88 results about "Candida albican" patented technology

The invention relates to the technical field of medicines, in particular to application of tedizolid combined with fluconazole in preparation of antifungal drugs. The tedizolid and the fluconazole are combined for use, so that the antibacterial activity of the fluconazole on the candida albicans can be enhanced, a synergistic antifungal effect can be generated, and the drug resistance of the candida albicans on the fluconazole can be reversed.

The invention relates to the technical field of PA resin, and particularly discloses glass fiber modified antibacterial PA resin suitable for children products and a preparation method of the antibacterial PA resin. The invention discloses glass fiber modified antibacterial PA resin suitable for children products. The glass fiber modified antibacterial PA resin comprises PA resin, glass fibers, talcum powder, nano calcium carbonate, a composite antibacterial agent, a compatilizer, an antioxidant and calcium stearate, the composite antibacterial agent comprises chitosan, an antibacterial peptide microcapsule and a porous silver-zinc-loaded antibacterial agent; the antibacterial peptide microcapsules are sodium alginate embedded antibacterial peptides. The antibacterial PA resin obtained in the invention has the highest bacteriostasis rates of 99.97%, 99.74% and 99.95% for staphylococcus aureus, escherichia coli and candida albicans respectively, the antibacterial property of the PA resin is improved, the compressive strength and notch impact strength are 170.6 MPa and 17.3 kJ / m < 2 > respectively, and high mechanical strength is maintained on the basis of high antibacterial property.

The invention relates to lactobacillus gasseri FMTA1121E with an effect of regulating a vaginal micro-ecological environment and application of the lactobacillus gasseri FMTA1121E. The lactobacillus gasseri FMTA1121E is classified and named as lactobacillus gasseri, and the preservation number of the lactobacillus gasseri FMTA1121E is CGMCC No.34962. The lactobacillus gasseri FMTA1121E can be metabolized to generate beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide so as to regulate the genital tract environment and improve the health degree; and the bacillus subtilis has excellent bacteriostasis and sterilization effects on various common vaginal pathogenic bacteria such as escherichia coli, staphylococcus aureus, gardnerella vaginalis, candida albicans, neisseria gonorrhoeae and the like. Therefore, the lactobacillus gasseri FMTA1121E strain can be applied to preparation of preparations for preventing and treating related genital tract diseases such as vaginitis.

The invention provides a plant fiber containing a ginger extract and a preparation process of the plant fiber. After the plant fiber is washed for 50 times, the bacteriostasis rates of the plant fiber to staphylococcus aureus, escherichia coli, klebsiella pneumoniae and candida albicans are all greater than or equal to 95%, the killing rates of the plant fiber to influenza viruses H3N2 and H1N1 are all greater than or equal to 99%, the far infrared emissivity is 0.89-0.95, the highest temperature rise of moisture absorption and heating is 4-12 DEG C, and the average temperature rise is 3-8 DEG C. A vapor deposition method is adopted, a biomass component A and a biomass component B are combined to form a biomass component C, on one hand, the biomass component B serves as a tube bundle-shaped base material, rhizome plants are calcined to form a porous carbon structure framework, the porous carbon structure framework serves as a solid for vapor deposition, and a solution containing the biomass component A is small in gas molecular weight; after being vaporized along with the solution, the solution is caught by a porous structure of the biomass component B and uniformly filled into pores of the biomass component B, so that the durability of plant functions is ensured, and meanwhile, a protection effect at high temperature is achieved.

The invention relates to the technical field of pharmaceutical preparations, in particular to application of phencycloqualinium bromide as an antibacterial active component and a preparation of the phencycloqualinium bromide. It is found that benzene ring quinaldinium bromide can be used as an antibacterial active component and has an inhibiting effect on various common bacteria and fungi (including but not limited to staphylococcus aureus, pseudomonas aeruginosa, escherichia coli, aspergillus niger, candida albicans and the like); triethanolamine or other bacteriostatic activity enhancers are mixed with the phencycloqualinium bromide, so that the bacteriostatic activity of the phencycloqualinium bromide can be remarkably improved; when a benzene ring quinaldinium bromide related preparation is prepared, other bacteriostatic agent components are not added, a good bacteriostatic effect can still be achieved, and the safety is higher.

