312 results about "Hydrogel microspheres" patented technology

The invention relates to a bone organ constructed based on oxygen-releasing immune hydrogel microspheres and a preparation method and application thereof. An oxygen release material, macrophages and bone marrow mesenchymal stem cells are loaded in the oxygen release immune hydrogel microspheres. And adding the oxygen-releasing immune hydrogel microspheres into a culture medium for culturing to obtain the bone organ constructed based on the oxygen-releasing immune hydrogel microspheres. The oxygen release material (CaO2-HAp) is entrapped in the hydrogel microspheres, so that continuous oxygen supply can be provided in a defect area, the low-oxygen environment is improved, the activity of osteoblasts is improved, osteogenic differentiation is promoted, macrophages are entrapped by the microspheres, the immune microenvironment is regulated and controlled, the release of proinflammatory cytokines is reduced, the osteogenic efficiency is improved, and bone defect repair is accelerated. The micro-fluidic technology is utilized to accurately control the size and shape of the microspheres, so that the microspheres can adapt to irregular bone defects, bone organs are formed through long-term in-vitro culture, and the biological activity and adaptability of the bone repair material are improved.

The invention discloses a preparation method of a high-activity hierarchical pore boric acid imprinted hydrogel microsphere adsorbent and application of the adsorbent to selective adsorption of a flavonoid compound naringin NRG. According to the invention, dopamine is used for modifying COFs so as to enhance surface functionalization of COFs; preparing a sulfydryl functionalized covalent organic framework microsphere; synthesizing sulfydryl microspheres by utilizing an emulsion interfacial polymerization method; preparing a COFs boron affinity imprinting microsphere adsorbent based on boron affinity interaction; the adsorbent is applied to selective adsorption of NRG in agricultural wastewater. The prepared adsorbent has a remarkable multilayer adsorption effect, and the adsorption capacity is remarkably improved through the boron affinity effect. The multi-stage pore structure of the COFs microspheres provides abundant sites for adsorption, and the mass transfer rate is remarkably improved. In addition, the prepared adsorbent shows remarkable specificity in the aspects of adsorption and separation of NRG, and a promising adsorption material is provided for industrial separation of NRG.

The invention discloses a leak-free core-shell hydrogel microsphere delivery system for non-contact flora transplantation as well as a construction method and application of the leak-free core-shell hydrogel microsphere delivery system. According to the invention, bacteria are encapsulated in a core of a core-shell microsphere through a two-step photo-initiation emulsion polymerization method of methacrylic acid gelatin, and a non-contact microbiota transplantation system (NMTS) is constructed. The NMTS can be used for biological encapsulation of various strains, shows encapsulation efficiency close to 100%, and has little influence on bacterial activity at the same time. NMTS demonstrates: a shielding effect that protects sealed bacteria from low pH values in the gastrointestinal tract and bile acid disruption; sufficient mechanical strength ensures that bacterial leakage is prevented and the infection risk is eliminated in the whole gastrointestinal tract delivery process; and internal and external substance exchange is realized, and the intestinal microorganism structure is remodeled. The invention provides a unique bacterial cell microencapsulation method which is a non-contact, safe and effective micropopulation transplantation method.

The present invention relates to the field of biomedical materials. Particularly provided is a DNA-silk fibroin composite hydrogel microsphere. The DNA-silk fibroin composite hydrogel microsphere is prepared from DNA and silk fibroin on the basis of the micro-fluidic technology by means of combination of self-assembly physical crosslinking and photo-crosslinking. The introduction of a silk fibroin network into the composite hydrogel microsphere can provide mechanical performance for a DNA hydrogel network and reduce the production cost. RGD can remarkably improve the cell loading capability of the microsphere. The hydrogel microsphere can simulate a microenvironment of cartilage tissue by means of three-dimensional loading of high-density cells, so as to enhance substance exchange and signaling between cells, and more effectively promote the proliferation and adhesion of bone marrow mesenchymal stem cells and regulating the chondrogenic differentiation, thus promoting cartilage regeneration and repair, and providing an available material for preparing medicaments or medical instruments for cartilage defect repair.

