15 results about "ATP synthase" patented technology

The application belongs to the technical field of biological medicine, and particularly relates to an anti-aging ergothioneine composition for improving mitochondrial function and a preparation method thereof. The composition comprises the following components: ergothioneine, sea hao polysaccharide and entada extract. The ergothioneine has good mitochondrial targeted antioxidant activity, can up-regulate the expression of Sirt1 to activate PGC-1a, and promote mitochondrial biosynthesis; the sea hao polysaccharide is helpful to restore mitochondrial function, promote the generation of mitochondrial high-energy phosphoric compounds, improve cell activity and energy supply for regeneration, and can up-regulate the expression of key genes for mitochondrial biosynthesis and ATP synthase related genes. The entada extract can synergize with the ergothioneine and the sea hao polysaccharide, significantly down-regulate the expression of aging related proteins such as p53, p21 and p16 in cells, simultaneously inhibit the transcription of aging related genes, and has a good protective effect on aging cells.

The present invention provides anti-NTM compounds that target the NTM F1FO-ATP synthase. The present invention provides the use of the anti-NTM compounds as a medicament to treat NTM. The present invention also provides the use of the anti-NTM compounds as a medicament to treat NTM with a second antibiotic.

The present invention discloses an RNAi molecule for inhibiting the ATP synthase gene of radish aphids, which is a double-stranded RNA molecule consisting of a sense strand and a complementary antisense strand, wherein the nucleotide sequence of the sense strand is SEQ ID NO: 2. RNAi pesticides containing the RNAi molecule can effectively kill radish aphids.

With supporting experimental data, this disclosure teaches that IF1 protein activity is a molecular determinant of lifespan, therein explaining why different species have different maximal lifespans, and it teaches a IF1 protein / fragment (or sequence variant thereof), or a fusion protein thereof, optionally a fusion protein comprising a Cell Penetrating Peptide (CPP) sequence, as an agent to slow / delay / reduce aging in a subject, optionally as a component of a cosmetic, optionally to treat an age-correlated disease / disorder. Moreover it teaches other inhibitors of F1F0 ATP hydrolysis, including small molecules, of a number of different scaffolds, for this purpose. Furthermore, with supporting experimental data, it teaches that compounds that slow the ATP-hydrolysing mode of ATP synthase are useful for treating various diseases and disorders, including cancer, particularly cancers that utilise the Warburg effect.

This invention discloses a photosynthetic nanomotor powered by a biomolecular motor and its preparation method, belonging to the field of colloidal motors. This invention aims to address the current limitations of research on the rotational dynamics of FoF1-ATP synthase molecular machines, which is limited to the motion of single and isolated objects. The photosynthetic nanomotor is prepared based on supramolecular self-assembly technology through the reconstruction of thylakoid vesicles and lecithin vesicles. The photophosphorylation system on the thylakoid membrane surface is reconstructed on the photosynthetic nanomotor. Utilizing the preserved biomolecular motor FoF1-ATPase as the power engine, under external visible light irradiation, protons generated by the photosystem accumulate in the photosynthetic liposome motor, driving the FoF1-ATPase to synthesize the energy currency ATP. Through metabolic reactions, light energy is converted into chemical energy ATP, ultimately generating self-propulsion. Due to its unique energy currency regeneration capability, the photosynthetic liposome motor has broad application prospects in the biomedical field.

The present invention relates to novel in vivo uses in the treatment of non-tuberculous Mycobacterium, in particular Mycobacterium avium complex bacteria.

Compounds of the following formula, and pharmaceutically-acceptable salts, solvates, hydrates and prodrugs thereof, formula (A) are useful to preferentially inhibit the ATP-hydrolysing mode of ATP synthase, and are thereby useful for treating various diseases and orders including cancer, particularly cancers that utilise the Warburg effect.

The invention discloses an ATP synthase beta subunit gene as well as an expression vector and application thereof, and belongs to the technical field of gene engineering. The nucleotide sequence of the ATP synthase beta subunit gene is as shown in SEQ ID NO. 1. The ATP synthase beta subunit gene AhatpB and the protein AhatpB coded by the ATP synthase beta subunit gene AhatpB are cloned from peanuts for the first time, the gene CDS is inserted into an overexpression vector pCAMBIA1300S, and the obtained recombinant vector pCAMBIA1300S: AhatpB of the gene is transferred into hairy roots of a peanut variety Huayu 22, so that the number of root nodules on the hairy roots of the peanuts can be remarkably increased. The AhatpB is used for genetic engineering breeding and is introduced into a peanut variety with low-efficiency root nodules, so that peanut germplasm with efficient nodulation and nitrogen fixation can be obtained, and the AhatpB has important significance for improving the peanut variety with efficient root nodule nitrogen fixation.

