Adjustable targeting area type cryoablation needle with heating function and novel refrigerant hole structure

Abstract

The invention discloses an adjustable targeting area type cryoablation needle with a heating function and a novel refrigerant hole structure, and belongs to the technical field of interventional medical instruments, the adjustable targeting area type cryoablation needle comprises a needle rod, a vacuum wall, a J-T groove, a J-T groove sleeve and an adjusting device; the vacuum wall is sleeved with the needle rod, the area from the far end of the needle rod to the far end of the vacuum wall is a target area, the area of the vacuum wall is a vacuum heat insulation area, and the vacuum wall comprises a vacuum wall outer pipe and a vacuum wall inner pipe; the J-T groove is formed in the vacuum wall inner tube, the far end of the J-T groove is located in the far end of the needle rod, and a side hole is formed in the side wall of the J-T groove; the J-T groove is sleeved with the J-T groove sleeve; the J-T groove sleeve and the vacuum wall are fixed together through a connecting piece and can move synchronously and axially. And the adjusting device is used for adjusting the length of the target area. By innovatively designing the arrangement of the cooling ablation air holes and the heat conduction isolation layer, more accurate control over the cryoablation range is achieved, and the safety and effectiveness of cryoablation interventional therapy are improved.

Description

Technical Field

[0001] This invention belongs to the field of interventional medical device technology, and in particular relates to an adjustable targeted cryoablation needle with heating function and a novel refrigerant pore structure. Background Technology

[0002] Cryoablation interventional therapy refers to the percutaneous insertion of a cryoablation needle into the target area under imaging guidance (CT / CMR / ultrasound). Through the Joule-Thomson effect of the refrigerant gas, the high-pressure refrigerant gas can lower the temperature of the target tissue to -140 to -170°C, causing the target cells to freeze, the cell membrane to rupture, and the release of cell contents, resulting in microvascular occlusion, tissue ischemia and necrosis. In contrast, the rewarming with helium gas (argon-helium knife) can raise the temperature of the target tissue to 30°C to 40°C. Through multiple freeze-thaw cycles with temperature gradient changes, the ablation effect is improved, the target area cells are killed, and the treatment goal is achieved.

[0003] Cryoablation, with its focused energy, creates a clear boundary, offering advantages such as minimal invasiveness, high safety, and good efficacy. In recent years, it has been widely applied in the clinical treatment of solid organs throughout the body, including the liver, thyroid, kidneys, and breast. In the treatment of heart disease, cryoablation is currently mainly used for arrhythmias such as ventricular tachycardia and atrial fibrillation, with its safety and effectiveness clinically recognized. However, due to the lack of a suitable approach, cryoablation remains a blank area in the treatment of cardiomyopathy.

[0004] Currently, common cryoablation needles on the market have the following problems in the clinical interventional treatment of hypertrophic cardiomyopathy / tumor ablation:

[0005] (1) Currently, most cryoablation needles on the market are of fixed working length, and their ablation range becomes fixed after reaching a threshold time. Fixed-length cryoablation needles are not suitable for patients with hypertrophic cardiomyopathy whose thickness varies greatly at different locations of the interventricular septum. If the length of the fixed cryoablation needle is too large, the ablation range will be too large, which can easily cause damage to the myocardial conduction bundle and complications such as malignant arrhythmias. If the working length of the fixed cryoablation needle is too small, the cryoablation range will be too small. The operator needs to overlap the ablation range multiple times in the target area of ​​the interventricular septum and adjust the position of the cryoablation needle tip to complete the ablation treatment of all target areas. Changing the position multiple times can easily prolong the operation time and increase complications such as pericardial effusion. At the same time, in the process of ablation of multiple lesions in tumor patients, there are various differences in lesion size. Fixed-length cryoablation needles cannot meet the ablation of all different sizes of tumors at the same time. Minimally invasive intervention needs to minimize the damage to normal tissue cells during cryoablation and avoid missed ablation. Currently, fixed-length cryoablation needles on the market cannot achieve conformal ablation treatment based on the size of the ablation range.

