123 results about "Antibacterial efficacy" patented technology

The invention relates to the technical field of high-barrier composite packaging films, and discloses a high-barrier composite packaging film with an antibacterial function, which sequentially comprises a base layer, a nano composite barrier layer, an antibacterial functional layer and an outer protective layer from bottom to top, and the layers are tightly attached through a coated starch-based adhesive. According to the high-barrier composite packaging film with the antibacterial function, the cellulose nanowhiskers have the characteristics of high strength and high modulus and are mixed with the bio-based polylactic acid, so that the tensile strength and tear resistance of the bio-based polylactic acid can be remarkably improved, and the structural stability of the packaging film in the using process is guaranteed; nano titanium dioxide and nano cellulose aerogel are arranged in the nano composite barrier layer, so that the barrier property of the packaging film on oxygen and ultraviolet rays can be enhanced, and the packaging film also has a certain antibacterial effect; in addition, the nanocellulose aerogel has a loose porous structure, so that gas molecules can be effectively prevented from passing through, and the barrier property is further improved.

The invention discloses a multi-target joint optimized antibiotic molecule design system and method applied to the field of biological medicine, and the method comprises the steps: obtaining FabI enzyme and AcrAB-TolC efflux pump structure data, extracting double-target space and physicochemical characteristics, and constructing a joint pharmacophore model containing a FabI inhibition domain and an efflux pump blocking domain; screening candidate molecules meeting a double-domain space matching threshold, screening high-affinity double-target molecules through conformation sampling and free energy calculation, and forming a lead compound library through multi-layer filtration of metabolic stability, membrane penetrability, quantum chemical properties and synthesis feasibility; carrying out electron effect, chain length or heteroatom fine tuning on dominant molecules through in-vitro bacteriostasis and efflux inhibition experiment feedback, and carrying out iterative optimization until MIClt is met; 2 [mu] g / mL and the efflux inhibition rate is gt; according to the present invention, the antibacterial effect and the drug resistance inhibition ability are significantly improved, the molecular synthesizability and the biological safety are ensured, and the engineering design new path is provided for the Gram-negative bacterium drug resistance crisis.

Disclosed in the present application are an antibacterial anti-scale silica gel material, and a preparation method therefor and the use thereof. Raw materials for preparing the silica gel material comprise a component A and a component B, wherein the component A comprises vinyl polysiloxane, a first silane coupling agent, fumed silica and a platinum catalyst; and the component B comprises vinyl polysiloxane, a first silane coupling agent, fumed silica, hydrogen-containing polysiloxane, an inhibitor and a composite scale-inhibiting antibacterial material, the composite scale-inhibiting antibacterial material being prepared by encapsulating a scale inhibitor and an antibacterial agent in cyclodextrin. In the present invention, the scale inhibitor and the antibacterial agent are encapsulated in cyclodextrin under certain conditions so as to prepare the composite scale-inhibiting antibacterial material; then, under the action of the platinum catalyst, the composite scale-inhibiting antibacterial material undergoes graft polymerization with the vinyl polysiloxane, and the vinyl polysiloxane also undergoes a homopolymerization and autopolymerization reaction, thereby preparing a silica gel material bonded with an antibacterial anti-scale sustained-release body; and the prepared silica gel material ensures that the scale inhibitor and the antibacterial agent can be slowly released outwards in a usage scenario, thereby achieving long-term scale-inhibiting and antibacterial effects.

The present invention relates to a microneedle-based transdermal delivery patch fabricated from a hydrogel composed of polyvinyl alcohol (PVA), arginine-modified chitosan, and a crosslinker. The arginine-modified chitosan is prepared by reacting a chitosan solution with an arginine solution preactivated with N-hydroxy succinimide and 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide at a specific pH. The hydrogel's formulation further comprises a PVA concentration ranging from 10% to 12% (w / v). arginine-modified chitosan and PVA solution are mixed in a 1:2 ratio by volume and are crosslinked using trimethyl orthoformate (TMOF). The patch is further loaded with curcumin, with a concentration of 120μg per patch, demonstrating a 70% release over 48 hours in a controlled manner. This invention represents the first application of PVA crosslinked arginine-modified chitosan hydrogel loaded with curcumin specifically for animal wound healing, providing enhanced wound healing and antibacterial efficacy.

