91 results about "Gingivitis" patented technology

Tooth brushing monitoring system is disclosed that includes a toothbrush with sensors and a base station. The sensors record data regarding the quality, quantity and location of brushing and the system can analyze the data to provide feedback on the quality of brushing. This feedback provides motivation for users to increase their brushing habits, leading to a decrease in plaque, tooth decay and gingivitis.

The invention provides application of polypeptide in preparation of a product for treating and / or preventing gingivitis and / or periodontitis. The polypeptide with the amino acid sequence shown as SEQ ID NO: 1 is adopted for treating a gingival epithelial cell inflammation model, it is found that the polypeptide can effectively reduce the expression level of inflammatory factors IL-8, IL-1beta and TNF-alpha, and it is indicated that the polypeptide can effectively treat and / or prevent gingivitis and / or periodontitis and is suitable for preparing products for treating and / or preventing gingivitis and / or periodontitis.

The invention discloses application of fermented lactobacillus mucus in preparation of a product for improving tooth color and gingivitis, and relates to the technical field of microorganisms. The lactobacillus fermentum NHNK-623 disclosed by the invention is preserved in the China Center for Type Culture Collection on November 18, 2024, and the preservation number of the lactobacillus fermentum NHNK-623 is CCTCC (China Center for Type Culture Collection) NO: M 20242574. The NHNK-623 has the effects of inhibiting proliferation and biofilm formation of pigment-generating pathogenic bacteria, agglutinating the pigment-generating pathogenic bacteria, inhibiting melanin generation of the pigment-generating pathogenic bacteria, inhibiting hyaluronidase activity of the pathogenic bacteria, promoting growth of gingival fibroblasts, inhibiting gingival cell inflammation and apoptosis induced by the pigment-generating pathogenic bacteria, and inhibiting melanin generation of the pigment-generating pathogenic bacteria. And the product can be used for preparing products for improving tooth color and gingivitis.

The invention discloses a traditional Chinese medicine composite lactobacillus acidophilus NM probiotic preparation for improving oral bacterial flora and a preparation process thereof, and relates to the related field of biotechnology. According to the traditional Chinese medicine composite lactobacillus acidophilus NM probiotic preparation, the synergistic effect of probiotics and traditional Chinese medicine is combined, the traditional Chinese medicine composite lactobacillus acidophilus NM probiotic preparation has the multiple advantages of regulating oral flora, resisting bacteria and diminishing inflammation, resisting oxidation, relieving fatigue and the like, lactobacillus acidophilus NM can tolerate acid and cholate, pathogenic bacteria such as escherichia coli, staphylococcus aureus and salmonella are effectively inhibited, and the traditional Chinese medicine composite lactobacillus acidophilus NM probiotic preparation is suitable for oral administration. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition can be used for reducing dental caries, gingivitis and ozostomia, is free of antibiotic drug resistance and is safer after being used for a long time, radix scutellariae, honeysuckle and green tea extracts are rich in flavonoids and tea polyphenols and can further resist bacteria and inflammation and improve oral health, and meanwhile, the probiotics can reduce blood lactic acid, blood urea nitrogen and blood ammonia, enhance SOD, CAT and GSH-Px vitality and inhibit lipid peroxidation, so that body fatigue is relieved, and the traditional Chinese medicine composition can be used for preventing and treating dental caries, gingivitis and ozostomia. The immunity is improved, and preparation forms are diversified.

Oral care compositions that contain a particular mixture of mono-rhamnolipids and di-rhamnolipids are disclosed. The compositions have antimicrobial efficacy against oral microbes, such as P. gingivalis, S. mutans, and C. rectus. Also disclosed is a method for treating or preventing gingivitis in a subject. Also disclosed is a method for preventing growth of microorganisms as biofilm and / or reducing a population of microorganisms present as biofilm in the oral cavity of a subject.

An oral care composition containing a specific mixture of a single rhamnolipid and a double rhamnolipid is disclosed. The composition has antibacterial efficacy against oral microorganisms, such as Porphyromonas gingivalis, Streptococcus mutans, and Campylobacter rectum. A method of treating or preventing gingivitis in a subject is also disclosed. Also disclosed are methods of preventing microorganisms from growing into a biofilm and / or reducing the number of microorganisms present in the form of a biofilm in the oral cavity of a subject.

