14results about How to "Improve pathological damage" patented technology

The invention discloses procyanidine B2G2 from purple sweet potato Ningzi No.4 and application thereof, and belongs to the technical field of biological medicine, the molecular formula of the procyanidine B2G2 is C44H34O20, and the molecular weight of the procyanidine B2G2 is 882.736 Da. The procyanidine B2G2 remarkably relieves acute lung injury ALI by inhibiting inflammatory response and ferroptosis induced by klebsiella pneumoniae KP; experiments show that B2G2 can reduce the lung tissue injury score, the lung wet / dry ratio, the expression of inflammatory factors TNF-alpha, IL-6 and IL-1beta and the bacterial load, and up-regulate the expression of ferroptosis related proteins GPX4, SLC7A11 and HO-1; in addition, B2G2 is non-toxic to liver and kidney functions and has good safety, and the application provides a new drug candidate scheme for preparation of drugs for treating acute lung injury.

The application provides a low-deuterium water red ginseng and rhodiola compound mask as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The low-deuterium water red ginseng and rhodiola compound mask provided by the application comprises the following raw materials: a red ginseng and rhodiola compound, low-deuterium water, hydroxyethyl cellulose, carbomer-980, carbomer-981, panthenol, 1,2-hexanediol, p-hydroxyphenylacetone, glycerol, dipropylene glycol, beta-glucan, sodium alginate, disodium EDTA, betaine, allantoin, 1,3-butanediol, PEG-40 hydrogenated castor oil and tromethamine; the red ginseng and rhodiola compound is composed of red ginseng extract and rhodiola extract. The low-deuterium water red ginseng and rhodiola compound mask provided by the application has the effects of antioxidation, whitening and anti-photoaging, and can realize synergistic whitening and anti-photoaging.

The invention belongs to the technical field of biological medicines, and particularly discloses a liposome containing a natural extract composition as well as a preparation method and application of the liposome. The method for preparing the liposome containing the natural extract composition comprises the following steps: S1, adding the grape, poria cocos and apple extract, cholesterol and lecithin into an organic solvent, heating, stirring and dissolving to obtain an organic phase; adding the soybean extract and the ginseng extract into ultrapure water, heating and stirring to obtain a water phase; and S2, slowly adding the organic phase into the water phase while stirring, continuing stirring and emulsifying, and removing the organic solvent by reduced pressure distillation to obtain a liposome suspension. And S3, filtering the suspension, adding a freeze-drying protective additive, and freeze-drying to obtain the liposome. The invention also covers the application of the liposome in treating renal failure. In the invention, through the combination of natural extracts and the combination of a specific composition and liposome administration, the components generate a synergistic effect, and the pharmaceutical composition has a remarkable treatment effect on renal failure, especially chronic renal failure.

This invention discloses the application of Polygonatum oligosaccharides in the preparation of products that improve sperm motility. The molecular weight of the Polygonatum oligosaccharides is 1 × 10⁻⁶. 4 ~5×10 4 This oligosaccharide, Da, can be prepared through steps including ethanol defatting, water extraction, 30%-50% ethanol precipitation, and protein removal. Experiments show that this oligosaccharide can significantly improve sperm motility, particularly restoring the forward sperm motility rate in asthenospermia model mice to over 32%, reaching the clinical treatment threshold; it can also effectively alleviate cyclophosphamide-induced reproductive damage and improve testicular tissue pathological damage. Furthermore, this oligosaccharide can upregulate the expression of sperm motility-related genes such as Crisp2 and Catsper, downregulate miR-27 expression, and has multiple effects including reducing oxidative stress, inhibiting inflammation, and improving reproductive hormone levels. Therefore, this oligosaccharide can be used to prepare products that improve sperm motility, prevent and / or treat asthenospermia, and alleviate chemotherapy-related reproductive damage.

The invention discloses goose plasma protein source oligopeptide capable of improving liver lipid metabolism disorder and application of the goose plasma protein source oligopeptide, and relates to the technical field of biology. The goose plasma protein source oligopeptide capable of improving liver lipid metabolism disorder is obtained through screening, and the amino acid sequence is GDWIVK. Animal experiments prove that the goose plasma protein source oligopeptide can effectively reduce the levels of triglyceride, total cholesterol and low-density lipoprotein cholesterol in serum and liver affected by high fat diet, increase the content of high-density lipoprotein cholesterol, reduce liver lipid deposition and improve pathological injury of the liver. Meanwhile, the structure and diversity of intestinal flora can be adjusted, the abundance of beneficial bacteria and the content of short-chain fatty acid in excrement are increased, the reaction of colitis is relieved, and the synergistic adjustment effect is achieved through an intestinal tract-liver axis.

The invention discloses application of piperlongumine in treating and preventing lung injury, and belongs to the technical field of medicines. Aiming at the technical bottlenecks of limited treatment means and high case fatality rate of the existing acute lung injury (ALI) / acute respiratory distress syndrome (ARDS), the invention discovers that piperlongumine can specifically inhibit cGAS-STING signal channel activation for the first time, and expression release of inflammatory factors IFN-beta, IL-6 and TNF-alpha is reduced by regulating phosphorylation of a downstream interferon regulatory factor 3 (IRF3). In-vitro experiments prove that piperlongumine inhibits ISD-induced inflammatory response in a dose-dependent manner, and in-vivo experiments show that piperlongumine can significantly relieve LPS-induced mouse acute lung tissue inflammatory cell infiltration, reduce serum IL-6 and TNF-alpha levels, and improve lung tissue pathological injury. According to the invention, the medicinal application of piperlongumine is expanded, a new lung injury treatment scheme based on natural active compounds is provided, and the piperlongumine can be widely applied to prevention and treatment of acute lung injury and related inflammatory lung diseases.

