65 results about "Antibacterial efficacy" patented technology

The invention discloses a multi-target joint optimized antibiotic molecule design system and method applied to the field of biological medicine, and the method comprises the steps: obtaining FabI enzyme and AcrAB-TolC efflux pump structure data, extracting double-target space and physicochemical characteristics, and constructing a joint pharmacophore model containing a FabI inhibition domain and an efflux pump blocking domain; screening candidate molecules meeting a double-domain space matching threshold, screening high-affinity double-target molecules through conformation sampling and free energy calculation, and forming a lead compound library through multi-layer filtration of metabolic stability, membrane penetrability, quantum chemical properties and synthesis feasibility; carrying out electron effect, chain length or heteroatom fine tuning on dominant molecules through in-vitro bacteriostasis and efflux inhibition experiment feedback, and carrying out iterative optimization until MIClt is met; 2 [mu] g / mL and the efflux inhibition rate is gt; according to the present invention, the antibacterial effect and the drug resistance inhibition ability are significantly improved, the molecular synthesizability and the biological safety are ensured, and the engineering design new path is provided for the Gram-negative bacterium drug resistance crisis.

Disclosed in the present application are an antibacterial anti-scale silica gel material, and a preparation method therefor and the use thereof. Raw materials for preparing the silica gel material comprise a component A and a component B, wherein the component A comprises vinyl polysiloxane, a first silane coupling agent, fumed silica and a platinum catalyst; and the component B comprises vinyl polysiloxane, a first silane coupling agent, fumed silica, hydrogen-containing polysiloxane, an inhibitor and a composite scale-inhibiting antibacterial material, the composite scale-inhibiting antibacterial material being prepared by encapsulating a scale inhibitor and an antibacterial agent in cyclodextrin. In the present invention, the scale inhibitor and the antibacterial agent are encapsulated in cyclodextrin under certain conditions so as to prepare the composite scale-inhibiting antibacterial material; then, under the action of the platinum catalyst, the composite scale-inhibiting antibacterial material undergoes graft polymerization with the vinyl polysiloxane, and the vinyl polysiloxane also undergoes a homopolymerization and autopolymerization reaction, thereby preparing a silica gel material bonded with an antibacterial anti-scale sustained-release body; and the prepared silica gel material ensures that the scale inhibitor and the antibacterial agent can be slowly released outwards in a usage scenario, thereby achieving long-term scale-inhibiting and antibacterial effects.

The present invention relates to a microneedle-based transdermal delivery patch fabricated from a hydrogel composed of polyvinyl alcohol (PVA), arginine-modified chitosan, and a crosslinker. The arginine-modified chitosan is prepared by reacting a chitosan solution with an arginine solution preactivated with N-hydroxy succinimide and 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide at a specific pH. The hydrogel's formulation further comprises a PVA concentration ranging from 10% to 12% (w / v). arginine-modified chitosan and PVA solution are mixed in a 1:2 ratio by volume and are crosslinked using trimethyl orthoformate (TMOF). The patch is further loaded with curcumin, with a concentration of 120μg per patch, demonstrating a 70% release over 48 hours in a controlled manner. This invention represents the first application of PVA crosslinked arginine-modified chitosan hydrogel loaded with curcumin specifically for animal wound healing, providing enhanced wound healing and antibacterial efficacy.

The invention discloses bacillus subtilis S1703 and application thereof, and belongs to the technical field of plant disease and pest control. The name of the bacterial strain is bacillus subtilis S1703, and the preservation number of the bacterial strain is GDMCC No: 66890. The bacterial strain S1703 has a wider antibacterial spectrum, and can effectively inhibit the growth of pathogenic bacteria such as fusarium oxysporum, colletotrichum gloeosporioides, alternaria alternata, aspergillus, phyllosticta, citrus reticulata, fusarium and the like; fermentation liquor of the S1703 has a good antibacterial effect on the psidium guajava wilt pathogen and the psidium guajava branch blight pathogen; the bacteriostasis rate on sigatoka sigatoka and guava leaf spot germs reaches 95% or above, and an excellent bacteriostasis effect is achieved. The strain S1703 can avoid potential adverse effects of chemical pesticides on the environment and crop safety, and has potential commercial development and application values in biological prevention and control practice of diseases.