The preparation method comprises the following steps: after raw materials are subjected to a pre-preparation process, dividing the raw materials into a water-phase material and a powder material, after the water-phase material passes through a pre-dissolving solution, mixing the water-phase material with the powder material to prepare glue, after the glue is prepared, adding essence, mixing to prepare paste, storing the paste, and filling to finish the preparation of the toothpaste. After being used for 30 days, the toothpaste disclosed by the invention has a relatively good gingival bleeding healing effect, also has a relatively good change on the condition of gingivitis, can prevent the occurrence of gingivitis under the condition of long-term use, and is suitable for people of different ages to use.

The present invention relates to compositions for oral hygiene comprising Crocus sativus flower extracts and their uses for protecting the oral cavity. The invention also relates to therapeutic compositions for use in the prevention and treatment of diseases of the oral cavity, in particular periodontitis and gingivitis.

The invention belongs to the technical field of daily chemicals, and particularly relates to Chinese herbal medicine three-color strip toothpaste and a preparation method thereof. The Chinese herbal medicine three-color strip toothpaste comprises a faint yellow paste body, a green paste body and a blue paste body, the faint yellow paste body comprises, by mass, 0.1%-2% of chitosan quaternary ammonium salt and 0.1%-1% of an ovateleaf holly bark extract, and the green paste body comprises, by mass, 0.002%-0.15% of sodium copper chlorophyllin and 0.1%-1% of the ovateleaf holly bark extract. The blue paste is prepared from the following components in percentage by mass: 0.03 to 0.15 percent of guaiazulene sodium sulfonate and 0.1 to 1 percent of ovateleaf holly bark extract. According to the Chinese herbal medicine three-color-strip toothpaste and the preparation method thereof provided by the invention, the three-color-strip toothpaste is obtained under the condition that exogenous pigments are not added; the toothpaste can achieve the compound effects of freshening breath, inhibiting dental plaque and oral pathogenic bacteria, resisting inflammation, diminishing swelling, resisting allergy, relieving gingivitis and promoting healing and repairing of recurrent oral ulceration, can promote enamel remineralization and pore repairing, and is high in effect synergy, paste stability and use safety.

The invention relates to a composition for improving gingivitis, a preparation method of the composition and gargling and relates to the technical field of gingivitis, and the composition for improving gingivitis comprises the following components in parts by weight: 20-40 parts of shiny-leaved yellowhorn leaves, 5-15 parts of peach gum and 10-25 parts of humulus lupulus. The shiny-leaved yellowhorn leaves, the peach gum and the humulus lupulus which can be used as both medicines and foods are matched to be used as functional raw materials, and meanwhile, effective components are extracted by combining a modern supercritical carbon dioxide extraction process under proper parameters, so that the treatment effect of the obtained composition on gingivitis diseases is remarkably improved, and the use safety of patients is greatly improved. On the basis, the invention further provides the suhuang capable of improving oral diseases such as gingivitis, and the suhuang has the advantages of being safe, effective and the like and is wide in application prospect.

The invention discloses a dental disease image recognition method and system, computer equipment and a storage medium, and the method achieves the bidirectional interaction knowledge transmission between students and a teacher model through constructing a dynamic agent teacher model and integrating the multi-level features of a teacher network, and solves the problem of knowledge stagnation caused by traditional one-way distillation. A comparison relation distillation module is further designed, the relation between samples is optimized based on a cosine similarity matrix and positive and negative sample masks, feature redundancy is reduced in combination with a covariance regularization technology, and the feature alignment capability of the model is improved. And finally, through joint optimization of interactive distillation loss, comparison loss and covariance loss, a lightweight student model is trained. According to the method, the early classification accuracy of dental diseases such as decayed teeth and gingivitis is remarkably improved while the model calculation complexity and the storage requirement are reduced, and the method is suitable for medical scenes with limited resources and has important clinical application value.

The invention relates to the technical field of marine microorganisms, in particular to application of lactobacillus salivarius NHNK-603 in preparation of products for improving tooth color and gingivitis. The strain provided by the invention is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC NO: M 2024416. Experiments show; the NHNK-603 has the effects of inhibiting proliferation and biofilm formation of pigment-generating pathogenic bacteria, agglutinating the pigment-generating pathogenic bacteria, inhibiting melanin generation of the pigment-generating pathogenic bacteria, inhibiting hyaluronidase activity of the pathogenic bacteria, promoting growth of gingival fibroblasts, inhibiting gingival cell inflammation and apoptosis induced by the pigment-generating pathogenic bacteria, and inhibiting melanin generation of the pigment-generating pathogenic bacteria. And the product can be used for preparing products for improving tooth color and gingivitis.

