52 results about "Selective ablation" patented technology

The present invention relates to a radiofrequency electrode for selective ablation of a body tissue, comprising a first electrode 110 and a second electrode 120 to be inserted, through a catheter 60, into the body tissue, wherein the first electrode tip 112 formed at the end of the first electrode 110 and the second electrode tip 122 formed at the end of the second electrode 120 are bonded at a predetermined interval. Specifically, a coil spring is bonded to the ends of the first electrode 110 and the second electrode 120, and the coil spring is configured to have its end part bent in the free state and be transformed by pulling either or both of the first electrode and the second electrode. By using the electrode, ablation of a desired tissue region in a body with radiofrequency by easily controlling the direction and the position of the electrode tip can be easily performed.

The present invention provides devices and systems, as well as methods, of electric field delivery and non-thermal or selective ablation of target tissue regions, including selective ablation of cancerous cells and solid tumors. A method of the present invention includes delivering an electric field to a tissue, including positioning an electrode within a target tissue region comprising cancerous cells, and applying an alternating electrical current to the target tissue so as to non-thermally ablate cancerous cells of the target tissue region around the electrodes.

The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment and tolerance.

The invention relates to methods and apparatus for processing biological tissue and dental materials which involves providing or distributing a substance containing abrasive particles to an area in front of at least a portion of a surface of the tissue / material and irradiating both the substance and the portion of the surface with light from a selected source, the light being selected and delivered in a manner such that selective ablation is caused on the substance sufficient to force the abrasive particles under a selected pulse against the portion of the surface. Ablation may be of the particles themselves or the particles may be contained within a shell, with ablation being of the shell. The substance is preferably delivered as a series of distribution pulses with the light being delivered either continuously or as light pulses having a predetermined relationship to the distribution pulses.

An apparatus for ablating deposits along the blood vessel of human and animals is disclosed. The apparatus has an extracting and pressurizing unit for extracting blood from a supply vessel and pressurizing it plus a downstream delivering and injecting unit for delivering and injecting the filtered and pressurized source blood into a blood vessel under treatment. Besides inducing a blood circulation and having ablation devices like ultrasound and RF heating, the apparatus ablates the deposits from a nearby portion of the vessel. The characteristics of selective ablation and self-termination make the proposed apparatus safe and effective in treating early-stage atherosclerosis. A DC discharging device can be included to neutralize excess surface charge generation on the wounded healthy tissues following ablation for disinfection and anti-inflammation. Placement of the blood extracting point just downstream of the blood injecting point insures thorough collection and removal of blood-clogging plaque and calcification fragments.

The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. In addition, certain embodiments of the present invention relate to the micropatterning of multiple cell types on curved surfaces, multiwell plates, and flat bottom flasks. The invention also features kits for use with the subject methods.

The invention relates to a crystal silicon surface femtosecond laser selective ablation method based on electron dynamic control, and belongs to the technical field of femtosecond laser application. The crystal silicon surface femtosecond laser selective ablation method based on the electron dynamic control enables laser polarization parameters and crystal lattice properties of crystal silicon materials to be integrated, through the operation that femtosecond laser rays or the included angel of elliptic polarization and monocrystal silicon is adjusted effectively, the selective induction generation of crystal silicon surface periodical ripple micro nano structures is controlled by regulating and controlling material surface instant electron excitation dynamic states, and the induction generation of the crystal silicon surface periodical ripple micro nano structures can be achieved effectively and accurately according to preliminary design. According to the crystal silicon face femtosecond laser selective ablation method based on the electron dynamic control, selective ablation control is carried out on the silicon surface periodic ripple nano structures with diamond lattice structures from the aspect of static laser irradiation and the aspect of laser direct writing, the processing accuracy and the processing efficiency of the surface processing of the silicon surface periodic ripple nano structures are improved greatly, and the application value of the method on the aspects such as information storage is high.