The invention discloses bacillus subtilis S1703 and application thereof, and belongs to the technical field of plant disease and pest control. The name of the bacterial strain is bacillus subtilis S1703, and the preservation number of the bacterial strain is GDMCC No: 66890. The bacterial strain S1703 has a wider antibacterial spectrum, and can effectively inhibit the growth of pathogenic bacteria such as fusarium oxysporum, colletotrichum gloeosporioides, alternaria alternata, aspergillus, phyllosticta, citrus reticulata, fusarium and the like; fermentation liquor of the S1703 has a good antibacterial effect on the psidium guajava wilt pathogen and the psidium guajava branch blight pathogen; the bacteriostasis rate on sigatoka sigatoka and guava leaf spot germs reaches 95% or above, and an excellent bacteriostasis effect is achieved. The strain S1703 can avoid potential adverse effects of chemical pesticides on the environment and crop safety, and has potential commercial development and application values in biological prevention and control practice of diseases.

The present application relates to a kind of plant anti-dandruff composition with oil control and bacteriostasis efficacy and application thereof, belong to the field of cosmetics.The composition includes soapberry fruit extract, camellia seed extract, artemisia annua extract, valerian root extract, phyllanthus emblica fruit extract;The valerian root extract is extracted after being inoculated with mixed inoculant consisting of bacillus licheniformis and lactobacillus bulgaricus and then fermented with valerian root as raw material.The valerian root extract obtained by the fermentation of specific strains and strain ratio mixture is significantly improved in the bacteriostatic effect on malassezia and propionibacterium acnes.Further, the present application selects specific soapberry fruit extract, camellia seed extract, artemisia annua extract, phyllanthus emblica fruit extract and the obtained valerian root extract within a specific proportion range, and the obtained composition has synergistic effect of each component, which can significantly improve its oil control, bacteriostasis and anti-dandruff effect.

The invention discloses an application of cacumen platycladi ketone in preparation of an apramycin sulfate antibacterial synergist. Through a large number of experimental researches, the inventor accidentally finds that the cacumen platycladi ketone can effectively improve the antibacterial effect of apramycin sulfate on gram-positive bacteria separated from clinical cow mastitis. The discovery is beneficial to the exertion of the antibacterial effect of apramycin sulfate on gram-positive bacteria, and meanwhile, more drug choices are provided for clinical treatment of cow mastitis.

The application belongs to the technical field of cosmetics, and discloses a fucoidan polysaccharide composition with bacteriostatic efficacy, and a preparation method and application thereof. The fucoidan polysaccharide composition comprises phaeophycus triquetrum fucoidan, small new moon rhombus fucoidan and false micro-halochain fucoidan, and the mass ratio of the phaeophycus triquetrum fucoidan, the small new moon rhombus fucoidan and the false micro-halochain fucoidan is (1-2):(1-2):(1-2). The fucoidan polysaccharide composition is prepared by compounding specific phaeophycus triquetrum fucoidan, small new moon rhombus fucoidan and false micro-halochain fucoidan, has a synergistic effect, and has excellent antibacterial efficacy. When the fucoidan polysaccharide composition is applied to cosmetics, it has good formula adaptability, does not affect the exertion of efficacy and the stability of the cosmetics.

The present invention relates to the field of pharmaceutical technology, and more particularly to a compound sodium picosulfate oral solution and a preparation method thereof. The oral solution comprises the following components: sodium picosulfate, anhydrous citric acid, magnesium oxide, a stabilizer, an antibacterial agent, and a pH adjuster, wherein the antibacterial agent comprises methylparaben and propylparaben in a mass ratio of 15:1-6:1. The present invention has the advantages of high stability and good antibacterial efficacy.

This invention discloses a bioactive glass and its preparation method, belonging to the field of bioactive glass technology. It aims to solve the problems of insufficient synergistic effect between antibacterial efficacy and bone-promoting activity in existing materials, as well as the inability to monitor in vivo degradation processes in real time. The bioactive glass comprises 44-48 parts silica; 22-27 parts calcium oxide; 22-27 parts sodium oxide; 5-7 parts phosphorus pentoxide; 2-4 parts europium zinc complex; 10-20 parts chitosan; 1-5 parts lidocaine; and 2-5 parts dilute acetic acid solution. The addition of the europium zinc complex promotes bone formation and enhances antibacterial activity, achieving a highly efficient synergy between anti-infection and tissue regeneration. Simultaneously, it provides optical tracking capabilities, allowing for non-destructive real-time monitoring of the material's degradation behavior and tissue integration in vivo via fluorescence imaging. This invention offers superior material performance and a simple preparation process, providing an innovative solution for the repair of infected bone defects.