[0006] (2) During cryoablation, after the temperature of the ablation needle drops to an ultra-low temperature of about -150°C, an elliptical ice ball is spread outward from the tip of the cryoablation needle. When the ablation time is reached, helium is generally used to gradually restore the temperature to 20-40°C, and then the cryo-ablation cycle is repeated to improve the ablation effect on the tissue. However, the current helium rewarming speed is slow and the maximum rewarming temperature is low (<40°C). At the same time, due to the high price of helium, conventional gas stations may not have it stored, making its widespread application inconvenient. Since the risk of needle tract bleeding after cryoablation puncture is high, if the needle tract can be burned after cryoablation, it can effectively reduce the risk of myocardial ablation bleeding or tumor ablation needle tract implantation complications. Therefore, there is an urgent need for a new cryoablation needle that can replace helium to achieve rapid rewarming during cryoablation treatment, and can be easily promoted to increase the rewarming temperature and reduce complications.

[0007] (3) In myocardial cryoablation, ensuring the precision of the ablation range during the cryoablation needle procedure is crucial. Deviations between the adjusted length of the working end of the cryoablation needle and the actual ablation range may result in incomplete ablation or excessive damage to normal tissue cells, leading to various complications and other serious consequences. Furthermore, it is essential to achieve excellent freezing results while ensuring efficiency and speed. Therefore, it is necessary to innovatively design and prepare a cryoablation needle with a more precise ablation range and better freezing effect to improve the safety and precision of the surgical procedure.

[0008] (4) In current technology, the vent of the JT groove is generally located at the far end of the JT groove, that is, there is only one vent along the axis. This structure causes a large amount of cold energy in the target area to be concentrated at the far end of the target area (i.e., near the needle tip), while the cold energy in the target area further away from the needle tip is smaller. As a result, the ice ball will form a teardrop or pear shape with a full distal end and a thin proximal end. This shape of ice ball is often not conducive to the ablation treatment of tumors, because the ice ball needs to completely cover the tumor and extend more than 5 mm beyond the tumor boundary to achieve complete irreversible necrosis. Therefore, the small diameter of the proximal ice ball often leads to the ice ball not being able to effectively cover the tumor. Summary of the Invention

[0009] This invention provides an adjustable targeted cryoablation needle with heating function and novel refrigerant pore structure to solve the problems in the prior art.

[0010] The present invention employs the following technical solution: an adjustable targeting zone cryoablation needle with heating function and a novel refrigerant hole structure, comprising a needle rod, a vacuum wall, a JT groove, a JT groove sleeve, and an adjustment device; the needle rod is sleeved on the vacuum wall, the region from the distal end of the needle rod to the distal end of the vacuum wall is the targeting zone, the vacuum wall region is the vacuum insulation zone, and the vacuum wall comprises an outer vacuum wall tube and an inner vacuum wall tube; the JT groove is placed inside the inner vacuum wall tube, its distal end being located inside the distal end of the needle rod, and the side wall of the JT groove is provided with a side hole; the JT groove sleeve is sleeved on the JT groove, and the JT groove sleeve is provided with a sleeve sealing gasket at least at its proximal end; the JT groove sleeve and the vacuum wall are fixed together by a connector and can move axially synchronously; the adjustment device is used to adjust the length of the targeting zone.

[0011] Furthermore, the adjustable targeting area is adjusted by fixing the needle rod and adjusting the vacuum wall back and forth.

[0012] Furthermore, the adjustable targeting area is adjusted by fixing it with a vacuum wall and adjusting the needle rod back and forth.

[0013] Furthermore, the sleeve sealing gasket is located between the JT groove sleeve and the JT groove, serving a dynamic sealing function; the sleeve sealing gasket is located outside the far end or near end of the vacuum wall.

[0014] Furthermore, the connector is a welding point, an adhesive point, or a specific structural component; the connector is located outside the far end or near end of the vacuum wall.

[0015] Furthermore, the connector is composed of a large end and a small end, and a plurality of equally spaced air return holes are provided between the large end and the small end.

[0016] Furthermore, the distal end of the JT groove sleeve is close to the distal end of the vacuum wall. In the maximum targeting region state, the distal end of the JT groove sleeve does not block any side hole. In the minimum targeting region state, the distal end of the JT groove sleeve retains at least one distal outlet of the JT groove or at least one distal side hole.

[0017] Furthermore, the sleeve sealing gasket is made of fluorinated organic polymers such as polytetrafluoroethylene and is in the form of a tube; a proximal sealing section and a proximal compression section are provided at the proximal end of the JT groove sleeve, and the sleeve sealing gasket is located in the gap between the proximal sealing section and the JT groove.

