220 results about "Candida albican" patented technology

The invention provides lactobacillus crispatus, which is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms on February 7, 2023, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No. 26503. The bacillus subtilis can play a relatively strong role in inhibiting pathogenic bacteria such as gardnerella vaginalis, escherichia coli and staphylococcus aureus at the same time, and also has a certain role in inhibiting candida albicans, two-way proteurella and Atortoria vaginalis. Therefore, the lactobacillus crispatus has the potential of maintaining the environment in the vagina to be faintly acid and improving the mucosal immunity and infection resistance of a host, and can be used for preventing and treating vaginal infection and inflammation, and maintaining, improving or recovering the steady state of the environment in the vagina.

A breast milk-derived Limosilactobacillus fermentum MSJK0025 capable of improving the intestinal flora condition and the use thereof. The breast milk-derived Limosilactobacillus fermentum MSJK0025 is deposited in the China General Microbiological Culture Collection Center with a deposit number of CGMCC No. 26426. The breast milk-derived Limosilactobacillus fermentum is a new strain isolated from breast milk of healthy puerperae, and is referred to as Limosilactobacillus fermentum MSJK0025. The strain has a good antibiotic sensitivity and stable inheritance of traits, has a good tolerance to acid, bile salts and artificial gastric / intestinal fluid, and has a fast growth rate and good safety. Furthermore, the strain has a strong intestinal colonization capability and can effectively inhibit intestinal pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, Salmonella typhimurium and Candida albicans, but has no inhibitory effects on intestinal probiotics such as Lactobacillus and Bifidobacterium.

The invention discloses a bacillus strain H7 and an application thereof. The invention provides bacillus velezensis H7 or a progeny of the bacillus velezensis H7, and the preservation number of the bacillus velezensis H7 in the China Center for Type Culture Collection (CCTCC) is CCTCC NO: M 2025630. The bacillus velezensis H7 disclosed by the invention has a very good antibacterial effect on various common clinical pathogenic bacteria (including klebsiella pneumoniae, escherichia coli, candida albicans, enterobacter cloacae complex, acinetobacter baumannii and the like), and particularly shows a very high inhibition rate on some drug-resistant clinical pathogenic bacteria; therefore, the compound has important application value in development of drug and non-drug antibacterial products (such as medical antibacterial materials and the like), a new choice can be provided for drug and non-drug prevention and control of clinical pathogenic bacterium infection, and particularly, the compound has a supplementary effect in the aspects of reducing drug-resistant bacterium propagation risk and reducing drug dependence.

The present invention belongs to the field of biomedicine, and specifically relates to an antimicrobial peptide derived from lactoferrin and its application. The antimicrobial peptide derived from lactoferrin, whose amino acid sequence is shown in any one of SEQ ID NOs: 1 to 98, has a broad-spectrum antimicrobial effect, especially significant antibacterial effect against Pseudomonas putida, Rhodococcus erythropolis, Bacillus subtilis, Malassezia furfur, Cryptococcus neoformans, and Candida albicans, and has great application value.

The invention relates to a broad-spectrum antibacterial peptide 910302 and application thereof, and relates to the technical field of biology. The antibacterial peptide has broad-spectrum antibacterial activity, can inhibit gram-positive bacteria such as staphylococcus aureus, gram-negative bacteria such as escherichia coli, klebsiella pneumoniae, acinetobacter baumannii and pseudomonas aeruginosa, and fungi such as candida auriculata and candida albicans, and has high antibacterial activity. The compound has a relatively strong inhibition effect on clinically separated drug-resistant strains with multiple drug resistance. In addition, the antibacterial peptide is low in hemolytic activity, small in toxicity, short in synthetic sequence, small in molecular weight and easy to chemically synthesize. And the in-vivo safety is ensured while efficient sterilization is realized.

The invention relates to the technical field of medicines, in particular to application of tedizolid combined with fluconazole in preparation of antifungal drugs. The tedizolid and the fluconazole are combined for use, so that the antibacterial activity of the fluconazole on the candida albicans can be enhanced, a synergistic antifungal effect can be generated, and the drug resistance of the candida albicans on the fluconazole can be reversed.

