64 results about "Gingivitis" patented technology

The invention discloses application of fermented lactobacillus mucus in preparation of a product for improving tooth color and gingivitis, and relates to the technical field of microorganisms. The lactobacillus fermentum NHNK-623 disclosed by the invention is preserved in the China Center for Type Culture Collection on November 18, 2024, and the preservation number of the lactobacillus fermentum NHNK-623 is CCTCC (China Center for Type Culture Collection) NO: M 20242574. The NHNK-623 has the effects of inhibiting proliferation and biofilm formation of pigment-generating pathogenic bacteria, agglutinating the pigment-generating pathogenic bacteria, inhibiting melanin generation of the pigment-generating pathogenic bacteria, inhibiting hyaluronidase activity of the pathogenic bacteria, promoting growth of gingival fibroblasts, inhibiting gingival cell inflammation and apoptosis induced by the pigment-generating pathogenic bacteria, and inhibiting melanin generation of the pigment-generating pathogenic bacteria. And the product can be used for preparing products for improving tooth color and gingivitis.

The preparation method comprises the following steps: after raw materials are subjected to a pre-preparation process, dividing the raw materials into a water-phase material and a powder material, after the water-phase material passes through a pre-dissolving solution, mixing the water-phase material with the powder material to prepare glue, after the glue is prepared, adding essence, mixing to prepare paste, storing the paste, and filling to finish the preparation of the toothpaste. After being used for 30 days, the toothpaste disclosed by the invention has a relatively good gingival bleeding healing effect, also has a relatively good change on the condition of gingivitis, can prevent the occurrence of gingivitis under the condition of long-term use, and is suitable for people of different ages to use.

The present invention relates to compositions for oral hygiene comprising Crocus sativus flower extracts and their uses for protecting the oral cavity. The invention also relates to therapeutic compositions for use in the prevention and treatment of diseases of the oral cavity, in particular periodontitis and gingivitis.

The invention belongs to the technical field of daily chemicals, and particularly relates to Chinese herbal medicine three-color strip toothpaste and a preparation method thereof. The Chinese herbal medicine three-color strip toothpaste comprises a faint yellow paste body, a green paste body and a blue paste body, the faint yellow paste body comprises, by mass, 0.1%-2% of chitosan quaternary ammonium salt and 0.1%-1% of an ovateleaf holly bark extract, and the green paste body comprises, by mass, 0.002%-0.15% of sodium copper chlorophyllin and 0.1%-1% of the ovateleaf holly bark extract. The blue paste is prepared from the following components in percentage by mass: 0.03 to 0.15 percent of guaiazulene sodium sulfonate and 0.1 to 1 percent of ovateleaf holly bark extract. According to the Chinese herbal medicine three-color-strip toothpaste and the preparation method thereof provided by the invention, the three-color-strip toothpaste is obtained under the condition that exogenous pigments are not added; the toothpaste can achieve the compound effects of freshening breath, inhibiting dental plaque and oral pathogenic bacteria, resisting inflammation, diminishing swelling, resisting allergy, relieving gingivitis and promoting healing and repairing of recurrent oral ulceration, can promote enamel remineralization and pore repairing, and is high in effect synergy, paste stability and use safety.

The invention relates to a composition for improving gingivitis, a preparation method of the composition and gargling and relates to the technical field of gingivitis, and the composition for improving gingivitis comprises the following components in parts by weight: 20-40 parts of shiny-leaved yellowhorn leaves, 5-15 parts of peach gum and 10-25 parts of humulus lupulus. The shiny-leaved yellowhorn leaves, the peach gum and the humulus lupulus which can be used as both medicines and foods are matched to be used as functional raw materials, and meanwhile, effective components are extracted by combining a modern supercritical carbon dioxide extraction process under proper parameters, so that the treatment effect of the obtained composition on gingivitis diseases is remarkably improved, and the use safety of patients is greatly improved. On the basis, the invention further provides the suhuang capable of improving oral diseases such as gingivitis, and the suhuang has the advantages of being safe, effective and the like and is wide in application prospect.