The invention provides a preparation method of starch hydrogel microspheres, and belongs to the technical field of embolism microsphere manufacturing. The preparation method of the starch hydrogel microspheres comprises the following steps: adding a first cross-linking agent into a starch solution, and mixing to obtain a water-phase solution; adding the oil phase solution into the water phase solution, and mixing to obtain a mixed liquid; adding a second cross-linking agent into the mixed liquid, mixing and reacting to obtain the starch hydrogel microspheres, and the starch hydrogel microspheres prepared by the method have the advantages of long in-vivo degradation time and adjustable degradation time, and can be suitable for more disease types.

The invention belongs to the technical field of biomedical materials, and particularly relates to a multi-layer multifunctional hydrogel microsphere for diabetic wounds as well as a preparation method and application of the multi-layer multifunctional hydrogel microsphere. The preparation method comprises the following steps: firstly, synthesizing a chitosan derivative with proper amino and aldehyde group contents, oxidized macromolecules and modified chitin; then preparing photocuring hydrogel microspheres by utilizing a microfluidic technology, and sequentially immersing the photocuring hydrogel microspheres into an oxidized polymer solution, a modified chitin solution, a tannic acid solution and a metal salt solution, so as to construct the hydrogel microspheres with a multifunctional layer structure. The invention further provides specific application intervals of parameters such as solvents used by various solutions, concentration ranges and soaking time. The preparation method provided by the invention has expansibility and universality, various types of microspheres can be constructed for sequential release of bioactive substances, and the requirements of tissue repair are met.

The invention provides a mechano-electric coupling hydrogel microsphere with stable mechanical property and low loss transduction as well as a preparation method and application thereof, and belongs to the technical field of tissue engineering bioremediation materials. According to the invention, supramolecular engineering and microfluidic technologies are utilized, and a slip ring structure polyrotaxane and conductive polypyrrole network is introduced to construct stress-electric coupling hydrogel microspheres. The molecular slippage mechanism of the slip ring structure stores and releases mechanical energy to reduce mechanical loss, and the conjugated pi-electron movement in the conductive network improves the electron transfer efficiency in the microsphere, so that the loss in stress-electricity conversion is reduced for the first time. Compared with the traditional piezoelectric hydrogel microspheres, the stress-electric coupling efficiency of the low-dissipation microspheres is improved by 2.3 times, and the energy dissipation rate is reduced to 43%. The mechano-electric coupling hydrogel microspheres can reduce cartilage injury of rats, improve behavior results and promote treatment of osteoarthritis by recovering low-loss transduction between tissues.

The invention belongs to the technical field of drug delivery, and particularly relates to a multi-response colitis disease targeting hydrogel microsphere as well as a preparation method and application thereof. The hydrogel microsphere comprises a calcium ion cross-linked sodium alginate microsphere and HA-Cys / Cur NPs which is encapsulated in the calcium ion cross-linked sodium alginate microsphere, the preparation method comprises the following steps: self-assembling cysteine ethyl ester modified hyaluronic acid and curcumin to form nano-particles, encapsulating HA-Cys / Cur NPs into sodium alginate microspheres by an emulsification method, and carrying out calcium ion crosslinking, so as to obtain the hydrogel. The hydrogel microspheres have pH and GSH response characteristics and hyaluronic acid-mediated active targeting capability, are stable in a gastric acid environment, are accurately released at a colon part and target macrophages at an inflammation part, and NPs disconnects disulfide bonds and releases curcumin in an intracellular high GSH environment, so that synergistic treatment of anti-inflammation, anti-oxidation and intestinal mucosa repair is realized, and the curative effect is good. The medicine has a good application prospect in treatment of ulcerative colitis.

The invention relates to a two-phase hydrogel system based on space-time gradient regulation and control as well as a preparation method and application of the two-phase hydrogel system. The biphase hydrogel system can also be expressed as a GelMA composite hydrogel scaffold of a porous structure, the whole biphase hydrogel system is of a core-shell structure, the inner layer core mineralizes SilMA hydrogel microspheres, the porous GelMA hydrogel scaffold is used as an outer layer, and the angiogenesis promoting factor dimethyl oxalaminoacetic acid, the human umbilical vein endothelial cells and the bone marrow mesenchymal stem cells are loaded on the outer layer. Wherein the inner-layer core mineralized SilMA hydrogel microspheres realize continuous release of osteogenesis signals by slowly releasing nHAp, and the outer-layer porous GelMA hydrogel stent releases DMOG by rapid degradation to realize early angiogenesis, so that space-time coupling construction of blood vessels and bone tissues is realized. Through differential degradation characteristics of inner and outer layers of hydrogel, precise time sequence cooperative regulation and control of angiogenesis and bone tissue remodeling can be realized, and the bionic property and function integration capability of a vascularized bone organ structure can be improved, so that the clinical transformation potential of the vascularized bone organ structure is improved.