The present application relates to a kind of plant anti-dandruff composition with oil control and bacteriostasis efficacy and application thereof, belong to the field of cosmetics.The composition includes soapberry fruit extract, camellia seed extract, artemisia annua extract, valerian root extract, phyllanthus emblica fruit extract;The valerian root extract is extracted after being inoculated with mixed inoculant consisting of bacillus licheniformis and lactobacillus bulgaricus and then fermented with valerian root as raw material.The valerian root extract obtained by the fermentation of specific strains and strain ratio mixture is significantly improved in the bacteriostatic effect on malassezia and propionibacterium acnes.Further, the present application selects specific soapberry fruit extract, camellia seed extract, artemisia annua extract, phyllanthus emblica fruit extract and the obtained valerian root extract within a specific proportion range, and the obtained composition has synergistic effect of each component, which can significantly improve its oil control, bacteriostasis and anti-dandruff effect.

The application belongs to the technical field of cosmetics, and discloses a fucoidan polysaccharide composition with bacteriostatic efficacy, and a preparation method and application thereof. The fucoidan polysaccharide composition comprises phaeophycus triquetrum fucoidan, small new moon rhombus fucoidan and false micro-halochain fucoidan, and the mass ratio of the phaeophycus triquetrum fucoidan, the small new moon rhombus fucoidan and the false micro-halochain fucoidan is (1-2):(1-2):(1-2). The fucoidan polysaccharide composition is prepared by compounding specific phaeophycus triquetrum fucoidan, small new moon rhombus fucoidan and false micro-halochain fucoidan, has a synergistic effect, and has excellent antibacterial efficacy. When the fucoidan polysaccharide composition is applied to cosmetics, it has good formula adaptability, does not affect the exertion of efficacy and the stability of the cosmetics.

This invention discloses a bioactive glass and its preparation method, belonging to the field of bioactive glass technology. It aims to solve the problems of insufficient synergistic effect between antibacterial efficacy and bone-promoting activity in existing materials, as well as the inability to monitor in vivo degradation processes in real time. The bioactive glass comprises 44-48 parts silica; 22-27 parts calcium oxide; 22-27 parts sodium oxide; 5-7 parts phosphorus pentoxide; 2-4 parts europium zinc complex; 10-20 parts chitosan; 1-5 parts lidocaine; and 2-5 parts dilute acetic acid solution. The addition of the europium zinc complex promotes bone formation and enhances antibacterial activity, achieving a highly efficient synergy between anti-infection and tissue regeneration. Simultaneously, it provides optical tracking capabilities, allowing for non-destructive real-time monitoring of the material's degradation behavior and tissue integration in vivo via fluorescence imaging. This invention offers superior material performance and a simple preparation process, providing an innovative solution for the repair of infected bone defects.

The invention relates to the technical field of biological preparations, and discloses a periodontitis improving compound preparation containing fermented lactobacillus mucus and traditional Chinese medicine extracts, and the periodontitis improving compound preparation comprises the following raw materials: an oral preparation: fermented lactobacillus mucus CQPC202403 bacterial powder; the gel comprises scutellaria baicalensis, honeysuckle, salvia miltiorrhiza, liquorice and a hydrogel matrix; the preservation number of the lactobacillus mucus CQPC202403 in the China General Microbiological Culture Collection Center (CGMCC) is CGMCC NO.31106, and the preservation date of the lactobacillus mucus CQPC202403 is June 27, 2024. The lactobacillus mucilaginosus adopted by the invention inhibits pathogenic bacteria through competitive rejection and immunoregulation; the traditional Chinese medicine extracts such as the radix scutellariae directly destroy bacterial pellicles, and the radix scutellariae and the traditional Chinese medicine extracts cooperate with each other, so that the antibacterial effect is enhanced on the premise of not causing drug resistance.

This invention discloses a natural antibacterial polydopamine microcapsule and its preparation method. The shell material of the natural antibacterial polydopamine microcapsule is polydopamine, and the core material is Artemisia argyi oil. Using a soft template method with dimethyldiethoxysilane (DMDES) as the raw material, dopamine is in-situ self-polymerized on the surface of polydimethylsiloxane (PDMS) emulsion droplets solubilized with Artemisia argyi oil to prepare natural antibacterial polydopamine microcapsules encapsulating Artemisia argyi oil. The microcapsules prepared by this invention are micrometer-sized, monodisperse, and have high sphericity, with an average size of 1 μm. They exhibit high encapsulation efficiency for Artemisia argyi oil, with the highest encapsulation efficiency reaching 21.5% of the total mass of the microcapsules. This invention overcomes the disadvantages of high cost and environmental pollution caused by the large use of surfactants in classic emulsions. The preparation process is simple; it overcomes the defects of Artemisia argyi oil's volatility and instability; it has good monodispersity and certain antibacterial efficacy; and it can have a potential long-lasting antibacterial effect through the sustained release of Artemisia argyi oil. The preparation of monodisperse natural antibacterial polydopamine microcapsules has broad application potential in the industrial production of aromatic microcapsules.