The invention discloses a dental disease image recognition method and system, computer equipment and a storage medium, and the method achieves the bidirectional interaction knowledge transmission between students and a teacher model through constructing a dynamic agent teacher model and integrating the multi-level features of a teacher network, and solves the problem of knowledge stagnation caused by traditional one-way distillation. A comparison relation distillation module is further designed, the relation between samples is optimized based on a cosine similarity matrix and positive and negative sample masks, feature redundancy is reduced in combination with a covariance regularization technology, and the feature alignment capability of the model is improved. And finally, through joint optimization of interactive distillation loss, comparison loss and covariance loss, a lightweight student model is trained. According to the method, the early classification accuracy of dental diseases such as decayed teeth and gingivitis is remarkably improved while the model calculation complexity and the storage requirement are reduced, and the method is suitable for medical scenes with limited resources and has important clinical application value.

The invention relates to the technical field of marine microorganisms, in particular to application of lactobacillus salivarius NHNK-603 in preparation of products for improving tooth color and gingivitis. The strain provided by the invention is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC NO: M 2024416. Experiments show; the NHNK-603 has the effects of inhibiting proliferation and biofilm formation of pigment-generating pathogenic bacteria, agglutinating the pigment-generating pathogenic bacteria, inhibiting melanin generation of the pigment-generating pathogenic bacteria, inhibiting hyaluronidase activity of the pathogenic bacteria, promoting growth of gingival fibroblasts, inhibiting gingival cell inflammation and apoptosis induced by the pigment-generating pathogenic bacteria, and inhibiting melanin generation of the pigment-generating pathogenic bacteria. And the product can be used for preparing products for improving tooth color and gingivitis.

The invention belongs to the technical field of medicines, and particularly relates to application of an echinacea caffeic acid derivative to preparation of a medicine or a feed additive for treating animal periodontal diseases and a composition containing the echinacea caffeic acid derivative. The invention discloses application of an echinacea caffeic acid derivative in preparation of a medicine for treating animal periodontal diseases. Experiments prove that the echinacea caffeic acid derivative has the effects of improving feline gingivitis, gingival bleeding, gingival atrophy, alveolar bone loss and the like, can be used for treating and preventing animal periodontal diseases, and has smaller toxic and side effects while ensuring that a better periodontal disease treatment effect can be realized.

The present invention relates to a compound of formula (I) or a salt thereof, wherein the group R is as defined in the specification; and also relates to a method for preparing the compound and its use as a photosensitizer in photodynamic therapy. The monosubstituted protoporphyrin derivatives involved in the present invention all have high permeability, high activity, and good biosafety. The preparation method is simple, low-cost, and can obtain the target product in good yield. It is particularly suitable for industrial production and can be used as a highly effective photosensitizer in photodynamic therapy to treat oral diseases such as periodontitis, gingivitis, dental plaque, and caries caused by Gram-negative anaerobic cocci and other bacteria such as Porphyromonas gingivalis.

The traditional Chinese medicine mouthwash comprises a traditional Chinese medicine compound and a mouthwash matrix, and the traditional Chinese medicine compound comprises the following components in parts by weight: 10-20 parts of golden cypress, 15-30 parts of angelica sinensis, 15-30 parts of honeysuckle, 15-30 parts of chrysanthemum and 15-30 parts of liquorice. The invention also provides a preparation method of the traditional Chinese medicine mouthwash for relieving gingivitis. The traditional Chinese medicine mouthwash for relieving gingivitis can promote proliferation of gingival fibroblasts, promote secretion of gingival fibroblast collagen and effectively inhibit proliferation of oral anaerobic bacteria, thereby relieving gingivitis.

The invention provides a machine learning model structure for predictive periodontitis evaluation by using a divide-and-conquer technology, which comprises a first machine learning model and a second machine learning model, wherein the first machine learning model is adapted to predict a health status of the user with respect to gingivitis formation based at least in part on measurement data captured by a personal oral care device used by the user; and wherein the second machine learning model is adapted to predict a state of health of the user with respect to periodontitis formation based at least in part on the predicted state of health of the user with respect to gingivitis formation obtained using the first machine learning model.

Composition for use for the treatment and / or prevention of infections or lesions of the (oral) mucosa, in particular originating from at least one selected the group consisting of: perleche; scarlet fever; pharyngitis; acute necrotising ulcerative mucositis; impetigo contagiosa; chelitis glandularis apostem atosa; gingivostomatitis herpetica; herpes simplex; herpes stabistis recidivans; herpes zoster; hand-foot-mouth; human papilloma virus; HIV; oral candidiasis; oral lichen planus; lichen ruber planus; leukoplakia, erythroplakia; methicillin-resistant staphylococcus aureus; gingivitis / periodontitis; mucositis / peri- implantitis; alveolar osteolytis; wherein the composition comprises or consists of the following components: (a) polyhexanide (PHMB); (b) an organic or inorganic buffer different from a); (c) further additives; (d) optionally water.