The invention relates to an antibacterial gel and a preparation method thereof. The gel mainly comprises silver ions, avocado oil, a radix puerariae extract, wheat germ oil, emulsifying wax, a folium artemisiae argyi extract, glycerol, a styrene / butadiene copolymer, purified water and hydroxyethyl cellulose. Extracts containing specific small-molecule polypeptides are extracted from Artemisia rubescens and Radix Puerariae through a specific extraction method, and the polypeptides are Artemisia rubescens polypeptides (SEQ ID No: 1) and Radix Puerariae polypeptides (SEQ ID No: 2) respectively. The extracts have a synergistic effect with silver ions, so that the antibacterial effect of the gel is remarkably improved, and particularly, the gel has a remarkable inhibiting effect on staphylococcus aureus, escherichia coli and candida albicans. The bacteriostatic gel is simple in preparation method, convenient to use and suitable for bacteriostasis of female vaginal mucosa and maintenance of vaginal micro-ecological internal environment.

The invention discloses a plant extract-containing composite antibacterial external spray for pets and a preparation method of the plant extract-containing composite antibacterial external spray, and belongs to the technical field of pet nursing materials. The external spray comprises the following components in percentage by mass: 0.5-1.0% of a cortex dictamni extract, 0.75-1.5% of a tomato fruit extract, 0.75-1.5% of a folium artemisiae argyi extract and 5-8% of anthemis nobilis hydrolat, and can also be matched with auxiliary components such as an emulsifier and a preservative. The cortex dictamni extract is prepared by combining a supercritical CO2 extraction method with a specific compound entrainer, and active ingredients are fully reserved; the spray is prepared through step-by-step preparation of a water phase and an oil phase and then high-shear emulsification, and the stability is good. The product shows a high bacteriostatic effect on staphylococcus aureus, salmonella and candida albicans, can significantly reduce the content of an inflammatory mediator NO and a proinflammatory factor IL-1beta, has bacteriostatic, bactericidal and anti-inflammatory effects, is suitable for preparation of pet skin care related products, and has a wide application prospect.

The present application provides a kind of endo beta-1, 3-glucanase and its application, the amino acid sequence of the endo beta-1, 3-glucanase is SEQ ID NO:1.The endo beta-1, 3-glucanase of the present application can efficiently hydrolyze laminarin and curdlan, its enzyme activity can still be kept above 80% in the range of 40-60 DEG C and pH 4.5-6.0, and it shows good stability under low temperature conditions, which is conducive to reduce the energy consumption in the process of practical application.At the same time, the enzyme has significant high salt tolerance, and has certain resistance to 5%-15% ethanol.The endo beta-1, 3-glucanase of the present application has obvious inhibitory effect on the formation of Candida albicans biofilm, and the laminarin oligosaccharide generated by hydrolyzing laminarin also shows good antioxidant capacity, indicating that the enzyme has broad application prospect and significant practical value in the fields of antibacterial, biological medicine and the like.

The invention relates to the technical field of antibacterial composition preparation, in particular to a gynecological antibacterial composition and a preparation method thereof, and the gynecological antibacterial composition comprises the following raw materials: modified radix sophorae flavescentis, angelica sinensis, modified cortex phellodendri, radix paeoniae rubra, ligusticum wallichii, bombyx batryticatus, salvia miltiorrhiza, safflower carthamus, fructus cnidii, gallnut, calamine, pomegranate rind, catechu, rhizoma atractylodis, dragon's blood, fructus kochiae, borneol, alum, dried alum, purpurea sal ammoniac, magnesium stearate and starch. According to the invention, after the modified radix sophorae flavescentis is subjected to ethanol ultrasonic extraction, purification and micronization treatment, the dissolution rate and purity of effective components such as sophocarpidine are improved, the cell membrane structure of gram-negative bacteria such as escherichia coli can be quickly destroyed, and efficient bacteriostasis is realized; the modified cortex phellodendri is subjected to alkali dissolution extraction, acid precipitation purification and refined drying, berberine hydrochloride is efficiently enriched, the purity is improved, and the berberine hydrochloride can kill fungi such as candida albicans more accurately and strongly; and through high-temperature calcination and acetic acid activation, the calamine and the catechu are tightly combined at a microscopic level, so that the inherent convergence, granulation promoting and antibacterial effects of the calamine and the catechu are enhanced.

