12 results about "Molecular motor" patented technology

The invention belongs to the field of organic photoelectric materials, and discloses preparation and application of a D-pi-A type molecular motor. A molecule composed of a donor and an acceptor between a C = N double bond and a pi bridge has the following structures I and II: # imgabs 0 #, Ar is two donor groups, namely nitrosobenzene and N-(3, 4, 5-trimethoxyphenyl) ethylenediamine, # imgabs 1 #, imino indole and cyano indanone groups are introduced to one end of the donor, and the structure I and the structure II are shown in the specification. A D-pi-A type molecular motor material mainly based on non-radiative transition is constructed, due to the existence of C = N double bonds, a donor rotates to generate light response under illumination, the molecular motor material enables potential energy under the molecular level to be transferred, and the operation of converting absorbed light energy to near-infrared light has great prospects. Macroscopically speaking, the molecular motor is a molecular-level motor capable of converting optical energy into mechanical energy. Therefore, the introduction of C = N double bonds provides possibility for constructing a D-pi-A type molecular motor material which is mainly based on non-radiative transition. A thought is provided for the design of the molecules.

The invention is applicable to the technical field of covalent organic framework materials, and provides a three-dimensional molecular motor covalent organic framework material and a preparation method thereof, and the preparation method comprises the following steps: carrying out a dehydration condensation reaction on an aldehyde group monomer and an amino monomer in the presence of a catalyst and a solvent to obtain a crude product; washing, filtering and drying the crude product to obtain a three-dimensional molecular motor covalent organic framework material; wherein the aldehyde group monomer is 4, 4 '-(9-(2-methyl-2, 3-dihydro-1H-cyclopenta [a] naphthalene-1-yl-alkene)-9H-fluorene-2, 7-diyl) dibenzaldehyde, and the aldehyde group monomer is 4, 4'-(9-(2-methyl-2, 3-dihydro-1H-cyclopenta [a] naphthalene-1-yl) alkene. The amino monomer is tetra (2-fluoro-4-aminobiphenyl) methane. The embodiment of the invention realizes an example of embedding the molecular motor into a three-dimensional COF skeleton, and has clear crystallinity and a repeatable synthesis route.

This invention discloses a photosynthetic nanomotor powered by a biomolecular motor and its preparation method, belonging to the field of colloidal motors. This invention aims to address the current limitations of research on the rotational dynamics of FoF1-ATP synthase molecular machines, which is limited to the motion of single and isolated objects. The photosynthetic nanomotor is prepared based on supramolecular self-assembly technology through the reconstruction of thylakoid vesicles and lecithin vesicles. The photophosphorylation system on the thylakoid membrane surface is reconstructed on the photosynthetic nanomotor. Utilizing the preserved biomolecular motor FoF1-ATPase as the power engine, under external visible light irradiation, protons generated by the photosystem accumulate in the photosynthetic liposome motor, driving the FoF1-ATPase to synthesize the energy currency ATP. Through metabolic reactions, light energy is converted into chemical energy ATP, ultimately generating self-propulsion. Due to its unique energy currency regeneration capability, the photosynthetic liposome motor has broad application prospects in the biomedical field.

The invention belongs to the field of organic photoelectric materials and biomedical treatment, and discloses a preparation method and application of an intramolecular proton transfer fluorescent material. The fluorescent molecule is constructed by constructing different receptor units on the basis of donor-receptor configuration. Ar is 3-(ethylidene amino) naphthalene-2-alcohol # imgabs 1 #. According to the invention, imino indole and cyano indanone groups are introduced to one end of a donor, so that a donor-acceptor and a charge transfer state are constructed, and meanwhile, non-radiative transition and intermolecular pi-pi accumulation of molecules in an aggregation state are inhibited; and meanwhile, the material also retains the excellent light response property of the molecular motor, and the introduction of OH bonds enables the material to inhibit the non-radiative transition process of the molecular motor through intramolecular proton transfer, so that the ratio of radiative transition is greatly increased. A thought is provided for the design of the molecules.

The application discloses a kind of based on DNA molecule traffic's nanopore real-time high-throughput sequencing system and method, including DNA encoding module, molecular hopper loads DNA sequence chain module, nanopore sequencing module and DNA decoding module;The transmission data required by user is stored in DNA sequence by base pairing;The DNA sequence obtained by encoding is linked with molecular hopper, is transported on the track of nanopore protein, and molecular motor of DNA chain transmission is transmitted on track;Real-time sequencing is completed by the different base pair blocking current different ability;By DNA decoding module, redundancy error caused by molecular hopper in the track of nanopore protein is eliminated.The system provided by the application solves the repeated data deletion error LT real-time error correction algorithm, to eliminate the redundant information generated by hopper bounce back;Eliminate the redundancy caused by hopper back, so as to reduce the high communication cost brought by this kind of error code, obtain greater signal-to-noise ratio, facilitate the application of DNA molecular communication to be popularized.

