The invention relates to a medical biological dressing, particularly to a medical biological scar-inhibiting rhytidectomy dressing and a preparation method thereof. The dressing is composed of modified chitosan, silicone, glycerol, camellia oil, olive oil, almond oil, an aloe extracting solution, active growth factors, hyaluronic acid and a ginger extracting solution. With adoption of the formula, skin regeneration organs are retained and activated furthest, and a good foundation is laid for wound repair. The formula is reasonable and scientific and has the efficacies of clearing away heat and toxic materials, removing slough and promoting growth of tissue regeneration, promoting blood circulation and removing blood stasis, and relieving swelling and pain on scars, has an impressive preliminary therapeutic effect on scars of skin epidermis bruise, trauma, traumatism, burning, scald, and post-operation wound, has the advantages of high efficacy, rapid pain relieving, low possibility of infection, simple preparation method, and good convenience in usage and popularization, and is used for burning, scald, trauma, bruise, traumatism, post-operation wound hemostasis, inflammation diminishing, pain relieving, wound infection prevention, scar inhibition, skin wrinkle and crack prevention, and wrinkle inhibition.