The invention discloses an antibacterial composition which comprises 5-8 wt% of sodium lauroyl sarcosinate, 5-8 wt% of cocamidopropyl betaine and 2-4 wt% of sodium laureth sulfate, the pH value is 4-5.5, through reasonable combination and compatibility of different surfactants, the antibacterial composition has an obvious antibacterial synergistic effect, the antibacterial rates of candida albicans, staphylococcus aureus and escherichia coli are all larger than 90%, and the antibacterial effect is good. The compound can be used for preparing various washing and nursing materials such as laundry detergents, hand sanitizers, bath foam and private part care solutions.

The invention relates to the technical field of PA resin, and particularly discloses glass fiber modified antibacterial PA resin suitable for children products and a preparation method of the antibacterial PA resin. The invention discloses glass fiber modified antibacterial PA resin suitable for children products. The glass fiber modified antibacterial PA resin comprises PA resin, glass fibers, talcum powder, nano calcium carbonate, a composite antibacterial agent, a compatilizer, an antioxidant and calcium stearate, the composite antibacterial agent comprises chitosan, an antibacterial peptide microcapsule and a porous silver-zinc-loaded antibacterial agent; the antibacterial peptide microcapsules are sodium alginate embedded antibacterial peptides. The antibacterial PA resin obtained in the invention has the highest bacteriostasis rates of 99.97%, 99.74% and 99.95% for staphylococcus aureus, escherichia coli and candida albicans respectively, the antibacterial property of the PA resin is improved, the compressive strength and notch impact strength are 170.6 MPa and 17.3 kJ / m < 2 > respectively, and high mechanical strength is maintained on the basis of high antibacterial property.

The invention relates to lactobacillus gasseri FMTA1121E with an effect of regulating a vaginal micro-ecological environment and application of the lactobacillus gasseri FMTA1121E. The lactobacillus gasseri FMTA1121E is classified and named as lactobacillus gasseri, and the preservation number of the lactobacillus gasseri FMTA1121E is CGMCC No.34962. The lactobacillus gasseri FMTA1121E can be metabolized to generate beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide so as to regulate the genital tract environment and improve the health degree; and the bacillus subtilis has excellent bacteriostasis and sterilization effects on various common vaginal pathogenic bacteria such as escherichia coli, staphylococcus aureus, gardnerella vaginalis, candida albicans, neisseria gonorrhoeae and the like. Therefore, the lactobacillus gasseri FMTA1121E strain can be applied to preparation of preparations for preventing and treating related genital tract diseases such as vaginitis.

The invention discloses a lactobacillus plantarum YM-7, the preservation number of the lactobacillus plantarum YM-7 in Guangdong Microbial Culture Collection Center is GDMCC No: 65465, and the lactobacillus plantarum YM-7 obtained from fermented food is high in safety, has an inhibition effect on staphylococcus aureus, escherichia coli and candida albicans, and can be used for preparing a food additive. The strain TN-7 has the effect of removing DPPH, hydroxyl free radicals and superoxide anion free radicals, so that the strain TN-7 can be used as a food additive, and a new way is provided for development of antioxidant and antibacterial food additives.

The invention relates to a talaromyces purpureogenus strain D01 and application of the talaromyces purpureogenus strain D01, and belongs to the technical field of microorganisms. The talaromyces purpurogenus D01 disclosed by the invention is preserved in Guangdong Microbial Culture Collection Center, and the preservation number of the talaromyces purpurogenus D01 is GDMCC NO.66458. The strain is obtained by separating and purifying soil samples near exits of Guangzhou Taitai and subway stations, and tests show that bacteriostatic active substances generated by fermentation of the strain have good bacteriostatic effects on burkholderia cepacia, staphylococcus aureus, pseudomonas putida, pseudomonas aeruginosa, escherichia coli and candida albicans. And the antibacterial active substance has high temperature resistance and excellent preservative effect, can be used as an antibacterial preservative raw material to be applied to the fields of food, health care products or daily chemical products and the like, and has wide application prospects and important conversion research values.