The application discloses a cat oral cavity nursing probiotic composition and application thereof, and the probiotic composition comprises animal bifidobacterium and lactic acid bacteria, wherein the lactic acid bacteria is any one or a combination of multiple of salivarius, lactobacillus casei, enterococcus faecalis, lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus acidophilus and lactobacillus reuteri; compared with single probiotic, the probiotic composition has better effect on oral cavity odor removal, can effectively improve cat oral cavity source halitosis, and can also reduce dental plaque formation, relieve gingivitis and dental caries, and can be applied to preparation of a cat oral cavity odor cleaner, and has good application prospect.

A system (100) for detecting tissue inflammation, gingivitis specifically, including a light emitter (102) configured to emit light at a tissue region within a user's mouth; at least four wavelength-sensitive photodetectors (110, 112, 114, and 116) configured to detect optical signals diffusely reflected through the tissue region, each of the at least four wavelength-sensitive photodetectors comprising a filter (BPF1, BPF2, BPF3, and BPF4) and a photodiode (D1, D2, D3, and D4), where the photodiodes are stacked on top of each other to generate current differential signals for amplifiers corresponding with the photodiodes, wherein the generation of the current differential signals removes an unwanted component from the optical signals prior to amplification; and an inflammation detection unit (136) configured to receive outputs from the corresponding amplifiers and detect inflammation at the tissue region.

The present invention relates a process for preparing a compound of Formula XX wherein: R1 is hydrogen, optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R2 is an N-containign heterocyclyl or heteroaryl; and Q is optionally substitued aryl or heteroaryl. Furthermore a compound of the present invention are useful in the treamtment of various inflammatory, autoimmune and allergic diseases, such as method of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoartluitis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the overexpression and over-activation of a matrix metalloproteinase using the compound.

A brush head of a toothbrush includes a plurality of bristles for cleaning teeth and a sensor unit for monitoring the health status of a user regarding development of paradontitis, cavities, periodontitis, and / or for health monitoring. The sensor unit is exchangeably arranged on or in the brush head.

The invention belongs to the technical field of medical instruments, and particularly relates to a biological memristor for periodontitis detection and a preparation method and application thereof. Through an electrical response test, the biological memristor can effectively distinguish normal saliva, gingivitis saliva and I-stage periodontitis saliva, shows remarkably different current response and a larger resistance window, highlights the potential of the biological memristor in early detection of periodontitis, provides a low-cost and convenient solution for real-time oral health monitoring, and has wide application prospects. And a new way is opened up for early diagnosis of oral diseases.

This invention provides a combination of medicine and device for treating dental diseases. The method for preparing the medicine is as follows: Boil 1 dan (approximately 50 catties) of cocklebur root and stems, 30 jin (approximately 15 catties) of wild chrysanthemum stems and leaves, and 5 jin (approximately 2.5 kg) of licorice root in a pot until thoroughly cooked. Remove the dregs, and bring the remaining liquid to a boil over high heat, then simmer over low heat until it becomes a paste. When the paste is about 70% cooked, for the treatment of gingivitis and periodontitis, add 100g of indigo naturalis, 50g of mirabilite, 150g of borax, 100g of gypsum, and an appropriate amount of edible preservative. Set aside when fully cooked. For the treatment of toothache, when the paste is about 70% cooked, add 50g of asarum, 100g of angelica dahurica, 100g of Sichuan pepper, 50g of bee honeycomb, 50g of rosin, 100g of borax, 50g of gypsum, and an appropriate amount of edible preservative. (These herbs should be pulverized before being added.) Set aside when fully cooked. The treatment device is a long, narrow, isosceles trapezoid with a hollowed-out center and top base, leaving a wall thickness of 0.2-0.4 mm. The device's dimensions are: base 13 mm, sides 13 mm, and length 18 mm. It can be made of metal or non-toxic plastic. A strip of cloth of the corresponding size is attached to the device, and the prepared ointment is applied to the cloth. When using it, the ointment-coated device is placed on the affected area, ensuring close contact with the lesion and maximizing the medication's effectiveness.