The invention relates to the technical field of textile fibers, in particular to a solid kapok viscose fiber and a preparation method thereof. According to the solid kapok viscose fiber provided by the invention, the viscose fiber is modified by adopting active components of kapok, so that the solid kapok viscose fiber with an antibacterial effect is prepared. The solid kapok viscose fiber combines the advantages of the kapok and the viscose fiber, and has the advantages of light weight, good heat retention property, high antibacterial and acarus killing effect, good moisture absorption and quick drying property and strong mechanical property. The solid kapok viscose fiber provided by the invention overcomes the defects of poor antibacterial property, low fiber strength and low stability of common viscose fibers, and the solid kapok viscose fiber is remarkably superior to traditional viscose fibers in functionality, sustainability and application range; wide application prospects are realized in the fields of clothes, home textiles, industrial textiles, filling materials and the like.

The present application relates to the technical field of oral abrasive, in particular to a pectin-coated volcanic stone oral abrasive loaded with saussurea involucrate extract and a preparation method thereof. The oral abrasive comprises volcanic stone particles, saussurea involucrate extract, calcium pectin and an auxiliary agent. The volcanic stone particles serve as a natural porous abrasive, providing strength support and drug loading; the saussurea involucrate extract serves as an active ingredient, providing anti-inflammatory and antibacterial effects; the calcium pectin serves as a controlled-release agent and coating material, forming a gel network with calcium ions to control the release of the saussurea involucrate extract and wrapping the volcanic stone particles to form a flexible contact, buffering the direct friction of the abrasive on the tooth enamel; the components synergistically achieve the integrated effects of "physical cleaning-gel protection-traditional Chinese medicine treatment", ensuring the cleaning effect while reducing the dentin abrasion value, reducing the damage to the tooth enamel and effectively inhibiting oral pathogenic bacteria. The preparation method of the oral abrasive is simple, low in cost and has a broad application prospect.

The present application relates to the technical field of oral care products, and particularly relates to an IgY oral explosion bead with bacteriostatic effect and a preparation method thereof. The oral explosion bead comprises a capsule skin and a core liquid, and the core liquid contains IgY and aniseed essential oil. The oral explosion bead can effectively cause Helicobacter pylori, Porphyromonas gingivalis and the like which cause oral odor, and the IgY and the aniseed essential oil are used in combination to jointly achieve a bacteriostatic effect. The IgY and the aniseed essential oil are prepared into an IgY-aniseed essential oil wrapping liquid form in the present application, and the stability and the bacteriostatic effect of the oral explosion bead are further improved. The mixing ratio and the adding ratio of the IgY and the aniseed essential oil are researched in a large amount in the present application, and the optimal formula and the preparation method are confirmed. The technical scheme can solve the technical problems that the bacteriostatic effect of the IgY in the oral explosion bead is difficult to fully exert and the stability is poor, raw materials of the formula are easy to obtain, the production method is simple, the cost is low, the effect is remarkable, and the present application is suitable for vigorous promotion.

This invention provides an antibacterial and antiviral fabric comprising a fabric substrate and an antimicrobial coating. The antimicrobial coating formed on the fabric substrate has an antimicrobial agent embedded or surface-adhered in a three-dimensional porous network of nano-binder particles. The three-dimensional porous network is formed by interconnecting the nano-binder particles through van der Waals forces or Coulomb forces. The antibacterial and antiviral fabric has at least 99% antibacterial efficacy while retaining physical properties comparable to uncoated fabric. This invention also provides an antibacterial and antiviral formulation and a method for preparing antibacterial and antiviral nanoparticles.

The invention belongs to the field of ophthalmic polypeptides and drugs thereof, and provides an ophthalmic fusion polypeptide with a xerophthalmia relieving effect and an antibacterial effect at the same time, and an ophthalmic preparation containing the polypeptide. The ophthalmic fusion polypeptide provided by the invention has an antibacterial effect, and can reduce or eliminate the use of an antibacterial agent in a preparation, so that the prepared preparation has small irritation and is safer and more effective.