This invention belongs to the field of biomedical technology, specifically relating to the application of dexphosserine in the preparation of drugs for the prevention and / or treatment of kidney injury. The dexphosserine can alleviate glycerol-induced acute kidney injury in mouse models, significantly reduce serum creatinine and urea nitrogen levels in mice with acute kidney injury, and improve kidney pathological damage, thus having a therapeutic effect on acute kidney injury and broad application prospects.

The invention discloses an active peptide capable of directionally inducing IPSCS cracking, a preparation method of the active peptide and application of the active peptide in a preparation for repairing liver injury. Experiments prove that the active peptide provided by the invention has a remarkable protective effect on a liver injury model induced by cyclophosphamide and shows a definite anti-oxidative stress effect. The result shows that a key path of chemotherapy injury can be intervened from the source by simulating or enhancing an endogenous protection mechanism of the liver. Compared with the existing exogenous synthetic drugs or single-component natural products, the product provided by the invention has the potential advantages of more comprehensive action mechanism and better biogenic property. Meanwhile, the extract is derived from directionally differentiated functional cells, and a brand new thought and material basis are provided for developing a novel chemotherapy liver protective agent which does not affect the chemotherapy curative effect and has good biocompatibility.

This invention relates to a traditional Chinese medicine composition for delaying the progression of kidney deficiency and blood stasis syndrome in diabetic nephropathy, its application, and preparation method. The composition is made from Astragalus membranaceus, Salvia miltiorrhiza, Paeonia lactiflora, Anemarrhena asphodeloides, Phellodendron chinense, Cistanche deserticola, Scutellaria baicalensis, Euonymus alatus, Schisandra chinensis, raw oyster shell, Plantago asiatica, and Artemisia annua. It has the effects of nourishing the kidneys, clearing heat, eliminating toxins, and unblocking the meridians. This traditional Chinese medicine composition can effectively delay the decline in renal function in patients with massive proteinuria during the diabetic nephropathy stage, improve the clinical symptoms of patients with kidney deficiency and blood stasis syndrome, and improve their quality of life. Simultaneously, it has a low risk of hyperkalemia and gastrointestinal bleeding, and no significant damage to liver function has been observed, indicating high safety.

The invention relates to application of erucic acid in flu secondary bacterial infection, and relates to the technical field of medicines. The erucic acid improves the weight change and the lung index of a patient suffering from the influenza secondary bacterial infection by remarkably reducing the bacterial adhesion condition in the influenza secondary bacterial infection, reduces the lung virus titer and the bacterial load and improves lung pathological injury, and has an excellent application prospect in the aspect of development of medicines for treating the influenza secondary bacterial infection.

The invention discloses a network pharmacological target screening method of nano curcumin applied to plateau skin burn and wound combined injury and application of the nano curcumin in preparation of a medicine for treating plateau burn and wound combined injury, and relates to the technical field of medicine. The invention relates to application of nano curcumin obtained by adopting a network pharmacological target screening method for applying nano curcumin to plateau skin burn and wound combined injury in preparation of a medicine for treating plateau burn and wound combined injury. Nano curcumin in the medicine plays a role in promoting recovery in the early stage of the wound surface by promoting wound surface healing of the burn and wound combined wound; the medicine can relieve the inflammatory reaction and oxidation reaction of a body by inhibiting an AKT-I kappa B-NF kappa B signal channel; the nano curcumin effectively relieves wound inflammatory response and oxidative stress injury by accurately regulating and controlling AKT / ikB / NF kB signal channels, and a new medical strategy is provided for promoting healing of burn and wound combined wounds in a plateau special environment.

This invention discloses a therapeutic drug for chronic obstructive pulmonary disease (COPD), belonging to the field of medical technology. The active ingredient of this drug is syringin. Experimental results show that syringin can significantly alleviate airflow obstruction, inhibit airway inflammation, and improve lung tissue damage. More importantly, this invention demonstrates the synergistic effect of syringin combined with aminophylline. This combined treatment regimen not only significantly improves efficacy but also significantly reduces the dosage and toxic side effects of aminophylline. Therefore, this invention provides a more efficient and safer innovative drug and its combination therapy strategy for COPD treatment, possessing significant clinical application value.

A traditional Chinese medicine composition for clearing the lung and benefiting the throat, a pharmaceutical preparation and a use. The traditional Chinese medicine composition is made of the following traditional Chinese medicine raw materials: forsythia 20-40 parts, honeysuckle 20-40 parts, mulberry leaf 20-40 parts, radix scrophulariae 20-40 parts, ophiopogon 7-11 parts and licorice 4-8 parts. In the mouse animal model experiment, the traditional Chinese medicine composition described herein not only can alleviate the phenomenon of neutrophil infiltration in the lung alveolar lavage fluid caused by LPS, reduce the inflammatory response; also helps to improve the lung tissue pathological damage induced by LPS, maintain the alveolar structure integrity, inhibit pulmonary edema, down-regulate the level of inflammatory factors in the lung alveolar lavage fluid, inhibit the expression of inflammatory factors in the lung tissue, thereby preventing and treating acute lung injury caused by LPS.

The application discloses a preparation method and application of a discodermolide compound. Aspergillus nidulans The discodermolide compound is obtained from a strain of Aspergillus nidulans SE44 Aspergillus nidulans The strain of Aspergillus nidulans SE44 is preserved in the Guangdong Microbial Culture Collection Center on April 15, 2026, and has a preservation number of GDMCC No:68088. It is found that discodermolide A can target the activation of LXR alpha by covalently combining with the R305 site of the LXR alpha protein, thereby regulating the LXR alpha-SLC31A1 signal pathway, inhibiting the generation of ROS, reducing the damage of oxidative stress to kidney tissue, and achieving the treatment effect on acute kidney injury.