The application relates to the field of biomaterials, and particularly relates to application of a giant salamander mucus extract hydrolysate in preparation of an anti-dentin sensitivity agent. The anti-dentin sensitivity agent comprises a hydrolysate retaining the biological activity of SSAD, the hydrolysate being a product of reduction of the giant salamander mucus extract by an acid solution with a pH value of 1-5, and the product comprising five active proteins, namely MHC class I molecule alpha chain, homeobox protein Hox-D13, abnormal heavy chain 3 of axonemal dynein, ATP synthase protein and cytochrome b; the particle size of the giant salamander mucus extract is 1-50 mu m; and the pH value of the anti-dentin sensitivity agent is 5.5-7.5. The giant salamander mucus extract is treated by the acid solution to obtain the hydrolysate containing the multiple active proteins, the hydrolysate can effectively promote deep closure of dentin tubules, and has long-term stable biocompatibility; the pH value is controlled to ensure that the biological activity is completely retained, and the curative effect of the anti-dentin sensitivity agent is remarkably improved.

The invention belongs to the technical field of cosmetics, and particularly relates to a skin repairing and anti-aging composition capable of improving cell viability and application of the skin repairing and anti-aging composition in cosmetics. The skin repairing and anti-aging composition is prepared from the following components in parts by mass: 0.5 to 5 parts of crithmum maritimum cell-glowing essence, 0.5 to 2.5 parts of coastal eryngii repairing cell essence, 0.7 to 1.8 parts of vitamin granule and 0.3 to 0.5 part of artemisia sphaerocephala krasch extract. The composition provided by the invention can simultaneously promote epidermis repair, dermis anti-aging, true epidermis connecting band repair and increase the ATP synthase content, has obvious repair and anti-aging effects, and has a wide market prospect.

The invention relates to the technical field of microorganisms, in particular to a microbial system for enhancing acetic acid metabolism and a construction method and application thereof. The microbial system comprises microorganisms capable of growing with acetic acid as a carbon source, and ACS genes are overexpressed in the microorganisms and used for converting acetic acid into acetyl coenzyme A; visual purple protein is expressed on a microbial cell membrane and is used for forming a transmembrane proton gradient under visible light irradiation by utilizing a light-driven proton pump function so as to drive ATP synthase to synthesize ATP; cdS nano-particles are loaded on the surfaces of the microorganisms or in the cells and are used for supplementing NADPH / NADH and assisting ATP regeneration. Through the synergistic effect of ACS gene overexpression, a light-driven proton pump and a CdS hybridization module in microorganisms, a light energy-ATP-NADPH dual-energy supply system is formed, and the problem of insufficient energy and reducing power in acetic acid metabolism is remarkably relieved.

Provided are isolated, recombinant, and modified recombinant adenosine triphosphate (ATP) synthase and fragments thereof, and methods of using the ATP synthase fragments. The ATP synthases and fragments thereof are useful for treating a number of conditions. The ATP synthase fragments may be derived from A. franciscana or human ATP synthases.

The present invention relates to a novel ATP synthase variant and a method of producing an L-aromatic amino acid using the same. The ATP synthase variant is obtained by substituting one or more amino acids in the amino acid sequence constituting ATP synthase to change the enzymatic activity of the ATP synthase, and a recombinant microorganism comprising the ATP synthase variant is capable of efficiently producing an L-aromatic amino acid.

The present invention relates to the field of marine ecological engineering technology, and specifically relates to a method for blue carbon ecological restoration of an offshore wind farm assisted by quantum frequency regulation, including the following steps: S1: generating a quantum resonance field matching the opening and closing cycle of the ion channels of the microbial cell membrane; S2: performing directional migration of free protons in seawater through the quantum resonance field; S3: regulating the conformational transformation efficiency of the intracellular ATP synthase of photosynthetic microorganisms; S4: generating a dynamic mapping atlas of carbon sequestration flux; S5: adjusting the generation frequency of microscale vortices in seawater through the quantum resonance field; S6: when detecting microbial metabolic saturation, switching to a carbon deposition enhancement mode. In the present invention, by means of quantum frequency regulation, the processes of proton migration, microbial carbon sequestration and carbonate deposition are linked, and a blue carbon ecological restoration closed-loop system that can operate in coordination with an offshore wind power platform is constructed, realizing precise regulation of the entire process of carbon fixation and deposition.

The application discloses a bacillus cereus ATP synthase beta subunit antibacterial peptide BaD9, and the amino acid sequence of the bacillus cereus ATP synthase beta subunit antibacterial peptide BaD9 is KLVVHRARRIQFFLSQNFH, and the molecular weight of the antibacterial peptide is 2396.831 Dalton. The antibacterial peptide has obvious inhibiting effect on Vibrio parahaemolyticus, Staphylococcus aureus and Staphylococcus haemolyticus, and can be used for preparing medicines for preventing or inhibiting Vibrio parahaemolyticus, Staphylococcus aureus and Staphylococcus haemolyticus infection, food preservatives or feed additives.