The invention relates to an organ-like microsphere embedding slicing method. The method specifically comprises the following steps: 1) preparing hydrogel microspheres and dyeing the hydrogel microspheres with fuchsin; (2) dehydrating the dyed hydrogel microspheres and the organoid together, then putting the dehydrated hydrogel microspheres and the organoid into an embedding mold, adding an embedding agent for embedding, and obtaining an embedded sample after the embedding agent is solidified; and 3) slicing the embedded sample, and receiving the sliced sample by using a glass slide. According to the method, the hydrogel microspheres are firstly dyed, and the dyed hydrogel microspheres and the organoid are embedded together, so that the peripheral area of the organoid can be obviously red, and the magenta dyeing area on the section sample can be clearly observed even after the section sample is sliced. The hydrogel microspheres dyed by fuchsin can be used as positioning marks of organoid-containing microspheres, can provide obvious prompts in the early transparent dehydration process and the later embedding section process, and effectively help an operator to judge the section repairing degree and the section collecting degree.

The invention relates to a weight-losing and stomach-occupying device and a manufacturing method thereof.The weight-losing and stomach-occupying device is arranged in an inhalable mode and comprises a jelly substrate and hydrogel microspheres at least partially wrapped in the jelly substrate, and each hydrogel microsphere comprises a hydrogel microsphere body and a waterproof degradable film wrapping the hydrogel microsphere body; the material of the waterproof degradable film comprises chitosan and sodium alginate, the particle size of the hydrogel microsphere is 300-500 [mu] m, the waterproof degradable film can prevent the volume expansion of the hydrogel microsphere body in the jelly matrix, and the waterproof degradable film can be decomposed in a gastric acid environment to expose the hydrogel microsphere body wrapped in the waterproof degradable film, so that the size of the hydrogel microsphere body is reduced, and the hydrogel microsphere body is protected. The hydrogel microsphere body absorbs water to swell, stomach occupying is achieved, gastric emptying is prolonged, food intake is reduced through stomach occupying, the weight losing effect is achieved, and the weight losing and stomach occupying device is free of a rigid mechanical structure, has the amorphous characteristic, is smaller in compression and stimulation on the stomach, has flavor and can achieve the weight losing function when being taken, and the weight losing and stomach occupying device is suitable for being used for people. And a user can use the device more comfortably, so that the acceptability is higher, and the compliance of the user is improved.

The invention belongs to the technical field related to tumors, and discloses a preparation method of self-developing embolism microspheres. Comprising the following steps: producing calcium alginate microspheres through cross-linking, obtaining polyelectrolyte hydrogel microspheres through electrostatic complexation, and obtaining the self-developing embolism microspheres through amino cross-linking. According to the invention, sodium alginate and polyamino acid are used as raw materials for preparation, so that the preservative is safe and non-toxic and has biodegradability, and the degradation product has no toxic or side effect on human body. The microspheres are prepared by adopting an electrostatic spraying method, organic solvents are not used, and the microspheres are green and environment-friendly and have no toxic residues.

The invention relates to a heparinized gelatin / sodium alginate pancreas islet packaging material with an anti-fibrosis function as well as a preparation method and application of the heparinized gelatin / sodium alginate pancreas islet packaging material. The preparation method comprises the following steps: adding gelatin into normal saline, soaking, performing autoclaved sterilization to obtain a gelatin solution, then adding epsilon-polylysine hydrochloride into the gelatin solution, and finally adding glutamine transaminase for reaction to obtain an epsilon-polylysine grafted gelatin solution; adding heparin into the solution, and reacting to obtain a heparinized gelatin solution; adding sodium alginate and glutamine transaminase, reacting, diluting, preparing hydrogel microspheres by adopting an electrostatic spraying method, and cross-linking to obtain the hydrogel microspheres. According to the invention, heparin molecules are incorporated into a pancreas islet packaging system, so that fibrosis at the periphery of the microspheres can be relieved, the pancreas islet cells are packaged by using the pancreas islet packaging material to prepare the biological artificial pancreas, the pancreas islet cell proliferation and insulin secretion can be promoted, and the pancreas islet packaging material has a good diabetes treatment effect.