An apparatus for ablating deposits along the blood vessel of human and animals is disclosed. The apparatus has an extracting and pressurizing unit for extracting blood from a supply vessel and pressurizing it plus a downstream delivering and injecting unit for delivering and injecting the filtered and pressurized source blood into a blood vessel under treatment. Besides inducing a blood circulation and having ablation devices like ultrasound and RF heating, the apparatus ablates the deposits from a nearby portion of the vessel. The characteristics of selective ablation and self-termination make the proposed apparatus safe and effective in treating early-stage atherosclerosis. A DC discharging device can be included to neutralize excess surface charge generation on the wounded healthy tissues following ablation for disinfection and anti-inflammation. Placement of the blood extracting point just downstream of the blood injecting point insures thorough collection and removal of blood-clogging plaque and calcification fragments.

The present invention provides methods and kits for the selective ablation of pain-sensing neurons. The methods comprise administration of a vanilloid receptor agonist to a ganglion in an amount that causes death of vanilloid receptor-bearing neurons. Accordingly, the present invention provides methods of controlling pain and inflammatory disorders that involve activation of vanilloid receptor-bearing neurons.

Method for preparing micro-optical structure on a film based on chemical mechanical polishing etching, combining photolithography technology with chemical mechanical polishing technology to make preparation and large-scale integration of large-size high-quality micro optical devices on-chip possible. The method comprises coating metal on film surface, selectively removing the metal film by photolithography (such as femtosecond laser selective ablation, ultraviolet photolithography, electron beam etching, ion beam etching, and reactive ion etching), chemical mechanical polishing, chemical corrosion or over polishing and other steps. Micro-optical devices on-chip prepared by the method have extremely high surface finish and extremely low optical loss. The method is applicable to preparing high-quality micro-optical structures (including but not limited to microdisc cavities, microring cavities, optical waveguides and coupled devices thereof) on various films on-chip (including but not limited to lithium niobate single crystal films, quartz films, silicon films, silicon dioxide films, diamond thin films, etc.).

The invention relates to a method for electronic dynamic control of crystal silicon surface periodic micro-nano structures based on square hole assistance and belongs to the technical field of femtosecond laser application. The method is based on local transient electronic excitation dynamic control, and femtosecond laser linear polarization is focused through an objective lens and then is focused on the surface of a material through a square hole copper wire mesh to achieve various precise control of different surface periodic micro-nano structures; by controlling laser scanning speed and pulse energy, ablation of strip-shaped surface corrugated structures and multi-point array micro-nano structures is achieved; by controlling the relative positions of the laser polarization direction and the direction (x axis) of the edge of a square hole, direction control of the periodic micro-nano structures can be achieved; by effectively adjusting the included angle between the linear polarization laser direction and the direction (x axis) of the edge of the square hole, selective ablation of the crystal silicon surface periodic micro-nano structures is achieved. Compared with existing methods, the method has the advantages that surface processing precision and efficiency are improved effectively, and efficient and accurate form control of the surface periodic micro-nano structures is achieved.

Systems, methods and apparatus for performing selective ablation of a corneal surface of an eye to effect a desired corneal shape, particularly for correcting a hyperopic / astigmatic condition by laser sculpting the corneal surface to increase its curvature. In one aspect of the invention, a method includes the steps of directing a laser beam onto a corneal surface of an eye, and changing the corneal surface from an initial curvature having hyperopic and astigmatic optical properties to a subsequent curvature having correctively improved optical properties. Thus, the curvature of the anterior corneal surface is increased to correct hyperopia, while cylindrical volumetric sculpting of the corneal tissue is performed to correct the astigmatism. The hyperopic and astigmatic corrections are preferably performed by establishing an optical correction zone on the anterior corneal surface of the eye, and directing a laser beam through a variable aperture element designed to produce a rectangular ablation (i.e., cylindrical correction) on a portion of the optical correction zone. The laser beam is then displaced by selected amounts across the optical correction zone to produce a series of rectangular ablations on the correction zone that increases the curvature of the corneal surface to correct the hyperopic refractive error.