[0018] Furthermore, the adjustment device includes a handle and a handle sleeve rotatably connected to the handle. A manual clamping and locking structure is provided between the handle and the handle sleeve. The lower positions of the handle and the handle sleeve are provided with a first external thread and a first internal thread that are threaded together. The middle positions of the handle and the handle sleeve are provided with a second external thread and a second internal thread that are threaded together. A ratchet force measuring device is provided inside the handle.

[0019] Furthermore, the upper part of the handle is a micrometer cylinder with 50 circumferential graduations (each graduation corresponds to a displacement of 0.01 mm), and an external fluorescent coating facilitates reading in low-light environments.

[0020] The above-described at least one technical solution adopted in the embodiments of the present invention can achieve the following beneficial effects:

[0021] (1) This invention addresses the shortcomings of conventional ablation needles in that they cannot adjust the target area. This invention can adjust the target area in a timely manner, not limited to before or during the operation. The target area can be adjusted during the freezing process. If the required ice ball size is found to be different from the expected size, the target area can be adjusted during the freezing process without having to remove the needle. This can shorten the operation time, avoid repeated freezing, and avoid over-freezing.

[0022] (2) This product improves the precision of the targeting area in cryoablation. In this product, the vacuum insulation layer primarily protects the handle, preventing frostbite to the user's hand during use. The vacuum insulation layer mainly controls the size of the targeting area (controlling the predetermined ice ball size). The sealing structure primarily isolates the gas between the vacuum insulation layers. See [link to product details]. Figure 1 .

[0023] This product adjusts the target area by adjusting the position of the vacuum insulation layer, thereby adjusting the size of the ice puck and forming an adjustable target area.

[0024] The specific structure features a fixed blade housing, while the internal vacuum insulation layer is adjustable. This is achieved by exposing the vacuum insulation layer behind the needle shaft and adjusting it using a lever fixed to the exposed layer. A sealing ring is installed between the vacuum insulation layer and the rear end of the blade housing, and between the vacuum insulation layer and the front end of the handle section to prevent internal gas leakage. Besides preventing gas leakage, this design also allows the vacuum insulation layer to move freely within the blade housing during freezing, a feature superior to any similar product on the market. Furthermore, this structural design ensures more precise ablation of the target area.

[0025] (3) This product has been improved for the JT tank, which greatly enhances the freezing effect and can reach extremely low temperatures in a very short time, thereby ensuring the efficiency and speed of freezing. This product is based on the Joule-Thomson effect and the principle of phase change refrigeration: nitrogen, argon or nitrogen-argon mixture at room temperature and high pressure (15MPa) is cooled into low temperature and high pressure gas by the equipment and then introduced into this product. Inside the target area, the Joule-Thomson effect of the JT tank throttles the gas to a low temperature of -130℃ to -170℃, realizing gas liquefaction. Liquid nitrogen or liquid argon absorbs heat and evaporates from the tumor tissue outside the effective freezing zone (phase change refrigeration), realizing tumor cryoablation.

[0026] Based on this, this product modifies the JT groove by creating a variety of tiny holes (ablation vents) on the sidewalls of the JT groove, with different numbers and arrangements of holes of varying sizes, especially near the target area. These ablation vents increase gas flow, lower sidewall temperature, and improve the freezing effect, thereby accelerating cooling and resulting in better and more uniform cooling (uniform cooling between the target area and the needle tip, and more uniform cooling of the entire target area during freezing).

[0027] By adjusting the vacuum wall, the JT slot sleeve connected to the vacuum wall is exposed and shielded after adjustment, so that the overall cooling of the target area is more uniform in both large and small target areas. Attached Figure Description

[0028] The accompanying drawings, which are included to provide a further understanding of the invention and form part of this invention, illustrate exemplary embodiments of the invention and are used to explain the invention, but do not constitute an undue limitation of the invention. In the drawings:

[0029] Figure 1 This is a schematic diagram of the ablation needle in this invention;

[0030] Figure 2 This is a schematic diagram of the JT groove structure in this invention;

[0031] Figure 3 This is a schematic diagram of the adjusting device in this invention;

[0032] Figure 4 This is a partial schematic diagram of the adjusting device in this invention;

[0033] Figure 5 This is a schematic diagram of the maximum target area of ​​the ablation needle in this invention;

[0034] Figure 6 This is a schematic diagram of the minimum target area of ​​the ablation needle in this invention;

[0035] Figure 7 This is a partial structural diagram of the present invention;

[0036] Figure 8 This is a three-dimensional structural diagram of the connector in this invention;

