679 results about "Interventional therapy" patented technology

Disclosed are compositions, systems and methods for treating a subject's body, body part, tissue, body fluid cells, pathogens, or other undesirable matter involving the administration of a targeted thermotherapy that comprises a bioprobe (energy susceptive materials that are attached to a target-specific ligand). Such targeted therapy methods can be combined with at least one other therapy technique. Other therapies include hyperthermia, direct antibody therapy, radiation, chemo- or pharmaceutical therapy, photodynamic therapy, surgical or interventional therapy, bone marrow or stem cell transplantation, and medical imaging, such as MRI, PET, SPECT, and bioimpedance. The disclosed therapies may be useful in the treatment of a variety of indications, including but not limited to, cancer of any type, such as bone marrow, lung, vascular, neuro, colon, ovarian, breast and prostate cancer, epitheleoid sarcomas, AIDS, adverse angiogenesis, restenosis, amyloidosis, tuberculosis, cardiovascular plaque, vascular plaque, obesity, malaria, and illnesses due to viruses, such as HIV.

MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.

The vasoocclusive apparatus can be used in a method of interventional therapy and vascular surgery by inserting the apparatus into a portion of a vasculature, for treatment of a body vessel such as an aneurysm in conjunction with a secondary vasoocclusive device to be placed within the vessel. The vasoocclusiveVasooclusive apparatus includes a plurality of strut members connected together at a central hub that extend from a collapsed position to an expanded configuration to cross the neck of the aneurysm, dividing the neck into smaller openings, allowing the deployment of the secondary vasoocclusive device within the aneurysm but preventing migration of the secondary vasoocclusive device from the aneurysm. The strut members can be made from a twisted cable of strands of a superelastic material, such as a shape memory nickel titanium alloy, with at least one radiopaque strand. A shape memory collar is provided for detachably mounting the vasoocclusive apparatus to a pusher member and for detaching the vasoocclusive apparatus for deployment when a desired placement within an aneurysm to be treated and out of a parent vessel is achieved.

A screening method can be used to determine whether a subject is a suitable candidate for interventional therapy. The method can be used to determine the likelihood the subject will receive a therapeutic effect from denervation therapy. The determination is based, at least in part, on lung information obtained by performing lung function tests with and without treating the subject's lungs with a test agent. Based on the response to a test agent, the subject's response to a therapy is predicted.

A recoverable, safe and reliable valve stent for unidirectional flow of human lumen which can be implanted temporarily or for a long term and is used in the interventional therapy so as to obstruct from anisotropic flow, in the case of lung diseases. It comprises a cylindrical stent made up of memory alloy material. In particular, an elastic diaphragm is arranged inside the cylindrical stent and at least one gap is arranged on the diaphragm so that the spring piece is divided into a bendable section. One end of the cylindrical stent is provided with a fixed rear clip which is used to fix the alloy material making up the cylindrical stent. The rear clip is provided with screwthreads which can be connected with the conveyor. The stent in the present invention is in a structure without hook body, so the stent can be accurately positioned, adjusted and placed or recovered in double directions with strong anti-backflow ability.

Electrical activity can be chronically detected in first and second cardiac regions in the subject. Discordant alternans in at least one component of the detected electrical activity can by identified. Interventional therapy can be initiated in the subject responsive to the identification of discordant alternans.

The invention provides a visualization calculation method for a whole intracranial aneurysm interventional therapy stent implantation process, establishes a stent release expansion model, provides an effective numerical simulation method for the intracranial aneurysm interventional therapy stent implantation, and provides a visualization method used for detection, calculation and analysis of the surgical planning of intracranial aneurysm interventional therapy. The adopted technical scheme is as follows: firstly, a blood vessel centerline is utilized to implant a numerical simulation stent into the blood vessel, and an active contour model is utilized to perform stent expansion, then the distance of each two nodes of the stent is changeless through optimization, and finally hemodynamics calculation and analysis are performed, and optimal configuration for stent implantation is simulated and calculated. The image simulation method can be directly applied to three-dimensional vascular angiography tomographic images, enables the stent to keep own geometric morphological characters through optimization, and can utilize weight adjustment to enable the stent to be clung to the blood vessel wall as far as possible. The simulation process can control the stent implantation position conveniently, and better clinical application value is achieved in the surgical planning of interventional therapy.

