The invention relates to an optimum design method for staged fracturing perforation cluster parameters of a horizontal well of a shale reservoir. The optimum design method includes the following steps of S1, selecting high-fracture-performance fracturing well sections; S2, building a mathematical model for hydrofracture fracture progressing, analyzing an induction stress field model for fracture extension, and analyzing a fracture diverting mechanism; S3, analyzing extending conditions of main fractures, and selecting cluster distances capable of allowing the main fractures to evenly extend forwards; S4, analyzing change conditions of stress fields around the main fractures, selecting the perforation cluster distances with the horizontal principal stress ratios smaller than 1.3, and determining the optimal perforation cluster distances in cooperation with the step S3; S5, further improving the complexity of the fractures through an alternate fracturing principle, and setting the perforation density of perforation clusters in the middle to range from 10 to 16 per m and the perforation density of perforation clusters in the two sides to be larger than 16 per m. By means of the optimum design method, the perforation cluster distances can be optimized, largest fracture transforming sizes can be obtained, the practical effect of reservoir transforming can be improved, and high construction cost and the poor fracturing effect which are caused by aimlessly setting the perforation cluster distances can be avoided.