4328results about How to "Delay drug resistance" patented technology

An automated, controllable, and affixable pulsatile agent delivery system having an automated controller for controlling the delivery of drug to a patient, an agent delivery reservoir containing an agent operatively connected to the automated controller, a reservoir controller operatively connected to the automated controller and the reservoir for controlling the delivery of agent to a patient, and a feedback control operatively connected to the automated controller for providing feedback with regard to the drug requirements of the patient. A method of delivering an agent to a patient in need of the same by administering the above agent delivery system to a patient, determining an amount of agent needed for the patient, and affecting administration of the agent to the patient via the agent delivery system.

The invention belongs to the field of pesticide, which mainly relates to an ultralow-volume solvent containing pleocidin or spinetoram. The ultralow-volume solvent is an active component I or an active ingredient compounded by the active component I or an active component II, and the balance is solvent and accessory ingredient, wherein the active component I is pleocidin or spinetoram; and the active component II is insecticide of the other type of action mechanism. The ultralow volume solvent is simple to process and has the advantages of water conservation, high work efficiency, long efficacy continuing period, small possibility of generating resistance to drug for a target, small environment pollution, synergy and the like. Ultralow volume spraying, low-volume spraying or low-volume electrostatic spraying is applied to effectively prevent and control various pests, such as Cnaphalocrocis medinalis, Chilo suppressalis, rice planthopper, Ostrinia nubilalis, plutella xylostella, cabbage caterpillar, Spodoptera litura, Spodoptera exigua, aphids, Lesser green leaf hopper, Icerya purchase, aleyrodid, Thrip, stinkbug, acridid, flea beetle, leafminer, looper and the like.

The invention provides a fungicide composition containing an active component A and an active component B, and application thereof in preventing and controlling various agricultural fungal diseases. The active component A in the composition is one of two methoxyl acrylic ester compounds; and as shown above, the active component B of the compound A1 and the compound A2 is one of the following fungicide varieties: thiocarbamate compounds or salt thereof, aliphatic compounds or salt thereof, carbamate compounds or salt thereof, oxazole compounds or salt thereof, thiazole compounds or salt thereof, amide compounds or salt thereof, organophosphorus compounds or salt thereof, imidazole compounds or salt thereof, antibiotic compounds or salt thereof, pyridine compounds or salt thereof and triazole compounds or salt thereof.

The invention relates to the field of pesticides, in particular to ultralow volume liquid containing benzoylurea insecticide, which comprises active ingredients, solvent and adjuvant. The active ingredient I is optional one of lufenuron, diflubenzuron, triflumuron, chlorfluazuron and chlorbenzuron belonging to benzoylurea, and the active ingredient II is insecticide of another type of function mechanism. The ultralow volume liquid containing benzoylurea insecticide has the advantages of simplicity in processing, high efficiency, water saving, long-term effect, a target being not easy to resist the insecticide, low environmental pollution, synergy and the like. Application of ultralow volume spray, low volume spray or ultralow volume static spray is well effective in controlling ostrinia furnacalis, sugarcane borer, locust, peach fruit borer, lesser green leaf hopper, striped flea beetle, bean fly, diamond back moth, prodenia litura, cabbage caterpillar, leaf beetle, thrip, leaf miner, inchworm, red spider and the like, and the ultralow volume liquid containing benzoylurea insecticide can be used for effectively controlling various pests on wheat, maize, vegetables, tobacco plants, tea plants, fruit trees, cotton plants, woods and sugarcanes.

The invention relates to a pesticide composition containing indoxacarb, mainly used in crops disinfestation, which comprises emulsifiable concentrate, wettable powder and suspension agent. The active ingredients of the pesticide composition are indoxacarb and active ingredient B which is any one or composition of more than one with any proportion of Methylamino abamectin benzoate, hexaflumuron, nitenpyram, avermectin, fipronil, chlorfenapyr, acetamiprid, profenofos, phoxim, high-efficiency cypermethrin, cyhalothrin, triazophos and chlorpyrifos. The pesticide composition has the advantages of enlarging the application range, having strong contact toxicity and stomach poisoning action, having low mammalian toxicity and better compatibility of environment, being effective to the pest of every growth period, increasing the effect of every component of the composition significantly, reducing the production cost and agricultural cost of the pesticide, having wide insecticidal spectrum and high efficiency, delaying the occurrence of the drug resistance of the pests, prolonging the service life of the pesticide agent, enabling the high yield and high quality of the crops, having strong activity, long persistent period and stable drug efficacy to the pests.