The invention relates to a method for efficiently manufacturing a micro channel by combining femtosecond laser polarization selective ablation with chemical acid etching, and belongs to the technical field of femtosecond laser application. For the characteristics of crystalline state materials, the partial instant electronic dynamic state in the mutual action process of laser and the materials is adjusted by adjusting the laser polarization parameter and the included angle of the material crystal axis, materials in the laser machining area are triggered to be modified, and the machining efficiency and accuracy of the micro channel are improved with the assistance of chemical acid etching. The method is simple and efficient and has important study significance in the field of micro fluid machining.

A method for elevating a TRAIL-R1 expression in cancer cells to induce apoptosis. The method comprises the steps of receiving electrical energy having a specific voltage, frequency and power from an electrosurgical generator, up-converting the voltage and down-converting the frequency with a high voltage transformer having a primary coil and a secondary coil, the secondary coil having a larger number of turns than the primary coil, applying said converted electrical energy to an electrode in an electrosurgical hand piece, flowing an inert gas through said electrosurgical hand piece to produce a cold plasma at a distal end of said electrosurgical hand piece; and applying said cold plasma to cancer cells for 1 to 3 minutes. The inert gas may comprise, for example, helium or argon. In a preferred embodiment the cold plasma is applied to cancer cells for about 2 minutes.

The invention relates to a preparation method of an on-chip high-quality thin film micro-optical structure, comprising the steps of plating a metal layer on the surface of a thin film, carrying out femtosecond laser selective ablation on a metal film, carrying out chemical mechanical polishing and carrying out chemical corrosion. The on-chip micro-optical device prepared by adopting the method provided by the invention has extremely high surface finish and extremely low optical loss. The method is applicable to preparation of high-quality micro-optical structures (including but not limited toa micro disk cavity, a microring cavity, an optical waveguide and coupled devices thereof) on all kinds of on-chip thin films (including but not limited to a lithium niobate single crystal thin film,a quartz thin film, a silicon thin film, a silicon dioxide thin film, a diamond thin film and the like).

The present technology relates to a method for causing cell death. The method comprises the step of genetically manipulating chromosomal DNA of a cell such as by, for example, using a recombinase system, to lose an autosome during cell division and wherein loss of the autosome results in death of the cell. The technology also relates to a method for selective ablation of proliferative cells within a population of cells.

The present invention provides methods and kits for the selective ablation of pain-sensing neurons. The methods comprise administration of a vanilloid receptor agonist to a ganglion in an amount that causes death of vanilloid receptor-bearing neurons. Accordingly, the present invention provides methods of controlling pain and inflammatory disorders that involve activation of vanilloid receptor-bearing neurons.

The invention provides a preparation method for a three-dimensional crystal optics echo wall micro-cavity. The preparation method comprises the steps: carrying out femtosecond laser selective ablation on crystals soaked in liquid and grinding the lateral wall of the micro-cavity by using a focused ion beam. The three-dimensional crystal optics echo wall micro-cavity prepared by adopting the method provided by the invention can be used for limiting light through continuous total internal reflection of the cavity and an outside face, and has the advantages of extremely high surface smoothness, small mode volume and high quality factor. The preparation method is applicable to various crystal materials, glass and the like.

The invention relates to motor bearing components with features such as fine groove pitch (<100 microns), fine feature widths (<25 microns), varying groove depths and surface profiles in 3D for optimum bearing performance. A method for manufacturing the workpiece, the electrode design features to make the final part and the method for manufacturing such an electrode are disclosed. An electrode including a conductive block having the desired profile is disclosed. The electrode of the embodiments of the invention could be made out of a wide range of materials including hard and difficult to machine materials. The electrode can be made out of a solid blank, or a sleeve with hollow core or a sleeve with a filled core. Such an electrode can be used for achieving optimized groove geometry on the workpiece. The electrode of the embodiments of the invention could also be made by method of manufacturing including formation of a groove pattern on a surface of a hollow conductive block by laser ablation of portions of the hollow conductive block and with or without formation of a dielectric material in the groove pattern. Additional methods involving photo-polymerization, selective ablation, plating and reverse ECM for recessed lands are disclosed.