[0037] Figure 9 This is a schematic diagram of the ablation needle handle and needle head structure in this invention;

[0038] Figure label:

[0039] Needle bar 1, JT groove 2, side hole 21, JT groove sleeve 3, proximal main section 31, proximal sealing section 32, proximal compression section 33, sleeve sealing gasket 4, vacuum wall 5, vacuum wall outer tube 51, vacuum wall inner tube 52, connector 6, connector large end 61, connector small end 62, connector return air hole 63, adjusting device 17, ratchet force measuring device 171, handle outer sleeve 174, first external thread 173, first internal thread 172, second external thread 175, axial value line 176, arc value line 177, micrometer drum 178, handle 179, manual tightening locking structure 1710, second internal thread 1711. Detailed Implementation

[0040] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below in conjunction with specific embodiments and corresponding drawings. Obviously, the described embodiments are only a part of the embodiments of this invention, and not all of them. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0041] The following detailed description, in conjunction with the accompanying drawings, illustrates the technical solution of an adjustable targeted cryoablation needle with heating function and a novel refrigerant pore structure, according to various embodiments of the present invention.

[0042] Reference Figures 1 to 9As shown, this embodiment of the invention provides an adjustable target area cryoablation needle with heating function and a novel refrigerant hole structure, including a needle rod 1, a vacuum wall 5, a JT groove 2, a JT groove sleeve 3, and an adjustment device 17; the needle rod 1 is sleeved on the vacuum wall 5, the region from the distal end of the needle rod 1 to the distal end of the vacuum wall 5 is the target area, the region of the vacuum wall 5 is the vacuum insulation area, and the vacuum wall 5 includes a vacuum wall outer tube 51 and a vacuum wall inner tube 52; the JT groove 2 is placed inside the vacuum wall inner tube 52, its distal end is located inside the distal end of the needle rod 1, the side wall of the JT groove 2 is provided with side holes 21, the outlet of the distal end of the JT groove 2 can be blocked or not blocked, when the distal end is blocked, at least two side holes 21 are provided, and these two or more side holes 21 are evenly distributed in the target area; when the distal end is not blocked, at least one side hole 21 is provided, and at least one of these one or more side holes 21 is close to the proximal end of the target area. When multiple side holes 21 exist, they can be evenly distributed axially, or more side holes 21 can be set near the proximal end of the target area, or the diameter of the side holes 21 near the proximal end of the target area can be larger than the diameter of the side holes 21 far from the proximal end of the target area; the side holes 21 can be single-sided holes or through holes. When multiple side holes 21 exist axially, it is preferable to distribute the opening direction in a spiral at a certain angle; the JT groove sleeve 3 is sleeved on the JT groove 2, and the JT groove sleeve 3 is provided with at least one sleeve sealing gasket 4 at its proximal end; the JT groove sleeve 3 and the vacuum wall 5 are fixed together by the connector 6 and can move synchronously axially; the adjustment device 17 is used to adjust the length of the target area.

[0043] Option 1:

[0044] Specifically, the adjustable targeting area is adjusted by fixing the needle rod 1 and adjusting the vacuum wall 5 back and forth. When using the adjustable targeting area scheme of fixing the needle rod 1 and adjusting the vacuum wall 5 back and forth, the JT groove 2 is fixed, and the vacuum wall 5 drives the JT groove sleeve 3 to move axially.

[0045] Option 2:

[0046] Specifically, the adjustable targeting area is adjusted by fixing the vacuum wall 5 and adjusting the needle rod 1 back and forth. When using the adjustable targeting area scheme of fixing the vacuum wall 5 and adjusting the needle rod 1 back and forth, the JT groove sleeve 3 is fixed, and the needle rod 1 drives the JT groove 2 to move axially.

[0047] Option 1 is preferred for myocardial ablation, as it ensures that the position of the ablation needle in the myocardium remains unchanged, making it safer.

[0048] Specifically, the sleeve sealing gasket 4 is located between the JT groove sleeve 3 and the JT groove 2, and plays a dynamic sealing role; the sleeve sealing gasket 4 is located outside the far end or near end of the vacuum wall 5; to avoid obstructing the return gas.

[0049] Specifically, the connector 6 is a welding point, an adhesive point, or a specific structural component; the connector 6 is located outside the far end or near end of the vacuum wall 5 to avoid obstructing the return gas.