The present invention discloses a traditional Chinese medicine compound Lactobacillus acidophilus NM probiotic preparation for improving oral bacterial flora and its preparation process, which relates to the related field of biotechnology. The traditional Chinese medicine compound Lactobacillus acidophilus NM probiotic preparation of the present invention combines the synergistic effects of probiotics and traditional Chinese medicine, and has multiple advantages such as regulating oral flora, antibacterial and anti-inflammatory, antioxidant, and relieving fatigue. Lactobacillus acidophilus NM can tolerate acid and bile salts, effectively inhibit pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, and Salmonella, reduce the occurrence of dental caries, gingivitis, and halitosis. It has no antibiotic resistance and is safer for long-term use. The extracts of Scutellaria baicalensis, honeysuckle, and green tea are rich in flavonoids and tea polyphenols, which can further antibacterial and anti-inflammatory and improve oral health. At the same time, this probiotic can reduce blood lactic acid, blood urea nitrogen, and blood ammonia, enhance the activities of SOD, CAT, and GSH-Px, and inhibit lipid peroxidation, thereby relieving body fatigue and enhancing immunity. The preparation forms are diverse.

The invention belongs to the technical field of medicines, and particularly relates to application of an echinacea caffeic acid derivative to preparation of a medicine or a feed additive for treating animal periodontal diseases and a composition containing the echinacea caffeic acid derivative. The invention discloses application of an echinacea caffeic acid derivative in preparation of a medicine for treating animal periodontal diseases. Experiments prove that the echinacea caffeic acid derivative has the effects of improving feline gingivitis, gingival bleeding, gingival atrophy, alveolar bone loss and the like, can be used for treating and preventing animal periodontal diseases, and has smaller toxic and side effects while ensuring that a better periodontal disease treatment effect can be realized.

The present invention relates to a compound of formula (I) or a salt thereof, wherein the group R is as defined in the specification; and also relates to a method for preparing the compound and its use as a photosensitizer in photodynamic therapy. The monosubstituted protoporphyrin derivatives involved in the present invention all have high permeability, high activity, and good biosafety. The preparation method is simple, low-cost, and can obtain the target product in good yield. It is particularly suitable for industrial production and can be used as a highly effective photosensitizer in photodynamic therapy to treat oral diseases such as periodontitis, gingivitis, dental plaque, and caries caused by Gram-negative anaerobic cocci and other bacteria such as Porphyromonas gingivalis.

The traditional Chinese medicine mouthwash comprises a traditional Chinese medicine compound and a mouthwash matrix, and the traditional Chinese medicine compound comprises the following components in parts by weight: 10-20 parts of golden cypress, 15-30 parts of angelica sinensis, 15-30 parts of honeysuckle, 15-30 parts of chrysanthemum and 15-30 parts of liquorice. The invention also provides a preparation method of the traditional Chinese medicine mouthwash for relieving gingivitis. The traditional Chinese medicine mouthwash for relieving gingivitis can promote proliferation of gingival fibroblasts, promote secretion of gingival fibroblast collagen and effectively inhibit proliferation of oral anaerobic bacteria, thereby relieving gingivitis.

The invention provides a machine learning model structure for predictive periodontitis evaluation by using a divide-and-conquer technology, which comprises a first machine learning model and a second machine learning model, wherein the first machine learning model is adapted to predict a health status of the user with respect to gingivitis formation based at least in part on measurement data captured by a personal oral care device used by the user; and wherein the second machine learning model is adapted to predict a state of health of the user with respect to periodontitis formation based at least in part on the predicted state of health of the user with respect to gingivitis formation obtained using the first machine learning model.

Composition for use for the treatment and / or prevention of infections or lesions of the (oral) mucosa, in particular originating from at least one selected the group consisting of: perleche; scarlet fever; pharyngitis; acute necrotising ulcerative mucositis; impetigo contagiosa; chelitis glandularis apostem atosa; gingivostomatitis herpetica; herpes simplex; herpes stabistis recidivans; herpes zoster; hand-foot-mouth; human papilloma virus; HIV; oral candidiasis; oral lichen planus; lichen ruber planus; leukoplakia, erythroplakia; methicillin-resistant staphylococcus aureus; gingivitis / periodontitis; mucositis / peri- implantitis; alveolar osteolytis; wherein the composition comprises or consists of the following components: (a) polyhexanide (PHMB); (b) an organic or inorganic buffer different from a); (c) further additives; (d) optionally water.

