5 results about "Molecular motor" patented technology

This invention discloses a photosynthetic nanomotor powered by a biomolecular motor and its preparation method, belonging to the field of colloidal motors. This invention aims to address the current limitations of research on the rotational dynamics of FoF1-ATP synthase molecular machines, which is limited to the motion of single and isolated objects. The photosynthetic nanomotor is prepared based on supramolecular self-assembly technology through the reconstruction of thylakoid vesicles and lecithin vesicles. The photophosphorylation system on the thylakoid membrane surface is reconstructed on the photosynthetic nanomotor. Utilizing the preserved biomolecular motor FoF1-ATPase as the power engine, under external visible light irradiation, protons generated by the photosystem accumulate in the photosynthetic liposome motor, driving the FoF1-ATPase to synthesize the energy currency ATP. Through metabolic reactions, light energy is converted into chemical energy ATP, ultimately generating self-propulsion. Due to its unique energy currency regeneration capability, the photosynthetic liposome motor has broad application prospects in the biomedical field.

The application discloses a kind of based on DNA molecule traffic's nanopore real-time high-throughput sequencing system and method, including DNA encoding module, molecular hopper loads DNA sequence chain module, nanopore sequencing module and DNA decoding module;The transmission data required by user is stored in DNA sequence by base pairing;The DNA sequence obtained by encoding is linked with molecular hopper, is transported on the track of nanopore protein, and molecular motor of DNA chain transmission is transmitted on track;Real-time sequencing is completed by the different base pair blocking current different ability;By DNA decoding module, redundancy error caused by molecular hopper in the track of nanopore protein is eliminated.The system provided by the application solves the repeated data deletion error LT real-time error correction algorithm, to eliminate the redundant information generated by hopper bounce back;Eliminate the redundancy caused by hopper back, so as to reduce the high communication cost brought by this kind of error code, obtain greater signal-to-noise ratio, facilitate the application of DNA molecular communication to be popularized.

The invention relates to a lung-targeted drug-loaded micromotor as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing mPEG (Polyethylene Glycol), N-t-Boc-glycine, DMAP (Dimethylaminopyridine), DCC (Dendritic Cellulose) and a solvent for reaction, and sequentially obtaining an intermediate product preparation process of mPEG-CH2CH2NH-Boc, CH3OPEG-NH2 and mPEG-NH2; performing mixed reaction on NHS, EDC and a sodium alginate solution in a buffer system to obtain a carboxyl activation process of an activated product; the mPEG-NH2 and the activated product are mixed and subjected to a reaction, and a precursor material of Alg-g-mPEG is obtained; a saturated alpha-CD aqueous solution of an FOF1-ATPase molecular motor is mixed with the Alg-g-mPEG aqueous solution, and the Alg-g-mPEG self-assembled micro-capsule with the FOF1-ATPase molecular motor coating is obtained in the carrier preparation process; mixing a drug with the self-assembled micro-capsule to obtain a lung-targeted drug-loading micro-motor; the invention further discloses application of the lung-targeted drug-loaded micromotor prepared according to the preparation method in preparation of a drug delivery system for treating lung adenocarcinoma. The double-site high-drug-loading-capacity hydrogel has the advantages of being high in double-site high drug loading capacity, high in biological safety, high in pH response self-driving capacity, good in lung tumor targeting capacity, good in lung retention capacity and the like.

The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a Hel308 helicase or amolecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. The helicase or molecular motor controls the movement of the target polynucleotide through the pore.

This invention discloses a light-driven molecular machine and its application in transmembrane delivery of trivalent metal drugs. The molecular machine features a light-driven molecular motor based on a tetrasubstituted crowded olefin, which consists of a core unit, a polyethylene glycol chain, and trivalent metal ion coordinating groups. This invention utilizes the directional rotational motion of the molecular motor under light irradiation, embedding it into a phospholipid bilayer membrane, and achieving light-controlled transmembrane transport of trivalent metal ions through a "bind-release" mechanism. This molecular machine can selectively complex trivalent metal ions (such as Bi...) 3+ Ga 3+ Ce 3+ (etc.), and accelerates ion transmembrane transport under light-driven conditions, thereby disrupting the intracellular and extracellular ion balance of bacteria. Experiments have shown that this system has significant light-controlled antibacterial activity against Staphylococcus aureus. This invention has advantages such as controllable structure, precise spatiotemporal targeting, and ease of derivatization, and has promising applications in antibacterial therapy and biomedicine.