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62 results about "Ecdysone receptor" patented technology
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The ecdysone receptor is a nuclear receptor found in arthropods, where it controls development and contributes to other processes such as reproduction. The receptor is a non-covalent heterodimer of two proteins, the EcR protein and ultraspiracle protein (USP). It binds to and is activated by ecdysteroids. Insect ecdysone receptors are currently better characterized than those from other arthropods, and mimics of ecdysteroids are used commercially as caterpillar-selective insecticides.
Methods for modulating expression of exogenous genes in mammalian systems
InactiveUS7045315B2Short half-lifeImprove pharmacokineticsBiocideHydroxy compound active ingredientsHormones regulationGene transfer
In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in an isolated cell and in a mammalian subject employing modified ecdysone receptors. Also provided are modified ecdysone receptors, as well as homomeric and heterodimeric receptors containing same, nucleic acids encoding invention modified ecdysone receptors, modified hormone response elements, gene transfer vectors, recombinant cells, and transgenic animals containing nucleic acids encoding invention modified ecdysone receptor.
Owner:SALK INST FOR BIOLOGICAL STUDIES
Novel ecdysone receptor-based induicible gene expression system
InactiveUS20070161086A1Fusion with DNA-binding domainAntibody mimetics/scaffoldsHigh-Throughput Screening AssaysBiotechnology
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic plants and animals.
Owner:PRECIGEN INC
Diacylhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
Owner:PRECIGEN INC
Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
Owner:PRECIGEN INC
Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
The present invention relates to a novel isolated leafhopper ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the leafhopper ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation system and methods for identifying molecules that modulate leafhopper ecdysone receptor activity.
Owner:RHEOGENE INC DE
Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
InactiveUS20080263687A1FungiFusion with DNA-binding domainHigh-Throughput Screening AssaysBiotechnology
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel ecdysone receptor / chimeric retinoid X receptor-based inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large-scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Owner:RHEOGENE INC DE
Novel ecdysone receptor-based inducible gene expression system
Owner:RHEOGENE INC DE
Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel ecdysone receptor / chimeric retinoid X receptor-based inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large-scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Owner:RHEOGENE INC DE
Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
Owner:PRECIGEN INC
Novel ecdysone receptor/invertebrate retinoid X receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel ecdysone receptor / invertebrate retinoid X receptor-based inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large-scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Owner:PRECIGEN INC
Methods for modulating expression of exogenous genes in mammalian systems, and products related thereto
InactiveUS20060014711A1Precise and potent inductionImprove pharmacokineticsVectorsGenetic material ingredientsResponse elementGene transfer
In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in a mammalian subject employing modified ecdysone receptors. Also provided are modified ecdysone receptors, as well as homomeric and heterodimeric receptors containing sane, nucleic acids encoding invention modified ecdysone receptors, modified ecdysone response elements, gene transfer vectors, recombinant cells, and transgenic animals containing nucleic acids encoding invention modified ecdysone receptor.
Owner:EVANS RONALD +2
Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
ActiveUS8076517B2Inhibit expressionUrea derivatives preparationOrganic active ingredientsGene expression levelOrganism
The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.
Owner:PRECIGEN INC
Novel substitution mutant receptors and their use in an ecdysone receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Owner:PRECIGEN INC
Pest-killing and mite-killing composition
ActiveCN104663705ASynergistic effect is obviousImprove the effect of prevention and controlBiocideAnimal repellantsSynergyEcdysone receptor
The present invention belongs to the field of insecticides, and relates to a pest-killing and mite-killing composition, which contains an active component A and an active component B, a weight part ratio of the component A to the component B is 1:99-99:1, the active component A is selected from a compound I represented by the following structural formula, the active component B is selected from an organic phosphorus pest / mite killing agent, a nicotine type acetylcholine receptor (nAChR) agonist pest / mite killing agent, an apastia pest / mite killing agent, a proton gradient interference and oxidative phosphorylation affecting uncoupling pest / mite killing agent, a nereistoxin analog pest / mite killing agent, a Ryania receptor regulating pest / mite killing agent, a voltage-dependent sodium ion channel blocking pest / mite killing agent, an ecdysone receptor stimulating pest / mite killing agent, an amino butyric acid (GABA) gated chloride channel antagonism pest / mite killing agent, a microorganism pest / mite killing agent or other pest / mite killing agents, and the active component A has the following structure. The composition of the present invention has advantages of significant synergy, resistance delaying and the like, and can be used for prevention and control of a variety of pests. The compound I is defined in the instruction.
Owner:SHENYANG SCIENCREAT CHEM
Diacylhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
The present invention relates to methods to use non-steroidal ligands in nuclear receptor-based inducible gene expression system to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
Owner:PRECIGEN INC
Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
Owner:RHEOGENE INC DE
Boron-Containing Diacylhydrazines
The present disclosure provides boron-containing diacylhydrazines having Formula I:and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.
Owner:PRECIGEN INC
Leafthopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
Owner:RHEOGENE INC DE
Boron-containing diacylhydrazines
The present disclosure provides boron-containing diacylhydrazines having Formula I:and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.