The invention belongs to the technical field of medicines, and discloses a gynecological bacteriostatic lotion and a preparation method and application thereof.The lotion is prepared from extracts of traditional Chinese medicinal materials such as radix sophorae flavescentis, cortex phellodendri, coptis chinensis, scutellaria baicalensis, rhizoma smilacis glabrae, cortex dictamni, fructus cnidii, areca nuts, cortex meliae, golden larch bark, lithospermum erythrorhizon, lavender, rheum officinale and honeysuckle as main raw materials, and parachloroxylenol, salicylic acid and borneol as auxiliary materials. A compound preparation with multiple effects is formed through scientific proportioning and a preparation process, the product can effectively inhibit common pathogenic bacteria such as Candida albicans, Staphylococcus aureus and Escherichia coli, shows a broad-spectrum and efficient antibacterial effect, and is small in irritation, high in safety to vaginal mucosa and genital tract environment and free of toxic and side effects. The product can maintain local micro-ecological balance and reduce inflammation recurrence while cleaning and nursing, has the advantages of long-term conditioning of a traditional Chinese medicine compound and rapid sterilization of western medicine components, and is suitable for clinical popularization and application.

The invention belongs to the technical field of biological model construction, and particularly relates to a method for constructing a vasculitis model in zebra fish. The compound is obtained by inducing a Candida albicans water soluble substance (CAWS), and the specific method is micro-injection or soaking. According to the method, whether modeling succeeds or not can be judged in the living body state of the model animal, the method is more suitable for visually observing the inflammation occurrence position, a research method for vasculitis (including Kawasaki disease) is developed, follow-up scientific research data can be richer and more accurate, and a more solid theoretical basis is laid for clinical transformation of targeted therapy of vasculitis (including Kawasaki disease).

The invention discloses an effective part for chemoradiotherapy-induced oral mucositis in traditional Chinese medicinal material white flower and a preparation process of the effective part. The effective part is identified as a flavonoid component through standard substance spectrogram comparison. Tests prove that the production process of the effective part is practical and feasible, and the total flavonoids in the finally obtained extracting solution are greater than or equal to 50%. Besides, pharmacodynamic studies show that the effective part has a remarkable bacteriostasis effect on staphylococcus aureus, escherichia coli and candida albicans, the bacteriostasis rate is larger than or equal to 80%, the effective part has a remarkable treatment effect on rat oral mucosa acute inflammation caused by chemoradiotherapy, and the application prospect of the effective part in the adaptation disease is shown.

The invention discloses a 2-(imidazo [1, 5-a] pyridine-1-yl)-1-methylpyridine-1-onium compound as well as a preparation method and an antibacterial and mildew-proof application thereof. The structural formula of the 2-(imidazo [1, 5-a] pyridine-1-yl)-1-methylpyridine-1-onium compound is shown as a formula (II), and the 2-(imidazo [1, 5-a] pyridine-1-yl)-1-methylpyridine-1-onium compound is easy to synthesize, shows good antibacterial and mildew-proof activity, has good antibacterial activity on staphylococcus aureus, escherichia coli, candida albicans and aspergillus fumigatus, serves as a novel antibacterial and mildew-proof agent, and has good application prospects. The method has great application value in the technical field of antibiosis. Formula (II)

