The invention relates to an anti-disease greenhouse vegetable fertilizer which is characterized by comprising bacterial enzyme with effective viable count of (2.0-3.0)*10<9>CFU / 9, shale, straw powder, dry chicken manure, bone meal, fish meal, soybean meal, borax, magnesium sulfate, ferrous sulfate, potassium dihydrogen phosphate and manganese sulfate. The greenhouse vegetable fertilizer consists of bacterial enzyme, organic matters and microelements and can comprehensively meet the growth and development needs of crops and increase the output by over 15%; the fertilization cost is reduced, and the output-input ratio is increased by over 18%; and moreover, the greenhouse vegetable fertilizer enhances the ability of resisting pest and disease damage of crops, and can perfectly prevent gray mold, leaf mold, anthracnose, early blight, late blight, leaf spot disease and the like.