Owner:PRECIGEN INC
Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
The present invention relates to a novel isolated whitefly ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the whitefly ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation system and methods for identifying molecules that modulate whitefly ecdysone receptor activity.
Owner:RHEOGENE INC DE
Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The ligands comprise a class of ketones.
Owner:PRECIGEN INC
Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
The present invention relates to a novel isolated whitefly ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the whitefly ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation system and methods for identifying molecules that modulate whitefly ecdysone receptor activity.
Owner:PRECIGEN INC
Genetic sequences encoding steroid and juvenile hormone receptor polypeptides and insecticidal modalities therefor
InactiveUS7297781B2High affinityImprove thermal stabilityVirusesSugar derivativesDiagnostic Radiology ModalitySterol
The present invention provides isolated nucleic acid molecules encoding polypeptides comprising functional steroid hormone and juvenile hormone receptors, in particular isolated nucleic acid molecules which encode polypeptides comprising the Lucilia cuprina and Myzus persicae ecdysone receptors and juvenile hormone receptors. The present invention further provides functional recombinant steroid and juvenile hormone receptors and recombinant polypeptide subunits thereof and derivatives and analogues thereof. The present invention further provides screening systems and methods of identifying insecticidally-active agents which are capable of agonising or antagonising insect receptor function, or alternatively or in addition, which modify the affinity of said receptors for their cellular stimuli (eg. insect steroids or juvenile hormones) or analogues thereof, or alternatively or in addition, which act as insecticides by virtue of their ability to agonise or antagonise the activity of insect hormones.
Owner:COMMONWEALTH SCI & IND RES ORG
Compositions and methods for the modification of physiological responses in plants
InactiveUS20090077684A1Tight regulationEasy to useSugar derivativesMutant preparationRipeningPlant cell
A gene expression system for controllable expression of ethylene response in a plant cell includes an activation cassette comprising a DNA-binding domain that recognizes a response element; an ecdysone receptor ligand binding domain; and an activation domain; and a target cassette comprising an inducible promoter, which comprises, in operative association, the response element and a minimal promoter responsive to the activation domain. The inducible promoter controls the expression of a nucleic acid sequence that encodes a selected protein that modifies sensitivity to ethylene in the plant. Interaction among the components of the activation cassette and target cassette, when in a plant cell, in the presence of an inducing composition, modulates expression of the selected protein and selectively modulates ethylene sensitivity in the plant cell. This modulation in the expression of the protein is controlled by the timing, the concentration and the duration of the application of the inducing composition. Transgenic plant cells, tissues, organs and entire plants are provided, which in the presence of the inducing composition control ethylene sensitivity. Ethylene sensitivity and / or ethylene production in such transgenic plants and tissues may be controlled for purposes of manipulating ripening, flower senescence and other ethylene sensitive functions of the plant.
Owner:AGROFRESH
Ultraspiracle protein of green plant bug, coding sequence, carrier and strain thereof
The invention discloses a DNA (Deoxyribonucleic Acid) sequence for coding an ultraspiracle protein of a green plant bug. The invention further discloses the ultraspiracle protein of the green plant bug, a recombinant expression vector, a transgenic cell system or a transgenic recombinant bacterium of the DNA sequence for coding the ultraspiracle protein of the green plant bug, application of the recombinant expression vector, the transgenic cell system or the transgenic recombinant bacterium in production of the ultraspiracle protein of the green plant bug as well as a preparation method of the ultraspiracle protein of the green plant bug. The protein is prepared by the following steps: constructing a pEGX-6P-1 prokaryotic expression vector by means of the ultraspiracle protein gene of the green plant bug; generating an inclusion body of the protein through IPTG (Isopropyl-beta-D-Thiogalactoside) induction in escherichia coli Rostetta gami B; then, denaturing and renaturing to form the protein and purifying the protein. The molecular weight of the prepared protein is about 65KD, and the protein concentration is 1.67mg / ml. The purified ultraspiracle protein can provide a previous theoretical basis for a novel insecticide taking an ecdysone receptor as a target.
Owner:JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
Substitution mutant receptors and their use in an ecdysone receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Owner:PRECIGEN INC
Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
Owner:RHEOGENE INC DE
Screening method of ecdysone analogue and lead compound
InactiveCN108231206AReduce in quantityReduce economic costsChemical property predictionMolecular designVirtual screeningPharmacophore
The present invention provides a screening method of an ecdysone analogue. The method comprises the steps of: 1) determining an active pocket; S2) screening SPECS library according to a receptor-ligand pharmacophore model and a ligand pharmacophore model, and establishing a database 1; S3) performing clustering and drug-likeness analysis of compounds in the database 1, and establishing a database2; S4) performing docking of compounds in the database 2 and the receptor to establish a database 3, screening the receptor binding activity of the compounds in the database 3, and obtaining virtual screening compounds; S5) screening binding activity of the compounds and the receptor in the database 2, and obtaining virtual screening compounds; S6) performing determination of ecdyson receptor binding activity of the virtual screening compounds, and obtaining a hit lead compound; and S7) performing similarity retrieval of the hit lead compound. The virtual screening method can reduce the numberof the experiment screening compounds, can shorten the research and development period and can reduce the economic cost.
Owner:CHINA AGRI UNIV
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