[0050] Specifically, the connector 6 is composed of a large end 61 and a small end 62, and a plurality of equally spaced air return holes 63 are provided between the large end 61 and the small end 62.

[0051] Specifically, the distal end of the JT groove sleeve 3 is close to the distal end of the vacuum wall 5. In the maximum targeting area state, the distal end of the JT groove sleeve 3 does not block any side hole 21. In the minimum targeting area state, the distal end of the JT groove sleeve 3 retains at least one distal outlet of the JT groove 2 or at least one distal side hole 21.

[0052] Specifically, the sleeve sealing gasket 4 is made of fluorinated organic polymers such as polytetrafluoroethylene (PTFE) to provide a low-temperature seal and is tubular in shape. A proximal sealing section 32 and a proximal compression section 33 are provided at the proximal end of the JT groove sleeve 3. The sleeve sealing gasket 4 is located in the gap between the proximal sealing section 32 and the JT groove 2. The outer diameter of the proximal sealing section 32 is larger than the outer diameter of the proximal main section 31. A dynamic seal is formed by radially compressing the proximal sealing section 32 to a certain extent. The outer diameter of the proximal compression section 33 is smaller than the outer diameter of the proximal sealing section 32 to prevent the sleeve sealing gasket 4 from axially sliding out of the JT groove sleeve 3.

[0053] Specifically, the adjustment device 17 includes a handle 179 and a handle sleeve 174 rotatably connected to the handle 179. A manual clamping locking structure 1710, consisting of a spring and a buckle, is provided between the handle 179 and the handle sleeve 174 to fix the handle 179 and the handle sleeve 174. The lower part of the handle 179 and the handle sleeve 174 is provided with a first external thread 173 and a first internal thread 172 that are threaded together. The middle part of the handle 179 and the handle sleeve 174 is provided with a second external thread 175 and a second internal thread 1711 that are threaded together. The handle 179 is provided with a ratchet force measuring device 171 with a built-in spring pre-tightening mechanism. When the needle tip pressure exceeds a preset value, a buffer is triggered to prevent overpressure. The upper part of the handle 179 is a micrometer cylinder 178 with 50 circumferential graduations, each graduation corresponding to a displacement of 0.01 mm. An external fluorescent coating facilitates reading in low-light environments. The differential cylinder 178 is provided with an axial numerical line 176 and a circular arc numerical line 177.

[0054] Rotation allows the handle 179 to move along the engagement axis with the handle sleeve 174, thus enabling fine adjustment of the needle extension length down to the millimeter level. Readings are taken through the axial numerical line 176 and the arc numerical line 177 on the differential cylinder 178.

[0055] The cryoablation needle of this invention has the following technical features:

[0056] 1. This cryoablation needle adopts a coaxial double-helix transmission structure design, and uses a precision adjustment mechanism to optimize the puncture accuracy and freezing range control of the cryoablation needle, thereby improving surgical safety and treatment effect.

[0057] 2. The cryoablation needle is equipped with a thermocouple heating guidewire in the middle, which can realize the rapid rewarming of the frozen tissue during the operation and the subsequent high-temperature heating of the needle tract for hemostasis.

[0058] 3. By innovatively designing the arrangement of cooling ablation pores and the heat conduction insulation layer, more precise control of the cryoablation range is achieved, improving the safety and effectiveness of cryoablation interventional therapy.

[0059] Based on the above-mentioned adjustable structure design of the cryoablation needle, thermocouple rewarming device design, and innovative design of cooling vents and insulation layer, the adjustable structure of the cryoablation needle allows for real-time adjustment of the working end length during the procedure. The designed thermocouple heating rewarming method can better heat the cryoablation needle, reduce thawing time when the ablation position needs to be changed, and improve surgical efficiency. At the same time, the high temperature of the thermocouple can keep the ablation needle temperature above 70°C, which can solve the complication of pericardial effusion bleeding that is prone to occur during cryoablation. The cold medium vents and cold conduction isolation jacket inside the cryoablation needle tip can significantly increase the tissue cryoablation range and avoid errors between the ablation size and the marked size. This adjustable working length thermocouple rewarming cryoablation needle can provide a safer and more stable ablation treatment solution for interventional surgery of hypertrophic cardiomyopathy and tumors.

[0060] Manual precision advance: The puncture depth can be adjusted in increments of 0.01 mm by rotating the micrometer cylinder 178;

[0061] Force-adaptive buffer: integrates ratchet mechanism and spring buffer device to limit the propulsion pressure to ≤50mN.

