Medicament for preventing and treating ischemic brain injury, and preparation method thereof

An ischemic brain injury and drug technology, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve problems such as the need to improve the efficacy of

Inactive Publication Date: 2010-06-16
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine has certain advantages in the prevention and treatment of this disease, but most of the research on the treatment of this disease focuses on promoting blood circulation and removing blood stasis or nourishing qi and promoting blood circulation. It has a certain curative effect, but there are still many adverse effects to be solved, and the curative effect needs to be improved. It is urgent to develop The idea of ​​treatment of this disease is to seek therapeutic drugs and methods with definite curative effect on the prevention and treatment of this disease, especially new Chinese medicines with the theoretical basis and clinical experience of traditional Chinese medicine, so as to improve the clinical curative effect

Method used

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  • Medicament for preventing and treating ischemic brain injury, and preparation method thereof
  • Medicament for preventing and treating ischemic brain injury, and preparation method thereof
  • Medicament for preventing and treating ischemic brain injury, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0155] Embodiment 1, granule preparation

[0156] a) 900g of raw Astragalus membranaceus plus 10 times the amount of ethanol with a mass concentration of 90% was soaked for 12 hours, refluxed and extracted twice, the extracts were combined, centrifuged (15000 rpm), and the supernatant was recovered under reduced pressure at 60-70°C Ethanol, concentrated to a relative density of 1.13 at 50-60 ° C, to obtain the extract I. After soaking raw Radix Astragalus in water for 2 hours, extracting 3 times, the extract was centrifuged (15,000 rpm), and the supernatant was concentrated to a relative density of 1.16 at 50-60°C after separation to obtain the extract II.

[0157] b) After soaking 900g Pueraria Radix and 600g Scutellaria baicalensis with 10 times the mass concentration of 60% ethanol for 12 hours, reflux extraction twice, combine the extracts, centrifuge (15000 rpm), and reduce the supernatant at 60-70°C The ethanol was recovered under pressure, and concentrated to a relativ...

Embodiment 2

[0160] Embodiment 2, granule preparation

[0161] a) 750g of raw Astragalus membranaceus plus 10 times the amount of ethanol with a mass concentration of 90% was soaked for 12 hours, refluxed and extracted twice, the extracts were combined, centrifuged (15000 rpm), and the supernatant was recovered under reduced pressure at 60-70°C Ethanol, concentrated to a relative density of 1.13 at 50-60 ° C, to obtain the extract I. After soaking raw Radix Astragalus in water for 2 hours, extracting 3 times, the extract was centrifuged (15,000 rpm), and the supernatant was concentrated to a relative density of 1.16 at 50-60°C after separation to obtain the extract II.

[0162] b) After soaking 750g Pueraria Radix and 500g Scutellaria baicalensis with 10 times the mass concentration of 60% ethanol for 12 hours, reflux extraction twice, combine the extracts, centrifuge (15000 rpm), and reduce the supernatant at 60-70°C The ethanol was recovered under pressure, and concentrated to a relativ...

Embodiment 3

[0165] Embodiment 3, capsule preparation

[0166] a) 900g of raw Astragalus membranaceus plus 10 times the amount of ethanol with a mass concentration of 90% was soaked for 12 hours, refluxed and extracted twice, the extracts were combined, centrifuged (15000 rpm), and the supernatant was recovered under reduced pressure at 60-70°C Ethanol, concentrated to a relative density of 1.13 at 50-60 ° C, to obtain the extract I. After soaking raw Radix Astragalus in water for 2 hours, extracting 3 times, the extract was centrifuged (15,000 rpm), and the supernatant was concentrated to a relative density of 1.16 at 50-60°C after separation to obtain the extract II.

[0167] b) After soaking 900g Pueraria Radix and 600g Scutellaria baicalensis with 10 times the mass concentration of 60% ethanol for 12 hours, reflux extraction twice, combine the extracts, centrifuge (15000 rpm), and reduce the supernatant at 60-70°C The ethanol was recovered under pressure, and concentrated to a relativ...

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Abstract

The invention relates to the field of Chinese medicaments, in particular to a Chinese medicinal composition for preventing and treating ischemic brain injury, and a preparation method thereof. The Chinese medicinal composition for preventing and treating ischemic brain injury is an orally taken preparation prepared from extracts of raw astragalus roots, panax notoginseng, kudzuvine roots, baikal skullcap roots and gardenia serving as main active components, as well as pharmaceutical auxiliary materials. The preparation has obvious therapeutic effects on cerebral infarction convalescent symptoms of which the clinical manifestations are eye-mouth distortion, glossolalia, slobbering or hemiplegia, dark red tongue or yellow greasy tongue coating, weak or uneven pulse and the like.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating ischemic brain injury and a preparation method thereof. Background technique [0002] Ischemic stroke is equivalent to the acute ischemic cerebrovascular disease called by modern medicine. It has the characteristics of high morbidity, high mortality, high disability rate, and high recurrence rate. It seriously endangers human health. Research on the prevention and treatment of this disease has been It has become one of the important topics concerned by the society and the medical field. Traditional Chinese medicine has certain advantages in the prevention and treatment of this disease, but most of the research on the treatment of this disease focuses on promoting blood circulation and removing blood stasis or nourishing qi and promoting blood circulation. It has a certain curative effect, but there...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61K36/744A61P9/10
Inventor 万海同张宇燕杨洁红
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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