This invention belongs to the field of biopharmaceutical technology and specifically discloses size-controlled bacteriophage hydrogel microspheres and their preparation method. The hydrogel microspheres are composed of bacteriophage, a polymer carrier, and a curing agent and are prepared using electrostatic spray technology. Compared with existing hydrogel microsphere preparation methods, these hydrogel microspheres can significantly prolong the sustained release time of bacteriophage in the intestinal environment and improve their stability in the gastric environment. Furthermore, by adjusting the preparation parameters, the size of the microspheres can be flexibly controlled to meet different application scenarios and needs.

The invention discloses a preparation method of compound polysaccharide microspheres capable of releasing NO. The preparation method comprises the following steps: cross-linking swallow polysaccharide with L-ARG, and preparing L-ARG-containing swallow polysaccharide hydrogel through a Mannich reaction; then loading EGCG (epigallocatechin gallate) onto the L-ARG-containing swallow polysaccharide hydrogel through a Schiff base reaction, and obtaining the compound polysaccharide microspheres capable of releasing NO by utilizing an emulsification method. The invention also discloses an application thereof. The hydrogel microsphere capable of targeting the colon is prepared, and the hydrogel microsphere can be accurately exploded at the colon part after being swallowed. A dextran sodium sulfate (DSS)-induced IBD mouse model is established to test the drug effect, and the result shows that the compound polysaccharide microspheres have a remarkable treatment effect on DSS-induced ulcerative colitis, can obviously improve the symptoms of ulcerative colitis, and provides a theoretical basis and a clinical basis for new drugs for clinically preventing and treating ulcerative colitis.

The invention relates to a three-level lymphoid structure model and a preparation method thereof, and belongs to the technical field of cell biology. The method for preparing the three-stage lymphoid structure model comprises the following steps: S1, inducing and activating peripheral blood mononuclear cells by using an extracellular matrix to obtain activated peripheral blood mononuclear cells; s2, the peripheral blood mononuclear cells and the mesenchymal stem cells activated in the step S1 are coated with hydrogel, and hydrogel microspheres are obtained; and S3, culturing T cells and B cells by using the hydrogel microspheres obtained in the step S2 to obtain the three-stage lymphatic structure. The three-level lymphoid structure model obtained by the invention maintains long-term stability in vitro, the form is normal, and the activity of T cells and B cells is strong. The method can be used for dynamically observing the three-level lymphoid structure in the subsequent research immunotherapy and drug screening process, is used for high-throughput experiments, effectively improves the efficiency of drug screening experiments, and is high in accuracy.

The invention discloses a hydrogel microsphere system for sequential delivery of drugs as well as a preparation method and application thereof, and particularly relates to the technical field of biomedical materials. The microsphere system comprises inflammation responsive hydrogel microspheres obtained by grafting molecules containing inflammation responsive groups with hyaluronic acid as a skeleton, common microspheres obtained by grafting non-responsive molecules with hyaluronic acid as a skeleton, an anti-inflammatory drug and a healing promoting drug. Wherein the molecular weight of the hyaluronic acid is 74-800kDa, the inflammation responsive hydrogel microspheres are loaded with anti-inflammatory drugs, and the common microspheres are loaded with healing promoting drugs. According to the hydrogel microsphere system, the drug release rate and degradation time of the microspheres are adjusted by limiting the molecular weight of hyaluronic acid, and a molecular basis is provided for subsequent differentiated drug release.

The invention discloses a functional hydrogel microsphere and a preparation method and application thereof, and relates to the technical field of medicines.The preparation method comprises the steps that a hyaluronic acid methacrylic acid precursor solution and an IL-1beta shRNA adenovirus stock solution are mixed to obtain an Ad-atHAMA precursor solution; preparing the Ad (at) HAMA precursor solution through an oil-in-water micro-fluidic technology to obtain an Ad (at) HAMA microsphere; and sequentially adding the Ad (at) HAMA microspheres, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide into a 2-morpholinoethanesulfonic acid buffer solution, carrying out activating treatment, adding E selectin, and incubating to obtain the functionalized hydrogel microspheres. The functionalized hydrogel microspheres can inhibit a related mechanism of acute spinal cord injury pathological progress and promote neural function repair by targeting adsorption of neutrophil to regulate Nets-triggered innate immune inflammation cascade.