The invention relates to a degradable drug loading stent and a preparation method of the degradable drug loading stent. The degradable drug loading stent is characterized by comprising a skeleton structure made of a medical degradable metal or an alloy of the metal, a degradable macromolecular transition layer adhered to the surface of the skeleton structure and a drug loading layer. The degradable metal/macromolecular/drug multilayer composite stent provided by the invention has excellent mechanical property, degradable property and biocompatibility, and such drugs as taxol, taxol derivative, actinomycin D, 5-fluorouracil and sirolimus are loaded to the stent to perform active directional treatment on the focus position, so the stent is a functional degradable stent. The degradable multifunctional drug loading stent provided by the invention is suitable for interventional therapy in the blood vessel field and non-blood vessel fields and is especially suitable for interventional therapy of stenosis, obstruction or tumor of such non-blood vessel cavities as esophagus, bile duct, ductus pancreaticus, intestinal tract, urethral canal, trachea and bronchus, etc.

The present invention discloses a percutaneous interventional puncture instrument through CT positioning, which is used in the guiding positioning of puncture needle in CT-guided percutaneous interventional surgery or other percutaneous interventional instrument. The device comprises a frame body and a cross bar fixed in the frame body. The cross bar is provided with an angular disk, which is provided with a position pointer. A hole is arranged in the position pointer. The fixing device for the puncture guiding device comprises a fixed block, a fixed bolt, a bolt sleeve and the fixing hole of the puncture guiding device arranged in the sleeve tube. The fixing device for the puncture guiding device is arranged in the hole of position pointer. The present invention is used in guiding positioning of needle in the targeted surgery or other percutaneous interventional instrument. Besides targeted interventional therapy for tumor, the present invention can be used in the treatment process of all CT guided percutaneous punctures requiring fixing needle or other percutaneous interventional instrument in a certain direction.

The invention relates to a preparation technology for a microspheric embolization agent. The preparation technology is used for preparing elastic microspheres cross-linked and polymerized by functionalized macromolecules with biocompatibility, wherein the grain range of the microspheres is 1-1500mu m. The preparation technology comprises the following steps that: a cross-linkable micromolecule with a crylic acid structure is connected on a polyvinyl alcohol, polyethylene glycol or polyose macromolecule in form of a covalent bond to form a functionalized macromolecule; and reversed phase suspension polymerization is conducted to the functionalized macromolecule and a 2-acrylamide-2-methylpropanesulfonic acid monomer to prepare cross-linked and polymerized microspheric embolization agent. The embolization agent has the advantages that the flexibility and the elasticity are high, the grain is even and is controllable, the dispersity is good, the raw materials are nontoxic and the biocompatibility and the stability are good. The preparation technology is a pure chemical synthesis technology, no virus pollution is caused to the raw materials and the preparation process, the requirements on international embolization agents are satisfied, and the embolization agent can substitute for all kinds of imported or domestic expensive embolization agent products and can be widely used in surgeries in the field of interventional therapy.

The invention discloses an ultrasonic probe calibration system and method based on a locatable puncture needle. The calibration method includes the steps that S1, a calibration model is designed and manufactured; S2, calibration model feature points in an ultrasonic image are extracted; S3, a calibration transformational matrix is solved according to the calibration feature points extracted from the ultrasonic image. The calibration problem of a tracking and locating ultrasonic probe in the current ultrasonic guidance interventional therapy and a free-type three-dimensional ultrasonic imaging system can be solved, so that more accurate calibration accuracy and more convenient calibration operation are obtained, and ultrasonic calibrated accurately can effectively improve the quality of the three-dimensional ultrasonic reconstructed image and improve safety and the success rate of operations.