The invention relates to the technical field of biological preparations, and discloses a periodontitis improving compound preparation containing fermented lactobacillus mucus and traditional Chinese medicine extracts, and the periodontitis improving compound preparation comprises the following raw materials: an oral preparation: fermented lactobacillus mucus CQPC202403 bacterial powder; the gel comprises scutellaria baicalensis, honeysuckle, salvia miltiorrhiza, liquorice and a hydrogel matrix; the preservation number of the lactobacillus mucus CQPC202403 in the China General Microbiological Culture Collection Center (CGMCC) is CGMCC NO.31106, and the preservation date of the lactobacillus mucus CQPC202403 is June 27, 2024. The lactobacillus mucilaginosus adopted by the invention inhibits pathogenic bacteria through competitive rejection and immunoregulation; the traditional Chinese medicine extracts such as the radix scutellariae directly destroy bacterial pellicles, and the radix scutellariae and the traditional Chinese medicine extracts cooperate with each other, so that the antibacterial effect is enhanced on the premise of not causing drug resistance.

This invention discloses a natural antibacterial polydopamine microcapsule and its preparation method. The shell material of the natural antibacterial polydopamine microcapsule is polydopamine, and the core material is Artemisia argyi oil. Using a soft template method with dimethyldiethoxysilane (DMDES) as the raw material, dopamine is in-situ self-polymerized on the surface of polydimethylsiloxane (PDMS) emulsion droplets solubilized with Artemisia argyi oil to prepare natural antibacterial polydopamine microcapsules encapsulating Artemisia argyi oil. The microcapsules prepared by this invention are micrometer-sized, monodisperse, and have high sphericity, with an average size of 1 μm. They exhibit high encapsulation efficiency for Artemisia argyi oil, with the highest encapsulation efficiency reaching 21.5% of the total mass of the microcapsules. This invention overcomes the disadvantages of high cost and environmental pollution caused by the large use of surfactants in classic emulsions. The preparation process is simple; it overcomes the defects of Artemisia argyi oil's volatility and instability; it has good monodispersity and certain antibacterial efficacy; and it can have a potential long-lasting antibacterial effect through the sustained release of Artemisia argyi oil. The preparation of monodisperse natural antibacterial polydopamine microcapsules has broad application potential in the industrial production of aromatic microcapsules.

The invention relates to a metastatic composite fiber with a targeted antibacterial effect and a preparation method and application thereof.The metastatic composite fiber comprises a core layer, a skin layer and a metastatic microcapsule coating wrapping the skin layer, and the core layer is prepared from polyester and / or polypropylene; the preparation material of the skin layer comprises polyethylene and / or modified polyethylene, and the preparation raw materials of the metagen microcapsule coating comprise a metagen microcapsule and a hydrophilic oil agent. The prepared metastatic composite fiber has excellent mechanical properties and relatively high softness, also has an excellent effect of selectively inhibiting genital tract pathogenic bacteria, and can effectively improve the vagina environment of a user and relieve vagina inflammation when being applied to preparation of hygienic products; the micro-ecological balance of the vagina of the user is maintained; when applied to underwear and other close-fitting textile clothes, the fabric can effectively inhibit bacteria and maintain the stability of the micro-ecological environment of the skin surface layer.

The invention relates to the technical field of textile fibers, in particular to a solid kapok viscose fiber and a preparation method thereof. According to the solid kapok viscose fiber provided by the invention, the viscose fiber is modified by adopting active components of kapok, so that the solid kapok viscose fiber with an antibacterial effect is prepared. The solid kapok viscose fiber combines the advantages of the kapok and the viscose fiber, and has the advantages of light weight, good heat retention property, high antibacterial and acarus killing effect, good moisture absorption and quick drying property and strong mechanical property. The solid kapok viscose fiber provided by the invention overcomes the defects of poor antibacterial property, low fiber strength and low stability of common viscose fibers, and the solid kapok viscose fiber is remarkably superior to traditional viscose fibers in functionality, sustainability and application range; wide application prospects are realized in the fields of clothes, home textiles, industrial textiles, filling materials and the like.