[0062] The above description is merely an embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principle of the present invention should be included within the scope of the claims of the present invention.

Claims

1. An adjustable-targeting cryoablation needle with heating function and novel refrigerant pore structure, characterized in that, The device includes a needle rod (1), a vacuum wall (5), a JT groove (2), a JT groove sleeve (3), and an adjustment device (17). The needle rod (1) is sleeved on the vacuum wall (5). The area from the distal end of the needle rod (1) to the distal end of the vacuum wall (5) is the target area. The area of ​​the vacuum wall (5) is the vacuum insulation area. The vacuum wall (5) includes an outer vacuum wall tube (51) and an inner vacuum wall tube (52). The JT groove (2) is placed inside the inner vacuum wall tube (52). Its distal end is located inside the distal end of the needle rod (1). The side wall of the JT groove (2) is provided with a side hole (21). The JT groove sleeve (3) is sleeved on the JT groove (2). The JT groove sleeve (3) is provided with a sleeve sealing gasket (4) at least at its proximal end. The JT groove sleeve (3) and the vacuum wall (5) are fixed together by a connector (6) and can move axially synchronously. The adjustment device (17) is used to adjust the length of the target area.

2. The adjustable targeted cryoablation needle with heating function and novel refrigerant pore structure according to claim 1, characterized in that, The adjustable target area is adjusted by fixing the needle rod (1) and adjusting the vacuum wall (5) back and forth.

3. The adjustable targeted cryoablation needle with heating function and novel refrigerant pore structure according to claim 1, characterized in that, The adjustable target area is adjusted by fixing the vacuum wall (5) and adjusting the needle rod (1) back and forth.

4. The adjustable targeted cryoablation needle with heating function and novel refrigerant pore structure according to claim 1, characterized in that, The sleeve sealing gasket (4) is located between the JT groove sleeve (3) and the JT groove (2) and plays a dynamic sealing role; the sleeve sealing gasket (4) is located outside the far end or near end of the vacuum wall (5).

5. The adjustable targeted cryoablation needle with heating function and novel refrigerant pore structure according to claim 1, characterized in that, The connector (6) is a welding point, an adhesive point, or a specific structural component; the connector (6) is located outside the far end or near end of the vacuum wall (5).

6. The adjustable targeted cryoablation needle with heating function and novel refrigerant pore structure according to claim 5, characterized in that, The connector (6) consists of a large end (61) and a small end (62), and a plurality of equally spaced air return holes (63) are provided between the large end (61) and the small end (62).

7. The adjustable targeted cryoablation needle with heating function and novel refrigerant pore structure according to claim 1, characterized in that, The distal end of the JT groove sleeve (3) is close to the distal end of the vacuum wall (5). In the maximum targeting state, the distal end of the JT groove sleeve (3) does not block any side hole (21). In the minimum targeting state, the distal end of the JT groove sleeve (3) retains at least one distal outlet of the JT groove (2) or at least one distal side hole (21).

8. The adjustable targeted cryoablation needle with heating function and novel refrigerant pore structure according to claim 1, characterized in that, The sleeve sealing gasket (4) is made of fluorinated organic polymers such as polytetrafluoroethylene and is in the form of a tube. A near-end sealing section (32) and a near-end compression section (33) are provided at the near end of the JT groove sleeve (3), and the sleeve sealing gasket (4) is located in the gap between the near-end sealing section (32) and the JT groove (2).

9. The adjustable targeted cryoablation needle with heating function and novel refrigerant pore structure according to claim 1, characterized in that, The adjusting device (17) includes a handle (179) and a handle sleeve (174) rotatably connected to the handle (179). A manual clamping locking structure (1710) is provided between the handle (179) and the handle sleeve (174). A first external thread (173) and a first internal thread (172) that are threaded together are provided at the lower position of the handle (179) and the handle sleeve (174). A second external thread (175) and a second internal thread (1711) that are threaded together are provided at the middle position of the handle (179) and the handle sleeve (174). A ratchet force measuring device (171) is provided inside the handle (179).

10. The adjustable targeted cryoablation needle with heating function and novel refrigerant pore structure according to claim 9, characterized in that, The upper part of the handle (179) is a micrometer cylinder (178) with 50 circumferential graduations (each graduation corresponds to a displacement of 0.01 mm), and an external fluorescent coating to facilitate reading in low-light environments.

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