The invention belongs to the technical field of scale inhibitors, and particularly relates to a slow-release scale inhibitor and a preparation method thereof.The preparation method comprises the steps that 3, 4, 5-allyl trihydroxybenzoate, itaconic acid, sodium hydrogen sulfite, methacryloyloxyethyl-n-hexadecyl-dimethyl ammonium bromide and deionized water are mixed, after water bath heating, an ammonium persulfate aqueous solution is slowly added, and the scale inhibitor is obtained after reaction; the preparation method comprises the following steps: dissolving agar in deionized water, adding polyethylene glycol modified sodium alginate and a scale inhibitor into the deionized water, stirring, dropwise adding into edible oil to obtain gel microspheres, adding the gel microspheres into a calcium chloride aqueous solution, slowly stirring, cross-linking, cleaning and drying to obtain the slow-release scale inhibitor. The hydrogel microspheres swell to slowly release the scale inhibitor, meanwhile, the released scale inhibitor is hydrolyzed in water, ester groups are slowly broken, polycarboxylic acid, 3, 4, 5-trihydroxybenzoic acid and hydroxyethyl-n-hexadecyl-dimethyl ammonium bromide are slowly released, and good scale inhibition and corrosion inhibition effects are achieved.

The invention discloses a hydrogel microsphere sorting method, an artificial organ preparation method, a system and a medium. The method comprises the following steps: acquiring a hydrogel microsphere image in the micro-fluidic chip; analyzing the hydrogel microsphere image through a neural network to obtain an analysis result; based on the analysis result, hydrogel microspheres wrapping the target cells are sorted out; the neural network comprises a feature extraction layer and a multi-scale joint output head, and the hydrogel microsphere image is processed by the multi-scale joint output head after being convolved by the feature extraction layer to obtain an analysis result. According to the method, the hydrogel microspheres wrapped with the target cells are accurately identified and sorted by using a droplet microfluidic technology, a standardized artificial organ can be prepared based on the sorted hydrogel microspheres, and the functional maturity and reliability of the artificial organ are remarkably improved.

The invention discloses an injectable multifunctional intelligent response type strontium-containing hydrogel microsphere as well as a preparation method and application thereof, the strontium-containing hydrogel microsphere comprises a hydrogel microsphere carrier and a loaded medicine, and the hydrogel microsphere is obtained from lycium barbarum polysaccharide and a temperature-sensitive polymer through a microfluidic technology; the loaded medicine is strontium ions and a near-infrared light conversion material, the strontium ions are combined with the lycium barbarum polysaccharide in the microspheres through ion coordination, and the near-infrared light conversion material is combined with the microspheres through physical adsorption. The lycium barbarum polysaccharide and the temperature-sensitive polymer are combined, the bone regeneration promoting capacity is improved through the synergistic effect of the lycium barbarum polysaccharide and the temperature-sensitive polymer, the hydrogel microspheres have intelligent adjustability further through the near-infrared response performance, the strategic purpose of individualized drug delivery in time and space is achieved, and the application prospect is wide. The limitation that a hydrogel carrier cannot be administrated according to needs is avoided, and the hydrogel carrier is small in particle size, injectable and convenient in administration.

The invention discloses a hydrogel microsphere with a core-shell structure, the hydrogel microsphere comprises a sodium hyaluronate hydrogel core and a sodium alginate shell, and the sodium hyaluronate hydrogel core also comprises a slow release factor and divalent metal ions. The hydrogel microspheres with the sodium hyaluronate hydrogel as the inner core and the alginic acid as the shell can realize accurate targeted blasting in the intestinal tract, and can be adhered to the local part of the intestinal wall to induce benign intestinal flora to treat the inflammatory bowel disease, so that the phenomenon that when the medicine arrives at the intestinal tract, the medicine cannot be damaged is avoided; due to peristalsis of the intestinal tract, the medicine can not be accurately released to a specific position. The mass ratio of sodium hyaluronate to sodium alginate is controlled to be (4-20): 1, and the explosion speed of the microspheres is controlled, so that the release speed and the position accuracy of the medicine are controlled, the problem that the blood concentration of the medicine cannot be effectively controlled due to the fact that the release speed of the medicine is too high or too low is solved, the curative effect of the medicine is improved, and side effects are reduced.