The invention relates to a molecular motor and a method of driving the molecular motor step-by-step on a track under bi-colour light irradiations. The molecular motor comprising a hairpin leg and a non-hairpin leg. The molecular motor can be instructed to move to specific states or positions on the track by illumination of alternate lights, such as ultraviolet light and visible light, presenting a translational molecular motor with capability of top-down control by selecting the irradiation wavelengths.

The invention relates to a lung-targeted drug-loaded micromotor as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing mPEG (Polyethylene Glycol), N-t-Boc-glycine, DMAP (Dimethylaminopyridine), DCC (Dendritic Cellulose) and a solvent for reaction, and sequentially obtaining an intermediate product preparation process of mPEG-CH2CH2NH-Boc, CH3OPEG-NH2 and mPEG-NH2; performing mixed reaction on NHS, EDC and a sodium alginate solution in a buffer system to obtain a carboxyl activation process of an activated product; the mPEG-NH2 and the activated product are mixed and subjected to a reaction, and a precursor material of Alg-g-mPEG is obtained; a saturated alpha-CD aqueous solution of an FOF1-ATPase molecular motor is mixed with the Alg-g-mPEG aqueous solution, and the Alg-g-mPEG self-assembled micro-capsule with the FOF1-ATPase molecular motor coating is obtained in the carrier preparation process; mixing a drug with the self-assembled micro-capsule to obtain a lung-targeted drug-loading micro-motor; the invention further discloses application of the lung-targeted drug-loaded micromotor prepared according to the preparation method in preparation of a drug delivery system for treating lung adenocarcinoma. The double-site high-drug-loading-capacity hydrogel has the advantages of being high in double-site high drug loading capacity, high in biological safety, high in pH response self-driving capacity, good in lung tumor targeting capacity, good in lung retention capacity and the like.

The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or amolecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore.

This invention discloses a light-driven molecular machine and its application in transmembrane delivery of trivalent metal drugs. The molecular machine features a light-driven molecular motor based on a tetrasubstituted crowded olefin, which consists of a core unit, a polyethylene glycol chain, and trivalent metal ion coordinating groups. This invention utilizes the directional rotational motion of the molecular motor under light irradiation, embedding it into a phospholipid bilayer membrane, and achieving light-controlled transmembrane transport of trivalent metal ions through a "bind-release" mechanism. This molecular machine can selectively complex trivalent metal ions (such as Bi...) 3+ Ga 3+ Ce 3+ (etc.), and accelerates ion transmembrane transport under light-driven conditions, thereby disrupting the intracellular and extracellular ion balance of bacteria. Experiments have shown that this system has significant light-controlled antibacterial activity against Staphylococcus aureus. This invention has advantages such as controllable structure, precise spatiotemporal targeting, and ease of derivatization, and has promising applications in antibacterial therapy and biomedicine.

The present invention discloses an active molecular motor, a cream composition, and its preparation and application with anti-wrinkle and anti-aging effects. The active molecular motor with anti-wrinkle and anti-aging effects comprises hexapeptide-11, arginine / lysine polypeptide, elastin, and molecular motor in a mass ratio of (0.1-2.0):(0.1-0.4):(2.2-7.3):(0.3-4.7). The raw material components contained in the cream composition are as follows: 0.1-15.7% of the active molecular motor with anti-wrinkle and anti-aging effects, 1-20% of a humectant, 1-12% of an emulsifier, 1-13.6% of an emollient, 1-10% of a thickener, 0.1-1% of a preservative, 0.01-1% of a pH regulator, and the balance being deionized water. Compared with the prior art, the components of the present invention cooperate synergistically, can solve the problems of poor permeability and long effective period of existing anti-aging products, achieve an immediate anti-wrinkle effect, and can promote the synthesis and supplementation of skin collagen, elastin, and extracellular matrix components after long-term use, restore the elastic structure of the skin, and reduce skin fine lines and wrinkles.

The invention relates to a molecular motor and a method of driving the molecular motor step-by-step on a track under bi-colour light irradiations. The molecular motor comprising a hairpin leg and a non-hairpin leg. The molecular motor can be instructed to move to specific states or positions on the track by illumination of alternate lights, such as ultraviolet light and visible light, presenting a translational molecular motor with capability of top-down control by selecting the irradiation wavelengths.

The invention belongs to the field of organic photoelectric and biomedical materials, and discloses preparation and application of a D-A type photoresponse / acid response molecular motor material. Based on an acceptor-donor configuration, the compound has the following structure: # imgabs0 #, wherein Ar is N, N-dimethylaniline and a derivative thereof. A strong electron-withdrawing cyano indanone group is introduced to one end of a donor N, N-dimethylaniline and a derivative thereof, so that innovative design and performance optimization of a molecular structure are realized. From the perspective of a molecular electron structure, a cyanindanone group and an N, N-dimethylaniline donor form a remarkable electron cloud density difference by virtue of the strong electron withdrawing characteristic of the cyanindanone group, and an efficient donor-acceptor (D-A) system is constructed. When molecules are illuminated, cis-trans isomerization of C = N double bonds initiates conformation change of the molecules, light energy is efficiently converted into heat energy, and therefore the excellent performance of the material in the photo-thermal application field is achieved.