The invention relates to a binding type pressing hemostasis device for the department of cardiology, and belongs to the technical field of medical instruments. The device comprises a base plate and an electric hemostasis pressing head, wherein a shock-absorbing retractable spring is arranged on the upper side of the electric hemostasis pressing head; a pressing head connecting rod is arranged on the upper side of the shock-absorbing retractable spring, and is connected with the shock-absorbing retractable spring through a pressing head rotary bolt; a pressing head fixing clamp is arranged on the pressing head connecting rod; a knife edge pressing block is arranged on the lower side of a connecting thrust lift head; disposable hemostatic cotton is arranged on the lower side of the knife edge pressing block; a vessel near-heart end pressing ball is arranged on the left side of the knife edge pressing block; a hemostatic cotton spare storage bin is arranged on the left lower side of a multi-purpose accommodating box; a medicament storage bin is arranged on the right side of the hemostatic cotton spare storage bin. According to the invention, the functions are complete, and the use is convenient; when a patient is subjected to cardiology department puncture interventional therapy pressing hemostasis, the device has the advantages that the operation is simple and convenient, time and labor are saved, and the working difficulty of medical staff is reduced.

The invention relates to a guiding wire comprising a guiding wire core (11) which consists of an inner core (18) and an outer layer (19), and an spring jacket; the inner core (18) is composed of alloy materials with great elasticity and the outer layer (19) coating the inner core (18) is composed of metal or alloy with high rigidity or a mixed material of the metal and alloy, and the inner core (18) is coaxial with the outer layer (19) thereof; the spring jacket is internally inserted with part of the guiding wire core (11). The interventional therapy guiding wire of the invention not only uses the high elasticity of the alloy material with great elasticity to entitle the guiding wire head end with softness and restoration properties, but also uses metal with high rigidity and alloy material with higher strength and rigidity to ensure the pushing property and relevant spiral-pressing property of the guiding wire, thus leading to good controllability of the guiding wire.

The invention discloses a film coating method of a self-expanding stent, which is characterized in that polymer nano-fibers are ejected by utilizing an electrostatic spinning method and cover the net structure surface of the self-expanding stent to form a polymer film. According to the film coating method of the self-expanding stent, a coating film on the outer surface of the stent is composed of the polymer nano-fibers; a fiber film is formed through ejection by utilizing the electrostatic spinning method; a tubular self-expanding stent is sleeved on a drum-type collector and used for collecting nano-fibers following the uniform rotation of the drum-type collector; a plurality of collectors can be arranged in parallel to be a parallel collect group to synchronously carry out film coating on a plurality of stents; and the nano-fibers of the stent coating film contain drugs and developers. The self-expanding film coated stent prepared by utilizing the method has the advantages of simple process, high collection efficiency, and low cost, is environmentally friendly, can be widely applied to interventional therapies of blood vessel, trachea, bronchi, esophagus, alimentary canal, bile duct, nasolacrimal duct and the like and has a wide application prospect.

The invention provides a sacculus dilatation catheter for blood vessel dilatation surgery. The sacculus dilatation catheter comprises a sacculus, a push rod, an inner tube and a connecting device, wherein the push rod is positioned between the sacculus and the connecting device and connects the sacculus and the connecting device, and the inner tube extends and passes through the internal spaces of the sacculus and the push rod. The sacculus dilatation catheter is characterized in that: at least one of the push rod and the inner tube is made of weaving silk reinforcing tube. The sacculus dilatation catheter can smoothly pass through circuitous, diffuse calcification and even long-segment occlusive blood vessels in vascular disease interventional therapy surgery.

The invention provides an ultrasonic interventional therapy system. The ultrasonic interventional therapy system comprises a therapeutic device, a control host and a feedback device, wherein the therapeutic device comprises a therapeutic conduit with a ultrasonic transducer array; the ultrasonic transducer array has two modes of therapy and display and is used for emitting focused ultrasonic waves to a therapeutic area of a human body; the control host is used for controlling the focal position, the frequency, the energy and the like of the focused ultrasonic waves emitted by the therapeutic device; the feedback device is used for feeding back the therapeutic area under the action of the focused ultrasonic waves, and outputting the feedback information to an operator and/or the control host. The ultrasonic interventional therapy system utilizes the feedback device to output the feedback information used for process monitoring and effect evaluation of the therapeutic area in the therapeutic process, so that the various parameters of the focused ultrasonic waves can be adjusted immediately according to the feedback information; according to the technical scheme of the ultrasonic interventional therapy system provided by the invention, a problem that the existing ultrasonic interventional therapy system is poor in safety can be avoided.