The invention relates to the field of biotechnology, in particular to an enhanced piezoelectric material for triggering sonodynamic response as well as a preparation method and application of the enhanced piezoelectric material. According to the invention, the UIO-66 (at) Cu-SS is prepared by introducing a Cu element to enhance the sonodynamic response of a metal organic framework material (UIO-66) with a piezoelectric property. According to the invention, the Cu-Cu composite material is beneficial to the valence state conversion process of the Cu element, can effectively improve the sonodynamic response characteristic and promote the explosive generation of active oxygen, also has the glutathione degradation performance, and can effectively promote the antibacterial effect. Therefore, the UIO-66 (at) Cu-SS is prepared by introducing the Cu element, so that the sonodynamic response characteristic of the UIO-66 is further enhanced.

The application relates to the technical field of biological medicine, and particularly discloses application of indole-3-methanol in preparation of polymyxin antibacterial synergist and a gram-negative bacterium-resistant pharmaceutical composition, the application of the indole-3-methanol in preparation of the polymyxin antibacterial synergist, the concentration of the polymyxin and the indole-3-methanol is 0.01-2 (mu g / mL):0.01-10 mM; the gram-negative bacterium-resistant pharmaceutical composition comprises the polymyxin and the indole-3-methanol, and further comprises pharmaceutically acceptable adjuvants and / or carriers; the composition can be prepared into injections, ointments or aerosols, and can be used for treating klebsiella pneumoniae, bauman acinetobacter, escherichia coli or pseudomonas aeruginosa and the like; the application discloses that the indole-3-methanol can synergize with the polymyxin, significantly improves the bactericidal activity of the polymyxin on gram-negative bacteria, reduces the use dosage of the polymyxin, improves the antibacterial efficacy, prolongs the antibacterial time, and delays the generation of drug resistance.

The invention discloses a vaginal balance peptide derived from a vaginal microbiome and application thereof, the vaginal balance peptide can selectively inhibit lower genital tract infection pathogens, has no inhibition effect on vaginal probiotic lactobacillus, and has: (a) an amino acid sequence as shown in SEQ ID NO.1; or (b) an amino acid sequence which is obtained by substitution, deletion and / or addition of one or more amino acids of the amino acid sequence as shown in SEQ ID NO.1 and has the same function as that of SEQ ID NO.1; or (c) an amino acid sequence which has at least 85% homology with the amino acid sequence shown in SEQ ID NO.1 and has the same function as the amino acid sequence shown in SEQ ID NO.1. The balance peptide is efficient in antibiosis, specifically inhibits growth of lower genital tract infection pathogens, and has a remarkable inhibiting effect on gardnerella vaginalis, group B streptococcus, candida albicans and the like; the selectivity is high, the effect of inhibiting growth of various common vaginal probiotics lactobacillus is avoided, and the effect of balancing micro-ecology is achieved; the safety and the treatment effect are good.

The application provides a preparation method of polyacrylate leather finishing agent with double antibacterial effect, characterized in that acrylic ester comonomer and antibacterial functional monomer are prepared into pre-emulsion under the emulsification of a surfactant, and then copolymerization of the antibacterial functional monomer and the acrylic ester monomer is initiated by an initiator to obtain the polyacrylate leather finishing agent. The antibacterial functional monomers used in the application include two categories of antibacterial and adhesive menthol derivative monomers and quaternary phosphonium salt monomers containing carbon-carbon double bonds. The quaternary phosphonium salt antibacterial monomer has excellent bactericidal performance, and the menthol derivative is of natural origin and has good antibacterial and adhesive performance. Through ingenious design and suitable polymerization method, the antibacterial monomers with different antibacterial effects are introduced into polyacrylate at the molecular level, and the prepared polyacrylate leather finishing agent has both bactericidal performance and antimicrobial adhesive performance.

The invention discloses a betulinic acid derivative as well as a synthesis method and application thereof. According to the betulinic acid derivative, the carboxyl position of betulinic acid C-28 is subjected to structural modification, and four halogenated aniline derivatives are obtained. Wherein the derivatives b, d and e show strong activity on staphylococcus aureus, the derivatives d and e also show strong activity on vancomycin-resistant staphylococcus aureus (VRSA), and the derivative o strongly inhibits streptococcus pneumoniae. Compared with a parent skeleton, the four derivatives show significantly enhanced antibacterial efficacy. Experimental data prove that the derivatives d and e and further derivatives thereof may provide a promising strategy for resisting drug-resistant gram-positive pathogens, and the derivative d can be further developed into a novel therapeutic agent for biofilm-mediated drug-resistant infection.