The invention discloses piggy creep feed, which mainly comprises corn, rice, full cream puffing soybean, fermentation bean pulp, peeled bean pulp, fish meal and other raw materials, wherein a yeast cell extractive is added to improve the immunity of the piggy, the complex enzyme preparation and probiotics replace the high copper and high zinc, so the pollution to the environment is reduced, meanwhile, the digestion and absorption of the feed are improved, and the normal flora of the intestinal canal is kept. The full organic trace element replaces the inorganic trace element, so the oxidation of the salt to the feed and the organism is reduced. The invention further discloses a method for preparing the creep feed, which utilizes the granulation process, the objectionable constituents and the beneficial constituents are effectively accepted or rejected, so the nutrient value of the feed is effectively maintained.

The invention discloses a gRNA sequence. The sequence in a CRISPR-Cas9 system is capable of editing a DNA sequence by taking a resistance plasmid specific site in bacteria as a target sequence. The gRNA sequence is shown as SEQ ID NO:1 and/or 2. The invention also discloses the CRISPR-Cas9 system of the gRNA sequence and an application of the CRISPR-Cas9 system in preparing a drug for treating resistant bacterial infection. The CRISPR-Cas9 system provided by the invention is capable of targeting two super resistance genes of NDM-1 and MCR-1, simultaneously eliminating the two resistance genes and guaranteeing the use effect of carbapenms and colistin antibiotics.

The invention relates to a novel veterinary antibacterial agent and in particular relates to a lauroyl arginine ethyl ester ion pair compound derivative which is prepared from lauroyl arginine ethyl ester LAE and an organic acid through reactions. As a livestock aquatic animal antibacterial agent, the derivative is capable of preventing and treating duckling riemerella anatipestifer diseases caused by riemerella anatipestifer, is capable of treating peritonitis diseases caused by escherichia coli and staphylococcus aureus, is capable of preventing and treating fish septicemia caused by aeromonas sobria, and has remarkably improved prevention and treatment effects when being compared with a conventional LAE veterinary antibacterial agent. The derivative can be completely degraded in human bodies and animal bodies and is small in toxic and side effect, environment drug resistance bacteria caused by residual antibacterial agents discharged into the environment can be avoided, and small adverse environment influence can be caused while an effective antibacterial effect is achieved.

The invention belongs to the technical field of medicine and specifically relates to an aniline substituted quinazoline derivative with a general formula (I), pharmaceutically acceptable salt thereof or stereo isomer thereof. R1, R2, R3, R4, R5, R6, L and n are defined in the instruction. The invention also relates to a preparation method of the compounds, medicinal preparations containing the compounds and purpose of the compounds in preparation of medicaments for treating tumour.

The invention provides a pymetrozine-containing ultralow volume liquid agent, and belongs to the field of pesticides. The ultralow volume liquid agent consists of pymetrozine or active ingredient compounded by using the pymetrozine and an active ingredient II, and the balance of aids and solvent; and the active ingredient II is any one of bifenthrin, beta-cypermethrin, lambda-cyhalothrin, cyfluthrin, fenpropathrin, deltamethrin, etofenprox, triazamate, tolfenpyrad, chlorantraniliprole, flubendiamide, ethiprole, abamectin, emamectin benzoate, ivermectin, sec-butyl phenyl-N-methyl carbamate, buprofezin, hexaflumuron, flufenoxuron, chlorbenzuron, diafenthiuron, indoxacarb, 1,2-Dibenzoyl-1-tert-butylhydrazine and tebufenozide. The ultralow volume liquid agent is used for preventing and controlling multiple pests on paddy, wheat, corn, vegetables, tobacco, tea trees, fruit trees and sugarcane by ultralow volume spraying, low volume spraying or ultralow volume electrostatic spraying. The ultralow volume liquid agent has the advantages of low water consumption, high effect, long acting time, synergy and the like.

A flow-forced generator adapted with a turbo-charging deflection hood having at the peripheral of the vortex ring in the generator provided with an automated directional turbo-charging deflection hood for the air or fluid to produce turbo-charging results due to the reducing deflection of the hood, thus to increase the power of the generator in case of insufficient flow force.