The invention belongs to the technical field of biology, and particularly relates to a primer probe composition and a kit for detecting lower respiratory tract infection pathogens. The primer probe composition is used for detecting mycobacterium tuberculosis, mycobacterium avium, mycobacterium abscessus, mycobacterium kansasii, pseudomonas aeruginosa, klebsiella pneumoniae, acinetobacter baumannii and haemophilus influenzae, and the primer probe composition is used for detecting mycobacterium tuberculosis, mycobacterium avium, mycobacterium abscessus, mycobacterium kansasii, pseudomonas aeruginosa, klebsiella pneumoniae, acinetobacter baumannii and haemophilus influenzae. The composition is one or more of a composition for detecting staphylococcus aureus, a composition for detecting streptococcus pneumoniae, a composition for detecting escherichia coli, a composition for detecting moraxella catarrhalis, a composition for detecting serratia marcescens, a composition for detecting mycoplasma pneumoniae, a composition for detecting candida albicans or a composition for detecting adenovirus; the RAA-RDB technology has the core advantages of rapidness, high sensitivity, low cost and easy operation, and is especially suitable for multiple pathogen screening and basic medical application.

The invention relates to bark-like nano-zinc oxide and a preparation method thereof, and belongs to the technical field of liquid-phase synthesis of nano-zinc oxide. According to the invention, the nano zinc oxide material with bark-like microstructure is prepared by regulating and controlling the liquid phase environment and the thermodynamic and kinetic parameters of the reaction. The material has obvious layering sense and pore characteristics, the material is endowed with significantly enhanced physicochemical characteristics, for example, the BET specific surface area is significantly increased, and meanwhile, the high porosity and the nanocrystal boundary effect have a synergistic effect, so that active oxygen species and zinc ion antibacterial active species can be efficiently generated, and the antibacterial performance of the material is significantly improved. An antibacterial experiment shows that the antibacterial rate of the material to escherichia coli and staphylococcus aureus exceeds 99.9%, and the antibacterial rate of the material to candida albicans exceeds 99.0%. The material has application potential in the fields of medical dressings, antibacterial textiles, water purification and the like.

The present invention relates to an anti-mite down jacket fabric and a processing method thereof, wherein the anti-mite down jacket fabric comprises an inner layer and an outer layer hot-pressed and composited on the inner layer, wherein the outer layer is a plain fabric woven from cotton fiber, modified viscose fiber, and polylactic acid fiber; wherein the modified viscose fiber is prepared by mixing camel thorn alkaline essential oil and a thickener into viscose, and then heating, stirring, ultrasonically dispersing, and degassing the viscose mixture through a wet spinning process. The present invention adds camel thorn alkaline essential oil to the preparation of the modified viscose fiber, and the camel thorn alkaline essential oil has a strong antibacterial effect on Escherichia coli, Staphylococcus aureus, and Candida albicans, and the camel thorn alkaline essential oil has a strong inhibitory effect on the reproduction of mites, can also expel mites, has good durability, natural ingredients, less harmful to the human body, is safer, and can improve the wrinkle resistance of the anti-mite down jacket fabric.

The invention relates to the field of fiber technology, and in particular to a method for preparing an antibacterial and anti-mite intelligent constant temperature fiber, comprising the steps of preparing a soybean protein solution, preparing a temperature regulating solution, preparing a mixed spinning solution, pre-spinning injection, spinning and post-processing. The antibacterial and anti-mite intelligent constant temperature fiber prepared by the invention has better softness and hand feel than the same type of added functional fibers in the industry due to the addition of soybean protein isolate, and has obvious advantages. The melting enthalpy is 44.5-55.6 J / g, the crystallization enthalpy is 42.4-53.1 J / g, and the fiber has better constant temperature performance. The fiber has an antibacterial rate of more than 98% against Staphylococcus aureus, more than 94% against Escherichia coli, and more than 95% against Candida albicans, and has a very strong anti-mite effect, with a detection rate of 0 dust mites and an avoidance rate of ≥99%.