The invention discloses medical equipment of a micro-invasive interventional therapy for a pancreaticobiliary duct, which comprises a conduit, wherein the far-end of the conduit is provided with an operation part and the near-end thereof is provided with an operating part of the operation part; the conduit is at least provided with a visual orifice which can be passed through by a light pipe of an optical imaging system and a working orifice which can be passed through by an auxiliary instrument, and the visual orifice and the working orifice both pass through the near-end to reach the far-end; and the near-end of the conduit is provided with a plurality of insert tubes which are communicated with the visual orifice and the working orifice in a one-to-one correspondence mode. In the technical scheme, a visual orifice is added on the basis of ERCP medical equipment, thus not only realizing visualized operation diagnosis or therapy for the pancreaticobiliary duct, but also being simpler and having stronger technicality and lower cost compared with the endoscopic system structure. The medical equipment is disposable and the optical imaging system can be used repeatedly, thereby greatly lowering use cost and being convenient for operation manipulation.

The invention discloses a force feedback based reconstructed remote control medical operating device which comprises a remote control wire feeding mechanism, a force feedback operating platform, a control system, a monitoring device and a power supply management system. The control system, the power supply management system and the force feedback operating platform are arranged at an operating end; the remote control wire feeding mechanism and the monitoring device are arranged at a surgical end; an irradiation protection device is arranged between the operating end and the surgical end; the control system is connected with the monitoring system for obtaining real-time operation images; the control system is connected with the remote control wire feeding mechanism for receiving position motion parameters and outputting remote control instructions of reversing and conveying guide wires; the control system is connected with the force feedback operating platform for obtaining operating parameters and outputting precise reconstruction operating instructions; and the power supply management system is respectively connected with the remote control wire feeding mechanism, the force feedback operating platform, the control system and the monitoring device. In the invention, the force feedback based remote control operation in medical treatment is realized and the safety of medical personnel in radioactive interventional therapy can be ensured.

The invention discloses a cerebral aneurysm hemodynamic index evaluation method, system and device and a medium. The evaluation method comprises the following steps: acquiring human body cerebral artery image data; carrying out anatomical modeling on the human body cerebral artery medical image data to obtain a cerebral aneurysm anatomical model; fluid mechanics calculation processing is conductedon the cerebral aneurysm anatomical model, and outputting a calculation result; and adding the calculation result to a corresponding position of the cerebral aneurysm anatomical model, and carrying out visual display of hemodynamic indexes. According to the method, the system, the equipment and the medium, the hemodynamic indexes of the cerebral aneurysm can be obtained according to the medical image data of the human cerebral artery. Therefore, the relationship between the hemodynamic characteristics and the occurrence, development and rupture of the aneurysm can be analyzed based on the obtained hemodynamic indexes, and a theoretical basis is provided for risk factor assessment and interventional therapy of the cerebral aneurysm.

The invention relates to a biomedical absorbable Mg-Si-Sr-Ca multi-element magnesium alloy material as well as a production method and application thereof. The biomedical absorbable Mg-Si-Sr-Ca multi-element magnesium alloy material is suitable for being used as an implant material used in a human body environment. The biomedical absorbable Mg-Si-Sr-Ca multi-element magnesium alloy material comprises the following components in percentage by weight: 0.1%-20.0% of Si, 0.1%-8.0% of Sr, 0.1%-10.0% of Ca and the balance of Mg. The biomedical absorbable Mg-Si-Sr-Ca multi-element magnesium alloy material is a multi-element magnesium alloy system consisting of total nutrient elements of Mg, Si, Sr and Ca; the form, quantity and distribution of a plurality of second phases such as Mg2Si, Mg2Sr, Mg17Sr2, Mg2Ca, CaMgSi and the like in the magnesium alloy are controlled, so that the multi-element magnesium alloy with the optical comprehensive performances is obtained. The biomedical absorbable Mg-Si-Sr-Ca multi-element magnesium alloy material disclosed by the invention has good biocompatibility and mechanical properties, and is a biodegradable magnesium alloy material with excellent comprehensive performances. Besides, the biomedical absorbable Mg-Si-Sr-Ca multi-element magnesium alloy material has a high application value in the fields such as interventional therapy for cardiovascular diseases, intraosseous implant and the like.