The invention relates to a fungicidal composition containing a prochloraz manganese complex, belonging to the technical field of pesticides. The fungicidal composition comprises a raw pesticide compounded by a fungicide A and a fungicide B, wherein the mixture ratio of the fungicide A to the fungicide B is (1-90): (90:1); the fungicide A is the prochloraz manganese complex; and the fungicide B is any one type of the following fungicides: copper preparations, strobilurins, triazoles, amides, pyrimidinamines, benzimidazoles, thiocarbamates, dimethyl imides, imidazoles, morpholines, oxazoles, ureas, pyridines, pyrimidines, pyrroles, phthalimides, carbamates, antibiotics, heterocycles and others. The fungicidal composition disclosed by the invention contains the raw pesticide compounded by the prochloraz manganese complex and the fungicide B, and can expand the fungicidal spectrum, slow down the drug resistance of pathogenic bacteria and realize an obvious sustained synergistic effect.

The invention discloses a flonicamid-containing ultralow volume liquid agent. The ultralow volume liquid agent consists of flonicamid or active ingredient compounded by using the flonicamid and an active ingredient II, and the balance of aids and solvent; and the active ingredient II is any one of ethiprole, etofenprox, tolfenpyrad, chlorantraniliprole, flubendiamide, ivermectin, abamectin and emamectin benzoate. The ultralow volume liquid agent can be used for preventing and controlling the pests such as rice planthopper, cnaphalocrocis medinalis, nilaparvata lugens, sogatella furcifera and the like, and has the advantages of low water consumption, high effect, long acting time, synergy and the like.

The invention relates to a traditional Chinese medicine bactericide for preventing and controlling soft rot of konjak, and belongs to the filed of insect pests and plant disease prevention and control and biological pesticide. The traditional Chinese medicine bactericide comprises the following components by weight percentage: 12 to 36 percent of garlic extract, 3 to 12 percent of Chinese goldthread rhizome extract, 3 to 10 percent of Flos Lonicerae leave extract, 3 to 5 percent of wettable powder accessory ingredient for farm chemical, and the balance being packing carrier for the farm chemical. The components are compounded into the traditional Chinese medicine bactericide wettable powder which has obvious sterilizing effect on pathogen of the soft rot of konjak, namely Erwinia Aroideae Holland for preventing and controlling the soft rot of konjak. The traditional Chinese medicine bactericide wettable powder is environment-friendly, has strong specificity, is better than chemical agents to prevent and control the soft rot of konjak, has more than 65 percent of relative prevention effect, and can improve the yield of konjak when applied to konjak production, as proved by experiments.

The invention relates to a pesticide, in particular to a compound bactericide for mainly treating grey mold of fruits and vegetables. The compound bactericide consists of active ingredients, a filler and/or aids, wherein the active ingredients consist of fluazinam and other bactericides; the weight ratio of the fluazinam to other bactericides is 1-50:1-50; and other bactericides are one or a mixture of more of mancozeb, iprodione, fludioxonil, SYP-Z048, pyrametostrobin and azoxystrobin. Product forms of the compound bactericide for mainly treating the grey mold of fruits and vegetables are usually wettable powder, water dispersible granules and suspension agents. The compound bactericide is applicable to the prevention and control of the grey mold of various fruits and vegetables and has remarkable synergism and long effective duration, the medicaments have a novel action mechanism and a large number of action sites, and the occurrence and development of medicament resistance of grey mold bacteria can be effectively delayed; and the preparation method of the compound bactericide is simple, and the compound bactericide has high biological safety and remarkable economic benefit.

The invention discloses a bactericidal composition, which contains a synergy effective amount of fludioxonil, and one of propiconazol, carbendazim, thiram, JS399-19, cyprodinil and polyoxin. The weight part ratio of the two active ingredients in the bactericidal composition is 50:1 to 1:50. The bactericidal composition provided by the invention at least contains a surfactant which is favorable for dispersing the active ingredients in water when applied, integrates protection, treatment and eradication activities, and can be used for preventing and controlling the plant diseases, caused by the pathogenic bacteria of aseomycotina, basidiomycolina and deuteromycotina, of various crops, such as wheat, rice, vegetables, fruit trees and the like.