The present invention provides a purified and isolated nucleic acid encoding a sodium / iodide symporter. The present invention also provides purified sodium / iodide symporter, a vector comprising nucleic acid encoding sodium / iodide symporter, a host cell transformed with the vector, and a method for producing recombinant sodium / iodide symporter. In addition, the present invention provides nucleic acid probes and mixtures thereof specific for sodium / iodide symporter nucleic acid and antibodies immunoreactive with sodium / iodide symporter. The present invention also provides a method for diagnosing and treating thyroid disorders associated with non-functional sodium / iodide symporter. Furthermore, the present invention provides a method for the selective ablation of tissue. The present invention also provides a method for identifying an iodide transport protein in non-thyroid tissue. Finally, the present invention provides a non-human, transgenic model for a thyroid disorder.

A method of using a laser ablation system to clean an area of a surface with a laser beam, having a target fluence and a target irradiance. The area comprises scan regions, each having a scan width. The method comprises determining a traverse scan speed, a laser-beam average power, a laser pulse repetition rate, a laser pulse width, and a laser-beam spot area of the laser beam for each one of the scan regions to achieve the target fluence and the target irradiance. The scan width of at least one of the scan regions is different from the scan width of another one of the scan regions. The method also comprises sequentially scanning, across the scan width, each one of the scan regions of the area with the laser beam at the target fluence and the target irradiance.

The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells with a combination of antibodies specific for CD117, and agents that modulate immunoregulatory signaling pathways, e.g. agonists of immune costimulatory molecules, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment, even in immunocompetent recipients.

A laser can produce pulses of light energy for tissue-type selective ejection of a volume of the target tissue, and the energy can be delivered to a treatment site through a waveguide, such as a fiber optic waveguide. The incident laser energy can be absorbed within a volume of the target tissue with a tissue penetration depth and pulse direction such that the propagation of the energy from the tissue volume is inhibited and such that the target tissue within the volume reaches the spinodal threshold of decomposition and ejects the volume, for example without substantial damage to tissue adjacent the ejected volume. The pulses are set to be tissue selective.

The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. In addition, certain embodiments of the present invention relate to the micropatterning of multiple cell types on curved surfaces, multiwell plates, and flat bottom flasks. The invention also features kits for use with the subject methods.

Methods of selecting haploid embryos are disclosed. Methods of producing haploid embryos and non-viable diploid embryos on a plant are provided. Methods for selecting haploid embryos produced from haploid inducer maize lines are provided. Methods for producing improved maize haploid inducer lines are disclosed. Maize haploid inducer lines comprising transgenes causing ablated or abnormal diploid embryos are disclosed.

The invention relates generally to compounds and methods for imaging and / or selective ablation of nitroreductase-expressing cells and / or biological agents. More particularly, although not exclusively, the invention provides compounds that are selectively metabolised by bacterial nitroreductases and are substantially insensitive to metabolism under oxic or hypoxic conditions by human nitroreductase enzymes.

A method of fabricating an electrochemical device, comprising: depositing device layers, including electrodes and corresponding current collectors, and an electrolyte layer, on a substrate; and directly patterning at least one of said device layers by a laser light pattern generated by a laser beam incident on a diffractive optical element, the laser light pattern directly patterning at least an entire device in a single laser shot. The laser direct patterning may include, among others: die patterning of thin film electrochemical devices after all active layers have been deposited; selective ablation of cathode / anode material from corresponding current collectors; and selective ablation of electrolyte material from current collectors, Furthermore, directly patterning of the electrochemical device may be by a shaped beam generated by a laser beam incident on a diffractive optical element, and the shaped beam may be moved across the working surface of the device.