The application discloses a cat oral cavity nursing probiotic composition and application thereof, and the probiotic composition comprises animal bifidobacterium and lactic acid bacteria, wherein the lactic acid bacteria is any one or a combination of multiple of salivarius, lactobacillus casei, enterococcus faecalis, lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus acidophilus and lactobacillus reuteri; compared with single probiotic, the probiotic composition has better effect on oral cavity odor removal, can effectively improve cat oral cavity source halitosis, and can also reduce dental plaque formation, relieve gingivitis and dental caries, and can be applied to preparation of a cat oral cavity odor cleaner, and has good application prospect.

A system (100) for detecting tissue inflammation, gingivitis specifically, including a light emitter (102) configured to emit light at a tissue region within a user's mouth; at least four wavelength-sensitive photodetectors (110, 112, 114, and 116) configured to detect optical signals diffusely reflected through the tissue region, each of the at least four wavelength-sensitive photodetectors comprising a filter (BPF1, BPF2, BPF3, and BPF4) and a photodiode (D1, D2, D3, and D4), where the photodiodes are stacked on top of each other to generate current differential signals for amplifiers corresponding with the photodiodes, wherein the generation of the current differential signals removes an unwanted component from the optical signals prior to amplification; and an inflammation detection unit (136) configured to receive outputs from the corresponding amplifiers and detect inflammation at the tissue region.

The present invention relates to a compound of formula (I) or a salt thereof, wherein the group R is as defined in the description; the invention also relates to a preparation method of the compound and application of the compound as a photosensitizer in photodynamic therapy. The mono-substituted protoporphyrin derivative has high permeability, high activity and good biological safety, the preparation method is simple in process and low in cost, a target product can be obtained with good yield, and the mono-substituted protoporphyrin derivative is especially suitable for industrial production and has wide application prospects. The compound can be used as an efficient photosensitizer for treating hyperproliferative diseases such as cancers or precancerous lesions in photodynamic therapy, or treating oral diseases # imgabs0 # (I) such as periodontitis, gingivitis, dental plaque and decayed teeth caused by bacteria such as Gram-negative anaerobic bacillus such as porphyromonas gingivalis.

The present application discloses an application of a biomarker in the preparation of a product for diagnosing patients with oral diseases and a kit for detecting oral diseases, wherein the oral diseases include at least one of periodontitis, gingivitis and caries, and the biomarkers include cytokines and / or oral microorganisms, wherein the cytokines include at least one of IFN-γ, IL-6, IL-10, IL-18 and IL-1β, and the oral microorganisms include at least one of Neisseria, Porphyromonas, Fusobacterium and Treponema. In the present application, auxiliary diagnosis of oral diseases can be achieved by detecting biomarkers, which is conducive to timely detection of the condition in the early stage of oral diseases or before the disease progresses for timely intervention.

The present invention relates a process for preparing a compound of Formula XX wherein: R1 is hydrogen, optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R2 is an N-containign heterocyclyl or heteroaryl; and Q is optionally substitued aryl or heteroaryl. Furthermore a compound of the present invention are useful in the treamtment of various inflammatory, autoimmune and allergic diseases, such as method of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoartluitis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the overexpression and over-activation of a matrix metalloproteinase using the compound.

A brush head of a toothbrush includes a plurality of bristles for cleaning teeth and a sensor unit for monitoring the health status of a user regarding development of paradontitis, cavities, periodontitis, and / or for health monitoring. The sensor unit is exchangeably arranged on or in the brush head.

The invention belongs to the technical field of medical instruments, and particularly relates to a biological memristor for periodontitis detection and a preparation method and application thereof. Through an electrical response test, the biological memristor can effectively distinguish normal saliva, gingivitis saliva and I-stage periodontitis saliva, shows remarkably different current response and a larger resistance window, highlights the potential of the biological memristor in early detection of periodontitis, provides a low-cost and convenient solution for real-time oral health monitoring, and has wide application prospects. And a new way is opened up for early diagnosis of oral diseases.

