The invention provides a Chinese materia medica preparation for treating swelling and sore throat, which is made from the following raw traditional Chinese drugs comprising isatis root, honeysuckle flower, dwarf lilyturf tuber, smallflower epipactis root, corktree bark, dandelion, rhubarb, Hindu lotus seedpod, cinnabar, root of subprostrate sophora, magnolia bark, houttuynia, natural indigo, climbing groundsel, borneol, bitter almond kernel, peppermint, platycodon root, ledebouriella root, chrysanthemum, reed rhizome and tendril-leaved fritillary bulb. The preparation can eradicate symptoms of the swelling and pain in throat such as dysphagia and cough complicated by cold, fever and headache, pharyngoxerosis, thirst, constipation, yellow urine, reddened tongue, yellow tongue coating, and the like, realize treating the superficiality and origin at the same time, and take effect quickly after the preparation is taken, and has no toxic and side effect and adverse reaction, thus a wide popularization of the preparation can lead to good social and economic benefits.