The invention discloses a Chinese herbal microecological preparation for preventing and treating chicken Colibacillosis and a preparation method thereof. The Chinese herbal microecological preparation for preventing and treating chicken Colibacillosis is prepared by adding mixed bacterial liquid of bifidobacteria and bacillus subtilis with a total number of colonies of 0.5-1.0*10<8> CFU/ml into the extract of traditional Chinese medicines and carrying out hermetical anaerobic fermentation on an obtained mixture, wherein the traditional Chinese medicines comprise, by weight, 50 to 200 parts of coptis, 50 to 200 parts of phellodendron, 50 to 200 parts of rheum officinale, 50 to 200 parts of root of large-flowered skullcap, 50 to 200 parts of isatis root and 50 to 100 parts of licorice. The Chinese herbal microecological preparation for preventing and treating chicken Colibacillosis provided in the invention allows pharmaceutical activity of the compatible traditional Chinese medicines to be enhanced after fermentation treatment by using bacterial liquid of bifidobacteria and bacillus subtilis, reduces drug resistance exerted by the medicines on chicken on the basis of guaranteeing a good curative effect and maintains a good treatment effect after many times of administration.

The invention provides a nursing pig concentrated feed and belongs to the field of animal feeds. According to the nursing pig concentrated feed, an antibiotic is replaced by an antibiotic-substituting compound consisting of antimicrobial peptides, plant essential oil and an acidifying agent. The feed is purely green, safe and harmless, the immunity of pigs cannot be destroyed, and difficult pig breeding and severe food safety crisis which are caused by the excessive addition of the antibiotic are avoided.

The invention discloses a eugenol biological pesticide which comprises the following ingredients in percentage by weight: 0.1% to 70% of eugenol, 6% to 20% of surfactant, 0.01% to 0.5% of plant immunity regulator, 10% to 50% of synergist, and raw materials of alcohol and turpentine for the rest part. With the advantage of reasonable formula, the eugenol biological pesticide is characterized in that the active volatility of the active ingredient eugenol is improved, the pesticide effect of the eugenol is enhanced, pesticide doses are reduced, and the pesticide cost for farmers is reduced; pureplant solvents are used in the eugenol biological pesticide which belongs to low-carbon and environment-friendly pesticide, so pollution and harm to the environment are reduced, and the eugenol biological pesticide is safe and environment friendly for use. The eugenol biological pesticide is used for preventing and treating powdery mildew, botrytis and downy mildew and regulating plant immunity, and has the effects of synergy, simultaneous treatment, resistance prevention, resistance delay, etc.

The invention provides an ocean antifouling paint which consists of an antifouling type film forming material, a filler, pigments, a silane coupling agent, a flatting agent and a solvent. The antifouling type film forming material is a macromolecule complex prepared by carrying out a chelation reaction on salicylide as well as quaternary ammonium salt modified polyacrylate and antibacterial metal ionic compound as materials. The ocean antifouling paint provided in the invention has the following characteristics: (1) the preparation method of the ocean antifouling paint is simple and feasible, the source of the materials is abundant, and the cost is low; (2) the antifouling type film forming material contains two sterilization and antibacterial materials with different mechanisms, and sterilization and antibacterial synergistic effect is achieved, and the drug resistance of bacterial microorganisms can be effectively reduced.

The invention discloses a pesticidal composition comprising the active components including spirotetramat and (B) which is any one of abamectin or emamectin benzoate. The mass ratio of the spirotetramat to B is 100:1-1:40. By combining the spirotetramat and the abamectin or the emamectin benzoate, the composition has obvious synergistic effect and is conductive to retarding or overcoming the drugresistance of pests. The composition of the invention can be used for controlling diverse pests on agricultural crops and is especially suitable for controlling the pests such as aphids, whiteflies, thrips, plant lice and the like.

The present invention belongs to the field of insecticides, and relates to a pest-killing and mite-killing composition, which contains an active component A and an active component B, a weight part ratio of the component A to the component B is 1:99-99:1, the active component A is selected from a compound I represented by the following structural formula, the active component B is selected from an organic phosphorus pest/mite killing agent, a nicotine type acetylcholine receptor (nAChR) agonist pest/mite killing agent, an apastia pest/mite killing agent, a proton gradient interference and oxidative phosphorylation affecting uncoupling pest/mite killing agent, a nereistoxin analog pest/mite killing agent, a Ryania receptor regulating pest/mite killing agent, a voltage-dependent sodium ion channel blocking pest/mite killing agent, an ecdysone receptor stimulating pest/mite killing agent, an amino butyric acid (GABA) gated chloride channel antagonism pest/mite killing agent, a microorganism pest/mite killing agent or other pest/mite killing agents, and the active component A has the following structure. The composition of the present invention has advantages of significant synergy, resistance delaying and the like, and can be used for prevention and control of a variety of pests. The compound I is defined in the instruction.