The invention relates to a novel topical pharmaceutical composition comprising ceftizoxime, a third-generation cephalosporin antibiotic, complexed with sulfobutyl ether-β-cyclodextrin (SBE-β-CD) to enhance solubility and stability in aqueous environments. The sterile, sprayable formulation is intended for direct topical use or dilution for the treatment and prevention of bacterial skin and wound infections. To overcome ceftizoxime's aqueous instability, the invention employs inclusion complexation with 2–10% w / v SBE-β-CD, prepared by shaking at 30°C for 72 hours followed by sterile filtration. Differential Scanning Calorimetry (DSC) confirms molecular encapsulation through suppression of the ceftizoxime melting peak, indicating loss of crystallinity. Antibacterial efficacy is demonstrated against Staphylococcus aureus and Escherichia coli using zone of inhibition assays. UV–Vis spectrophotometry at 258 nm confirms high linearity (R² = 0.998) for quantitative analysis. The formulation offers a stable, scalable, and patient-friendly alternative for localized antibiotic therapy and surgical prophylaxis with reduced systemic exposure.

The invention relates to a plant anti-dandruff composition with oil control and bacteriostasis effects and application of the plant anti-dandruff composition, and belongs to the technical field of cosmetics. The composition comprises a soapberry fruit extract, a camellia seed extract, an artemisia annua extract, a valerian root extract and an emblic leafflower fruit extract. The radix valerianae extract is obtained by taking radix valerianae as a raw material, inoculating a mixed bacterial agent composed of bacillus licheniformis and lactobacillus bulgaricus, fermenting and then extracting. The radix valerianae extract, which is extracted after the radix valerianae is mixed and fermented according to a specific strain ratio, has a remarkably improved antibacterial effect on malassezia and propionibacterium acnes. Furthermore, a specific soapberry fruit extract, a camellia seed extract, an artemisia annua extract, an emblic leafflower fruit extract and the obtained valerian root extract are selected to be combined in a specific proportion range, all the components in the obtained composition play a synergistic effect, and the oil control, antibacterial and anti-dandruff effects of the composition can be remarkably improved.

The invention discloses application of daphnetin as an NDM-1 and NDM-5 double-target inhibitor in antibacterial synergism, and belongs to the technical field of medicines. In order to solve the problem that a method for effectively inhibiting metallo-beta-lactamase is lacked in the prior art, through NDM-1 and NDM-5 enzyme inhibition tests, a trace chessboard dilution method, a time-sterilization curve and other tests, it is found that daphnetin can significantly inhibit the activity of NDM-1 and NDM-5 enzymes and restore the antibacterial activity of meropenem to escherichia coli producing NDM-1 and NDM-5. Therefore, the daphnetin provided by the invention can be used as an NDM-1 and NDM-5 double-target inhibitor, is applied to antibiosis, synergism and treatment of bacterial infectious diseases, and has wide medical application.

The invention belongs to the field of polypeptide drugs, and particularly relates to a high-stability broad-spectrum antibacterial peptide and application thereof in prevention and treatment of drug-resistant bacteria. The amino acid sequence of the antibacterial peptide is as shown in SEQ ID NO: 2-10. Compared with Ursoriin, the antibacterial peptide has a better antibacterial effect, and the stability of the antibacterial peptide is further enhanced.

The invention discloses a detergent composition with a long-acting antibacterial effect, and relates to the technical field of daily chemical products. The detergent composition contains 0.03%-0.2% by mass of an antibacterial agent, and the antibacterial agent is ultrafine copper powder wrapped by ethanolamine; the ethanolamine-coated superfine copper powder is prepared from copper oxide and excessive ethanolamine through a reduction reaction, the particle size distribution of particles of the superfine copper powder is 90% or above, the particle size is larger than 5.5 micrometers, and the maximum particle size does not exceed 50 micrometers. According to the detergent composition with the long-acting bacteriostatic effect, the superfine copper powder wrapped by ethanolamine is used as a long-acting bacteriostatic agent; the ethanolamine-coated superfine copper powder has the advantages of being easy to synthesize and good in stability, can endow the detergent with excellent long-acting antibacterial performance, can be compatible with a sulfonic acid type anionic surfactant system, and is simple in production process, low in cost and wide in production and application prospect.

