40 results about "Bone erosion" patented technology

Devices and methods for stimulation of the vagus nerve to modulate (e.g., reduce, suppress, etc.) bone erosion. Methods and apparatus for modulating bone erosion may modulate levels of Receptor Activator for Nuclear Factor κ B Ligand (RANKL), and / or to modulate (increase, enhance, etc.) osteoprotegerin (OPG) and / or OPG / RANKL ratio. Devices may include electrical stimulation devices that may be implanted, and may be activated to apply current for a proscribed duration, followed by a period without stimulation.

The invention provides an artificial alpha femoral stem prosthesis, which comprises a femoral stem cone, a femoral neck and a stem body in integral connection. The upper end face of the femoral neck is provided with a tool operating hole, the stem body comprises a femoral stem near section, a femoral stem middle section and a femoral stem far section, and a deflection angle is formed between the femoral neck and the stem body. By adoption of the integral structure, problems of abrasion, bone erosion and the like among components are eliminated; the femoral neck is wide in a motion range, stability in prosthesis implantation and effectiveness in rotation resistance are realized, great conditions are created for growth and proliferation of bone cells and soft tissues, the fixing effect of the prosthesis in a human body is improved, the service life of the prosthesis is prolonged, the surgical success rate is increased, and post-surgical pains of patients are alleviated. In addition, thesurface of the prosthesis is coated with a titanium microporous coating, biocompatibility of the prosthesis is improved, strength, plasticity and toughness of the prosthesis are matched with those ofhuman bones, and accordingly perfect matching of the prosthesis with femora of patients is realized.

The present invention provides an artificial peptidomimetic, the structural formula of which is shown in Formula 1: the present invention also provides a preparation method and application of the artificial peptidomimetic. The preparation method provided by the invention has the advantages of reasonable selection of raw materials, easy availability, simple preparation process and easy industrialization. The artificial peptidomimetic provided by the present invention can be used to prepare drugs for preventing or treating redness and swelling of joints or / and swelling of joints or / and bone erosion or / and joint deformation or / and decrease of joint bone density, and can also be used for Medicines for preventing or treating inflammation-related cytokine IL-1β or / and IL-8 or / and TNF-α are prepared.

A Chinese medicine 'Gushizaizao pill' for treating femus head necrosis is prepared from 15 Chinese-medicinal materials including Chinese angelica root, red sage root, safflower, notoginseng, etc.