The invention provides a plant fiber containing a ginger extract and a preparation process of the plant fiber. After the plant fiber is washed for 50 times, the bacteriostasis rates of the plant fiber to staphylococcus aureus, escherichia coli, klebsiella pneumoniae and candida albicans are all greater than or equal to 95%, the killing rates of the plant fiber to influenza viruses H3N2 and H1N1 are all greater than or equal to 99%, the far infrared emissivity is 0.89-0.95, the highest temperature rise of moisture absorption and heating is 4-12 DEG C, and the average temperature rise is 3-8 DEG C. A vapor deposition method is adopted, a biomass component A and a biomass component B are combined to form a biomass component C, on one hand, the biomass component B serves as a tube bundle-shaped base material, rhizome plants are calcined to form a porous carbon structure framework, the porous carbon structure framework serves as a solid for vapor deposition, and a solution containing the biomass component A is small in gas molecular weight; after being vaporized along with the solution, the solution is caught by a porous structure of the biomass component B and uniformly filled into pores of the biomass component B, so that the durability of plant functions is ensured, and meanwhile, a protection effect at high temperature is achieved.

The invention belongs to the technical field of microbiological detection, and particularly relates to a real-time fluorescent quantitative PCR (polymerase chain reaction) primer, a probe and a kit for detecting a special drug-resistant pedigree of candida albicans. The nucleotide sequence of the specific primer F is as shown in SEQ ID NO. 1; the nucleotide sequence of the specific primer R is as shown in SEQ ID NO. 2; the nucleotide sequence of a probe matched with the primer for use is as shown in SEQ ID No.3. The kit prepared by the invention ensures high specificity and high sensitivity in a PCR amplification process, effectively distinguishes drug-resistant mutant strains from sensitive strains, keeps efficient detection capability in a low-copy-number DNA template, reduces non-specific amplification and background signal interference, and improves the reliability and accuracy of a detection result.

The present application relates to the field of pharmaceutical chemistry, and specifically discloses a emodin mannich base, a preparation method and application thereof. The emodin mannich base has a structure as shown in formula I, the structure is simple, has strong in-vitro antimicrobial activity, especially high inhibitory activity to staphylococcus aureus, bacillus subtilis, micrococcus luteus, escherichia coli, proteus vulgaris, pseudomonas aeruginosa, shigella dysenteriae, salmonella typhimurium and other bacteria, and candida utilis, candida albicans, saccharomyces cerevisiae, monascus and other fungi, and can be used for preparing antibacterial and / or antifungal drugs.

The invention belongs to the technical field of separation and purification, and particularly relates to a separation and purification method for active components of wasp venom. According to the invention, only an ultrafiltration membrane method is adopted, reverse operation is carried out according to a sequence from large to small, ultrafiltration membranes with molecular weight cutoff of 30kDa, 10kDa and 3kDa are respectively used for sequentially intercepting a vespa velutina venom solution, and freeze drying is carried out, so that three active components with antifungal (candida albicans) and antibacterial (escherichia coli and staphylococcus aureus) effects are obtained. The method is simple to operate and relatively high in efficiency, purification time is greatly saved, the whole process only relates to physical separation, inactivation of active components is greatly avoided, and the method is very beneficial to process amplification.

The invention relates to a lactobacillus plantarum, the name of the lactobacillus plantarum is lactobacillus plantarum 021, the classification name of the lactobacillus plantarum is lactobacillus plantarum, the preservation number is CGMCC No.22169, the preservation date is April 12, 2021, the preservation unit is China General Microbiological Culture Collection Center, the preservation number is CGMCC No.22169, the preservation number is CGMCC No.22169, the preservation number is CGMCC No.22169, the preservation number is CGMCC No.22169, the preservation number is CGMCC No.22169, the preservation number is CGMCC No.22169, and the preservation number is CGMCC No.22169. And Institute of Biology, Chinese Academy of Sciences, No. 3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing. After the lactobacillus plantarum 021 is mixed with the water-absorbent resin, the growth activity of the lactobacillus plantarum 021 is not inhibited, and meanwhile, the lactobacillus plantarum 021 keeps relatively strong inhibition capability on common pathogenic bacteria, such as candida albicans, staphylococcus aureus and escherichia coli. Therefore, the lactobacillus plantarum 021 disclosed by the invention can be applied to preparation of sanitary products such as sanitary towels and tampons after being mixed with water-absorbent resin.