The invention belongs to the technical field of in-vitro diagnostic reagents for rapid detection of human pathogenic microorganisms, and particularly relates to a kit for rapid combined detection of multiple pathogen nucleic acids related to a dyspnea pregnancy outcome and application of the kit. The pathogen is selected from one or more of escherichia coli, candida albicans, candida glabrata, group B streptococcus, streptococcus gonorrhoeae, chlamydia trachomatis or ureaplasma urealyticum, and the kit comprises a pathogen and lactobacillus rapid detection micro-fluidic chip. A primer group for detecting the pathogen and the lactic acid bacillus nucleic acid and an array consisting of an amplification control and a blank control are fixed on the micro-fluidic chip. According to the present invention, the microfluidic chip rapid detection technology and the nucleic acid amplification technology are adopted to achieve the purposes of rapid detection and multiple detection so as to rapidly and conveniently determine the poor prognosis risk of the pregnant woman at present, timely take the specific measures, and avoid the occurrence of the poor prognosis.

The invention belongs to the technical field of organic compounds, and particularly relates to an organic compound with antibacterial activity and a preparation method and application thereof. The organic compound provided by the invention has a structure as shown in a formula 1, a formula 2 or a formula 3. The organic compound provided by the invention has antibacterial activity, and the stenolnate C, the stenolnate H and the stenolnate I are various types of organic compounds, have activity on candida albicans, and show a relatively good antibacterial effect. The organic compound provided by the invention is a metabolite of Sterium sanguinol HF-41 and is prepared through microbial fermentation, the preparation method is short in period, mild in culture condition, few in by-products and low in cost, large-scale industrial production is easy to realize, and the requirements of modern environmental protection and low-carbon economy are met. .

The invention relates to biochar and application thereof in an anti-biological agent, and belongs to the technical field of biochar. The biochar is prepared by treating gramineous plants at high temperature. The anti-biological agent is low in raw material cost, green and environment-friendly, does not need additional irritants, and has an excellent inhibition rate on pathogens, and the inhibition rate on Escherichia coli, Staphylococcus aureus and Candida albicans reaches 99.99%. The biochar disclosed by the invention has relatively good cost performance and relatively high applicability, and can meet the rapid increase of the requirement for resisting pathogenic bacteria in infectious diseases such as epidemic situations.

The invention belongs to the technical field of biology, and discloses an antibacterial peptide with activity of inhibiting human pathogenic bacteria as well as a preparation method and application of the antibacterial peptide. The antibacterial peptide or the salt thereof is disclosed for the first time, and the antibacterial peptide has a good antibacterial effect on common genital tract bacteria (such as staphylococcus aureus, gardnerella and candida albicans), oral pathogenic bacteria (such as fusobacterium nucleatum and streptococcus gordoni) and other pathogenic bacteria (such as escherichia coli, salmonella enteritidis and streptococcus suis); and the compound shows slight cytotoxicity to mammalian cells only at a high concentration.

The invention discloses an application of a bacterial strain in production of an external product for improving the micro-ecology of the vagina of a human body, and the bacterial strain is Lactobacillus crispatus SPR005 and has 16S rDNA (ribosomal deoxyribonucleic acid) as shown in SEQ ID NO.1. The invention also discloses an application of the bacterial strain in production of the external product for improving the micro-ecology of the vagina of the human body. The preservation number is GDMCC NO: 66665; the strain produces H2O2 and only produces D-lactic acid, and no drug-resistant gene is found; the external product is suitable for improving changes, caused by vaginal pathogenic bacteria, of micro-ecology of the vagina of the human body. Compared with other lactobacillus crispatus of the same type, the strain disclosed by the invention can generate a strong bacteriostatic effect on staphylococcus aureus when the concentration of the strain is about 1 * 10 < 7 > CFU / ml, and the bacteriostatic rate reaches 99.78 or above. In addition, the strain disclosed by the invention is relatively high in acid production capacity, and the total amount of D-lactic acid produced in 48 hours is 16.28 mM; the D-lactic acid not only can effectively reduce the pH value of the vagina and maintain the pH value of the vagina between 3.8 and 4.0, but also can enhance the recognition and removal capability of pathogens by adjusting the immune response of the host. D-lactic acid can inhibit the growth of fungi, such as candida albicans; the D-lactic acid level is also positively correlated with the vaginal homeostasis, so that the treatment of BV patients is facilitated.

