6 results about "Bone erosion" patented technology

The application discloses application of myrtenal in preparation of a medicine for preventing and / or treating rheumatoid arthritis. The application verifies for the first time that myrtenal can block the RA inflammatory cascade from multiple aspects, and overcomes the limitation that single-target treatment is easy to produce drug resistance. Specifically, myrtenal can reduce the levels of inflammatory factors and metal proteins; inhibit the proliferation, migration and invasion of synovial fibroblasts SFs; inhibit the expression of glycolysis-related genes, reduce sugar metabolites; inhibit the synovial tissue hyperplasia, inflammatory cell infiltration, bone erosion and bone destruction of mice joints; promote the mental state of arthritis mice to be obviously improved, the food intake to be increased, the hair to be shiny, the joint swelling to be subsided, the bruise of the ankle joint to be subsided, the skin to be improved, and the activity to be sensitive. Therefore, the application proposes a new medical use of myrtenal in treating rheumatoid arthritis, and develops a brand-new therapeutic indication of myrtenal.

The invention discloses a supramolecular compound and a preparation method and application thereof.The supramolecular compound is carrier-free nanoparticles (CDN) obtained by conducting molecular self-assembly on tripterine (CeL) and demethylwedelolactone, and experiments show that the CDN can effectively relieve clinical symptoms, inflammation infiltration and bone erosion. Besides, the CDN can be transferred to an inflammation part of rheumatoid arthritis (RA) in a targeted manner, so that bone degenerative change and joint skeleton damage can be remarkably reduced, the inflammation part is targeted, the expression of proinflammatory cytokines is reduced, the drug concentration of the affected part is improved, and the toxic and side effects of the tripterine are reduced. The research provides a new strategy for improving the curative effect and safety of the traditional Chinese medicine, and provides a brand new solution for RA treatment.

The invention relates to the technical field of Tibetan medicine preparations, in particular to a Tibetan medicine composition for treating rheumatoid arthritis and a preparation method. The Tibetan medicine composition is prepared from 18 Tibetan medicines including fructus chebulae, fructus terminaliae billericae, emblic leafflower fruit and the like according to a specific weight ratio, and the monarch, minister, assistant and guide relationship is defined based on the Tibetan medicine true brucellosis theory; according to the preparation method, a low-temperature superfine grinding and step-by-step extraction process is innovatively adopted, three dosage forms of powder, a nano drug-loaded emulsion and a temperature-sensitive acupoint patch are developed, and a dual quality control system of HPLC (High Performance Liquid Chromatography) content determination and fingerprint spectrum is established. TNF-alpha and IL-6 target spots and nf-kb and PI3K-AKT inflammation pathways are synergistically regulated and controlled through multiple components, joint swelling and bone erosion are relieved, and gastrointestinal tract side effects of western medicines are avoided; the transdermal absorption efficiency is improved by a nano drug-loading technology, acupoint targeted drug delivery is realized by the temperature-sensitive patch, and verification shows that the joint swelling inhibition rate is greater than or equal to 70%, the inflammatory factor decrease amplitude is greater than or equal to 50%, and the patch is suitable for patients with mild, moderate and severe rheumatoid arthritis and has a wide clinical application prospect.

This invention provides a deep learning-based method and system for identifying bone erosion in X-ray images of rheumatoid arthritis, belonging to the field of image analysis technology. The invention acquires the frequency domain texture chaos degree and geometric grayscale manifold data of the image; inputs these data into a differentiable entropy-weighted topological neural network, and uses the frequency domain texture entropy as dynamic weights to reconstruct a simplex filtering sequence, generating a continuous homogeneous landscape feature tensor representing the pathological structure; cross-domain stitching and upsampling are then performed through a multi-scale feature fusion decoding network to generate a lesion probability mask; simultaneously, environmental adaptive degradation control is triggered in real time based on statistical dispersion. This effectively solves the problems of high-frequency texture detail loss and noise sensitivity in existing technologies, achieving accurate localization and robust identification of small bone erosion lesions under low-dose X-ray images.

The application relates to application of FGFR as an inhibition target in preparation of a drug for treating rheumatoid arthritis, and the application of the inhibitors Pemigatinib, Erdafitinib, Infigratinib and Sufatinib can obviously reduce the area of bone erosion by a vascular pannus cell, and the application proves that the inhibitors can be used for preparing a drug for treating rheumatoid arthritis, provides a new treatment for treating rheumatoid arthritis, and has a good application prospect.

Methods and apparatuses (e.g., devices and systems) for nerve stimulation to treat bone erosion, including in patients for having an inflammatory and / or autoimmune conditions, such as, but not limited to, rheumatoid arthritis (RA). In some cases, these methods may reduce or prevent bone erosion by applying electrical stimulation of the nerve (e.g., vagus nerve) in a patient that is desensitized to electrical nerve simulation to suppress inflammation (e.g., by decreasing cytokines such as RANK-L). In some cases this may include applying electrical energy in a manner that would desensitize the suppression of anti-inflammatory cytokines while reducing or preventing bone erosion. Alternatively or additionally, these methods may include applying electrical energy to a subject that is already desensitized to the electrical modulation of cytokines (e.g., RANKL) by nerve stimulation.