The invention discloses a CuS / PGS-PSBMA-calcium alginate hydrogel microsphere for treating inflammatory bowel disease and a preparation method thereof, and the preparation method of the oral hydrogel microsphere comprises the following steps: (1) crosslinking CuS / PGS and PSBMA, and preparing the CuS / PGS-PSBMA hydrogel microsphere by adopting an air flow control technology; and (2) performing calcium ion diffusion cross-linking to obtain a core-shell structure hydrogel microsphere with calcium alginate as a shell and CuS / PGS-PSBMA as a core, thereby obtaining the CuS / PGS-PSBMA-calcium alginate hydrogel microsphere for treating the inflammatory bowel disease. The core-shell structure hydrogel microsphere for treating the inflammatory bowel disease is prepared by utilizing an air flow control technology and an ion diffusion method, can be accurately dissolved and release hydrogel at the colon part after being orally taken, and is adhered to the local intestinal wall to promote polarization of intestinal M2 macrophages, so that the inflammatory bowel disease is treated, and the curative effect is good. The medicine is a safe and multi-effect enteritis treatment medicine with clinical transformation significance.

The invention relates to core-shell hydrogel microsphere preparation equipment which comprises a microsphere preparation device and a microsphere collection device, the microsphere preparation device is provided with a nuclear phase inlet, a shell phase inlet, a plurality of nuclear phase distribution runners communicated with the nuclear phase inlet, and a plurality of shell phase distribution runners communicated with the shell phase inlet; the nuclear phase distribution flow channels and the shell phase distribution flow channels are converged into coaxial flow channels at the tail ends in a one-to-one correspondence manner; the microsphere collecting device comprises a microsphere collecting pool, the microsphere collecting pool is arranged below the coaxial flow channel, and the microsphere collecting pool is used for containing oil phase fluid; the nuclear phase fluid entering from the nuclear phase inlet and the shell phase fluid entering from the shell phase inlet form layered fluid at the coaxial flow channel, and the layered fluid is dropped into the microsphere collecting pool. According to the core-shell hydrogel microsphere preparation equipment provided by the invention, high-flux preparation of core-shell hydrogel microspheres can be realized.

The utility model provides a hydrogel microsphere preparation device, relates to the field of hydrogel microsphere preparation, and solves the problems that hydrogel microspheres with highly uniform particle sizes cannot be prepared in the existing hydrogel microsphere preparation process, so that the lubrication performance of the hydrogel microspheres is poor, and the like. The hydrogel microsphere preparation device comprises: a reaction chamber; the microporous pipeline is arranged at the bottom of the reaction chamber and is communicated with the reaction chamber; the continuous phase conveying assembly is communicated with the reaction chamber; the dispersed phase conveying assembly is communicated with the reaction chamber through a microporous pipeline; in the using state, the continuous phase conveying assembly conveys a continuous phase into the reaction chamber, the dispersed phase conveying assembly evenly divides the dispersed phase through the micropore pipeline, and the divided dispersed phase is conveyed into the reaction chamber to react with the continuous phase. According to the scheme provided by the utility model, the hydrogel microspheres can be rapidly prepared, and meanwhile, the high uniformity of the particle size of the hydrogel microspheres is ensured, so that the lubricity of the hydrogel microspheres is improved.

The invention belongs to the technical field of anticorrosive paint, and discloses intelligent corrosion inhibition hydrogel with double functions of pH sensitivity and corrosion self-early warning, preparation of the intelligent corrosion inhibition hydrogel and application of the intelligent corrosion inhibition hydrogel in modified epoxy resin anticorrosive paint. The preparation method comprises the following steps: preparing a water phase from quaternary ammonium salt chitosan, methacrylic anhydride, a photoinitiator and a corrosion inhibitor, taking a Span emulsifier and paraffin as an oil phase, dropwise adding the water phase into the oil phase, rapidly stirring to form a water-in-oil emulsion system, and rapidly preparing the pH-sensitive hydrogel microspheres coated with the corrosion inhibitor through photo-crosslinking. And finally, forming the corrosion self-early-warning shell by using the tannic acid modified hydrogel microspheres by adopting an electrostatic adsorption layer-by-layer assembly method. The intelligent corrosion inhibitor hydrogel and the modified anticorrosive paint prepared by the invention have double functions of pH sensitivity and corrosion self-early warning. And meanwhile, the material is green and environment-friendly, the preparation process is simple, the cost is low, the corrosion resistance is effectively improved, the corrosion resistance is enriched, and long-acting corrosion prevention is realized.