Disclosed herein are methods for determining oral health of an animal by compositional analysis of oral microbiome. The abundance or relative abundance of one or more classified populations of microorganisms is determined using quantitative PCR and DNA sequencing techniques. A population of microorganisms whose abundance is identified as a marker of periodontitis and / or gingivitis.

The invention relates to the technical field of biology, in particular to lactobacillus paracasei and application of the lactobacillus paracasei to improvement of tooth color and gingivitis. The strain provided by the invention is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC NO: M 20251304. Experiments show; the NHNK-632 has the effects of inhibiting proliferation and biofilm formation of pigment-generating pathogenic bacteria, agglutinating the pigment-generating pathogenic bacteria, inhibiting melanin generation of the pigment-generating pathogenic bacteria, inhibiting hyaluronidase activity of the pathogenic bacteria, promoting growth of gingival fibroblasts, inhibiting gingival cell inflammation and apoptosis induced by the pigment-generating pathogenic bacteria, and inhibiting melanin generation of the pigment-generating pathogenic bacteria. And the product can be used for preparing products for improving tooth color and gingivitis.

The present invention relates to compounds of formula (I) or salts thereof, wherein the group R is as defined in the specification; and methods for preparing the compounds and their use as photosensitizers in photodynamic therapy. The monosubstituted protoporphyrin derivatives disclosed herein all exhibit high permeability, high activity, and good biosafety. Their preparation methods are simple, cost-effective, and capable of obtaining the target product in good yield, making them particularly suitable for industrial production. They can be used as highly effective photosensitizers in photodynamic therapy to treat hyperproliferative diseases such as cancer or precancerous lesions, or to treat oral diseases such as periodontitis, gingivitis, dental plaque, and dental caries caused by Gram-negative anaerobic cocci and other bacteria, such as Porphyromonas gingivalis.

The present invention relates to a compound of formula (I) or a salt thereof, wherein the group R is as defined in the specification; and also to a method for preparing the compound and its use as a photosensitizer in photodynamic therapy. The disubstituted ester porphyrin derivatives of the present invention have high ROS production, high activity, and good biosafety. The preparation method is simple, low-cost, and can obtain the target product in good yield, making it particularly suitable for industrial production. They can be used as highly effective photosensitizers for photodynamic therapy to treat hyperproliferative diseases such as cancer or precancerous lesions, particularly cervical cancer or precancerous lesions, or to treat oral diseases such as periodontitis, gingivitis, dental plaque, and dental caries caused by Gram-negative anaerobic cocci, such as Porphyromonas gingivalis.

A composition, in particular for the prophylaxis and / or treatment of caries, gingivitis, halitosis and / or arteriosclerosis, comprises N-cetylpyridinium chloride, at least one flavonoid, at least one polymer, in particular a homopolymer comprising at least one monomer having a polar functional group, in particular polylysine, and optionally chlorhexidine, wherein the weight ratio of chlorhexidine to N-cetylpyridinium chloride is between 0 and 7, in particular between 0.01 and 6, especially between 0.1 and 5, more especially between 0.2 and 4, for example between 0.4 and 3.2.

The invention belongs to the field of oral care, and particularly relates to an oral composition containing regenerative medical materials as well as a preparation method and application of the oral composition. The oral composition comprises a regenerative medical material and alcohol which are ultrasonically mixed, and does not comprise other antibacterial components; wherein the regenerative medical material is prepared from the following components in parts by mass: 10 to 25 parts of P2O5, 20 to 60 parts of SiO2 and 15 to 45 parts of CaO, and the regenerative medical material is a porous material. The oral composition is used as a main active ingredient or a unique active ingredient and is applied to an oral care product, and the oral care product has at least one of the following effects of freshening breath, inhibiting dental plaque, reducing gingivitis, reducing mouth-derived halitosis and reducing non-mouth-derived halitosis.