The invention discloses a Saccharomyces cerevisiae strain with an intestinal tract probiotic function, the Saccharomyces cerevisiae strain is named as GLMQ-1, the classification name is Saccharomyces cerevisiae, the preservation number is CGMCC NO.34261, the preservation date is April 18, 2025, and the preservation unit is China General Microbiological Culture Collection Center, No. 3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing. The saccharomyces cerevisiae is separated from yak yoghurt in Qinghai province, has relatively strong acid and cholate tolerance, has good co-aggregation capability on escherichia coli, staphylococcus aureus and candida albicans, and can relieve antibiotic-induced diarrhea symptoms of mice and improve the tolerance on antibiotic-related diarrhea. The saccharomyces cerevisiae disclosed by the invention can be used for preparing anti-diarrhea medicines or microecologics, and has a very wide application prospect.

The invention discloses a 1-methyl-2-(3-phenylimidazo [1, 5-a] pyridine-1-yl) pyridine-1-onium compound as well as a preparation method and an antibacterial and mildew-proof application thereof. The structural formula of the 1-methyl-2-(3-phenylimidazo [1, 5-a] pyridine-1-yl) pyridine-1-onium compound is shown as a formula (II), and the 1-methyl-2-(3-phenylimidazo [1, 5-a] pyridine-1-onium compound is easy to synthesize, shows excellent antibacterial activity on staphylococcus aureus and escherichia coli, has a remarkable mildew-proof effect on candida albicans and aspergillus fumigatus, and can be used for preparing an antibacterial agent for preventing and treating the staphylococcus aureus and the escherichia coli. Therefore, the method has important application value in the technical field of antibiosis and mildew prevention. Formula (II)

This invention belongs to the field of wet wipe technology, specifically relating to a sterilizing wet wipe and its manufacturing process. The sterilizing wet wipe includes a wet wipe substrate and a wet wipe soaking solution; the wet wipe soaking solution comprises the following components by weight: 10-15 parts sterilizing ingredient; 0.5-1 part plant essential oil; 90-100 parts water; the sterilizing ingredient is composed of modified carboxymethyl chitosan and modified sodium hyaluronate in a mass ratio of 1-2:1; this sterilizing wet wipe achieves a sterilization rate of over 98% against Staphylococcus aureus, Escherichia coli, Candida albicans, and Bacillus subtilis within a short time, exhibiting excellent sterilization performance, while also providing good moisturizing effects, no skin irritation, and high safety.

The invention discloses an oral antibacterial liquid for an oral antibacterial mucoprotective film, which has an excellent inhibition effect on escherichia coli, porphyromonas gingivalis, staphylococcus aureus, streptococcus mutans and candida albicans through the synergistic effect of lysozyme, lysostaphin, angelia and plant extract. The bacteriostasis rate can reach 99.99% or above after 5 minutes of action; through a specific ratio and a specific process, after the active ingredients in the product are subjected to an accelerated test at 37 DEG C for 90 days, the activity decline rate of lysozyme and lysostaphin is lower than 10%, the color and precipitation are not changed, the validity period of the product can stably reach 2 years, and the efficacy in the shelf life is ensured; an acute eye stimulation test verifies that the product has no stimulation to New Zealand rabbit eyes, which indicates that the product is safe and mild when being used for oral mucosa, and stimulation and side effects possibly brought by a chemical bacteriostatic agent are avoided.