This invention provides a combination of medicine and device for treating dental diseases. The method for preparing the medicine is as follows: Boil 1 dan (approximately 50 catties) of cocklebur root and stems, 30 jin (approximately 15 catties) of wild chrysanthemum stems and leaves, and 5 jin (approximately 2.5 kg) of licorice root in a pot until thoroughly cooked. Remove the dregs, and bring the remaining liquid to a boil over high heat, then simmer over low heat until it becomes a paste. When the paste is about 70% cooked, for the treatment of gingivitis and periodontitis, add 100g of indigo naturalis, 50g of mirabilite, 150g of borax, 100g of gypsum, and an appropriate amount of edible preservative. Set aside when fully cooked. For the treatment of toothache, when the paste is about 70% cooked, add 50g of asarum, 100g of angelica dahurica, 100g of Sichuan pepper, 50g of bee honeycomb, 50g of rosin, 100g of borax, 50g of gypsum, and an appropriate amount of edible preservative. (These herbs should be pulverized before being added.) Set aside when fully cooked. The treatment device is a long, narrow, isosceles trapezoid with a hollowed-out center and top base, leaving a wall thickness of 0.2-0.4 mm. The device's dimensions are: base 13 mm, sides 13 mm, and length 18 mm. It can be made of metal or non-toxic plastic. A strip of cloth of the corresponding size is attached to the device, and the prepared ointment is applied to the cloth. When using it, the ointment-coated device is placed on the affected area, ensuring close contact with the lesion and maximizing the medication's effectiveness.

Disclosed herein are methods for determining oral health of an animal by compositional analysis of oral microbiome. The abundance or relative abundance of one or more classified populations of microorganisms is determined using quantitative PCR and DNA sequencing techniques. A population of microorganisms whose abundance is identified as a marker of periodontitis and / or gingivitis.

The present invention relates to a compound of formula (I) or a salt thereof, wherein the group R is as defined in the description; the invention also relates to a preparation method of the compound and application of the compound as a photosensitizer in photodynamic therapy. The mono-substituted protoporphyrin derivative has high permeability, high activity and good biological safety, the preparation method is simple in process and low in cost, a target product can be obtained with good yield, and the mono-substituted protoporphyrin derivative is especially suitable for industrial production and has wide application prospects. The compound can be used as a high-efficiency photosensitizer for treating oral diseases # imgabs0 #, such as periodontitis, gingivitis, dental plaque, decayed teeth and the like, caused by bacteria such as Gram-negative anaerobic bacillus, such as porphyromonas gingivalis in photodynamic therapy.

The invention relates to the technical field of biology, in particular to lactobacillus paracasei and application of the lactobacillus paracasei to improvement of tooth color and gingivitis. The strain provided by the invention is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC NO: M 20251304. Experiments show; the NHNK-632 has the effects of inhibiting proliferation and biofilm formation of pigment-generating pathogenic bacteria, agglutinating the pigment-generating pathogenic bacteria, inhibiting melanin generation of the pigment-generating pathogenic bacteria, inhibiting hyaluronidase activity of the pathogenic bacteria, promoting growth of gingival fibroblasts, inhibiting gingival cell inflammation and apoptosis induced by the pigment-generating pathogenic bacteria, and inhibiting melanin generation of the pigment-generating pathogenic bacteria. And the product can be used for preparing products for improving tooth color and gingivitis.

The invention discloses traditional Chinese medicine toothpaste, and particularly relates to traditional Chinese medicine toothpaste for preventing and treating gingivitis and a preparation method of the traditional Chinese medicine toothpaste. The traditional Chinese medicine toothpaste is prepared from the following components in percentage by mass: 0.05 to 5 percent of rhizoma bletillae polysaccharide, 0.1 to 10 percent of inclusion compound obtained by inclusion of piper cubeba volatile oil with beta-cyclodextrin, 5 to 30 percent of silicon dioxide, 30 to 70 percent of humectant, 0.05 to 0.5 percent of aromatic, 0.05 to 5 percent of foaming agent, 0.1 to 1 percent of sweetening agent, 0.0001 to 0.5 percent of coloring agent, 0.1 percent of preservative and the balance of deionized water. The rhizoma bletillae polysaccharide and the piper cubeba volatile oil beta-cyclodextrin inclusion compound are combined for preventing and treating gingivitis, can synergistically resist bacteria and inflammation, improve gingival microcirculation and achieve the effects of diminishing inflammation, relieving pain and stopping bleeding, on the basis, healing of damaged gingiva is accelerated, the recovery time of gingivitis of a patient is shortened, and the pain of the patient is relieved; the effects of a thickening agent and essence in the auxiliary materials can be reduced or replaced, the effects of thickening and flavoring are achieved by utilizing the characteristics of the rhizoma bletillae polysaccharide and the piper cubeba volatile oil, and the medicines and the auxiliary materials are combined.