The invention relates to a high-efficiency anti-oxidation and anti-acne handmade soap, which is characterized in that: calculated according to the weight fraction, it includes the following components: 10-15 parts of Chinese medicine extract, 5-10 parts of Phyllostachys pubescens leaf extract, 1-10 parts of Pyracantha fruit extract 3 parts, 1-3 parts of indigo fruit extract, 1-2 parts of mangosteen husk extract, 1-2 parts of Italian Buglossia extract, 2-4 parts of lychee leaf extract, 2-4 parts of bayberry leaf extract, Perilla leaf extract 1‑2 parts, mugwort extract 1‑2 parts, nicotinamide 6‑10 parts, tea saponin 0.3‑1 part, seabuckthorn seed oil 70‑100 parts, natural soap base 250‑350 parts. The handmade soap raw material extract of the present invention is extracted by ultrasonic extraction. This process has high extraction efficiency, and the utilization rate of active ingredients in plant and fruit medicines is extremely high, because the biological transdermal accelerator is derived from plant extracts and has good biophase Capacitive, and will not cause damage to the skin, with safety.