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Polymer hydrogel microspheres and preparation method thereof

A technology for hydrogel microspheres and polymers, applied in the field of polymers, can solve problems such as unfavorable patterned assembly, unfavorable application, difficulty in washing and separation, etc., and achieve the effects of good fluorescence regulation response with temperature and excellent fluorescence optical properties.

Active Publication Date: 2013-08-14
JIANGXI INST OF RARE EARTHS CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the past, there are usually two types of hydrogel microspheres used for micropatterned assembly in water phase: one is nanoscale microgel, which is mainly composed of hydrogel monomers, but this microgel is uniformly dispersed in water, It is extremely hydrophilic, and it is very difficult to wash and separate from the polymerization system, which is not conducive to controllable patterned assembly; the second is to use the two-step method of seed emulsion polymerization to first synthesize hard hydrophobic seed microspheres, and then coat the outer layer with soft However, the preparation and purification process of the two-step polymerized core-shell hydrogel microspheres is cumbersome, time-consuming, and the production cost is high, which is not conducive to application.

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  • Polymer hydrogel microspheres and preparation method thereof
  • Polymer hydrogel microspheres and preparation method thereof
  • Polymer hydrogel microspheres and preparation method thereof

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preparation example Construction

[0045] The polymer hydrogel microspheres provided by the invention include copolymers with thermosensitive response. In the present invention, the temperature-sensitive responsive copolymer is obtained by the copolymerization reaction of temperature-sensitive polymerized monomers, hard hydrophobic polymerized monomers and negatively charged functional polymerized monomers. The temperature-responsive copolymer has a dual structure of internal rigid stability and strong hydrophilicity of the external hydrogel, which makes the obtained polymer hydrogel microspheres have better mechanical stability and are easy to self-assemble . In the present invention, the preparation method of the copolymer with temperature-sensitive response preferably includes the following steps:

[0046] The temperature-sensitive polymer monomer, the hard hydrophobic polymer monomer and the negatively charged functional polymer monomer are mixed, an initiator is added therein, and a copolymerization react...

Embodiment 1

[0080] Weigh 0.0366g EuCl 3 ·6H 2 0, 0.018g oxalamide and 0.0139g picolinic acid, in molar ratio is that 1:2:1 is uniformly mixed in twice distilled water, slowly to wherein dripping molar concentration is the NaOH aqueous solution of 0.5mol / L, Adjust and maintain the pH of the solution at 6.5 to 7.0 to obtain 30 mL of the rare earth complex Eu(Oxamide) 2 Picolinic aqueous solution; The present invention carries out fluorescence test to the rare earth complex that obtains, and the result is as follows figure 1 as shown, figure 1 The fluorescence spectrum curves of the rare earth complex obtained in Example 1 of the present invention at different temperatures are respectively the fluorescence spectrum curves obtained at 25°C, 30°C, 35°C and 40°C, which are obtained by figure 1 It can be seen that the rare earth complexes prepared in the present invention have stable fluorescence properties, and the fluorescence spectrum curves obtained at different temperatures overlap, whic...

Embodiment 2

[0087] Weigh 0.0187g TbCl 3 ·6H 2 O, 0.089g Oxamic acid, 0.0836g Cinchomeronic acid, uniformly mixed in double-distilled water at a molar ratio of 1:2:1, and slowly added dropwise a NaOH aqueous solution with a molar concentration of 0.1mol / L to adjust and maintain the pH value of the solution 6.5~7.0, get 25mL Tb(Oxamic) 2 Cinchomeronic aqueous solution;

[0088] The Tb(Oxamic) that the present invention will obtain 2 Cinchomeronic aqueous solution carries out fluorescence test, and the result shows, the Tb(Oxamic) prepared by the present invention 2 Cinchomeronic aqueous solution has a strong fluorescence emission spectrum;

[0089] Add 5g VCL, 8g GMA and 1.5g Maleic acid in the reactor that contains 200mL distilled water, under room temperature, stir with the speed of 350 rev / mins, in the mixed solution that obtains, nitrogen exhausts 30 minutes; The mixed solution was warmed up to 75°C, and 10mL of NaBO containing 0.1g was added thereto 3 4H 2 The aqueous solution o...

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Abstract

The invention provides polymer hydrogel microspheres and a preparation method thereof. The preparation method comprises the following steps of: carrying out copolymerization reaction on a thermosensitive polymerized monomer, a hard hydrophobic polymerized monomer and a polymerized monomer with negative electricity functionality by adopting a one-step emulsion polymerization method; and reacting the obtained polymer with thermosensitive response with a rare earth complex to obtain the polymer hydrogel microspheres with fluorescence properties. According to the method, a polymer hydrogel with thermosensitivity is obtained through one-step method emulsion polymerization, and then the polymer hydrogel is used for reacting with the rare earth complex to obtain the needed product, so that the method is simple in process, the consumed time is shortened, and the production cost is relatively low. Moreover, the polymer hydrogel microspheres provided by the invention have a property of temperature response and good fluorescence optical properties, are intelligent materials with multi-responsiveness, can be uniformly dispersed in water, can be controllably and automatically assembled on a hydrophilic base material easily, and have important values in the fields of optical materials, biological medicine and the like.

Description

technical field [0001] The invention relates to the field of polymers, in particular to a polymer hydrogel microsphere and a preparation method thereof. Background technique [0002] Smart material is a new type of material that has a perceptible response to the environment, such as electricity, light, stress, strain, chemical or nuclear radiation, etc., and has the ability to perform functions. It can respond to external changes, select and control the response according to the set method, The response is sensitive, timely and appropriate, and can quickly return to the original state when the external stimulus is eliminated. Although the history of research and development of intelligent materials is not long, due to their unique properties, they are not only widely used in industrial and agricultural production and daily life, but also play an important role in the development of high-tech. [0003] In recent years, the research work on intelligent materials has been unpr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L25/08C08L33/14C08L25/18C08L33/12C08K5/00C08F212/08C08F220/32C08F212/14C08F220/14C08F220/54C08F220/58C09K11/06
Inventor 姜英男宋春雷林权杨旭东周扬苗越卓刘霞
Owner JIANGXI INST OF RARE EARTHS CHINESE ACAD OF SCI
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