The present application relates to the technical field of oral abrasive, in particular to a pectin-coated volcanic stone oral abrasive loaded with saussurea involucrate extract and a preparation method thereof. The oral abrasive comprises volcanic stone particles, saussurea involucrate extract, calcium pectin and an auxiliary agent. The volcanic stone particles serve as a natural porous abrasive, providing strength support and drug loading; the saussurea involucrate extract serves as an active ingredient, providing anti-inflammatory and antibacterial effects; the calcium pectin serves as a controlled-release agent and coating material, forming a gel network with calcium ions to control the release of the saussurea involucrate extract and wrapping the volcanic stone particles to form a flexible contact, buffering the direct friction of the abrasive on the tooth enamel; the components synergistically achieve the integrated effects of "physical cleaning-gel protection-traditional Chinese medicine treatment", ensuring the cleaning effect while reducing the dentin abrasion value, reducing the damage to the tooth enamel and effectively inhibiting oral pathogenic bacteria. The preparation method of the oral abrasive is simple, low in cost and has a broad application prospect.

The present application relates to the technical field of oral care products, and particularly relates to an IgY oral explosion bead with bacteriostatic effect and a preparation method thereof. The oral explosion bead comprises a capsule skin and a core liquid, and the core liquid contains IgY and aniseed essential oil. The oral explosion bead can effectively cause Helicobacter pylori, Porphyromonas gingivalis and the like which cause oral odor, and the IgY and the aniseed essential oil are used in combination to jointly achieve a bacteriostatic effect. The IgY and the aniseed essential oil are prepared into an IgY-aniseed essential oil wrapping liquid form in the present application, and the stability and the bacteriostatic effect of the oral explosion bead are further improved. The mixing ratio and the adding ratio of the IgY and the aniseed essential oil are researched in a large amount in the present application, and the optimal formula and the preparation method are confirmed. The technical scheme can solve the technical problems that the bacteriostatic effect of the IgY in the oral explosion bead is difficult to fully exert and the stability is poor, raw materials of the formula are easy to obtain, the production method is simple, the cost is low, the effect is remarkable, and the present application is suitable for vigorous promotion.

The invention discloses an efficient antibacterial coating based on hexagonal boron nitride and a preparation process of the efficient antibacterial coating, and belongs to the field of antibacterial coatings. The coating is prepared by uniformly mixing h-BN micron particles with the particle size of 2-10 microns and h-BN nano particles with the particle size of 20-500 nm serving as core antibacterial components with auxiliary materials such as an adhesive, deionized water, a suspending agent, a dispersing agent and a defoaming agent. By innovatively adopting a nanoscale h-BN material, the product realizes the following technical breakthroughs: the antibacterial efficiency is remarkably improved; the environment-friendly characteristic is realized; the environmental stability is excellent; and the application adaptability is wide. Compared with the traditional silver-based, copper-based and other metal ion type antibacterial coatings, the product avoids the risk of metal ion migration, solves the technical bottlenecks of poor temperature resistance of an organic antibacterial coating and strong light dependence of a photocatalytic coating, and has important industrial application value in the fields of medical equipment, building decoration and the like.

The present invention provides a preparation method for a nano-drug composite dynamic cross-linked hydrogel with curcumin / nitric oxide / photothermal synergistic antibacterial effect. The present invention uses copper salt to chelate curcumin to form first nanoparticles, and then uses polydopamine to coat the first nanoparticles to form nano-drug P Cur Sodium nitroprusside and sodium phytate were used as raw materials and nano-coprecipitation method was used to prepare second nanoparticles; polydopamine was then used to coat the second nanoparticles to prepare a core-shell structure nano drug P NO ; The nano drug P cur and P NO The nanocomposite hydrogel is mixed evenly with carboxymethyl chitosan and oxidized hyaluronic acid to form a nanocomposite dynamically cross-linked hydrogel. In addition to its significant antibacterial properties, the nanocomposite hydrogel of the present invention also has significant advantages such as high antibacterial efficacy, good biosafety, convenient preparation, and low cost. The present invention also combines drug, photothermal, and gas therapy in a single device, facilitating synergistic and precise bacterial elimination.

The invention belongs to the technical field of biological medicines, and in particular relates to an application of hyssopus rigidus var. Cupidus essential oil in preparation of an antibiotic antibacterial sensitizer and / or preparation of an antibiotic combined medicine, and further relates to an application of the hyssopus rigidus var. Cupidus essential oil in preparation of the antibiotic antibacterial sensitizer and / or the antibiotic combined medicine. It is found that the hyssop officinalis essential oil can enhance the antibacterial sensitivity of various antibiotics including fluconazole and amphotericin B, the hyssop officinalis essential oil and the antibiotics are combined for use, the synergistic antibacterial activity is achieved, and the better antibacterial effect is achieved while the dosage of the antibiotics is reduced; important technical support is provided for improving the current situation of drug resistance of fungi.