This invention belongs to the field of personal care product technology, specifically relating to a male genital mousse wash containing PHMB and its preparation method. The wash uses polyhexamethylene biguanide hydrochloride (PHMB) as the core antibacterial agent, combined with cocoylpropyl betaine and sodium lauroyl sarcosinate as the cleansing surfactant system, compounded with sodium hyaluronate, panthenol, and dipotassium glycyrrhizate, supplemented with propylene glycol, glycerin, disodium EDTA, and phenoxyethanol. The pH is adjusted to 5.0–6.0 with L-lactic acid, and the remainder is water for injection. The preparation employs a low-temperature stepwise feeding process to obtain a weakly acidic mousse foam. The product exhibits an antibacterial rate of ≥99.99% against Escherichia coli, Staphylococcus aureus, and Candida albicans, is non-irritating to the skin, produces a dense and stable foam that is easy to rinse, and has good high and low temperature stability. It combines cleansing, antibacterial, and mucosal repair effects, solving the problems of traditional feminine hygiene products such as high irritation, easy allergy, and poor dosage form experience. It is suitable for daily cleaning and care of the male genitalia.

This invention discloses a bio-fertilizer and soil improvement method for reducing continuous cropping obstacles in cucumbers. By weight, the bio-fertilizer comprises the following raw materials: 30-40 parts of well-rotted livestock and poultry manure, 20-30 parts of straw or rice husks, 1-2 parts of borax, 2-3 parts of urea, 2-4 parts of ammonium sulfate, 2-3 parts of zinc sulfate, 2-3 parts of magnesium sulfate, 1-2 parts of humic acid, and 1-2 parts of a microbial compound agent. The microbial compound agent comprises 4-6 parts of Bacillus megaterium, 2-3 parts of Bacillus polymyxa, 2-4 parts of Trichoderma echinococcus, 2-3 parts of Trichoderma viride, 3-5 parts of Pseudomonas fluorescens, 4-5 parts of Azotobacter chrysogenum, and 2-4 parts of Candida albicans. Using this bio-fertilizer and soil improvement method for reducing continuous cropping obstacles in cucumbers can significantly reduce the impact of continuous cropping obstacles, not only significantly reducing the incidence of cucumber wilt and root-knot nematodes and significantly promoting cucumber seedling growth, but also significantly increasing cucumber yield.

The application provides a kind of double amidino-containing compound and the application of pharmaceutically acceptable salt in antifungal, belong to medical technical field.The double amidino-containing compound of the application has the structure shown in formula I R1 and R2 independently selected from hydrogen, substituted or unsubstituted C 1‑12 Alkyl or C 3‑12 Cycloalkyl, or R1 and R2 and N form substituted or unsubstituted 3-6 membered ring, R3 is independently selected from hydrogen, substituted or unsubstituted alkyl; or R2 and R3 are connected to form substituted or unsubstituted 5-7 membered ring with amidino, R1 is independently selected from hydrogen, substituted or unsubstituted alkyl; R is independently selected from hydrogen, halogen, haloalkyl or alkoxy; X and Y are independently selected from C or N; Q is independently selected from oxygen, amine group, alkylamine group, alkyne group, alkoxy or Q group is not present, i.e. two aromatic rings are directly connected.The double amidino-containing compound of the application has good Candida albicans activity and therapeutic index, and can be used for clinical treatment of Candida albicans, to solve the problem of fungal drug resistance.

This invention belongs to the field of hygiene protection technology, and relates to a pure physical antibacterial and antiviral mask based on the hyper-enrichment of polar groups, as well as its preparation method and system. The outer layer, inner layer, and filter layer of the mask body are all modified polypropylene fiber layers, containing a polar modifier. The polar modifier contains polar functional groups that can undergo dipole resonance with a physical field. After physical field treatment that can excite the polar functional groups to undergo dipole resonance, the ratio of the polar group concentration on the fiber surface to the internal concentration is ≥2.2, forming a positive charge enrichment layer on the surface. The antibacterial rate and antiviral activity rate against Staphylococcus aureus, Escherichia coli, and Candida albicans are all ≥99.9%. This invention achieves super-strong physical antibacterial performance through multi-component synergistic hyper-enrichment, gradient temperature control induction, and precise physical field treatment based on mathematical models. It also has the advantages of high biosafety, excellent antibacterial effect, and no impact on the core performance of the mask, making it suitable for high-requirement scenarios such as medical surgical masks and medical protective masks.