The application discloses a penicillium metabolic product and application thereof in preparation of bacteriostatic agents, and the penicillium Lp.PY-01 metabolic product of the application has a MIC of 0.3906 mg / mL for inhibiting staphylococcus aureus and a MIC of 0.7813 mg / mL for inhibiting candida albicans. As a natural bacteriostatic agent, the penicillium metabolic product is expected to provide a more sustainable and environment-friendly solution for the agricultural and medical fields.

The invention relates to the technical field of pharmaceutical preparations, in particular to application of phencycloqualinium bromide as an antibacterial active component and a preparation of the phencycloqualinium bromide. It is found that benzene ring quinaldinium bromide can be used as an antibacterial active component and has an inhibiting effect on various common bacteria and fungi (including but not limited to staphylococcus aureus, pseudomonas aeruginosa, escherichia coli, aspergillus niger, candida albicans and the like); triethanolamine or other bacteriostatic activity enhancers are mixed with the phencycloqualinium bromide, so that the bacteriostatic activity of the phencycloqualinium bromide can be remarkably improved; when a benzene ring quinaldinium bromide related preparation is prepared, other bacteriostatic agent components are not added, a good bacteriostatic effect can still be achieved, and the safety is higher.

Described herein are Staphylococcal toxins inspired peptides (STIPs) with antimicrobial activity, compositions and kits comprising the peptides, and use of the peptides to treat microbial infections. Also described are methods of inhibiting or preventing the growth of a microorganism, and methods of treating microbial infections such as bacterial infections including MRSA, and fungal infections including C. albicans.

The invention relates to an antibacterial gel and a preparation method thereof. The gel mainly comprises silver ions, avocado oil, a radix puerariae extract, wheat germ oil, emulsifying wax, a folium artemisiae argyi extract, glycerol, a styrene / butadiene copolymer, purified water and hydroxyethyl cellulose. Extracts containing specific small-molecule polypeptides are extracted from Artemisia rubescens and Radix Puerariae through a specific extraction method, and the polypeptides are Artemisia rubescens polypeptides (SEQ ID No: 1) and Radix Puerariae polypeptides (SEQ ID No: 2) respectively. The extracts have a synergistic effect with silver ions, so that the antibacterial effect of the gel is remarkably improved, and particularly, the gel has a remarkable inhibiting effect on staphylococcus aureus, escherichia coli and candida albicans. The bacteriostatic gel is simple in preparation method, convenient to use and suitable for bacteriostasis of female vaginal mucosa and maintenance of vaginal micro-ecological internal environment.

The invention belongs to the technical field of microorganisms, and discloses bacillus subtilis with a high nattokinase yield and a biological preservation function and application of the bacillus subtilis. The strain is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.34222. The serine protease gene of the strain carries specific mutations (SEQ ID NO: 1) which are mutated from G to C at the 217th site and the 230th site, so that the yield and the activity of nattokinase are remarkably improved. In the fermentation process, through an induction stage (38 DEG C heat preservation for 8 hours), a main fermentation stage (50 DEG C heat preservation for 7 hours) and a cooling after-ripening stage (4 DEG C heat preservation for 24 hours), the enzyme activity of the prepared natto product is larger than or equal to 57028 IU / mL, and the natto product is light in flavor, excellent in wiredrawing effect and appropriate in taste. In addition, the strain can inhibit the growth of Candida albicans (the inhibition zone is greater than or equal to 25mm), and the shelf life of natto is effectively prolonged. The problems that an existing strain is poor in stability, products are prone to pollution, and the flavor is poor are solved.

