single photon emission computed tomography (SPECT) imaging system (100, 200). Photons penetrating a protective shield (580) around a detector head (308, 408, 210) of the SPECT system (100, 200) may not be correctly processed by a reconstruction algorithm used to reconstruct an image from a plurality of projection views (701) acquired by the SPECT imaging system (100, 200), thereby generating artifacts (1121, 1112, 730) and reducing the quality of the image. In one embodiment, the artifacts (1121, 1112, 730) may be reduced or eliminated by selectively applying the reconstruction algorithm to a first partial column of pixels (1007, 1012) of the projected views (701) that does not include the artifacts (1121, 1112, 730), and not applying the reconstruction algorithm to a second partial column of pixels (1007, 1012) of the projected views that includes the artifacts (1121, 1112, 730). The number of the second partial pixel columns (1007, 1012) may be based on a sweep angle (550) of a detector (471) that acquires the projected view (701).

The application discloses an imaging lens system, which comprises eight lenses, and the eight lenses are sequentially arranged from the object side to the image side as a first lens, a second lens, a third lens, a fourth lens, a fifth lens, a sixth lens, a seventh lens and an eighth lens. The eight lenses respectively have an object side surface facing the object side direction and an image side surface facing the image side direction. The first lens has positive refractive power. The second lens has negative refractive power. At least one surface of at least one lens in the imaging lens system has at least one inflection point. The total number of the lenses in the imaging lens system is eight. When certain conditions are met, the imaging lens system can simultaneously meet the requirements of a large aperture and miniaturization.