The invention discloses a preparation process and application of potassium calcium sodium phosphosilicate fluoride, and belongs to the technical field of biological materials. By optimizing the low-temperature fluoride raw material and the bioactive glass powder and under the sintering treatment process, high fluorine loading capacity can be obtained, the fluorine element is combined with the bioglass in a chemical bond form, the stability is higher, and the application effect of the bioglass is guaranteed; and low-temperature sintering treatment is low in energy consumption, large-scale production can be achieved, and operability is high. Besides, the fluorinated sodium potassium calcium phosphosilicate prepared by the invention is high in biological safety, can play remarkable roles in inhibiting bacteria, preventing dental caries and tooth sensitivity symptoms, promoting oral soft tissue healing, inhibiting gingivitis and freshening breath when being applied to preparation of medical oral products and daily chemical products, can also be applied to preparation of foods, and has a wide application prospect. Especially in the preparation of betel nuts, as an active material, the betel nuts can relieve tooth sensitivity symptoms, promote oral soft tissue healing and inhibit gingivitis.

The present invention relates to a composition for preventing or treating oral diseases, comprising, as an active ingredient, one compound selected from the group consisting of sclareolide, astragaloside I, and brassinolide, or a pharmaceutically acceptable salt thereof. The composition of the present invention has an excellent antibacterial activity against bacteria that cause dental caries and periodontal diseases, inhibits PGE2, which is a marker of pain and inflammation in a concentration-dependent manner, and has excellent effects of inhibiting gingivitis formation, inhibiting symptoms of hemodia, and removing halitosis. As a result, it is highly active as a foreign medicine composition for preventing or ameliorating one or more oral diseases selected from the group consisting of dental caries, periodontal diseases, hemodia, and halitosis. In addition, the composition of the present invention can be used as a pharmaceutical composition and a food composition.

The present application belongs to the technical field of cosmetics or drugs, and particularly relates to a composition for treating gingivitis and application thereof. The composition is composed of shikonin acid and shikonin naphthoquinone, and the mass ratio of the shikonin acid to the shikonin naphthoquinone is 10-100:1. The present application has excellent effects in improving gingival bleeding and inhibiting alveolar bone absorption. The shikonin acid is prepared by high-pressure steam explosion combined with ethanol extraction, activated carbon decolorization and macroporous adsorption resin technology, and the shikonin naphthoquinone is prepared by supercritical CO2 extraction combined with molecular distillation technology. The preparation method is green, stable and controllable, the obtained active ingredient has high purity, and is suitable for industrial production. The composition of the present application is derived from natural plant ingredients, has high safety, can be prepared into various oral care dosage forms such as gels, toothpastes and mouthwashes, is used for the auxiliary treatment or daily care of gingivitis, and has good application prospect.

This invention discloses a traditional Chinese medicine composition for the prevention and treatment of throat and oral diseases, and its preparation method. The composition comprises poultry egg yolk oil, honey, platycodon root, dandelion, licorice, monk fruit, menthol, and maltose in specific weight proportions. Its preparation includes steps such as frying poultry egg yolk oil, preparing water extracts of platycodon root and dandelion, and mixing with maltose to form a final product. The composition of this invention uses only food-grade medicinal materials, ensuring safety and reliability. When formulated into topical dosage forms such as lozenges, it provides long-lasting effects on the affected area, offering multiple benefits including analgesia, anti-inflammation, mucosal repair, and cough suppression. It effectively solves the problems of significant side effects and limited duration of local application in existing oral medications. This product has a pleasant taste and high patient compliance, making it suitable for the prevention and treatment of throat and oral diseases such as pharyngitis, tonsillitis, oral ulcers, gingivitis, and sore throat.

The present invention relates to a composition for diagnosing periodontal diseases by using bacterial clusters in gingival crevicular fluid, and a use thereof, and the objective of the present invention is to distinguish the severity of periodontal diseases by using bacterial clusters distributed in the gingival crevicular fluid and relative ratios thereof, wherein differences in characteristics of bacterial clusters according to gingivitis, moderate periodontitis and severe periodontitis are exhibited, and thus a standard for distinguishing the severity of periodontal diseases by using same is proposed, and in addition, the present invention is advantageous in that, with respect to sample collection, gingival crevicular fluid is safe, easily and quickly accessible, and allows a non-invasive method to be used so that patient inconvenience can be minimized, and the development of a diagnostic kit using the gingival crevicular fluid can be helpful in identifying the degree of progression of periodontal diseases.

Tooth brushing monitoring system is disclosed that includes a toothbrush with sensors and a base station. The sensors record data regarding the quality, quantity and location of brushing and the system can analyze the data to provide feedback on the quality of brushing. This feedback provides motivation for users to increase their brushing habits, leading to a decrease in plaque, tooth decay and gingivitis