The formula comprises the following components: polyhexamethylene biguanide hydrochloride, benzalkonium chloride, glycerol, propylene glycol, borneol, menthol, a folium artemisiae argyi extract, a pepper extract, an R301 miticide and the balance of water. According to the spray prepared by the invention, the herbal raw materials are used as main raw materials, and are matched with the interaction of other various components, so that the antibacterial and mite-killing performance of the spray can be greatly improved. By introducing the folium artemisiae argyi extract and the matching effect of the pepper extract extracted by a specific method, the spray can be endowed with unique herbal fragrance, meanwhile, a remarkable antibacterial effect can be achieved, most of common pathogenic bacteria including staphylococcus aureus, escherichia coli, candida albicans and the like can be effectively inhibited, and the spray has a good antibacterial effect. The pathogenic bacteria are inhibited and killed.

The invention relates to bacillus velezensis B02 and application of the bacillus velezensis B02, and belongs to the technical field of microorganisms. The strain is preserved in Guangdong Microbial Culture Collection Center, and the preservation number of the strain is GDMCC NO.66439. The strain is obtained by separation, purification and screening from a soil sample, and tests show that bacteriostatic active substances generated by fermentation of the strain have good bacteriostatic effects on Burkholderia cepacia, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Pseudomonas putida, Enterococcus faecalis, Candida albicans and Aspergillus brazili. And the product also has excellent heat resistance, cold resistance, illumination stability, pH stability and preservative effect, belongs to a mild low-irritation raw material, and can be used for preparing daily chemical products. Therefore, the bacillus velezensis B02 and the bacteriostatic active substances generated by the bacillus velezensis B02 have wide application prospects and important transformation research values.

This invention belongs to the field of microbial technology, specifically relating to the multifunctional Lactobacillus curvatureii and its application in the preparation of health products. The Lactobacillus curvatureii (… Lactobacillus crispatus Lactobacillus crispatus The accession number for MCOlact00102 is CGMCC No. 34381. The described *Lactobacillus curvatureensis* (MCOlact00102) is... Lactobacillus crispatus ​ The two strains, MCOlact00126 (CGMCC No. 34382), exhibit significant inhibitory effects against bacterial vaginosis (BV) and infections caused by Gardnerella vaginalis, Group B Streptococcus (GBS), Escherichia coli, or Candida albicans. The safety of these strains was evaluated using a 3D vaginal epithelial organoid model, showing no irritant effect on cells. Furthermore, hemolytic activity tests, antibiotic resistance gene detection, and functional validation all demonstrated their good safety profile. In addition, the aerobic acclimation process significantly improved the stability and bioactivity of these two strains in actual production and clinical applications, laying a solid foundation for their industrialization and application.

The invention relates to the technical field of nano antibacterial materials. The invention relates to a carbon nanodot, in particular to an all-weather broad-spectrum antibacterial antivirus carbon nanodot and a preparation method and application thereof. The preparation method of the all-weather broad-spectrum antibacterial antivirus carbon nanodots comprises the following steps: 1) adding an auxiliary solution into a high-molecular polymer to obtain a precursor solution; 2) transferring the precursor solution into a reactor, and reacting for 1-24 hours under the condition of 100-500 DEG C; and 3) after the reaction is finished, cooling to room temperature, collecting reaction liquid, and separating and purifying to obtain the carbon nanodots, wherein the high-molecular polymer is selected from a structure shown in the specification. The carbon nanodot can have an efficient killing effect on pathogenic microorganisms including but not limited to escherichia coli, staphylococcus aureus, candida albicans and other bacteria, fungi, influenza viruses and the like in all-weather environments such as sunny days, cloudy days, daytime and night, and meanwhile, the carbon nanodot prepared by the preparation method is high in biological safety and high in cost performance.