This invention provides an antibacterial and antiviral fabric comprising a fabric substrate and an antimicrobial coating. The antimicrobial coating formed on the fabric substrate has an antimicrobial agent embedded or surface-adhered in a three-dimensional porous network of nano-binder particles. The three-dimensional porous network is formed by interconnecting the nano-binder particles through van der Waals forces or Coulomb forces. The antibacterial and antiviral fabric has at least 99% antibacterial efficacy while retaining physical properties comparable to uncoated fabric. This invention also provides an antibacterial and antiviral formulation and a method for preparing antibacterial and antiviral nanoparticles.

The invention relates to a preservative film with an antibacterial effect and a preparation process thereof, the preservative film comprises the following components: curcumin, chlorogenic acid, protein and a preservative film base material, and after the components are prepared by the process disclosed by the invention, the preservative film not only has a long-term antibacterial effect, but also can still keep an excellent antibacterial effect under the action of strong light.

The invention belongs to the field of ophthalmic polypeptides and drugs thereof, and provides an ophthalmic fusion polypeptide with a xerophthalmia relieving effect and an antibacterial effect at the same time, and an ophthalmic preparation containing the polypeptide. The ophthalmic fusion polypeptide provided by the invention has an antibacterial effect, and can reduce or eliminate the use of an antibacterial agent in a preparation, so that the prepared preparation has small irritation and is safer and more effective.

The invention relates to the field of biotechnology, in particular to an enhanced piezoelectric material for triggering sonodynamic response as well as a preparation method and application of the enhanced piezoelectric material. According to the invention, the UIO-66 (at) Cu-SS is prepared by introducing a Cu element to enhance the sonodynamic response of a metal organic framework material (UIO-66) with a piezoelectric property. According to the invention, the Cu-Cu composite material is beneficial to the valence state conversion process of the Cu element, can effectively improve the sonodynamic response characteristic and promote the explosive generation of active oxygen, also has the glutathione degradation performance, and can effectively promote the antibacterial effect. Therefore, the UIO-66 (at) Cu-SS is prepared by introducing the Cu element, so that the sonodynamic response characteristic of the UIO-66 is further enhanced.

The application relates to the technical field of biological medicine, and particularly discloses application of indole-3-methanol in preparation of polymyxin antibacterial synergist and a gram-negative bacterium-resistant pharmaceutical composition, the application of the indole-3-methanol in preparation of the polymyxin antibacterial synergist, the concentration of the polymyxin and the indole-3-methanol is 0.01-2 (mu g / mL):0.01-10 mM; the gram-negative bacterium-resistant pharmaceutical composition comprises the polymyxin and the indole-3-methanol, and further comprises pharmaceutically acceptable adjuvants and / or carriers; the composition can be prepared into injections, ointments or aerosols, and can be used for treating klebsiella pneumoniae, bauman acinetobacter, escherichia coli or pseudomonas aeruginosa and the like; the application discloses that the indole-3-methanol can synergize with the polymyxin, significantly improves the bactericidal activity of the polymyxin on gram-negative bacteria, reduces the use dosage of the polymyxin, improves the antibacterial efficacy, prolongs the antibacterial time, and delays the generation of drug resistance.

The invention discloses a vaginal balance peptide derived from a vaginal microbiome and application thereof, the vaginal balance peptide can selectively inhibit lower genital tract infection pathogens, has no inhibition effect on vaginal probiotic lactobacillus, and has: (a) an amino acid sequence as shown in SEQ ID NO.1; or (b) an amino acid sequence which is obtained by substitution, deletion and / or addition of one or more amino acids of the amino acid sequence as shown in SEQ ID NO.1 and has the same function as that of SEQ ID NO.1; or (c) an amino acid sequence which has at least 85% homology with the amino acid sequence shown in SEQ ID NO.1 and has the same function as the amino acid sequence shown in SEQ ID NO.1. The balance peptide is efficient in antibiosis, specifically inhibits growth of lower genital tract infection pathogens, and has a remarkable inhibiting effect on gardnerella vaginalis, group B streptococcus, candida albicans and the like; the selectivity is high, the effect of inhibiting growth of various common vaginal probiotics lactobacillus is avoided, and the effect of balancing micro-ecology is achieved; the safety and the treatment effect are good.