The application relates to an antibacterial polyester fiber and a preparation method thereof. The preparation method of the antibacterial polyester fiber comprises the following steps: S1. adding artemisia argyi essential oil and an initiator into ethyl acetate to obtain an ethyl acetate solution, wherein the initiator comprises dicyclohexyl peroxydicarbonate; S2. soaking polyester fiber in m-cresol, then washing and drying, and then carrying out grafting reaction in the ethyl acetate solution under a protective gas atmosphere, and then washing and drying to obtain the antibacterial polyester fiber. In the application, substances with antibacterial efficacy, such as terpineol and caryophyllene oxide, in the artemisia argyi essential oil are introduced into the polyester fiber in a chemical combination mode, the combination strength between the substances with antibacterial efficacy, such as terpineol and caryophyllene oxide, and the polyester fiber is improved, and the antibacterial performance persistence of the fabric made of the polyester fiber is improved.

The invention relates to an anti-biofilm peptide and application thereof, and belongs to the technical field of antibacterial peptides. The invention relates to an anti-biofilm peptide VKLR. The amino acid sequence of the anti-biofilm peptide VKLR is as shown in SEQ ID NO: 1: LVKLRVKLRVKLR. The broad-spectrum antibacterial agent aims at bacteria including gram-negative bacteria and gram-positive bacteria. The anti-biofilm peptide VKLR disclosed by the invention has broad-spectrum antibacterial activity and has a remarkable antibacterial effect on various gram-negative bacteria and gram-positive bacteria such as escherichia coli, pseudomonas aeruginosa, staphylococcus aureus and staphylococcus epidermidis, and infection caused by a pathogen biofilm seriously threatens human and animal health; in the breeding process, abuse of traditional antibiotics is likely to generate drug resistance risks, and people pay attention to novel antibacterial drug substitutes. According to the present invention, the 14-element library of the AMPs is obtained, the peptide VKLR shows the huge potential in the antibacterial effect aspect, and is the ideal candidate for treating bacterial infection, such that the research provides the new insight for the future design of the biofilm removing peptide, and the wide application of the biofilm removing peptide in the medicine and the animal husbandry is promoted.

The invention belongs to the technical field of biology, and particularly relates to a bacillus amyloliquefaciens strain sf28 and application thereof. The bacillus amyloliquefaciens strain sf28 is separated from rhizosphere soil of a peanut southern blight diseased plant, and the bacillus amyloliquefaciens strain sf28 has the effects of resisting fungi and bacteria and can effectively prevent and treat various plant diseases; comprise peanut bacterial wilt, peanut southern blight, peanut fruit rot, peanut root rot, peanut crown rot, ligustrum lucidum canker and tobacco root rot, and the potting test control effect on the peanut southern blight and the peanut bacterial wilt is remarkable.

The present invention pertains to a method for producing an antimicrobial composition preferably comprising piceol. Moreover, the invention relates to an antimicrobial composition comprising or consisting of piceol, preferably in an excess amount compared to picein, further plant-derived substances and optionally picein. The invention further relates to a cosmetic, personal care, household, home care, pet care or pharmaceutical product comprising said antimicrobial composition. Moreover, the invention relates to the use of a microorganism, preferably a lactobacillus species, for producing an antimicrobial composition comprising piceol from a composition, preferably a plant-extract, comprising picein. In addition, the invention relates to the use of shikimic acid for increasing the antimicrobial efficacy of piceol and / or to the use of piceol for increasing the antimicrobial efficacy of shikimic acid. Further embodiments and aspects of the invention are presented in the attached claims as well as in the description and examples below.

The present application relates to the field of microorganisms, and discloses a lactobacillus plantarum with antibacterial efficacy and application thereof, wherein the lactobacillus plantarum has a preservation number of CGMCC No.33151.The strain provided by the present application has strong abilities of resisting bile salt, resisting gastric acid, producing acid and producing H2O2, and has strong bacteriostatic effects on common pathogenic bacteria such as staphylococcus aureus, candida albicans, escherichia coli, salmonella and helicobacter pylori, and can inhibit the activity of urease, interfere with the colonization of helicobacter pylori and the like, so as to inhibit helicobacter pylori infection, reduce the symptoms of helicobacter pylori infection and reduce the disease degree of colonitis mice, and can be used for preparing a microbial preparation and has potential for preparing a medicine for preventing and / or treating diseases caused by helicobacter pylori infection.