The invention discloses a periodontal local drug delivery system with antioxidant, anti-inflammatory and antibacterial synergistic effects and a preparation method of the periodontal local drug delivery system, and belongs to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: firstly, preparing an organic phase from DSPC, cholesterol, SA and resveratrol, and preparing a cationic liposome by taking PBS as a water phase; then preparing a water phase from AlgMA and LAP, taking a surfactant solution as an oil phase, and preparing polydopamine hydrogel microspheres through PDA surface modification; and finally, carrying out physical adsorption loading. Through the synergistic effect of the resveratrol, the cationic liposome and the polydopamine, a periodontitis pathological chain is comprehensively intervened, synergistic treatment is achieved, excellent antibacterial performance, anti-inflammatory effect and antioxidant effect are achieved, the retention rate of the medicine is increased, and the problems that traditional treatment medicine cannot achieve antibacterial, inflammation regulation and oxidative stress synergistic treatment at the same time, and the treatment effect is poor are solved. The residence time of the medicine in the periodontal pocket is short, and frequent administration is needed.

The invention relates to the technical field of medical instruments, and discloses mineralized collagen hydrogel microspheres, a preparation method thereof and a bone repair material, the mineralized collagen hydrogel microspheres are prepared from mineralized collagen and sodium alginate composite liquid through electrospray, sodium alginate serves as a carrier of mineralized collagen, the degradation rate of the mineralized collagen is remarkably reduced, and the bone repair effect is improved. Meanwhile, the gel microspheres also have a higher specific surface area, so that the attached cells can quickly form tissues; according to the bone repair material, normal saline and mineralized collagen hydrogel microspheres are used, mineralized collagen in the mineralized collagen hydrogel microspheres can remarkably improve the corrosion resistance of sodium alginate in the normal saline, and the slow release effect of hydrogel in the mineralized collagen hydrogel microspheres can be remarkably improved.

The present application provides a compound for preparing an embolization bead, a hydrogel bead, a preparation method therefor and a use thereof, the compound having a structure as shown in formula I. A hydrogel bead capable of carrying a chemical drug has a core-shell structure, comprising a shell formed from the compound, and a core formed from an ionic monomer polymeric segment. A hydrogel bead capable of carrying a protein has a core-shell structure, comprising a shell formed from the compound, and a core formed from a zwitterionic polymeric segment. The compound of the present application has good stability, which makes it possible to improve the stability of a hydrogel bead when the compound is used to prepare the hydrogel bead. The hydrogel beads of the present application have a super-hydrophilic core-shell structure, and the dense shell layer and high hydrophilicity cause the beads to have strong toughness, and not break when swelling. Dry beads of the hydrogel beads can quickly adsorb a drug solution, achieving high-efficiency, rapid and high-load drug loading, with significant sustained release effects for drugs or proteins, which can effectively regulate drug release.

The invention relates to the technical field of hydrogel microspheres, and particularly discloses hydrogel microspheres as well as a preparation method and application thereof. Sodium alginate and acrylamide are used for constructing a stable hydrogel skeleton structure with a certain mechanical property, and in a specific oil phase-hydrogel solution system, the release time and the release rate of Fe ions from an EDTA-Fe complex are accurately controlled by adjusting the pH value, so that the stability and the stability of the hydrogel are improved. The iron ions are released at proper time and rate and participate in the crosslinking reaction of the hydrogel, so that the hydrogel microspheres which are uniform in crosslinking, stable in performance and capable of accurately regulating and controlling the metal ions are prepared; besides, the lithium chloride can enhance the structural stability of a hydrogel network and adjust the plasticity of the hydrogel, so that the hydrogel is more flexible, and a uniform microsphere structure is favorably formed in the stirring and dispersing processes. The hydrogel microspheres prepared by the method have wide application prospects in the fields of drug controlled release, biosensing, environmental restoration and the like.