Nanometer biological robot and application thereof

A robot and nanotechnology, applied in the new field of nanobiology, can solve the problems of vascular intima injury, small blood vessel embolism, and limited application

Inactive Publication Date: 2010-06-23
INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES +1
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Problems solved by technology

However, due to the inherent limitations of traditional processing technology in terms of device size, there are technical obstacles that are difficult to break through in terms of the design principle, size, and dynamic characteristics of the configurable device at the front end of the guide wire. The application range of interventional therapy is limited to For relatively large blood vessels, the technology itself has some limitations. For example, a large number of thrombus fragments wil...

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  • Nanometer biological robot and application thereof
  • Nanometer biological robot and application thereof
  • Nanometer biological robot and application thereof

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Embodiment Construction

[0034] The present invention is a further improvement on Chinese patent application No. 200410098929.9 (publication date: June 21, 2006, CN1789425, authorized), the difference is that in the present invention, the molecular motor is not only used as a biosensor, but Using it as the power device of nano-bio-robots, constructing nano-bio-machines and applying them in medical treatment.

[0035] With the help of the research progress on the structure, function and principle of molecular motors, the F 1 f 0 -New concept and new technology of ATP motor full-rotation nano-robot; provide a F 1 β (or F 1 α) subunit as a new technology of the target site of thrombus antibody connection; proposed a new technology of DNA chain as a brake pad in the rotation start control of molecular motors.

[0036] The main points of the content of the present invention: (1) changing static thrombolysis to dynamic thrombolysis, that is, transforming traditional drug thrombolysis into drug thrombolys...

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Abstract

The present invention relates to a nanometer biological robot. The nanometer robot is driven by molecular motors and guided by thrombus antibodies to assist in quickly dissolving thrombi. The rapid rotation of the molecular motors on partial thrombi produces the effect similar to that of a micro power agitator. The molecular motors are driven by light, so the nanometer biological robot is adjustable and controllable. The contact of drugs with fiber proteins is accelerated, the biological and machinery mechanics effect of the nanometer biological robot is synergetic with the medical enzymolysis, and the fibrinolysis is accelerated.

Description

technical field [0001] The invention belongs to the field of nano-biological new technology, and relates to the design, assembly and application of a light-driven nano-robot constructed by a rotary ATP motor and in assisting drug diffusion (thrombolysis). Background technique [0002] Traditional thrombolytic therapy methods include drug thrombolysis and device-assisted thrombolysis. In the rescue treatment of acute myocardial infarction, thrombolytic therapy is an effective method to quickly restore myocardial blood flow, and early use of thrombolytic therapy can reduce the mortality rate of patients with acute myocardial infarction by 30% [FEBS.Lett.2005, 579 (15 ): 3303-3309]. Recombinant tissue plasminogen activator (rt-PA) is currently the most effective thrombolytic drug. The main advantage of this drug is that it has a high affinity with fibrin and fast thrombolytic speed; the disadvantage is that it is easily cleared by the liver. , short half-life (4 minutes to 5 ...

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Application Information

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IPC IPC(8): A61B17/00A61K9/00A61M31/00
Inventor 乐加昌陶宁张先恩李峰
Owner INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
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