The invention provides a gas-jet silicon nitride-hydrogel microsphere and a preparation method thereof, and relates to the technical field of biological materials, and the preparation method comprises the following steps: adding silicon nitride into deionized water, carrying out ultrasonic dispersion, adding sodium alginate powder, and stirring until the sodium alginate powder is dissolved; and spraying the mixed solution into a CaCl2 solution through a sprayer of an injector by adopting a gas spraying technology, forming hydrogel microspheres through calcium ion crosslinking, and repeatedly cleaning by adopting deionized water to obtain the gas-sprayed silicon nitride-hydrogel microspheres. The hydrogel microspheres are prepared by adopting a gas spraying technology, and the three-dimensional network packaged silicon nitride is formed to prevent the silicon nitride from being locally accumulated at a wound; a photo-thermal shell layer is constructed through polydopamine surface modification and cooperates with internal silicon nitride for slow release, so that photo-thermal-ion dual-mode antibiosis is realized; the particle size of the microspheres can be accurately controlled by regulating and controlling gas spraying parameters to adapt to different wound depths; the release behavior is dynamically regulated and controlled based on a hydrogel porous structure, the antibacterial efficacy and the biological safety are balanced, and the multi-stage requirements of wound repair are met.

The present invention discloses the use of nootkatone in preparing a drug that enhances the antibacterial efficacy of polymyxin, as well as the use of a combination of nootkatone and polymyxin in preparing a drug with enhanced antibacterial efficacy. The present invention not only demonstrates the synergistic enhancement of the antibacterial activity of polymyxin by using a checkerboard minimum inhibitory concentration test and an in vitro bacterial growth curve, but also uses a mouse wound infection model to confirm that nootkatone can effectively enhance the antibacterial activity of polymyxin and its in vivo effectiveness. The present invention finds that the natural active substance nootkatone can significantly enhance the antibacterial activity of polymyxin, which can provide an auxiliary drug for the clinical treatment of multidrug-resistant Gram-negative bacterial infections, while reducing the dosage of polymyxin and reducing the occurrence of drug resistance, providing a new treatment strategy for the clinical treatment of bacterial infectious diseases.

The invention provides a perilla frutescens extract with an antibacterial effect of Porphyromonas gingivalis, wherein the perilla frutescens extract is obtained by extracting a whole plant of perilla frutescens, and the perilla frutescens extract has an antibacterial effect of Porphyromonas gingivalis. The invention also provides application of the perilla frutescens extract in preparation of the health-care composition for resisting porphyromonas gingivalis.

The application provides a preparation method of polyacrylate leather finishing agent with double antibacterial effect, characterized in that acrylic ester comonomer and antibacterial functional monomer are prepared into pre-emulsion under the emulsification of a surfactant, and then copolymerization of the antibacterial functional monomer and the acrylic ester monomer is initiated by an initiator to obtain the polyacrylate leather finishing agent. The antibacterial functional monomers used in the application include two categories of antibacterial and adhesive menthol derivative monomers and quaternary phosphonium salt monomers containing carbon-carbon double bonds. The quaternary phosphonium salt antibacterial monomer has excellent bactericidal performance, and the menthol derivative is of natural origin and has good antibacterial and adhesive performance. Through ingenious design and suitable polymerization method, the antibacterial monomers with different antibacterial effects are introduced into polyacrylate at the molecular level, and the prepared polyacrylate leather finishing agent has both bactericidal performance and antimicrobial adhesive performance.

The invention discloses an antibacterial peptide J-R-pG and application thereof in preparation of an antibacterial agent, and relates to the technical field of biological medicines. The amino acid sequence of the antibacterial peptide J-R-pG is as shown in SEQ ID NO. 5. A broad-spectrum antibacterial short peptide Jelleine-1 (J-1) from bee royal jelly is selected as a template peptide, design and transformation are performed according to amino acid sequence characteristics of the short peptide J-1, and a hydrophilic and hydrophobic amino acid alternate arrangement structural unit is obtained and serves as a self-assembly peptide fiber skeleton. Beta-hairpin peptide design is carried out by adopting two turning sequences of DPG and RRRF, so that the beta-hairpin peptide has dual effects of resisting bacteria and capturing bacteria. The antibacterial peptide J-R-pG provided by the invention can form a fiber network structure, has a good antibacterial effect, high stability and excellent biocompatibility, and provides an effective technical support for developing novel antibacterial drugs.