The invention discloses a plant extract-containing composite antibacterial external spray for pets and a preparation method of the plant extract-containing composite antibacterial external spray, and belongs to the technical field of pet nursing materials. The external spray comprises the following components in percentage by mass: 0.5-1.0% of a cortex dictamni extract, 0.75-1.5% of a tomato fruit extract, 0.75-1.5% of a folium artemisiae argyi extract and 5-8% of anthemis nobilis hydrolat, and can also be matched with auxiliary components such as an emulsifier and a preservative. The cortex dictamni extract is prepared by combining a supercritical CO2 extraction method with a specific compound entrainer, and active ingredients are fully reserved; the spray is prepared through step-by-step preparation of a water phase and an oil phase and then high-shear emulsification, and the stability is good. The product shows a high bacteriostatic effect on staphylococcus aureus, salmonella and candida albicans, can significantly reduce the content of an inflammatory mediator NO and a proinflammatory factor IL-1beta, has bacteriostatic, bactericidal and anti-inflammatory effects, is suitable for preparation of pet skin care related products, and has a wide application prospect.

The present invention relates to the field of modified proteins, immunogenic compositions and vaccines comprising the modified proteins, their manufacture and the use of such compositions in medicine. More particularly, it relates to a modified Sap2 (Secreted Aspartyl Proteinase 2 of Candida albicans') protein. The modified Sap2 protein can be used as a carrier protein for other antigens, particularly saccharide antigens or other antigens lacking T cell epitopes.

The present application provides a kind of endo beta-1, 3-glucanase and its application, the amino acid sequence of the endo beta-1, 3-glucanase is SEQ ID NO:1.The endo beta-1, 3-glucanase of the present application can efficiently hydrolyze laminarin and curdlan, its enzyme activity can still be kept above 80% in the range of 40-60 DEG C and pH 4.5-6.0, and it shows good stability under low temperature conditions, which is conducive to reduce the energy consumption in the process of practical application.At the same time, the enzyme has significant high salt tolerance, and has certain resistance to 5%-15% ethanol.The endo beta-1, 3-glucanase of the present application has obvious inhibitory effect on the formation of Candida albicans biofilm, and the laminarin oligosaccharide generated by hydrolyzing laminarin also shows good antioxidant capacity, indicating that the enzyme has broad application prospect and significant practical value in the fields of antibacterial, biological medicine and the like.

The invention relates to the technical field of biology, and discloses an antibacterial peptide and application thereof. The amino acid sequence of the antibacterial peptide is as shown in SEQ ID NO: 1, the antibacterial peptide shows antibacterial activity to escherichia coli, staphylococcus aureus and candida albicans, especially shows high antibacterial activity to the candida albicans, the minimum inhibitory concentration is 64 [mu] M, and the antibacterial peptide has good antibacterial activity. The compound can be used for preparing bacteriostatic products such as bacteriostatic agents, bacteriostatic drugs and the like for resisting escherichia coli, staphylococcus aureus and candida albicans.

The invention belongs to the technical field of papermaking, and relates to aramid paper and a preparation method thereof. According to the preparation method, aramid fibrid and ANF fiber are jointly used as raw materials, and the structural formula of ANF is as follows: # imgabs0 #, in the formula, n: m = (0.1-0.4): (0.6-0.9), m + n = 1, and-X is-F,-Cl,-Br or-I. The basis weight of the finally prepared aramid paper is 60 + / -1 g / m < 2 >, the thickness is 0.062-0.065 mm, the tensile strength is 4.58-5.5 kN / m, the tensile index is 48.1-51 N.m / g, the elongation at break is 7.88-8.9%, the electrical strength is 25-45 kV / mm, the effective diameter of an inhibition zone for staphylococcus aureus is 1.86-1.99 mm, the effective diameter of an inhibition zone for escherichia coli is 2.01-2.45 mm, and the effective diameter of an inhibition zone for candida albicans is 3.77-4.21 mm. The aramid paper has high insulativity and excellent mechanical property and antibacterial property, and the preparation method is simple and suitable for large-scale application.